Gene LRR8_z (S.moellendorffii)
LRR8_z
Species: S.moellendorffii
Alias: LRR8_z
External Links:
Annotation:
Sequence
Protein domains of LRR8_z.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRRNT_2 | LRR8_z.AA | LRRNT_2 | 22-62 | 39 | 5.2e-14 | 48.42 | Pfam | 1-46 (46) | Show / Hide |
Range on Protein: 22-62 Range on HMM: 1-46/46 Sequence Identity: 39% (18 aa) GFQDKSALLALKAAMI--DS-SGSLDDWTETD-D-TPCLWTGITCD .|. ||||.|... |. .|.| .|. .. | ..| |||.||| HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD |
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| LRR_1 | LRR8_z.AA | LRR_1 | 67-89 | 33 | 5.056357 | 4.25 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 67-89 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) RVVALDLSN-K--NLSGIFSSS-IGRL . ||||. ||.| ...| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 91-113 | 33 | 0.570572 | 7.61 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 91-113 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) ELINLTLDV-N--NFTGNLPSE-LATL | | |. | |.||..|.. . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 115-137 | 37 | 0.003442 | 15.48 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 115-137 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) DLHFLNVSH-N--TFTGDFPGR-FSNL | |..|. | .||..| . | || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 139-161 | 29 | 0.025434 | 12.4 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 139-161 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) LLEVLDAYN-N--NFSGPLPIE-LSRL |..|| . | |..| .| . . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 163-185 | 44 | 0.005081 | 14.88 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 163-185 Range on HMM: 1-26/26 Sequence Identity: 44% (12 aa) NLRHLHLGG-S--YFEGEIPPS-YGNM ||.||.|.| ..|.|||| |. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 187-209 | 40 | 0.030112 | 12.14 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 187-209 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) SLSYLALCG-N--CLVGPIPPE-LGYL .| .| | | | .|.| |||. . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 211-234 | 37 | 0.018263 | 12.91 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 211-234 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) GLEELYLGYFN--HFTGGIPPE-LGRL |..|.|...| ..|| |||. . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 236-258 | 44 | 0.000296 | 19.26 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 236-258 Range on HMM: 1-26/26 Sequence Identity: 44% (12 aa) NLQKLDIASC---GLEGVIPAE-LGNL |||.||. .| |.| || . . || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 260-282 | 40 | 0.162932 | 9.54 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 260-282 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) NLDSLFLQI-N--HLSGPIPPQ-LGDL || .| |. | .|.| ||| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 284-306 | 51 | 1.1e-05 | 24.31 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 284-306 Range on HMM: 1-26/26 Sequence Identity: 51% (14 aa) NLKSLDLSN-N--NLTGAIPIE-LRKL ||..||||. | |||| || . . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 308-330 | 37 | 1.416225 | 6.21 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 308-330 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) NLELLSLFL-N--GLSGEIPAF-VADL ||. |.| | |.|.|| | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 332-354 | 37 | 0.231366 | 9.0 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 332-354 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) NLQALLLWT-N--NFTGELPQR-LGEN ||| | | | |.||..| . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 356-375 | 50 | 0.001112 | 17.22 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 356-375 Range on HMM: 1-26/26 Sequence Identity: 50% (13 aa) NLTELDVSS-N--PLTGPLPP---NL ||..||.|. | .||| .|| || NLQHLDLSGCNCCNLTGHIPPSCFNL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 380-402 | 33 | 0.008433 | 14.1 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 380-402 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) QLEVLVLIE-N--GITGTIPPA-LGHC .|..| | | .||.||| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 404-426 | 37 | 0.009855 | 13.86 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 404-426 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) SLIKVRLAG-N--HLTGPIPEG-LLGL .| . | | | .||| ||.. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 428-449 | 33 | 24.479786 | 1.82 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 428-449 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) MLEMLELLD-N--RLTGMIPA--IVDA |. | | . | .||| || . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 451-473 | 40 | 0.052295 | 11.29 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 451-473 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) LLDFLDLSQ-N--ELQGSIPAG-VARL | |||| | |.|.|| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 475-497 | 33 | 0.018382 | 12.9 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 475-497 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLQKLFLHS-N--QFVGGIPVE-LGQL .||.| | . | ...| || . . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 499-521 | 37 | 0.001119 | 17.21 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 499-521 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) HLLHLDLHS-N--RLSGAIPAE-LAQC .| |||| . | .|.| || . . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 523-545 | 37 | 0.000352 | 18.99 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 523-545 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) KLNYLDVSD-N--RLTGPIPAE-LGSM .| .||.|. | .||| || . . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 547-569 | 33 | 0.633044 | 7.45 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 547-569 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) VLELLNVSR-N--RLSGGIPPQ-ILGQ |. |..|. | .|.| ||| . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRR8_z.AA | LRR_1 | 571-595 | 28 | 0.299992 | 8.6 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 571-595 Range on HMM: 1-26/26 Sequence Identity: 28% (8 aa) SLTSADFSY-N--DFSGTVPSDGHFGSL .|.. |.|. | ..|..|.. | .| NLQHLDLSGCNCCNLTGHIPPS-CF-NL |
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| Kinase | LRR8_z.AA | TKL | 708-983 | 22 | 1e-64 | 221.28 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 708-983
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)
IGRGGSGTVYRAEMPN---------GEVVAVKRLCKATSDETGSGSHD---------------------HGFSAEIQTLGKIRHRNIVKLLGCCSNEET-
||.||.|.||... . |..||||.. . .||. . | . . || . ..|| |||...|.| ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------NLLVYEYMPNGSLGELLHSKKRNLLDWTTRYSIAVQSAFGLCYLHHDCS-----PLIVHRDVKSNNILLDSGFE--------------
.|.||.|.||| ..|| | | ..| . | |..||| . | |.||| ||.|||.|. ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC
AHVADFGLAKFFQASSAGKCES---------------MSSIAGSYGYIAPEYA-----YT-----------LKVSEKADIFSFGVVLLELITGRKPTEQE
. ..||||..|.. |. .. . ... |.... ||| || .. |||.|..|||.|| |..|...| ...
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY
FRDSGLGIVKWVKKVMDEAKDGVLSIVDSTLRSS----QLPVHEVTSLVGVALICCEEYPSDRPTMRDVVQML
.. .. .. . . | | . .. . . . .|. . |... |..||.. .... |
PYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
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| Kinase | LRR8_z.AA | IRAK | 704-983 | 28 | 1.3e-57 | 197.68 | In-house | 3-317 (317) | Show / Hide |
Range on Protein: 704-983 Range on HMM: 3-317/317 Sequence Identity: 28% (93 aa) EDNIIGRGGSGTVYRAEMPNGE-VVAVKRLCKATSDETGSGSHDHGFSA---EIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPNGSLGELLHSKK-R .|| || || |.|||... | . ..|||.| . . .. ..|. | . |.... ..|| ||| |.| |. .. |||.||||||| |. . KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSW--NEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ NL---LDWTTRYSIAVQSAFGLCYLHHDCS--PLIVHRDVKSNNILLDSGFEAHVADFGLAKFF---QASSAGKC--ESMSSIAGSYGYIAPEYAY--TL . | | .| ||. .| |. .|| . . |.| |.|.|| ||||| |.. .||||. | ... .... | . |. | .||. . . CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPII-HGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG KVSEKADIFSFGVVLLELITGRKPTEQEFRDSGLGIVKWVKKVMDEAK--DGVLS----------------I------VDSTLRSSQLPVHEVTSLVGVA . . | |..|||.||||..||... . . . .. . .|.|.. | .| . .|. | . .| .. .. .| QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYY-LKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDH--RMPPCPPNMEKEMCQCA LICCEEYPSDRPTMRDVVQML . | .. |..|. |.| | CCCGHHRANRRCDMAWVMQQL |
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| Kinase | LRR8_z.AA | MLK | 702-910 | 29 | 1.6e-47 | 162.92 | In-house | 1-235 (291) | Show / Hide |
Range on Protein: 702-910 Range on HMM: 1-235/291 Sequence Identity: 29% (71 aa) LIEDNIIGRGGSGTVYRAEMPNGE----VVAVKRLC-KATSDETGSGSHDHGFSAEIQTLGKIRHRN----IVKLLGCCSNEETN-LLVYEYMPNGSLGE . . .|| |..| |..... | . .||||| . | ... . | |. | ...|.| |....|.|.... . ..| ||...||| . IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN LLHS-KKRNL-----------LDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDS------GFEAHVADFGLAKFFQASSAGKCES-MSSIA .||. .. | ..|.| | |. ||| . ..|.||| || |||.| . . ..|||...... . | . | | | VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQM----C-TNMMSNA GSYGYIAPEY---AYTLKVSEKADIFSFGVVLLELITGRKP |.| . ||| . |.|||.|..|.|||| |..|.. | GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP |
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| Kinase | LRR8_z.AA | Pkinase | 702-908 | 25 | 3.7e-41 | 146.6 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 702-908
Range on HMM: 1-209/293
Sequence Identity: 25% (59 aa)
LIEDNIIGRGGSGTVYRAEMPNGEV-VAVKRLCKATSDE--------TGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPNG----S
. .||.|..|.||.. . . ||||...| . .. . .||| . ...| |||.|.... .. .| ||...| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMD
LGELLH-SKKRNL-LDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEA----HVADFGLAKFFQASSAGKCESMSSIAGSYGYIAPEY
| .... ...... ... . ... | . || |.| |.|||.|. |||.|. . ...||||||.|. . . |....|...|.|||
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEV
AY-TLKVSEKADIFSFGVVLLELITGR
. . |.|..|.|..| |...||
IRGGQYYGPKVDMWSCGCILYEMLCGR
|
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| Kinase | LRR8_z.AA | TKL-Unique | 706-907 | 31 | 5.3e-41 | 142.34 | In-house | 3-224 (290) | Show / Hide |
Range on Protein: 706-907
Range on HMM: 3-224/290
Sequence Identity: 31% (72 aa)
NIIGRGGSGTVYRAEMPNGEVVAVKRLCKATSDETGSGSHDHGFSAEIQTLGKIR-HRNIVKLLGCCS----NEETNLLVYEYMPNGSLGELLHS-----
| ||.||.|.||... .|. ||.|.. . .| . . . |. |. .. |.. | |||.. | | . .| ||.| ||| ..||
NKIGEGGYGQVYKGKW-RGYPVAIKQFHP-NEDSSNEMMQE--FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN
---KKRNLLDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSG-----FEAHVADFGLAKFFQASSAGKCESM-----SSIAGSYGYIAPEY
.. . |.. |...| . | |..|||| | | ||| || |.|.|.. . . ..||||.|| ..... .. ||. ..|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV
AYT--LKVSEKADIFSFGVVLLELITG
. |||.|..|||.|| |..|.
LRMNFCQYSEKSDVYSFGIVLWEIATR
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| Kinase | LRR8_z.AA | RIPK | 708-915 | 30 | 4e-40 | 134.43 | In-house | 1-232 (290) | Show / Hide |
Range on Protein: 708-915
Range on HMM: 1-232/290
Sequence Identity: 30% (71 aa)
IGRGGSGTVYRAEMPNGEVVAVKRL--CKATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSNEET------NLLVYEYMPNGSLGELLHSKKR-
.|.||.|.|..| ....| || . . . | . . |.|...||...| | || .| |||.|||| ..||.| .
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY
----NLLDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQASSAGK--C-----ESMSSIA--GSYGYIAPEYAY-
... . | . .. . | ||| |. | | ||| | |||.|. | . .||||||.. . |. .. | || | | |..||
QHHPDPWPLRCR--MIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT
-TLKV----SEKADIFSFGVVLLELITGRKPTEQEF
| ..| |. ||..|. |. |...| | ..
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRK
|
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| Kinase | LRR8_z.AA | S_TKc | 702-983 | 22 | 1.9e-38 | 134.94 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 702-983
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)
LIEDNIIGRGGSGTVYRAEMPN-GEVVAVKRLCKATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPN--GSLGELLHSKKR
..||.|. |.||.. . |..||.|.. . ||| | | .| |||||.... . . .| ||... |.| .......|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
N-----LLDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQASSAGKCESMSSIAGSYGYIAPEYAYTLKVSE-KA
. . ..|. .. | . .| |.| |.|||.| |||||. . ..|||||... ... |. |.||| . . |.
HGLRFPFPE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKC
DIFSFGVVLLELITGRKPTEQEFRDSGLGIVKWVKKVMDEAKDGVLSIVDSTLRSSQLPVHEVTSLVGVALICCEEYPSDRPTMRDVVQ---------ML
|. |.|..| |...|. | . . . ||.. .. |.. |..||| .. | .
DWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | LRR8_z.AA | LISK | 707-922 | 26 | 2e-35 | 112.41 | In-house | 1-253 (296) | Show / Hide |
Range on Protein: 707-922 Range on HMM: 1-253/296 Sequence Identity: 26% (70 aa) IIGRGGSGTVYRAEMP-NGEVVAVKRLCK----ATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSN-EETNLLVYEYMPNGSLGELLHSK--KR .||.|. | ||. . |.|.|.| . . . .|. . . |.|.. ..||.|||. | | . . .| ||. | | ..|... . EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEY-----QKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHK NLLDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLD----SGFEAHVADFGLAKFFQASSAGKC----------------------------- | |. | .||. | |. ||| . |.||| ||.|.|.. ..... |.|||.|. .. .. . | IPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQ --ESMSSIAGSYGYIAPEYAYTLKVSEKADIFSFGVVLLELITGRKPTE-QEFRDS--GLGI ..| .| |. ||| . .|..|.||||.||.|.||..|... . |.. ..|. RKRRM-TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGL |
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| Kinase | LRR8_z.AA | STE | 703-908 | 24 | 1e-34 | 120.04 | In-house | 1-265 (359) | Show / Hide |
Range on Protein: 703-908 Range on HMM: 1-265/359 Sequence Identity: 24% (66 aa) IED-NIIGRGGSGTVYRA--------EMPNGEV---------VAVKRLCKATSD-----------ETGSGSHDHGFSAEIQTLGKIR--HRNIVKLLGCC |. .||.|..||||.| . ..||| .|.|.. . ... |. . . ||... | . | |||| .||. WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY SNE-------ETNLLVYEYMPNGSLGELLH---SKKRNL---------LDWTTRYSIAVQSAFG-LCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADF .| .. .. |||..||| .... .....| .. . |..| | | ||| |.|||.|. |||| . .|| FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF GLAKFFQASSAGK------------CESMSSIAGSYGYIAPEYAYT------LKVSEKADIFSFGVVLLELITGR |... .. |.|.. . ...|. . ||| . ..|.|| |.| ...|..||. GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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| Kinase | LRR8_z.AA | Dicty4 | 702-910 | 33 | 6.9e-34 | 110.53 | In-house | 1-216 (277) | Show / Hide |
Range on Protein: 702-910
Range on HMM: 1-216/277
Sequence Identity: 33% (75 aa)
LIEDNIIGRGGSGTVYRAEMPNGEVVAVKRL--CKATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCS----NEETNLLVYEYMPNGSLGELLHS
. ...||.|. |.||.. | |||| | . ..|| . | .|. ..|||| ||....| | . .. . | |||| |.| .|||.
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNE----FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHD
-----KKRNLLDWTTRYS---IAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQASSAGKCESMSSIAGSYGYIAPEYAYTLK
... |||... . .| | |. .|| | | |.||| || |.| | . . |.||||.. .. . | ... .|. .. |||
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDN-QMTACGTPCWMAPEVMMHQP
VSEKADIFSFGVVLLELITGRKP
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YNEKADVYSFGIVLWEILTRQEP
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| Kinase | LRR8_z.AA | LRRK | 702-910 | 26 | 9.7e-33 | 113.14 | In-house | 1-282 (351) | Show / Hide |
Range on Protein: 702-910 Range on HMM: 1-282/351 Sequence Identity: 26% (77 aa) LIEDNIIGRGGSG-TVYRAEMPN---------------------------GEVVAVKRLCK---------------------------ATSDETGSGSHD |.. . |||||.| .||||.. . .. ||.| . . . .| ..... LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR --HGFSAEIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPNGSLGELLHSKKRN-L------LDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNN . | |. . . .| |||.|.| | . . .| ||.|.|.| ..||.||.. . ..|.... ||.| | |. || |...| |.||| || | AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPN ILL---D---------SGFEAHVADFGLAK-FFQASSAGKCES--MSSIAGSYGYIAPEYAY---TLKVSEKADIFSFGVVLLELITGR-KP ||| . |..||||. | |. . . . | |. ||| . .||.|..|||..| ||.|.. | ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QC-----FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP |
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| Kinase | LRR8_z.AA | Pkinase_Tyr | 702-855 | 27 | 5.1e-32 | 109.06 | Pfam | 1-159 (270) | Show / Hide |
Range on Protein: 702-855 Range on HMM: 1-159/270 Sequence Identity: 27% (46 aa) LIEDNIIGRGGSGTVYRAEMP-----NGEVVAVKRLCKATSDETGSGSHD---HGFSAEIQTLGKI-RHRNIVKLLGCCS-NEET--NLLVYEYMPNGSL .. . .|.| |.||.... .. |||| | | |. ... | .|.... .. .| |||.|.|.|. .| ..| ||||.|.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL GELLHSK--KRNLLDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAK . |... .. |. . ....| | |. ||. ..|||. |.|..... . ..|||||. LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR |
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| Kinase | LRR8_z.AA | TK | 702-910 | 17 | 6.5e-32 | 103.69 | In-house | 1-394 (486) | Show / Hide |
Range on Protein: 702-910
Range on HMM: 1-394/486
Sequence Identity: 17% (69 aa)
LIEDNIIGRGGSG---TVYRAEMPNG--------------------------EVVAVKRLCK--ATSDET----------GSGSHDHG-----FSAEIQT
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ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG------GEDFLEEAEEMKM
LG--KIRHRNIVKLLGCCSNEET------------NLLVYEYMPNGS----LGELLHSKKRN--------------------------------------
. . .| |||.|.|.|. .|. ..| ||||.|. | . |......
MCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC
------------------------------------LLDWTTRYSIAVQSAFGLCYLHHD-CSPL---IVHRDVKSNNILLDSGFE-----------AHV
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PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKI
ADFGLAKFFQ--ASSAGKCESMSSIAGSYG----------------------------YIAPEYAY---------TLKVSEKADIFSFGVVLLELIT-GR
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ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQ
KP
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EP
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| Kinase | LRR8_z.AA | TyrKc | 702-983 | 23 | 1.9e-26 | 95.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 702-983 Range on HMM: 1-280/280 Sequence Identity: 23% (73 aa) LIEDNIIGRGGSGTVYRAEMPNGEVVAVKRLCKATSDETGSGSHDHGFSAEIQTLGKI--RHRNIVKLLGCCSNE-------ETNLLVYEYMPNGSLGEL . . ..|.| |.||.... . |||| | . . | |.. . |. .| |||.|.|.|. . | ..| ||||.|.| . ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LHSKKRNLLDWTTRYSIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQAS-------SAGKC----ESM--SSIAGSYGYIA |...... | . . |...| | | |||. ..||| |.|..... . ..||||... . . . | | LRKHRPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR----WMA PEYAYTLKVSEKADIFSFGVVLLELIT-GRKPTEQEFR--DSGLGIVKWVKKV-MDEAKDGVL--SIVDSTLRSSQLPVHEVTSLVGVALICCEEYPSDR || . | ..| |..||||.. |. | | .| . . | ....||. . . . .. | . |. . . . . |..| |.|| PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------F---VCCPDEMYQIMKQCWHEDPEDR PTMRDVVQML ||...... . PTFSEIHECF |
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| Kinase | LRR8_z.AA | TK | 965-983 | 36 | 5.2e-05 | 11.91 | In-house | 468-486 (486) | Show / Hide |
Range on Protein: 965-983 Range on HMM: 468-486/486 Sequence Identity: 36% (7 aa) CCEEYPSDRPTMRDVVQML |... |.||||.......| CWHYDPEDRPTFSQLHEQL |
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| Kinase | LRR8_z.AA | Pkinase_Tyr | 965-983 | 36 | 0.002976 | 11.64 | Pfam | 252-270 (270) | Show / Hide |
Range on Protein: 965-983 Range on HMM: 252-270/270 Sequence Identity: 36% (7 aa) CCEEYPSDRPTMRDVVQML | .. |.||||.......| CWHYDPEDRPTFSEIHEQL |
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| Kinase | LRR8_z.AA | MLK | 964-983 | 40 | 0.005584 | 6.33 | In-house | 272-291 (291) | Show / Hide |
Range on Protein: 964-983 Range on HMM: 272-291/291 Sequence Identity: 40% (8 aa) ICCEEYPSDRPTMRDVVQML .| .. |..||..| .|| | QCWNQDPHKRPSFRQIVQHL |
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| Kinase | LRR8_z.AA | LISK | 961-983 | 34 | 0.009904 | 4.47 | In-house | 274-296 (296) | Show / Hide |
Range on Protein: 961-983 Range on HMM: 274-296/296 Sequence Identity: 34% (8 aa) VALICCEEYPSDRPTMRDVVQML ... ||. |..||. ..|| | LCFDCCKYDPKNRPSFKEIVQWL |
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| Kinase | LRR8_z.AA | Pkinase_Tyr | 889-910 | 43 | 0.019303 | 8.89 | Pfam | 192-214 (270) | Show / Hide |
Range on Protein: 889-910 Range on HMM: 192-214/270 Sequence Identity: 43% (10 aa) SEKADIFSFGVVLLELIT-GRKP ..| |. ||||.. |..| |..| TTKSDVWSFGVLMWEIFTYGEQP |
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| Kinase | LRR8_z.AA | Dicty4 | 965-985 | 26 | 0.024171 | 3.82 | In-house | 255-277 (277) | Show / Hide |
Range on Protein: 965-985 Range on HMM: 255-277/277 Sequence Identity: 26% (6 aa) CCEEYPSDRPTMRDVVQM--LVD | ...|. ||.. ..| | CWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | LRR8_z.AA | TKL-Unique | 965-983 | 31 | 0.096612 | 2.14 | In-house | 272-290 (290) | Show / Hide |
Range on Protein: 965-983 Range on HMM: 272-290/290 Sequence Identity: 31% (6 aa) CCEEYPSDRPTMRDVVQML |. ||.||. ... | CWHHDPSQRPSFDEIIHRL |
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| Kinase | LRR8_z.AA | LRRK | 965-985 | 28 | 0.147534 | 1.26 | In-house | 331-351 (351) | Show / Hide |
Range on Protein: 965-985 Range on HMM: 331-351/351 Sequence Identity: 28% (6 aa) CCEEYPSDRPTMRDVVQMLVD | .. | .||.. ..|. | . CWQHDPKKRPHFSQIVKRLSQ |
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