Gene LRR8_n-2 (S.moellendorffii)

LRR8_n-2

Species: S.moellendorffii
Alias: LRR8_n-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_n-2.AA Protein None 1041 None Fasta, JSON
LRR8_n-2.NA RNA None 3126 None Fasta, JSON
LRR8_n-2.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of LRR8_n-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_n-2.AA LRRNT_2 32-76 26 3.1e-05 19.89 Pfam 1-46 (46) Show / Hide 
Range on Protein: 32-76
Range on HMM: 1-46/46
Sequence Identity: 26% (13 aa)

PTDEASILKSLAESMD---P-AKLLQDWWSDPSSGAAASHCQWSGVTCS
. |..  | ..  |..   | .  |..| .. |    ...|.|.||||.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSS---DSDCCSWTGVTCD
LRR_1 LRR8_n-2.AA LRR_1 81-103 25 15.746681 2.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 81-103
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

PVTSLDLHS-K--NLSGSLSSH-LGRL
  ..||| .    ||.|....  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 105-127 37 0.006016 14.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 105-127
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLSFLNLSD-N--ALSGPLPPA-IAEL
.|  |.||. |   |.| .||  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 129-151 33 0.010863 13.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 129-151
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLTVLDIAV-N--LFSGELPPG-LGSL
||..||.   |   ..|..||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 153-175 29 0.044171 11.55 Pfam 1-26 (26) Show / Hide 
Range on Protein: 153-175
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLRFLRAYN-N--NFSGAIPPD-LGGA
.|. |   . |  |..| |||. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 177-199 37 0.063543 10.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 177-199
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALEHLDLGG-S--YFDGAIPSE-LTAL
 |.||||.|     . | ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 201-223 48 0.000391 18.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 201-223
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

SLRLLRLSG-N--VLTGEIPAS-IGKL
.|. | ||| |   |||.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 225-248 44 0.001105 17.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 225-248
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ALQVLQLSY-N-PFLSGRIPDS-IGDL
 ||.| ||. | . |.| ||.| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 250-272 48 0.000253 19.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 250-272
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

ELRYLSLERC---NLSGAIPPS-IGNL
 |..|.| .|   ||.| |||| . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 298-320 48 0.000149 20.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 298-320
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

ELMSLDLSN-N--SLSGPIPDS-FAAL
 | .||||. |  .|.| ||.| | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 322-344 29 5.501651 4.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 322-344
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLTLLNLMI-N--DLSGPLPRF-IGEL
.|. |.|   |   |.| .|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 346-368 29 0.255037 8.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 346-368
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLQVLKIFT-N--SFTGSLPPG-LGSS
.||.| .   |  ..||..||. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 394-415 33 0.045629 11.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 394-415
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLVKLEFFA-N--RLTGSIPD--LSNC
.| .| .   |  .|||.||.  . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 370-393 29 1.310059 6.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 370-393
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLVWIDASS-N--RLSGPIPDWICRGG
 |  .| |. |  .|.| ||.... . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 417-439 25 0.161878 9.55 Pfam 1-26 (26) Show / Hide 
Range on Protein: 417-439
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

QLVRVRLHE-N--RLSGPVPRE-FGSM
.| .  |   |  .|.| .| . | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 441-463 29 2.573804 5.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 441-463
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLNKLELAD-N--LLSGEIPDA-LADA
 | .| | . |   |.|.||.  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 465-488 44 0.009176 13.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 465-488
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

QLSSIDLSG-N--RLSGGIPPRLFTVP
.| ..|||| |  .|.| |||. |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 489-511 37 0.02679 12.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 489-511
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

QLQELFLAG-N--GLSGVIPRG-IGEA
.||.| | | |   |.| || . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 513-535 40 9.2e-05 21.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 513-535
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLQKLDLSD-N--ALSGTIPEE-IAGC
.||.||||. |   |.|.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 537-559 37 0.048062 11.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 537-559
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RMIAVDLSG-N--RLSGEIPRA-IAEL
.    |||| |  .|.|.||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 561-583 37 0.92859 6.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 561-583
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

VLATVDLSR-N--QLTGAIPRV-LEES
 | . |||. |  .||| ||   .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_n-2.AA LRR_1 585-606 22 3.874613 4.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 585-606
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

TLESFNVSQ-N--ELSGQMPT--LGIF
.|.. ..|  |   |.|. |   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRR8_n-2.AA TKL 731-1011 20 2e-61 210.4 In-house 1-364 (364) Show / Hide 
Range on Protein: 731-1011
Range on HMM: 1-364/364
Sequence Identity: 20% (80 aa)

VGKGAAGTVYKAEMKN---------GEVLAVKKLNTSA----------------------RKDTAGHVQRGFLAEVNLLGGIRHRNIVRLLGYCSNGDT-
.|.|. |.|||.. ..         |.. ||||...                        . ..| . .  .  |....  .|| |||...||| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------SLLIYEYMPNGSLSDALHGKAGSVLADWVARYKVAVGIAQGLCYLHHDCF-----PQIVHRDVKSSNILLDADME-------------
              ...||.|.||| . ||         |  | . | .||.|..||| . .     |.|.||| ||.|||.| ...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-ARVADFGVAKLVECSDQ-------------------PMSVVAGSYGYIPPEYAYTM----------------RVDERGDVYSFGVVLLELLTGKRPVE-
 . ..||| .. .. | .                     . . |.... .||    .                  .|. ||||||.|| |.||..|| . 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

PEFGDNV------NIVEWVRHKILQ--CNTTSNNPASHKVSNSVLDPSIAAPGSSVEEEMVL--VLRIALLCTSKLPRERPSMRDVVTML
. . . .       . ..| .| |.  . .. .|                 .   . .. ..  . ...  | .  |..|||. ...  |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQN--------------HH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_n-2.AA IRAK 726-930 37 9.8e-58 198.12 In-house 2-224 (317) Show / Hide 
Range on Protein: 726-930
Range on HMM: 2-224/317
Sequence Identity: 37% (83 aa)

TDSNVVGKGAAGTVYKAEMKNGE-VLAVKKLNTSARKDTAGHVQRGFLA---EVNLLGGIRHRNIVRLLGYCSNGDTSLLIYEYMPNGSLSDALHGKAGS
  .|. |.|. |.||....|| . . |||||   |   . .| || |..   |. ..  .|| ||| |.|||. ..   |.|.||||||| | |.. .|.
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQR-FQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VL---ADWVARYKVAVGIAQGLCYLHHDC-FPQIVHRDVKSSNILLDADMEARVADFGVAKLV----ECSDQPM-----SVVAGSYGYIPPEYAY--TMR
.      |  | ... |.| |. .|| .     | |.|.||.|||||.....  .||| .       .  .|.      |.| |.  | |||. .  . .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VDERGDVYSFGVVLLELLTGKRPV
   . ||||||.||||.||| |.|
LTKKTDVYSFGIVLLEVLTGCRAV
Kinase LRR8_n-2.AA MLK 725-929 26 2.3e-44 151.8 In-house 1-235 (291) Show / Hide 
Range on Protein: 725-929
Range on HMM: 1-235/291
Sequence Identity: 26% (65 aa)

LTDSNVVGKGAAGTVYKAEMKNGE----VLAVKKLNTSARKDTAGHV--QRGFLAEVNLLGGIRHRN----IVRLLGYCSNGDT-SLLIYEYMPNGSLSD
.. . ..|.|. | |.|....| .    ..|||. ..... | .     |. |  |...|  ..|.|    |....| |..     ... ||...|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALHGKAG-----------------SVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDA------DMEARVADFGVAKLVECSDQPMSVV
 |||. .                 .....|      |. .|.|. ||| .  ..|.||| ||.|||.|.      .. ....|||... . .... |   
VLHGARSKWMDANHNQKNDRVYDHDHAMNW------ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN

AGSYGYIPPEY---AYTMRVDERGDVYSFGVVLLELLTGKRP
||.| .  ||    .   ...|  ||.|.|||| |.||.. |
AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_n-2.AA Pkinase 725-969 22 4.9e-42 149.7 Pfam 1-268 (293) Show / Hide 
Range on Protein: 725-969
Range on HMM: 1-268/293
Sequence Identity: 22% (64 aa)

LTDSNVVGKGAAGTVYKAEMKNGEV-LAVKKLNTSARKDTAG--HVQRGFLAEVNLLGGIRHRNIVRLLGYCSNGDTSLLIYEYMPNG----SLSDALHG
..   ..|.|. |.|||.  |. .   |||... . .|.     |. .   .|. ..  ..| |||||.... ..|   .. ||...|    .|.| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KAGSVL--ADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEA----RVADFGVAKLV-ECSDQPMSVVAGSYGYIPPEYAY-TMRVDE
... ..   .|... ...  |..|| |.|      |.|||.|..|||.| ...     ...|||.||.. . ... |....|...|..||        . 
WRHGCFYFSEWECK-FYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

RGDVYSFGVVLLELLTGKRPVEPEFGD----NVNIVEWVRHKILQCNTTSNNPASHKVS-----------------NSVLD
. |..|.|..| |.|.|.    |  |.    | .   ..  .|... . .. | .. .|                  . .|
KVDMWSCGCILYEMLCGR---PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD
Kinase LRR8_n-2.AA S_TKc 725-1015 20 5.3e-39 136.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 725-1015
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

LTDSNVVGKGAAGTVYKAEMKN-GEVLAVKKLNTSARKDTAGHVQRGFLAEVNLLGGIRHRNIVRLLGYCSNGDTSLLIYEYMPN--GSLSDALHGKAG-
 .  ...|||| |.|||.  |. |.. |.|...            . .. |...|   .| |||.|.... . |   .. ||...  |.| | .. . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

---SVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEARVADFGVAKLVECSDQPMSVVAGSYGYIPPEYAYTMRVDE-RGDVYSF
   ...   .||. ..  |...| |.|     .|.|||.| .|||||   .  ..|||.|...       . . |.  |..||       .  . |..|.
GLRFPFPE-HARF-YMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLLELLTGKRPVEPEFGDNVNIVEWVRHKILQCNTTSNNPASHKVSNSVLDPSIAAPGSSVEEEMVLVLRIALLCTSKLPRERPSMRDVVT-----ML
|..| |.|.|. | .    .   . . ..                                        .. .   |  | |..||.  .. .     ..
GCILYEMLCGYPPFP----QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

SEAM
 . .
HPWF
Kinase LRR8_n-2.AA TKL-Unique 727-929 31 2e-37 129.58 In-house 1-233 (290) Show / Hide 
Range on Protein: 727-929
Range on HMM: 1-233/290
Sequence Identity: 31% (75 aa)

DSNVVGKGAAGTVYKAEMKNGEVLAVKKLNTSARKDTAGHVQRGFLAEVNLLGGIR-HRNIVRLLGYCS----NGDTSLLIYEYMPNGSLSDALHG----
..|..| |..|.|||.. .  .| |.|...     |    . . |  |||..  .. | |||.. |||         . .. ||.| ||| | ||     
FWNKIGEGGYGQVYKGKWRGYPV-AIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----KAGSVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDAD-----MEARVADFGVAKLVECS-DQPMS--------VVAGSYGYIPP
    .  . | ..  |.| |  ||||..||||   | | ||| ||||.|.| .     . ....||| .|.   . . . .        .. ||. ...|
NNNNNNNCKL-NMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EYAYT--MRVDERGDVYSFGVVLLELLTGKR------P
|         .|  ||||||.|| |..|.|.      |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_n-2.AA Dicty4 725-929 33 2.9e-35 115.17 In-house 1-216 (277) Show / Hide 
Range on Protein: 725-929
Range on HMM: 1-216/277
Sequence Identity: 33% (73 aa)

LTDSNVVGKGAAGTVYKAEMKNGEVLAVKKLNTSARKDTA-GHVQRGFLAEVNLLGGIRHRNIVRLLGYCS----NGDTSLLIYEYMPNGSLSDALHG--
..  .  |||. |.|||.  .  || ||||||  ......       |..||.... ||| ||. ..|.|     .  . .   |||| |.|   ||   
INIEQRIGKGSFGEVYKGTWRGKEV-AVKKLN--NHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

--KAGSVLADWVARYK---VAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEARVADFGVAK---LVECSDQPMSVVAGSYGYIPPEYAYTMRVDE
  .  |.  ||  . .    |  .|.|. .||  | | |.||| ||.|.| |... . |.||| ..    .|   . .. ..|. ..  ||     . .|
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

RGDVYSFGVVLLELLTGKRP
  |||||| || |.||.. |
KADVYSFGIVLWEILTRQEP
Kinase LRR8_n-2.AA RIPK 731-934 29 7.6e-35 116.16 In-house 1-232 (290) Show / Hide 
Range on Protein: 731-934
Range on HMM: 1-232/290
Sequence Identity: 29% (69 aa)

VGKGAAGTVYKAEMKNGEVLAVKKLNTSARKDTA--GHVQRGFLAEVNLLGGIRHRNIVRLLGYCSNGDT------SLLIYEYMPNGSLSDALHGKA--G
||.|. |.|.||  .   . ..||  ..  ..|.    ..   . |.  .  .|...||...| |   .         .  |||.||||.. || |    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

SVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEARVADFGVAKLVECSDQPM------------SVVA-GSYGYIPPEYAY---T
     |  |    . |. | ||| |.  | | ||| | .|||.|... . .||||.|.  . | .              |    |   |.|||       
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

MR---VDERGDVYSFGVVLLELLTGKRPVEPEF
 .   |..  |||||..|. |.||.| | |...
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRK
Kinase LRR8_n-2.AA STE 725-929 23 1.3e-34 119.63 In-house 1-267 (359) Show / Hide 
Range on Protein: 725-929
Range on HMM: 1-267/359
Sequence Identity: 23% (66 aa)

LTDSNVVGKGAAGTVYKAEMKN----------------GEVLAVKKLNTSA------------RKDTAGHVQRGFLAEVNLLGGIR--HRNIVRLLGYCS
...  ..|||| ||||||  ..                ||. |.|..| .              ...    .  .| |....   .  | |||. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NG-------DTSLLIYEYMPNGSLSDALHGKAGSVL-------------ADWVARYKVAVGIAQG-LCYLHHDCFPQIVHRDVKSSNILLDADMEARVAD
..       |.  .. |||..|||.| .. | |                 ...|  .... | .| | |||      |.|||.|..||||     .  .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIA--YICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCD

FGVAKLVECS----------------DQPMSVVAGSYGYIPPEYAYTMR------VDERGDVYSFGVVLLELLTGKRP
|||.. .. |                .|    ..|.  .  ||    ..       |.. |..|.| ...|..||| |
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase LRR8_n-2.AA TK 725-929 16 1.3e-34 112.87 In-house 1-394 (486) Show / Hide 
Range on Protein: 725-929
Range on HMM: 1-394/486
Sequence Identity: 16% (64 aa)

LTDSNVVGKGAAG---TVYKAEMKNG--------------------------EVLAVKKLNTSARKDTAGHVQRG---------FLAEVNLLGGIR----
.|  .. |.|. |   .|||.|....                          .  ||| |   .  . . . ..          ||.|.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNIVRLLGYCSNGDT------------SLLIYEYMPNGS----LSDALHGKAGSVLADWVARYK----------------------------------
 | |||||.|.|. |..             ... ||||.|.    | | |. . .         .                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------VAVGIAQGLCYLHHDCF---PQIVHRDVKSSNILLDADME-----------ARVADFGVAK-
                                       .. ||.|. |||   .   ...||||.   |.|.. ..            ...|||| .. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LVECSDQ-PMSVVAGSYG----------------------------YIPPEYAY---------TMRVDERGDVYSFGVVLLELLT-GKRP
    |    ..    ....|||                            . .||            . .  .  ||.||||.. |..| |. |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase LRR8_n-2.AA Dicty4-Unclassified 725-929 32 2.4e-34 115.01 In-house 1-207 (263) Show / Hide 
Range on Protein: 725-929
Range on HMM: 1-207/263
Sequence Identity: 32% (70 aa)

LTDSNVVGKGAAGTVYKAEMKNGEVLAVKKLNTSARKDTAG-HVQRGFLAEVNLLGGIRHRNIVRLLGYCSNG----DTSLLIYEYMPNGSLSDALH---
.     .|||.   |.|   |  .| ||||.|    |. .   .   |..|| .|| | | | |.. ||| |      |   . | |. | |    |   
IQIDQFIGKGHFSKVHKGNWKGKDV-AVKKFNEN--KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKP

-GKAGSVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEARVADFGVAKLVECSDQPMSVVAGSYGYIPPEYAYTMRVDERGDVYS
  .  ..  |     |.|  ||||. .||      ..|||.||||||.| .  ...||||..  ..   . |  .||      ||         . ||||
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDF-NFNMTTIAGTPKWESPECLMHESYNQKSDVYS

FGVVLLELLTGKRP
....| ||.||  |
YAMMLYELATGDEP
Kinase LRR8_n-2.AA LRRK 725-931 25 2.3e-32 111.82 In-house 1-284 (351) Show / Hide 
Range on Protein: 725-931
Range on HMM: 1-284/351
Sequence Identity: 25% (73 aa)

LTDSNVVGKGAAG-TVYKAEMKN---------------------------GEVLAVKKLNT-----------------------------SARKDTAGHV
|   . .|.|. | .||.|....                           ..  |.||.|.                             . . . . ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QRGFLAEVNLLGGIRHRNIVRLLGYCSNGDTSLLIYEYMPNGSLSDALHGKAGSVL----AD--WVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNI
 | |  || .. . .| ||| |.|.| .     .. ||.|.|.|.. || |. . .    |.  |  ..|.|. || |. || |.. | |.||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------ADMEARVADFGVAKLVECSDQP--MSVVAGSYGYIPPEYAYTM---RVDERGDVYSFGVVLLELLTGK-RPVE
||   .         |.. | .||||   .   ....   . . |  |.  ||    .     .|  |.||||..| ||||.. .| .
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_n-2.AA Pkinase_Tyr 725-885 28 4.6e-28 95.68 Pfam 1-166 (270) Show / Hide 
Range on Protein: 725-885
Range on HMM: 1-166/270
Sequence Identity: 28% (50 aa)

LTDSNVVGKGAAGTVYKAEMK-----NGEVLAVKKLNTSARKDTAGHVQ---RGFLAEVNLLGGI-RHRNIVRLLGYCS-NGDT--SLLIYEYMPNGSLS
.|   . |.|| |.|||...|     ..   |||.|.     ..| | |   . |..|....  . .| |||||.| |.  |.    ... ||||.|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

DALHGK---AGSVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEARVADFGVAKLVECSDQ
| |. .    ...   .    . .. ||.|. ||.      ..|||.   |.|.. .. ....||| |....  |.
DYLRKHREDKQPLTMKD--LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase LRR8_n-2.AA TyrKc 725-1011 21 3.2e-23 84.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 725-1011
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

LTDSNVVGKGAAGTVYKAEMKNGEVLAVKKLNTSARKDTAGHVQRGFLAEVNLLGGI--RHRNIVRLLGYCSNG-------DTSLLIYEYMPNGSLSDAL
.|   . | || |.|||...|  .  |||.|. .|        .. |. | ...  .  .| |||||.|.|. .       .  ... ||||.|.| | |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

HGKAGSVLADWVARYKVAVGIAQGLCYLHHDCFPQIVHRDVKSSNILLDADMEARVADFGVAKLVECS-------DQPMS----VVA--GSYGYIPPEYA
. . .     .    . .. ||.|  |||.    ...|||    |.|....  ....||| .. ..         |  ..           .   .||  
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

YTMRVDERGDVYSFGVVLLELLTGKRPVEPEFG------DNVNIVEWVRHK-ILQCNTT----SNNPASHKVSNSVLDPSIAAPGSSVEEEMVLVLRIAL
 . .  .  ||.||||.. |..|  .  .|  |      .|  ..|.|..   . .       |                     . |.    .   | .
NYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------F-VCCPDEMYQ-IMK

LCTSKLPRERPSMRDVVTML
 |    | .||......  .
QCWHEDPEDRPTFSEIHECF
Kinase LRR8_n-2.AA TK 980-1011 15 0.000386 8.93 In-house 454-486 (486) Show / Hide 
Range on Protein: 980-1011
Range on HMM: 454-486/486
Sequence Identity: 15% (5 aa)

EEEMVLVL-RIALLCTSKLPRERPSMRDVVTML
....  .. .. . | .. |..||...... .|
PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_n-2.AA LRRK 992-1013 31 0.001739 8.18 In-house 330-351 (351) Show / Hide 
Range on Protein: 992-1013
Range on HMM: 330-351/351
Sequence Identity: 31% (7 aa)

LCTSKLPRERPSMRDVVTMLSE
.| .  |..||.. ..|  ||.
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_n-2.AA MLK 998-1011 50 0.011181 5.27 In-house 278-291 (291) Show / Hide 
Range on Protein: 998-1011
Range on HMM: 278-291/291
Sequence Identity: 50% (7 aa)

PRERPSMRDVVTML
|..|||.| .|. |
PHKRPSFRQIVQHL
Kinase LRR8_n-2.AA Pkinase_Tyr 912-929 52 0.048994 7.52 Pfam 196-214 (270) Show / Hide 
Range on Protein: 912-929
Range on HMM: 196-214/270
Sequence Identity: 52% (10 aa)

DVYSFGVVLLELLT-GKRP
||.||||.. |..| |. |
DVWSFGVLMWEIFTYGEQP
Kinase LRR8_n-2.AA Dicty4-Unclassified 993-1011 31 0.05681 2.5 In-house 245-263 (263) Show / Hide 
Range on Protein: 993-1011
Range on HMM: 245-263/263
Sequence Identity: 31% (6 aa)

CTSKLPRERPSMRDVVTML
| .  |. ||.| ...  |
CWHNDPNKRPTMNQIIQYL
Kinase LRR8_n-2.AA Pkinase_Tyr 998-1011 28 0.64446 3.73 Pfam 257-270 (270) Show / Hide 
Range on Protein: 998-1011
Range on HMM: 257-270/270
Sequence Identity: 28% (4 aa)

PRERPSMRDVVTML
| .||...... .|
PEDRPTFSEIHEQL