Gene LRR8_w-2 (S.moellendorffii)

LRR8_w-2

Species: S.moellendorffii
Alias: LRR8_w-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_w-2.AA Protein None 1131 None Fasta, JSON
LRR8_w-2.NA RNA None 3396 None Fasta, JSON
LRR8_w-2.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of LRR8_w-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_w-2.AA LRRNT_2 24-59 36 6.4e-12 41.62 Pfam 1-46 (46) Show / Hide 
Range on Protein: 24-59
Range on HMM: 1-46/46
Sequence Identity: 36% (17 aa)

ESQDAQALLAFAHTFNN-------TLGWNSS---SGPCGWLGVSCS
 ..|.||||||   .|.        . ||.|   |..| | ||.|.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 LRR8_w-2.AA LRR_1 88-110 44 0.000715 17.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 88-110
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ELQSLNLSS-T--NLTGRIPPE-IGRC
 ||.|.||. .  |||| |||. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 112-134 40 7.8e-05 21.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 112-134
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLEFLDLSN-N--EVSGAIPDT-IGNL
.|. ||||. |   ..| ||.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 136-158 40 0.000768 17.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 136-158
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLQILNLQA-N--QLVGRIPPS-IKGC
.||.|.|.  |  .|.| |||| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 160-182 37 0.015326 13.18 Pfam 1-26 (26) Show / Hide 
Range on Protein: 160-182
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLDTLQLFD-N--RLNGTIPPE-IGHL
.| .| | . |  .| |.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 184-207 25 25.617025 1.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 184-207
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLRIIRGGG-N-AGISGPIPHE-IGNC
.|...  .| |   ..| ||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 218-231 46 68.615547 0.23 Pfam 13-26 (26) Show / Hide 
Range on Protein: 218-231
Range on HMM: 13-26/26
Sequence Identity: 46% (7 aa)

TNISGPIPPT-FGRL
.|..| |||  |  |
CNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 233-255 33 0.209892 9.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 233-255
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLESLLLYG-A--ALTGSIPDE-LCEC
.|..| | |     |||.||.. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 257-279 40 0.008882 14.02 Pfam 1-26 (26) Show / Hide 
Range on Protein: 257-279
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

ALQNLHLFQ-N--KLTGTIPVN-LGQL
 || |.|   |  .|||.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 281-303 40 0.043038 11.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 281-303
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLRRLLLWQ-N--ELTGGIPPS-VGGC
.|..| |   |   ||| ||||   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 305-327 40 0.018382 12.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 305-327
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

LLTEIDLST-N--SLSGGIPPE-VGHL
 |...|||  |  .|.| |||.   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 329-351 44 0.048375 11.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 329-351
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLQNFLVSI-N--NLTGRIPPE-FGDC
.||   .|  |  |||| |||. |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 353-375 33 0.021763 12.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 353-375
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ELKVLELDT-N--RLSGPLPDS-IGRL
 |..| |.  |  .|.| .|.| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 377-399 37 0.074744 10.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 377-399
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTLLFCWE-N--QLEGPIPDS-IVNC
||. |     |  .|.| ||.| . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 401-423 40 0.000507 18.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 401-423
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

HLNTLDLSY-N--RLSGPIPSK-IFSL
.| .||||. |  .|.| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 425-442 33 1.043726 6.68 Pfam 1-21 (26) Show / Hide 
Range on Protein: 425-442
Range on HMM: 1-21/26
Sequence Identity: 33% (7 aa)

SLERLLLIH-N--RLSGVLPE
.|..| | . |  .|.| .|.
NLQHLDLSGCNCCNLTGHIPP
LRR_1 LRR8_w-2.AA LRR_1 449-471 33 9.01092 3.36 Pfam 1-26 (26) Show / Hide 
Range on Protein: 449-471
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

VLVRLRVKE-N--LLVGGIPRS-LGSL
 | .| .   |   |.| || | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 473-495 44 5.3e-05 21.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 473-495
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLTFLDLEG-N--GLSGEIPEE-IGSL
||. ||| | |   |.|.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 497-519 40 0.407061 8.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 497-519
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLQGLVLVK-N--ELTGPVPAS-LGRL
.|| | |   |   ||| .| | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 521-543 40 0.012532 13.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 521-543
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

ALQLLDASS-N--QLEGEIPPQ-IGDM
 || || |. |  .|.|.|||  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 545-567 37 0.000109 20.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 545-567
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALEYLKLSN-N--RLTGKIPDD-LGLC
 |..| ||. |  .|||.||.. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 569-591 33 0.005675 14.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 569-591
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLLSLELAN-N--RLSGEIPAT-LGGL
.| .| | . |  .|.|.||   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 598-616 47 0.060327 11.07 Pfam 5-26 (26) Show / Hide 
Range on Protein: 598-616
Range on HMM: 5-26/26
Sequence Identity: 47% (11 aa)

LDLHS-N--SLTGSIPER-FADL
||| . |  .|||.||.. |  |
LDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 618-639 33 0.111074 10.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 618-639
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HLVRLDLAH-N--NLFGGVQL--LDKL
.| .||| . |  || | ..   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_w-2.AA LRR_1 641-665 39 0.003649 15.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 641-665
Range on HMM: 1-26/26
Sequence Identity: 39% (11 aa)

NLNFLNVSY-N--SFTGIIPSTDAFRNM
||  |..|. |  ..|| ||.  .| |.
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_w-2.AA TKL 774-1048 20 4.4e-57 195.96 In-house 1-364 (364) Show / Hide 
Range on Protein: 774-1048
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

IGRGSSGSVFKAKLPD---------GNEIAIKEIDFSSS---------------------RRANANHASFNSEVHT-LGSKVRHKNIVRLIGYCTNTKT-
||.|..| |.|.|.           |...|.| .   ..                     .   | .. |  |. . . |. || |||...|||.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ALLLYDFKSNGNLEELLHDADKKRSLDWELRYKIALGAAQGIAYLHHDCN-----PPILHRDIKANNILLGDSLE-------------
              . ... ..|.|...||         |..| ..||..|.|..||| .       |||.|||.| .|||. . ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PYIADFGLAKVLAEEDFVYPGK------------------IPGTTGYIAPEYSCRV----------------NITTKSDVYSYGVVLLEILTGRRALEQ
 . |.||||.... ..     ..                  . ||... |||                       ..|.||||.|.|| ||||..|    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

DKNVVDWVHGLMVRQQEEQQQHQLR-------VEALDSRLRGMPD----------PFIHEMLQCLGIALMCVKESPVERPSMKDVVAVL
            . ...   .....       . . | .||  ..          |  . . .   .. .| .. | .|||.....  |
------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_w-2.AA IRAK 768-1048 28 1.5e-52 180.87 In-house 1-317 (317) Show / Hide 
Range on Protein: 768-1048
Range on HMM: 1-317/317
Sequence Identity: 28% (93 aa)

FSKAVPIGRGSSGSVFKAKLPDGNE--IAIKEIDFSSSRRANANHASFNS---EVHTLGSKVRHKNIVRLIGYCTNTKTALLLYDFKSNGNLEELLHDAD
|.|.  || |  | |..... ....   |.| .    .   |    .|..   |. .. .. ||.||| | |||| .    | |.. .|| ||  |.  |
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVC-CRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD

KKRS---LDWELRYKIALGAAQGIAYLHHDC-NPPILHRDIKANNILLGDSLEPYIADFGLAKVL----AEEDFVY----PGKIPGTTGYIAPEYSC--R
   .   | |  | .|..|.| || .|| .    || |.|||  |||| . ..| |.||||.       . |. .|      .. ||| | .||.     
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

VNITTKSDVYSYGVVLLEILTGR-RALEQDKNVVDWVHGLMVRQQEEQQ---------------------QHQLRVEALDSRLRGMPDPFIHEMLQCLGI
  .|.|.|||| |.||||.|||. ... ..  .   .  ...  .|. .                     . | ..  .|.|  ..|  .  ||.||   
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQC---

ALMCVKESPVERPSMKDVVAVL
|. |. .   .|..|. |.. |
ACCCGHHRANRRCDMAWVMQQL
Kinase LRR8_w-2.AA TKL-Unique 774-970 31 9.7e-38 130.7 In-house 5-224 (290) Show / Hide 
Range on Protein: 774-970
Range on HMM: 5-224/290
Sequence Identity: 31% (70 aa)

IGRGSSGSVFKAKLPDGNEIAIKEIDFSSSRRANANHASFNSEVHTLGSKVR-HKNIVRLIGYCT----NTKTALLLYDFKSNGNLEELLHD-------A
||.|..|.|.|.| . | ..||| . .  .   |     |..|| .. .| . |.|||...|||.      .   .  .... |.| ..||.        
IGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWM-KKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

DKKRSLDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDS-----LEPYIADFGLAKVLA--EEDFVY-------PGKIPGTTGYIAPEYSC
 ..  |....|.|.|. .|||  |||| |.|||.|||.|  |.|.        .   |.||||.|...   . ..        .... |.. ..|||  .
NNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRC-GSFRWMAPEVLR

R--VNITTKSDVYSYGVVLLEILTG
.    ...||||||.|.|| ||.|.
MNFCQYSEKSDVYSFGIVLWEIATR
Kinase LRR8_w-2.AA Pkinase 768-971 24 1.7e-35 126.59 Pfam 1-209 (293) Show / Hide 
Range on Protein: 768-971
Range on HMM: 1-209/293
Sequence Identity: 24% (53 aa)

FSKAVPIGRGSSGSVFKAKLPDGNE-IAIKEIDFSSSRRANANHASFN-SEVHTLGSKVRHKNIVRLIGYCTNTKTALLLYDFKSNG----NLEELLHDA
. .  .||.||.|.|.|..  . ..  |.|.|. . ... . . . .. ||.. . .  .|.|||||...... .   .  ..  .|     | ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

DKKRSL--DWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDSLEP----YIADFGLAKVLAEEDFVYPGKIPGTTGYIAPEYSC-RVNITTK
......  ...   ....  ..|..|.|      |.|||.|  |||. .  ..     |.||||||.. .   . .  . || .|.|||    .  ...|
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVYSYGVVLLEILTGR
.|..|.|..| | |.||
VDMWSCGCILYEMLCGR
Kinase LRR8_w-2.AA LRRK 765-976 24 1.4e-34 119.74 In-house 1-285 (351) Show / Hide 
Range on Protein: 765-976
Range on HMM: 1-285/351
Sequence Identity: 24% (71 aa)

VESFSKAVPIGRGSSG-SVFKAKLPD---------------------------GNEIAIKEIDFSS------------------------------SRRA
... ..   ||||..| .|..||. .                           ....||| ... .                              .. .
LKIEEQ---IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDC

NANHASFNSEVHTLGSKVRHKNIVRLIGYCTNTKTALLLYDFKSNGNLEELLHDADKKR------SLDWELRYKIALGAAQGIAYLHHDCNPPILHRDIK
  .. .|  ||. . |. .| ||| |.|.| .     .  .. ..|.| ..||.  . .      ...| |..||||  | |..|| |..||||.||| |
CRAFREFRHEVWIM-SHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLK

ANNILLGDSLEPY------------IADFGLAKVLAEEDFVYPG---KIPGTTGYIAPEYSC---RVNITTKSDVYSYGVVLLEILTGR-RALEQ
  ||||  | ...            |||||.   .     ...|   .  |. |. |||      ... |.|.|.||.|..| |.||.. .. ..
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase LRR8_w-2.AA Ciliate-E2 768-972 20 2.8e-31 104.64 In-house 1-294 (365) Show / Hide 
Range on Protein: 768-972
Range on HMM: 1-294/365
Sequence Identity: 20% (62 aa)

FSKAVPIGRGSSGSVFKAKL-PDGNEIAIKEIDFSSSRRAN------------------ANHASFNSEVHTLG---------------SKVRHKNIVRLI
. .   ||.|. |||.|.|   .....||| ||   . . .                   .  ....| | .                ... |.||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

GYCT--NTKTALLLYDFKSNGNLEELLHDADKKR--------SLDWELRYKIALGAAQ---------------GIAYLHHDCNPPILHRDIKANNILLGD
 .    ....  |  .. . |.|.... . .|||        ..... . .|    .|               .. |||   |  |.||||| .|||.  
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF--

SLEPYIADFGLAK---------------VLAEEDFVYPGKIPG----------------TTGYIAPEYSCRVN---------ITTKSDVYSYGVVLLEIL
   . |.||||.|                .  . ...  . ||                | || |||   . .          ..|.|..| ||.| | |
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGRR
.|..
FGKP
Kinase LRR8_w-2.AA Dicty4 822-970 35 1.2e-30 99.61 In-house 53-213 (277) Show / Hide 
Range on Protein: 822-970
Range on HMM: 53-213/277
Sequence Identity: 35% (58 aa)

SKVRHKNIVRLIGYCT----NTKTALLLYDFKSNGNLEELLHD----ADKKRSLDWELRYK---IALGAAQGIAYLHHDCNPPILHRDIKANNILLGDSL
.| || ||. . |.||    .  . .    . . |||..||||      .. .|||.|. .   .|. ||.|...||  ||| |.|||.|. |.|  ...
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNW

EPYIADFGLAK-VLAEEDFVY--PGKIPGTTGYIAPEYSCRVNITTKSDVYSYGVVLLEILTG
   ..||||..    .||.     . . ||... |||       . |.||||.| || ||||.
RVKVCDFGLSQYMKKHEDHKDNQMTAC-GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTR
Kinase LRR8_w-2.AA MLK 774-971 26 1.4e-30 103.31 In-house 7-233 (291) Show / Hide 
Range on Protein: 774-971
Range on HMM: 7-233/291
Sequence Identity: 26% (61 aa)

IGRGSSGSVFKAKLPDGNE-----IAIKEID---FSSSRRANANHASFNSEVHTLGSKVRHKN----IVRLIGYCTNT-KTALLLYDFKSNGNLEELLHD
|| ||.|.|.|..   ...     .|.|...   | .. .. .    |. |.  | ....|.|    |... | |... .  ...  . ..| | ..||.
IGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHL-RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHG

ADKKRS-----------LDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGD------SLEPYIADFGLAKVLAEEDFVYPGKIPGTTGYIAP
|..| .            | ..  ..||  |.|..||| .  .|| |||.|  |||. .       .   |.|||... . . .     . .||  . ||
ARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAP

EY---SCRVNITTKSDVYSYGVVLLEILTGR
|    .     . |.||.|.|||| |.||..
EVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase LRR8_w-2.AA TK 768-969 15 1.4e-29 95.72 In-house 1-389 (486) Show / Hide 
Range on Protein: 768-969
Range on HMM: 1-389/486
Sequence Identity: 15% (61 aa)

FSKAVPIGRGSSG---SVFKAKLPDGN--------------------------EIAIKEIDFSSSRRANANHA-------------SFNSEVHTLGS-KV
      .|.|  |    |.|... ..|                          . |.| .   ..  ... ..             .. .|   . . . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHKNIVRLIGYCTNTKT------------ALLLYDFKSNGN----LEELLHDADKKRS------------------------------------------
.|.|||||.|.||  ..             ...  . ..|.    | . |.. ..|..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWELRYKIALGAAQGIAYLHHD----CNPPILHRDIKANNILLGDSLE-----------PYIADFG--
                               |. . .  ... .|.| .|||        . . |||. | |.|.|...              |||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKVLAEEDFVYPGKIPGTTG-------------------------YIAPEYSC---------RVNITTKSDVYSYGVVLLEILT
      ||. . ..|  |  . .||..                         . |||                ||||||.|.||.. ||.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase LRR8_w-2.AA LISK 773-936 27 3.3e-26 82.0 In-house 1-187 (296) Show / Hide 
Range on Protein: 773-936
Range on HMM: 1-187/296
Sequence Identity: 27% (54 aa)

PIGRGSSGSVFKAKLP-DGNEIAIKEIDFSSSR-----RANANHASFNSEVHTLGSKVRHKNIVRLIGYCTN-TKTALLLYDFKSNGNLEELLHDAD-KK
 ||.|. |.|.|  .  .|...|||.|    .|       ...   .. || .. .  ||.|||. .| | .  .   ..  . . |.|...|.| | .|
EIGKGFFGKVYKGTHRQTGQVMAIKMI----HRQPNDPNDPEYQKFMLREVQMMKN-LRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHK

RSLDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDS----LEPYIADFGLAKVLAEED-------------------FVYPGKIPG
  | |..| ||||. |.| .|||  .   |.||| |..|.|....     .  ..|||.|... .|.                   ... .|||.
IPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPK
Kinase LRR8_w-2.AA S_TKc 768-1051 18 1e-25 92.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 768-1051
Range on HMM: 1-231/231
Sequence Identity: 18% (56 aa)

FSKAVPIGRGSSGSVFKAKLPD-GNEIAIKEIDFSSSRRANANHASFNSEVHTLGSKVRHKNIVRLIGYCTNTKTALLLYDFKSN--GNLEELLHDADKK
. .  .||.|. |.|.|..  . | . |||.|.            .. .|.  | .  .|.|||.|.... . .   .  .. ..  |.| .....  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

RS---LDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDSLEPYIADFGLAKVLAEEDFVYPGKIPGTTGYIAPEYSCRVNITT-KSDVYSY
.    ..     ...   .....|.|      |.|||.|  |||| .  .  |.|||||..|          . ||  |.|||       .. |.|..| 
GLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLLEILTGRRALEQDKNVVDWVHGLMVRQQEEQQQHQLRVEALDSRLRGMPDPFIHEMLQCLGIALMCVKESPVERPSMKDVVA------VLEQI
|..| | |.|.   .   ..    . ..                                 ... .   | .  | .||.  .. .        . .
GCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_w-2.AA DRK 822-969 33 2.3e-25 82.91 In-house 52-197 (258) Show / Hide 
Range on Protein: 822-969
Range on HMM: 52-197/258
Sequence Identity: 33% (50 aa)

SKVRHKNIVRLIGYCTNTKTALLLYDFKSNGNLEELLHDADKKRSLDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDSLEPYIADFGLAK
.. || ||.  .| |.|    .    . . | |   ||  | . ..|| |. .... .| |. |||  ||| |.||| |  | |  ..    .|||||. 
CQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH--DESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLST

-VLAEEDFVYPGKIPGTTGYIAPEYSCRVNITTKSDVYSYGVVLLEILT
     ..        ||.. .|||       | | ||||...|| |..|
RFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase LRR8_w-2.AA Pkinase_Tyr 768-927 24 1.4e-18 63.55 Pfam 1-165 (270) Show / Hide 
Range on Protein: 768-927
Range on HMM: 1-165/270
Sequence Identity: 24% (41 aa)

FSKAVPIGRGSSGSVFKAKLP-----DGNEIAIKEIDFSSSRRANANHASFNSEVHTLGSKV-RHKNIVRLIGYCT-NTKT--ALLLYDFKSNGNLEELL
 ..   .|.|. |.|.|...      .. . |.| .  ... ..|  ...| .|. .. ..  .|.|||||.| ||   .    ..   .  .|.| . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIM-KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HDA-DKKRSLDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDSLEPYIADFGLAKVLAEED
..  . |..|. .   ....  |.| .||.      . |||. | |.|.....   |.|||||. . ..|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase LRR8_w-2.AA TyrKc 768-1048 21 5.8e-18 66.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 768-1048
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

FSKAVPIGRGSSGSVFKAKLPDGNEIAIKEIDFSSSRRANANHASFNSEVHTLGSKV--RHKNIVRLIGYCTNT-------KTALLLYDFKSNGNLEELL
 ..   .|.|  | |.|...    . |.| .  ..       .. | .|   . .|.  .|.|||||.|.||         .  ...  . ..|.| . |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIM-CKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

HDADKKRSLDWELRYKIALGAAQGIAYLHHDCNPPILHRDIKANNILLGDSLEPYIADFGLAKVLAEE-------DFVYP-----GKIPGTTGYIAPEYS
..  .|  | ..   .... .|.| .|||.    .. |||. | |.|.|. .   |.||||.. . ..       |   .     || .      |||  
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

CRVNITTKSDVYSYGVVLLEILTGRRALEQD-----KNVVDWVHGLMVRQQEEQQQHQLRVEALDSRLRGMPDPFIHEMLQCLGIALMCVKESPVERPSM
     ||||||.|.||.. ||.|       .     ..  . .. .. .   .| .. .  . . .       .  .. .    | ..| .| | .||..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSF-------VCCPDEMYQ--IMKQCWHEDPEDRPTF

KDVVAVL
....  .
SEIHECF
Kinase LRR8_w-2.AA LISK 952-973 45 1e-06 17.2 In-house 217-238 (296) Show / Hide 
Range on Protein: 952-973
Range on HMM: 217-238/296
Sequence Identity: 45% (10 aa)

TTKSDVYSYGVVLLEILTGRRA
....||.|.|.||.|| |...|
DESCDVFSFGIVLCEIITRVKA
Kinase LRR8_w-2.AA Pkinase_Tyr 952-969 66 0.00013 16.25 Pfam 192-209 (270) Show / Hide 
Range on Protein: 952-969
Range on HMM: 192-209/270
Sequence Identity: 66% (12 aa)

TTKSDVYSYGVVLLEILT
||||||.|.||.. ||.|
TTKSDVWSFGVLMWEIFT
Kinase LRR8_w-2.AA TK 1026-1048 21 0.000384 8.94 In-house 464-486 (486) Show / Hide 
Range on Protein: 1026-1048
Range on HMM: 464-486/486
Sequence Identity: 21% (5 aa)

IALMCVKESPVERPSMKDVVAVL
. ..| .. | .||......  |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_w-2.AA DRK 1030-1050 42 0.000459 9.7 In-house 238-258 (258) Show / Hide 
Range on Protein: 1030-1050
Range on HMM: 238-258/258
Sequence Identity: 42% (9 aa)

CVKESPVERPSMKDVVAVLEQ
|  | |  |||| ...  || 
CWNEDPQHRPSMQECLERLEA
Kinase LRR8_w-2.AA Dicty4 1030-1050 30 0.012575 4.78 In-house 255-277 (277) Show / Hide 
Range on Protein: 1030-1050
Range on HMM: 255-277/277
Sequence Identity: 30% (7 aa)

CVKESPVERPSMKDVVAV--LEQ
|  ..|  |||.. ..    || 
CWDHDPQHRPSFEEIIQRRILEH
Kinase LRR8_w-2.AA LRRK 1030-1050 33 0.019049 4.45 In-house 331-351 (351) Show / Hide 
Range on Protein: 1030-1050
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CVKESPVERPSMKDVVAVLEQ
| .. | .||.. ..| .|.|
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_w-2.AA MLK 1029-1048 35 0.024061 4.1 In-house 272-291 (291) Show / Hide 
Range on Protein: 1029-1048
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

MCVKESPVERPSMKDVVAVL
.| .. | .|||.. .|  |
QCWNQDPHKRPSFRQIVQHL
Kinase LRR8_w-2.AA LISK 1026-1048 39 0.047895 2.21 In-house 274-296 (296) Show / Hide 
Range on Protein: 1026-1048
Range on HMM: 274-296/296
Sequence Identity: 39% (9 aa)

IALMCVKESPVERPSMKDVVAVL
....|.|  | .||| |..| .|
LCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_w-2.AA Pkinase_Tyr 1028-1048 23 0.084979 6.71 Pfam 250-270 (270) Show / Hide 
Range on Protein: 1028-1048
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LMCVKESPVERPSMKDVVAVL
..| .. | .||......  |
KQCWHYDPEDRPTFSEIHEQL