Gene LRR8_f-2 (S.moellendorffii)

LRR8_f-2

Species: S.moellendorffii
Alias: LRR8_f-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_f-2.AA Protein None 904 None Fasta, JSON
LRR8_f-2.NA RNA None 2715 None Fasta, JSON
LRR8_f-2.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of LRR8_f-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_f-2.AA LRRNT_2 45-84 34 8e-06 21.85 Pfam 1-46 (46) Show / Hide 
Range on Protein: 45-84
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

RSSDLQILHSFSQQLV--DS-NASLTSWKLES----PCSSWEGVLCR
 ..|.| | .| . |.  |. . .| ||.  |    .|| |.|| | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS-WTGVTCD
LRR_1 LRR8_f-2.AA LRR_1 113-135 48 0.000218 19.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 113-135
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

FLQRLDLSQ-N--GLSGHIPVE-LLKL
 ||.||||  |   |.|||| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-2.AA LRR_TYP 111-135 40 0.085379 8.61 SMART 1-24 (24) Show / Hide 
Range on Protein: 111-135
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LKFLQRLDLSQNGLSGHIPVELLKL
|  |..|||| | |  |.| ...  
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 96-111 42 48.049006 0.78 Pfam 9-26 (26) Show / Hide 
Range on Protein: 96-111
Range on HMM: 9-26/26
Sequence Identity: 42% (8 aa)

Y-N-KFLTGQISPS-LGHL
. |   |||.|.|| . .|
GCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 161-183 44 3e-06 26.3 Pfam 1-26 (26) Show / Hide 
Range on Protein: 161-183
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLEYLYLSR-N--NLSGSIPRS-LGSC
||..|.||. |  ||.|.|| | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-2.AA LRR_TYP 159-183 36 0.00367 17.75 SMART 1-24 (24) Show / Hide 
Range on Protein: 159-183
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LENLEYLYLSRNNLSGSIPRSLGSC
| ||. |.||.|.|  ..|. . ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 137-159 37 0.074744 10.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 137-159
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ELTMLSLSS-N--QLSGEIPRH-MEML
 |. |.||. |  .|.|.||      |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 185-207 37 0.000334 19.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 185-207
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLKELDVSG-N--YLEGNVPVE-LGQL
.|..||.|| |   |.|..| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 257-279 37 0.001442 16.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 257-279
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLLVLYLSS-N--RFTGTIPED-LCVN
|| .|.||. |  ..||.||.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-2.AA LRR_TYP 231-255 40 0.038761 11.42 SMART 1-24 (24) Show / Hide 
Range on Protein: 231-255
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LPRLQNLWLNDNQLSGDLPVKLGRH
|| |. | |..|||   ||  . ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 233-252 34 0.039298 11.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 233-252
Range on HMM: 1-26/26
Sequence Identity: 34% (9 aa)

RLQNLWLND-N--QLSGDLPV---KL
.|| | |.. |  .|.|..|    .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_TYP LRR8_f-2.AA LRR_TYP 256-279 33 0.561006 1.91 SMART 2-24 (24) Show / Hide 
Range on Protein: 256-279
Range on HMM: 2-24/24
Sequence Identity: 33% (8 aa)

SNLLVLYLSSNRFTGTIPEDLCVN
.|| .|.||.|..| ..|.... .
PNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 209-231 37 1.57128 6.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 209-231
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLEKLGVAM-N--NLTGNVHPS-VATL
.|..| .   |  ||||...||    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 281-303 33 0.013547 13.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 281-303
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLERVYLHD-N--NLQGEIPPK-LLTC
 |.. .| . |  ||.|.|||  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 305-327 29 0.043885 11.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 305-327
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLERLLLQN-N--MLTGQVPEE-VGQN
.|..| |.. |   |||..|..   . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-2.AA LRR_TYP 303-327 40 0.536347 2.07 SMART 1-24 (24) Show / Hide 
Range on Protein: 303-327
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

CPKLERLLLQNNMLTGQVPEEVGQN
 |.|..| |.|| || ..|... |.
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 329-351 37 0.001931 16.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 329-351
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

VLNYLDLSN-N--RLNGSLPAS-LNDC
 | .||||. |  .| |..| | .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 353-368 31 1.397951 6.23 Pfam 1-19 (26) Show / Hide 
Range on Protein: 353-368
Range on HMM: 1-19/26
Sequence Identity: 31% (6 aa)

NLTTLFLAC-N--RISGDL
||..| | . |  ...|..
NLQHLDLSGCNCCNLTGHI
LRR_1 LRR8_f-2.AA LRR_1 374-396 40 0.000463 18.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 374-396
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLRQLNLSH-N--RLTGLIPRH-FGGS
.|. |.||. |  .||| ||   | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 421-442 37 0.020662 12.72 Pfam 1-26 (26) Show / Hide 
Range on Protein: 421-442
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLEKLFLDG-N--QLEGTIPR--FIGT
.|..| |.| |  .|.|.||   | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-2.AA LRR_TYP 372-395 50 0.023904 13.14 SMART 1-24 (24) Show / Hide 
Range on Protein: 372-395
Range on HMM: 1-24/24
Sequence Identity: 50% (12 aa)

FEQLRQLNLSHNRLTGLIPRHFGG
  .|| |.||.|.|| | |. |.|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRR8_f-2.AA LRR_TYP 419-443 32 0.12442 7.27 SMART 1-24 (24) Show / Hide 
Range on Protein: 419-443
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LQRLEKLFLDGNQLEGTIPRFIGTF
|  |..| |..|||  ..|. .   
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 397-419 40 0.168309 9.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 397-419
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

DIFTLDLSH-N--SLHGEIPPD-MQIL
 . .||||. |  .| |.|||.    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 469-491 44 9e-06 24.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 469-491
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLRRLDLSS-N--RLSGTIPAR-LENL
.|..||||. |  .|.|.|| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 493-515 44 0.00174 16.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 493-515
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

MLEDLDLSA-N--NLEGNIPSQ-LERL
 |. ||||  |  ||.|.||.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-2.AA LRR_1 445-467 33 0.008999 14.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 445-467
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLLALVLNN-N--KFTGSIPGD-LGGL
.|  | |.. |  ..||.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-2.AA LRR_TYP 467-490 40 0.05617 10.1 SMART 1-24 (24) Show / Hide 
Range on Protein: 467-490
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LHSLRRLDLSSNRLSGTIPARL-EN
|..||.||||.|.|  ..|... ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR8_f-2.AA LRR_TYP 491-515 36 0.109026 7.74 SMART 1-24 (24) Show / Hide 
Range on Protein: 491-515
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LRMLEDLDLSANNLEGNIPSQLERL
|. |. |||| |.|   .|... . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-2.AA LRR_1 517-548 25 0.223975 9.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 517-548
Range on HMM: 1-26/26
Sequence Identity: 25% (9 aa)

SLEHLNVSY-N-NHLL-APIPSASSKFNSSSFLGL
.|.||..|. |  .|           . .|.| .|
NLQHLDLSGCNCCNLTGH--------IPPSCF-NL
Kinase LRR8_f-2.AA TKL 630-897 20 1.3e-62 214.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 630-897
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

IGQGGYGTVYRAEMES---------GKVLAIKKLTIAA-----------------------EDSLMHEWE-------TAGKVRHRNILKVLG---HYRHG
||.||.|.||...            ||. |.||. .                         .. .... .          . || ||.. .|     ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

G----------SALLVSNFMTNGSLGSLLHGRCSNEKISWQLRYEIALGIAHGLSYLHHDCV-----PKIIHRDIKANNILLDKDMV-------------
.             .|  .. .||| ..||         |..|  .||.|| |..||| .       |.|||||.| .|||.|...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKIADFGLAKLIEKEAETKSMSY-----------------IAGSYGYIAPEYAFTL----------------KVNEKSDIYSFGVILLELLLRKTPLD-
 .||.||||.. .... . . ...                 . |.... |||                     . .||.|.||||..| |.| |..| . 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

PLFSETDGNMTVWVRNETRGSSTGLESVADPEMWRE---ASRIEKKEMERVFQIALLCTKGNPADRPTMQQIVEML
. ... ...  . .  .  . .   .    |. |..   .   ..  .... ...  | . .| .||..|.|.. |
YPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKM-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_f-2.AA IRAK 625-817 33 5.9e-45 155.66 In-house 2-218 (317) Show / Hide 
Range on Protein: 625-817
Range on HMM: 2-218/317
Sequence Identity: 33% (72 aa)

NQEFIIGQGGYGTVYRAEMESGK-VLAIKKL-------TIAAEDSLMH---EWETAGKVRHRNILKVLGHYRHGGSALLVSNFMTNGSLGSLLHGRCSNE
.... ||.||.|.|||...     . |.|||       ..  . ..     | ..  . || ||. ..|    ..   ||  .|.||||   |...    
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

K---ISWQLRYEIALGIAHGLSYLHHDC--VPKIIHRDIKANNILLDKDMVPKIADFGLAKLI----EKEAETK---SMSYIAGSYGYIAPEYAF--TLK
     ||. | .|..|.| |. .|| .   .| |||.|||  |||||....|||.||||.       .||. |      | . |.  | .||.    . .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTP-IIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VNEKSDIYSFGVILLELL
   |.|.||||. |||.|
LTKKTDVYSFGIVLLEVL
Kinase LRR8_f-2.AA MLK 624-822 25 5.4e-44 150.52 In-house 1-235 (291) Show / Hide 
Range on Protein: 624-822
Range on HMM: 1-235/291
Sequence Identity: 25% (61 aa)

LNQEFIIGQGGYGTVYRAEMESGK----VLAIKKLTIAA---------EDSLMHEWETAGKVRHRN----ILKVLGH-YRHGGSALLVSNFMTNGSLGSL
.. . .|| |..| |.....        ..|.|. .. .          . .  | . . ...|.|    | ...|   ...   ..|. .. .||| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGRCSNEK-----------ISWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLD------KDMVPKIADFGLAKLIEKEAETKSMSYIAGSYG
|||. |..            .. ..   .|| .|.|..||| . ...|||||.|  |||.|      .... ||.|||... . .    . |   ||.| 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTYA

YIAPEYAF----TLKVNEKSDIYSFGVILLELLLRKTP
. ||| ..      |..||.|..|.||.| |.| |..|
WMAPE-VIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_f-2.AA Pkinase 624-822 26 7.7e-39 138.41 Pfam 1-211 (293) Show / Hide 
Range on Protein: 624-822
Range on HMM: 1-211/293
Sequence Identity: 26% (57 aa)

LNQEFIIGQGGYGTVYRAEMESG-KVLAIKKLTIAAEDSLMH-------EWETAGKVRHRNILKVLGHYRHGGSALLVSNFMTNG----SLGSLLHGRCS
.  . .||.|..|.||..   .  |. |.|..    |.| ..       | .   ...| ||.. .. .. ...  .|  .. .|    .| .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

NEKI--SWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVP----KIADFGLAKLIEKEAETKSMSYIAGSYGYIAPEYAF-TLKVNEKS
. ..  |..    ... |. || |.|     .|||||.|  |||.|.....    ||.||||||... .     |. ..|...|.|||      .   |.
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIYSFGVILLELLLRKTP
|..|.|.|| |.|....|
DMWSCGCILYEMLCGRPP
Kinase LRR8_f-2.AA LISK 629-822 26 6.5e-35 110.72 In-house 1-238 (296) Show / Hide 
Range on Protein: 629-822
Range on HMM: 1-238/296
Sequence Identity: 26% (63 aa)

IIGQGGYGTVYRAEME-SGKVLAIKKLTI--------AAEDSLMHEWETAGKVRHRNILKVLGHYRH-GGSALLVSNFMTNGSLGSLLHGRCS-NEKISW
.||.|..| ||. .   .|.| |||....        ...  .  | ..  . ||.||..  | ..|  |.  .|  ..  | |  .|. . .    ..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLD----KDMVPKIADFGLAKLIEKEAET---------------------------------KSM
..|  |||.|| |.||||  .   ||||| |..|.|..     .   |..|||.|.....|                                    ..|
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

SYIAGSYGYIAPEYAFTLKVNEKSDIYSFGVILLELLLRKTP
. | |.    |||     . .|..|..|||..|.|.  |...
T-ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase LRR8_f-2.AA Dicty4 624-817 34 6.8e-34 110.55 In-house 1-211 (277) Show / Hide 
Range on Protein: 624-817
Range on HMM: 1-211/277
Sequence Identity: 34% (73 aa)

LNQEFIIGQGGYGTVYRAEMESGKVLAIKKLTIAAED-------SLMHEWETAGKVRHRNILKVLGHYR----HGGSALLVSNFMTNGSLGSLLHG----
.| | .||.|..|.||..    ||  |.|||    ..       .. .| .  .| || ||.. .|       | |. . |. .|  |.| ||||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

RCSNEKISWQLRYE---IALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAETKS-MSYIAGSYGYIAPEYAFTLKVNEKS
  .. |..| |.     .|. .| |. .||  | | |||||.|. |.| ||... |..||||.... |. . |  ..  .|. .. |||       |||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DIYSFGVILLELL
| |||| .| |.|
DVYSFGIVLWEIL
Kinase LRR8_f-2.AA S_TKc 624-899 21 4.8e-33 117.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 624-899
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

LNQEFIIGQGGYGTVYRAEMES-GKVLAIKKLTIAAEDSLMHEWETAGKVRHRNILKVLGHYRHGGSALLVSNFMTN--GSLGSLLHGRCSNEK---ISW
     .||.|..|.||..   . |.. |||..     .... | .   | .| || | ...... ..  .|  .. .  |.| .... | .. .   .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAETKSMSYIAGSYGYIAPEYAFTLKVNE-KSDIYSFGVILLEL
     ..  |. .| |.|     .|||||.|  |||||.  . ||.|||||...         . . |.  |.|||     . .  |.|..|.|.|| |.
-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LLRKTPLDPLFSETDGNMTVWVRNETRGSSTGLESVADPEMWREASRIEKKEMERVFQIALLCTKGNPADRPTMQQIVE-------MLRT
| ...| .        .| .  ..                             . . ..   | . .|..|||  .. .       .   
LCGYPPFP--------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_f-2.AA RIPK 630-822 27 2.4e-32 107.53 In-house 1-227 (290) Show / Hide 
Range on Protein: 630-822
Range on HMM: 1-227/290
Sequence Identity: 27% (63 aa)

IGQGGYGTVYRAEMESGKVLAIKKL-----TIAA-----EDSLMHEWETAGKVRHRNILKVLGHYRHG-----GS-ALLVSNFMTNGSLGSLLHGRC--S
.| || |.|..|   . .. ..||       ...     .  .  | .   | |...|....|  .       .    .|  .| ||||  .|| ..   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

NEKISWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAETK----------SMSYIA-GSYGYIAPEYAF--TL
.  . | ||  .   |. |  || |.  | ||||| |  |||.| ..  ||||||||.  .    ..          . |    |   |..||  .    
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

KV----NEKSDIYSFGVILLELLLRKTP
|     ..|.|.|||.... |.| .| |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR8_f-2.AA TK 624-817 14 2.1e-31 101.97 In-house 1-388 (486) Show / Hide 
Range on Protein: 624-817
Range on HMM: 1-388/486
Sequence Identity: 14% (58 aa)

LNQEFIIGQGGYG---TVYRAEMESGK--------------------------VLAIKKLTIAAEDSLMH-----------------EWETAGKVR----
.  .  .|.| .|   .||..|.....                            |.| |.  ...| .                  |.| . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNILKVLGHYRHG------------GSALLVSNFMTNGS----LGSLLHGRCS---------------------------------------------
 | ||.. .|.  .|            .  ..|  .| .|.    | . |. .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NEKISWQLRYEIALGIAHGLSYLHHD----CVPKIIHRDIKANNILLDKDMV-----------PKIADFGLA
                            ..... . .  ... || |..|||        ....|||. | |.|.....|            |||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KLIE----KEAETKSMSYIAGSYG----------------------------YIAPEYAF---------TLKVNEKSDIYSFGVILLELL
.  .    .. . ..  | ..|||                            . |||  .         . |  .|||..|||| . |..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase LRR8_f-2.AA TKL-Unique 629-822 32 5.7e-31 106.54 In-house 4-233 (290) Show / Hide 
Range on Protein: 629-822
Range on HMM: 4-233/290
Sequence Identity: 32% (76 aa)

IIGQGGYGTVYRAEMESGKVLAIKKLTIAAEDSLMH-------EWETAGKVR-HRNILKVLGHYR----HGGSALLVSNFMTNGSLGSLLH-------GR
 ||.||||.||...  . .| |||.. .  |||          |  .  | . | ||..  |       . .   .|. ..  ||| ..||         
KIGEGGYGQVYKGKWRGYPV-AIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

CSNEKISWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKD-----MVPKIADFGLAKLIEKE-AETKSMS------YIAGSYGYIAPEYAFT
 .| |...|.|. .|. || |. ||||   | |||||.|  |.|.| .     .  ||.||||.|.  |. ..|....         ||. ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--LKVNEKSDIYSFGVILLELLLRKT------P
   . .||||.||||..| |.. ||       |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_f-2.AA RAF 624-822 27 4.4e-30 94.49 In-house 1-220 (282) Show / Hide 
Range on Protein: 624-822
Range on HMM: 1-220/282
Sequence Identity: 27% (61 aa)

LNQEFIIGQGGYGTVYRAEMESG---KVLAIKKLTIAAEDS---LMHEWETAGKVRHRNILKVLGHYRHGG--SALLVSNFMTNGSLGSLLHGRCSNEKI
.     ||.| .|||||..       |.| ....| .          |     | || |||  .|  ..    .   | ..    ||   .|   . || 
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

SWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEA--ETKSMSYIAGSYGYIAPEYAF--------------TLK
  .   .|.. .. |..|||     .|||||.| |||.|. ||  || ||||...  ..     . .    ..  ..||| .               .. 
DMHWLIDISRQVCQGMDYLHAK---NIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP

VNEKSDIYSFGVILLELLLRKTP
   .||.||||... ||..|. |
YSFQSDVYSFGIVMYELMTRHMP
Kinase LRR8_f-2.AA LRRK 696-824 35 6.2e-26 88.73 In-house 136-284 (351) Show / Hide 
Range on Protein: 696-824
Range on HMM: 136-284/351
Sequence Identity: 35% (54 aa)

FMTNGSLGSLLHGRCSNE------KISWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILL---D---------KDMVPKIADFGLAKLIEKEAET
....|.| ..|| . ...      .|||.|...||| || |. || |.. |.||||| |  ||||   .          ... ||||||.  .  .   .
YAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHM

KSMSYIAGSYGYIAPEYAF---TLKVNEKSDIYSFGVILLELLLRK-TPLD
.  .   |  |. |||      .   .||.|.||||.|| ||| |.  | |
GVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_f-2.AA Pkinase_Tyr 624-811 25 8.4e-25 84.62 Pfam 1-202 (270) Show / Hide 
Range on Protein: 624-811
Range on HMM: 1-202/270
Sequence Identity: 25% (53 aa)

LNQEFIIGQGGYGTVYRAEME-----SGKVLAIKKL--TIAAE----DSLMHEWETAGKV-RHRNILKVLGHYR-HGGS--ALLVSNFMTNGSLGSLLHG
.     .|.| .|.||....       .   |.|.|  .   |    ...|.| ..  .  .| ||.. .|    .|..   ..|  .| .|.| . |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R-CSNEKISWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAET-KSMSYIAGSYGYIAPEYAFTLKVNEKSDI
.  ...... .   .... || |..||.      .||||. | |.|.....| ||.|||||..|... .  .. .         |||  .. | ..|||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGV
.||||
WSFGV
Kinase LRR8_f-2.AA TyrKc 624-897 21 6.6e-20 73.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 624-897
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

LNQEFIIGQGGYGTVYRAEMESGKVLAIKKLTIAAEDSLMHEWETAGKV--RHRNILKVLGHYRHG-------GSALLVSNFMTNGSLGSLLHGRCSNEK
.  . ..| | .|.||....      |.|.|   |.  .|.| .   |.  .| ||.. .|  ...       .  ..|  .| .|.| . |. .  .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ISWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKE------AETKSMSY--IA---GSYGYIAPEYAFTLKVNEK
....   .... || | .|||.    ..||||. | |.|.... . ||.||||.. |. .       ......    .     .   |||  .. | ..|
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDIYSFGVILLELLLRKTPLDPLFSETDGNMTVWVRNETRGSSTGLES----VADPEMW---REASRIEKKEM----------ERVFQIALLCTKGNPAD
||..|||| . |..                        |.| .   .     . . |.    ..  | .. .           . ..|| . | . .|.|
SDVWSFGVCMWEIF------------------------TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RPTMQQIVEML
|||...|.| .
RPTFSEIHECF
Kinase LRR8_f-2.AA TK 869-897 27 2e-06 17.04 In-house 447-486 (486) Show / Hide 
Range on Protein: 869-897
Range on HMM: 447-486/486
Sequence Identity: 27% (11 aa)

M-----------ERVFQIALLCTKGNPADRPTMQQIVEML
|           | .... . | . .|.||||..|..|.|
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_f-2.AA LRRK 624-656 24 5e-06 17.19 In-house 1-61 (351) Show / Hide 
Range on Protein: 624-656
Range on HMM: 1-61/351
Sequence Identity: 24% (15 aa)

LNQEFIIGQGGYG-TVYRAEMES---------------------------GKVLAIKKLTI
|  |  ||.||.| .||||....                           ..  ||||...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNR
Kinase LRR8_f-2.AA LRRK 878-899 36 1e-05 16.29 In-house 330-351 (351) Show / Hide 
Range on Protein: 878-899
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

LCTKGNPADRPTMQQIVEMLRT
.| ...| .||...|||. | .
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_f-2.AA Pkinase_Tyr 870-897 32 0.000168 15.87 Pfam 243-270 (270) Show / Hide 
Range on Protein: 870-897
Range on HMM: 243-270/270
Sequence Identity: 32% (9 aa)

ERVFQIALLCTKGNPADRPTMQQIVEML
. . .. ..| . .|.||||...|.|.|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LRR8_f-2.AA MLK 883-897 46 0.000215 11.3 In-house 277-291 (291) Show / Hide 
Range on Protein: 883-897
Range on HMM: 277-291/291
Sequence Identity: 46% (7 aa)

NPADRPTMQQIVEML
.|..||...|||. |
DPHKRPSFRQIVQHL
Kinase LRR8_f-2.AA RAF 879-899 33 0.001655 6.9 In-house 262-282 (282) Show / Hide 
Range on Protein: 879-899
Range on HMM: 262-282/282
Sequence Identity: 33% (7 aa)

CTKGNPADRPTMQQIVEMLRT
| | .. .||  |||....  
CWKFQREERPLFQQILKRITV
Kinase LRR8_f-2.AA TKL-Unique 879-897 31 0.001763 8.35 In-house 272-290 (290) Show / Hide 
Range on Protein: 879-897
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CTKGNPADRPTMQQIVEML
| . .| .||. ..|.. |
CWHHDPSQRPSFDEIIHRL
Kinase LRR8_f-2.AA Dicty4 883-899 26 0.001988 7.49 In-house 259-277 (277) Show / Hide 
Range on Protein: 883-899
Range on HMM: 259-277/277
Sequence Identity: 26% (5 aa)

NPADRPTMQQIVEM--LRT
.|  ||....|..   | .
DPQHRPSFEEIIQRRILEH
Kinase LRR8_f-2.AA LISK 873-897 32 0.008675 4.66 In-house 272-296 (296) Show / Hide 
Range on Protein: 873-897
Range on HMM: 272-296/296
Sequence Identity: 32% (8 aa)

FQIALLCTKGNPADRPTMQQIVEML
..... |.| .| .||.   ||. |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_f-2.AA IRAK 865-897 18 0.160572 1.36 In-house 285-317 (317) Show / Hide 
Range on Protein: 865-897
Range on HMM: 285-317/317
Sequence Identity: 18% (6 aa)

EKKEMERVFQIALLCTKGNPADRPTMQQIVEML
.... .  .| |. |. .  . |..| . .. |
PPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR8_f-2.AA Pkinase 883-897 35 2.726302 2.11 Pfam 277-293 (293) Show / Hide 
Range on Protein: 883-897
Range on HMM: 277-293/293
Sequence Identity: 35% (6 aa)

NPADRPTMQQIVEM--L
.|..||| .||..   .
DPKKRPTAEQILQHPWF