Gene LRR8_l-2 (S.moellendorffii)

LRR8_l-2

Species: S.moellendorffii
Alias: LRR8_l-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_l-2.AA Protein None 1318 None Fasta, JSON
LRR8_l-2.NA RNA None 3957 None Fasta, JSON
LRR8_l-2.kin_dom Protein Kinase Domain None 210 None Fasta, JSON

Protein domain

Protein domains of LRR8_l-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_l-2.AA LRRNT_2 23-73 30 2.8e-11 39.53 Pfam 1-46 (46) Show / Hide 
Range on Protein: 23-73
Range on HMM: 1-46/46
Sequence Identity: 30% (16 aa)

SSPDLQWLLELKAGFQA-DP-LNATGDWIPPDRHRNGSTSSSDPCSWSGISCS
.. |.| ||..|....  || ...  .| | .        .||.|||.|..|.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSS-------DSDCCSWTGVTCD
LRR_1 LRR8_l-2.AA LRR_1 77-100 25 0.155692 9.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 77-100
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RVTAINLTS-T--SLTGSISSSAIAHL
. . ..| . .  .|||.|..|.. .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 102-121 34 0.030704 12.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 102-121
Range on HMM: 1-26/26
Sequence Identity: 34% (9 aa)

KLELLDLSN-N--SFSGPMPS---QL
.|. ||||. |  ...|  |.   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR8_l-2.AA LRR_1 124-146 37 0.01237 13.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 124-146
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLRSLRLNE-N--SLTGPLPAS-IANA
.|..| |.  |  .||| .| | . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 148-170 29 0.425992 8.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 148-170
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

LLTELLVYS-N--LLSGSIPSE-IGRL
 |..| . . |   |.|.||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 172-194 29 0.036589 11.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 172-194
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLRVLRAGD-N--LFSGPIPDS-IAGL
.|..|  .. |   ..| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 196-218 37 0.052295 11.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 196-218
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQILGLANC---ELSGGIPRG-IGQL
.||.| | .|    |.| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 220-242 37 0.048375 11.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 220-242
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALESLMLHY-N--NLSGGIPPE-VTQC
 |..| | . |  ||.| |||.   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 244-266 40 0.005601 14.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 244-266
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLTVLGLSE-N--RLTGPIPRG-ISDL
.|..| ||  |  .||| || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 268-290 25 0.034963 11.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 268-290
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALQTLSIFN-N--SLSGSVPEE-VGQC
 ||.|.. . |  .|.|..|..   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 292-314 40 0.000255 19.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 292-314
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLLYLNLQG-N--DLTGQLPDS-LAKL
.| .|.|.| |   |||..|.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 316-338 37 0.000228 19.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 316-338
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALETLDLSE-N--SISGPIPDW-IGSL
 |..||||  |  ...| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 340-362 40 0.002362 16.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 340-362
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLENLALSM-N--QLSGEIPSS-IGGL
.|. | ||  |  .|.|.||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 364-386 29 0.006546 14.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 364-386
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLEQLFLGS-N--RLSGEIPGE-IGEC
.|. | |.. |  .|.|.|| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 388-410 51 9e-06 24.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 388-410
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

SLQRLDLSS-N--RLTGTIPAS-IGRL
.||.||||. |  .|||.|| | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 412-434 33 0.015227 13.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 412-434
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

MLTDLVLQS-N--SLTGSIPEE-IGSC
 |. | |.. |  .|||.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 436-458 40 0.039812 11.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 436-458
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLAVLALYE-N--QLNGSIPAS-IGSL
|| .| |   |  .| |.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 460-482 33 0.002047 16.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 460-482
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLDELYLYR-N--KLSGNIPAS-IGSC
.| .|.| . |  .|.|.|| | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 484-506 44 0.019363 12.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 484-506
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

KLTLLDLSE-N--LLDGAIPSS-IGGL
.|. ||||  |   | | ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 508-530 29 0.058399 11.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 508-530
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ALTFLHLRR-N--RLSGSIPAP-MARC
 |. |.|.. |  .|.|.||      .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 532-554 29 0.117759 10.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 532-554
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KMRKLDLAE-N--SLSGAIPQD-LTSA
. ..|||   |  .|.| || . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 557-579 37 0.162932 9.54 Pfam 1-26 (26) Show / Hide 
Range on Protein: 557-579
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

DLEMLLLYQ-N--NLTGAVPES-IASC
 |. | |   |  |||| .|.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 582-604 37 0.082391 10.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 582-604
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTTINLSD-N--LLGGKIPPL-LGSS
||....||. |   | |.|||  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 606-625 42 0.108226 10.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 606-625
Range on HMM: 1-26/26
Sequence Identity: 42% (11 aa)

ALQVLDLTD-N--GIGGNIPP---SL
 ||.||| . |   . |.|||   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR8_l-2.AA LRR_1 630-652 33 0.092008 10.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 630-652
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLWRLRLGG-N--KIEGLIPAE-LGNI
.| .| |.| |  ...| || . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 654-676 33 0.150718 9.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 654-676
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ALSFVDLSF-N--RLAGAIPSI-LASC
 |   |||  |  .| | ||.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 678-700 40 0.000227 19.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 678-700
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTHIKLNG-N--RLQGRIPEE-IGGL
||.|. |.| |  .|.| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 702-725 40 0.004887 14.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 702-725
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLGELDLSQ-N--ELIGEIPGSIISGC
.| .||||  |   | |.|| |.. ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 727-749 29 1.644349 5.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 727-749
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KISTLKLAE-N--RLSGRIPAA-LGIL
.. .| |   |  .|.| ||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 751-773 44 0.0006 18.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 751-773
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLQFLELQG-N--DLEGQIPAS-IGNC
.|| | |.| |   |.|.|| | . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 775-797 33 0.038043 11.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 775-797
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLLEVNLSH-N--SLQGGIPRE-LGKL
 | . .||. |  .|.| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 802-822 44 0.046225 11.48 Pfam 3-26 (26) Show / Hide 
Range on Protein: 802-822
Range on HMM: 3-26/26
Sequence Identity: 44% (11 aa)

TSLDLSF-N--RLNGSIPPE-LGML
..||||  |  .| |.|||. .  |
QHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 824-846 37 0.000548 18.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 824-846
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLEVLNLSS-N--AISGMIPES-LANN
.|..|.||. |   ..| ||.| . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-2.AA LRR_1 849-873 35 0.019237 12.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 849-873
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

SLLSLNLSS-N--NLSGPVPSGPVFDRM
.| .|.||. |  ||.| .|..  |  .
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_l-2.AA TKL 1004-1279 21 1e-63 217.99 In-house 1-364 (364) Show / Hide 
Range on Protein: 1004-1279
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

IGSGGFGTVYKAILPS---------GEVLAVKKVDVAG-----------------------DGDPTQDKSFLREVS-TLGKIRHRHLVRLVGFCSHKGV-
|||||||.|||...           |.. ||||  .                         | .. . . |..|.   . ..|| ..|...|.|   .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLVYDYMPNGSLFDRLHGSACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCA-----PRIVHRDIKSNNVLLDSRDE--------
              .|..|.|.|||...||              |. |.|.| .|| |..||| .       | |.|||.||.|.|.|.  .        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN

------PHLGDFGLAKIIDSSSSSH-----------------TLSVFAGSYGYIAPEYAYTM----------------RASEKTDIYSFGVVLMELVTGK
      . ..||||.. .. |...                  |..   |.... |||    .                 .|||.|.||||.|| |..|..
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

LPVDPTFPDGVDIVSWVRLRISQKASVDDLIDPLLQKVSRT------ERLEMLLVLKAALMCTSSSLGDRPSMREVVDKL
.| .   .. ...   . . . ..  .|.   |..  . ..      .   .  . | . .| ..   .|||. |....|
RPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_l-2.AA IRAK 999-1279 28 9.6e-60 204.79 In-house 2-317 (317) Show / Hide 
Range on Protein: 999-1279
Range on HMM: 2-317/317
Sequence Identity: 28% (92 aa)

SDLNIIGSGGFGTVYKAILPSGE-VLAVKKVDVAGDGDPTQ-DKSFLR---EVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPNGSLFDRLHGSACTE
.  | ||.||||.||.. .   . . ||||.    |  ... ...|.    |. .. ..|| ..| | |.|.  .   |||.|||||||.|||.   |. 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLW---CQD

KNNA-GVLDWESRHRIAVGIAEGIAYLHHDC-APRIVHRDIKSNNVLLDSRDEPHLGDFGLAKII--DSSSSSHTL-----SVFAGSYGYIAPEYAY--T
  ..   | |  |. |. |.| || .|| .  .  | |.|||| |.||| . .| ..||||.      |.. ..|.     |.. |.  | .||. .  .
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

MRASEKTDIYSFGVVLMELVTGKLPVDPTFPDGVDIVSWVRLRISQKAS-------------------------VDDLIDPLLQKVSRTERLEMLLVLKA
 . . |||.||||.||.|..||  .|.   |    ..  ..   .. ..                         . ..||..   . ... .||   . .
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEM---CQC

ALMCTSSSLGDRPSMREVVDKL
|. |.   .  |..|..|. .|
ACCCGHHRANRRCDMAWVMQQL
Pkinase LRR8_l-2.AA Pkinase 998-1207 26 8.6e-52 183.17 Pfam 1-211 (293) Show / Hide 
Range on Protein: 998-1207
Range on HMM: 1-211/293
Sequence Identity: 26% (60 aa)

LSDLNIIGSGGFGTVYKAILPSGEV-LAVKKVDVAGDGDPTQDKSFLR--EVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPNG----SLFDRLHGSA
.  . .||||.||.|||..  . .   |||....  . .. .|.. .|  |.. . ...| . ||| ...  |.   .| .|...|    .|||....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

CTEKNNAGVL--DWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEP----HLGDFGLAKIIDSSSSSHTLSVFAGSYGYIAPEYAY-TM
     . |..  ...   ...  |..|..|.|     .|.|||.|. |.|.|.....    ...|||||| .|   ... ...|.|...|.|||      
----WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQ

RASEKTDIYSFGVVLMELVTGKLP
  . | |..|.|..| |...|..|
YYGPKVDMWSCGCILYEMLCGRPP
Kinase LRR8_l-2.AA MLK 998-1207 28 1.9e-45 155.6 In-house 1-235 (291) Show / Hide 
Range on Protein: 998-1207
Range on HMM: 1-235/291
Sequence Identity: 28% (67 aa)

LSDLNIIGSGGFGTVYKAILPSGE----VLAVKKVDVAGDGDPTQ----DKSFLREVSTLGKIRHRH----LVRLVGFCSHKGVN-LLVYDYMPNGSLFD
.  . .||||.|| |.|.     .    ..|||.|.   . |  .    .. | .|.  | ...|.      ....| |.  . . ..|  |...|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLHG-------SACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDS------RDEPHLGDFGLAKIIDSSSSSHTLSVFAGS
 |||       ..  .| |..| | ..  ..|. .|.|..||| .  . |.|||.|| |.|.|        .     |||... . ..    .   .||.
VLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

YGYIAPEY---AYTMRASEKTDIYSFGVVLMELVTGKLP
| . |||    .   . ||| |..|.|||| |..|...|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_l-2.AA S_TKc 998-1260 22 3.6e-38 134.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 998-1260
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

LSDLNIIGSGGFGTVYKAILPS-GEVLAVKKVDVAGDGDPTQDKSFLREVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPN--GSLFDRLHGSACTEK
   |..||.|.||.|||..  . |.. |.|...          ....||.. | | .| ..|.| ... . .   .| .|...  |.|||...   .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

NNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKIIDSSSSSHTLSVFAGSYGYIAPEYAYTMRASE-KTDIYS
.   ...     ...  |.....|.|     .|.|||.|  |.|||.  .  ..|||||...         . | |.  |.|||       .  | |..|
R--FPFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGVVLMELVTGKLPVDPTFPDGVDIVSWVRLRISQKASVDDLIDPLLQKVSRTERLEMLLVLK-------AALM
.|..| |...|. | .    .   .   ..       .. |.|. .|||   ..|.    .|.          .
CGCILYEMLCGYPPFP----QMQMMFKKIG-----SPEAKDFIRKCLQKD-PEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_l-2.AA TKL-Unique 1000-1207 32 4.3e-38 131.95 In-house 1-233 (290) Show / Hide 
Range on Protein: 1000-1207
Range on HMM: 1-233/290
Sequence Identity: 32% (76 aa)

DLNIIGSGGFGTVYKAILPSGEVLAVKKVDVAGDGDPTQDKSFLREVSTLGKIR-HRHLVRLVGFCS----HKGVNLLVYDYMPNGSLFDRLHGSACTE-
..| ||.||.|.|||.. .. .| |.|.  .  |  ..  . | .||... |.. |  .|...|.|     . .   .| .|.| ||| | || .     
FWNKIGEGGYGQVYKGKWRGYPV-AIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-KNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSR-----DEPHLGDFGLAKIIDSSSSSHTL-------SVFAGSYGYIAPEYA
  ||   |... | ..|  || |  ||||  .| | |||.|| |.|.|..         . ||||.|. .... . .        ... ||. ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

YT--MRASEKTDIYSFGVVLMELVTGKL------P
       ||| |.||||.|| |..|.|.      |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_l-2.AA TK 998-1207 15 8.8e-38 123.7 In-house 1-394 (486) Show / Hide 
Range on Protein: 998-1207
Range on HMM: 1-394/486
Sequence Identity: 15% (61 aa)

LSDLNIIGSGGFG---TVYKAILPSG--------------------------EVLAVKKVDVAGDGDPTQDKS-----------FLREVSTLGKIR----
.  .. .|.| ||   .|||... ..                          .  ||| .    . .... .            ||.|.. . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRHLVRLVGFCSHK------------GVNLLVYDYMPNGS----LFDRLHGSACTEKN-----------------------------------------
 | ..|||.| |...            .  ..|  |||.|.    | | |. .  ....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------NAGVLDWESRHRIAVGIAEGIAYLHHD----CAPRIVHRDIKSNNVLLDSRDE-----------PHLGDFG--
                           . . |. . .. ... ||.| .|||        ...||||.   |.|.....              ..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKIIDSSSSSHTLSVFAGSYG------------------------YIAPEYAY---------TMRASEKTDIYSFGVVLMELVT-GKLP
      ||. |.|..  .. |   .. .                        . |||            . . ..|.|..||||.. |..| |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase LRR8_l-2.AA LRRK 998-1209 25 1.9e-37 130.03 In-house 1-284 (351) Show / Hide 
Range on Protein: 998-1209
Range on HMM: 1-284/351
Sequence Identity: 25% (75 aa)

LSDLNIIGSGGFG-TVYKAILPS---------------------------GEVLAVKKVDVA-------------------------------GDGDPTQ
|   . ||.|||| .||.|.. .                           ..  |.|| ..                                ... .. 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

DKSFLREVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPNGSLFDRLHGSACTE----KNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKS
  .| .||. . . .| ..| |.||| |     .| .|.|.|.| ..|| .. ..    |    ...|  ...||. ||.|..|| |.. | |.||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMK---AHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKS

NNVLLDSRDEPH----LGDFGLAKIIDSSSSS------HT-LSVFAGSYGYIAPEYAYTM---RASEKTDIYSFGVVLMELVTGK-LPVD
 |.|| | ...|    ....  |||.| . |.      .. .. . |  |. |||    .     .||.|.||||..| ||.|.. .| |
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_l-2.AA STE 998-1207 23 4.6e-36 124.87 In-house 1-267 (359) Show / Hide 
Range on Protein: 998-1207
Range on HMM: 1-267/359
Sequence Identity: 23% (64 aa)

LSDLNIIGSGGFGTVYKAILP----------------SGEVLAVKKVDVAGD--------------GDPTQDKSFLREVSTLGKIR--HRHLVRLVGFCS
. .. .||.|.|||||||.                  .||. |.|....  .               .... ...|.|.... | .  | . |.  | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HKG-------VNLLVYDYMPNGSLFDRLH---GSACTEKNNA---GVLDWESRHRIAVGIAEG-IAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFG
..|          ..  ||..||| | ..   |  .. ..|    .... .   .|.. | .|  .|||      |.|||||. |.||       | |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKIIDSS--------------SSSHTLSVFAGSYGYIAPEYAYTMR------ASEKTDIYSFGVVLMELVTGKLP
.......|              ...     |.|.  . |||    ..       ..| ||.|.| ...|..||| |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase LRR8_l-2.AA CAMK 1003-1207 16 1.7e-33 104.78 In-house 1-333 (425) Show / Hide 
Range on Protein: 1003-1207
Range on HMM: 1-333/425
Sequence Identity: 16% (57 aa)

IIGSGGFGTVYKAILP-SG------------EVLAVKKVDVA--------------------GDG-----DPTQDKSFLREVSTLGK-------IRHRHL
..|.|.||.|...|   ..            .  |.| .|                      ...     .|   |...||.. . |       ..|...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLVGFCSHKGV-------------------NLLVY---DYMPNG----SLFDRLH-GSACTEKNNA-------GVLDWESRHRIAVGIAEGIAYLHHDC
..|  .   . .                     .|    .|...|     |||..   . ..|.. .       | .. .  .|.   |.....|.|   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-DQFDIVERGRFTEREARRYFRQICSAVHYCHSH-

APRIVHRDIKSNNVLLDSRD-----------------EPHLGDFGLAKIIDSSSSSH---------------------TLSVFAGSYGYIA-PEYAYTMR
   |||||.|  |.|||...                    . |||.|...|......                      .. | |. .|.| ||     .
--NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

--------------ASEKTDIYSFGVVLMELVTGKLP
               ..|.|. | ||.|  ...|..|
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP
Kinase LRR8_l-2.AA Pkinase_Tyr 998-1207 26 2.1e-30 103.6 Pfam 1-214 (270) Show / Hide 
Range on Protein: 998-1207
Range on HMM: 1-214/270
Sequence Identity: 26% (60 aa)

LSDLNIIGSGGFGTVYKAILP-----SGEVLAVKKVDVAGDGDPTQ--DKSFLREVSTLGKI-RHRHLVRLVGFCS-HKGV--NLLVYDYMPNGSLFDRL
.. .  .|.| ||.|||...       .   |||..    . .. |   ..|.||.... .. .| ..|||.| |. ...    ..|  |||.|.| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HGSACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKII--DSSS-SSHT---LSVFAGSYGYIAPEYA
.       .. . |. .    ... ||.| .||.      ..|||.   |.|...      .|||||. |  |.    ...   | ..       |||  
RKHR----EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK-----WMAPECI

YTMRASEKTDIYSFGVVLMELVT-GKLP
 ... ..|.|..||||.. |..| |. |
NYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_l-2.AA Dicty4 998-1205 34 2.7e-29 95.01 In-house 1-214 (277) Show / Hide 
Range on Protein: 998-1205
Range on HMM: 1-214/277
Sequence Identity: 34% (74 aa)

LSDLNIIGSGGFGTVYKAILPSGEVLAVKKVDVAGDG-DPTQDKSFLREVSTLGKIRHRHLVRLVGFCS----HKGVNLLVYDYMPNGSLFDRLHGSACT
.   ..||.|.||.|||..    || ||||     .. |    ..|..||. ..|||| ... . | |     |.|  . |  ||| |.|.  || .   
INIEQRIGKGSFGEVYKGTWRGKEV-AVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH-DKPS

EKNNAGVLDWESRHR---IAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKIIDSSSSSHT-LSVFAGSYGYIAPEYAYTMRASEK
|.     |||. . |   .|  .| |...||  | |.|.|||.|| | | |       .||||....   ..  . ..  .|. .. |||     .  ||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

TDIYSFGVVLMELVTGK
 | |||| || |..|..
ADVYSFGIVLWEILTRQ
Kinase LRR8_l-2.AA LISK 1003-1157 33 7.6e-28 87.39 In-house 1-156 (296) Show / Hide 
Range on Protein: 1003-1157
Range on HMM: 1-156/296
Sequence Identity: 33% (55 aa)

IIGSGGFGTVYKAILP-SGEVLAVKKVDV--AGDGDPTQDKSFLREVSTLGKIRHRHLVRLVGFCSH-KGVNLLVYDYMPNGSLFDRLHGSACTEKNNAG
.||.|.|| |||  .  .|.| |.|.         ||   | .|||| .. ..||.. |. .| | | .|   .|  |.  | |...|. ..        
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK----HKI

VLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSR-DEPH---LGDFGLAKIID
.| |. | .||..||.| .|||  .   |.||| ||.|.|.. . ...    ..|||.|...|
PLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMD
Kinase LRR8_l-2.AA TyrKc 998-1279 21 8.5e-25 89.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 998-1279
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

LSDLNIIGSGGFGTVYKAILPSGEVLAVKKVDVAGDGDPTQDKSFLREVSTLGKI--RHRHLVRLVGFCSHK-------GVNLLVYDYMPNGSLFDRLHG
.. . ..|.| ||.|||...   .  |||..           . |.|| . . |.  .| ..|||.| |...       .  ..|  |||.|.| |.|. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKIIDSS------SSSHT-----LSVFAGSYGYIAP
.  .       | ..  . ... ||.| .|||.    ...|||.   |.|....     .||||.. |..       ..  .      . .   .   ||
HRPK-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYAYTMRASEKTDIYSFGVVLMELVT-GKLPVDP-TF--PDGVDIVSWVRLRISQKASVDDLIDPLLQKVSRTERLEMLLVLKAALMCTSSSLGDRPSMR
|   . . ..|.|..||||.. |. | |. |    ..   .  ... .|. .   .   .|.  | .  |  .. . ..      ..|      |||...
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIM-----KQCWHEDPEDRPTFS

EVVDKL
|.....
EIHECF
Kinase LRR8_l-2.AA LISK 1186-1205 45 1e-05 14.39 In-house 217-236 (296) Show / Hide 
Range on Protein: 1186-1205
Range on HMM: 217-236/296
Sequence Identity: 45% (9 aa)

SEKTDIYSFGVVLMELVTGK
.|. |..|||.|| |..|..
DESCDVFSFGIVLCEIITRV
Kinase LRR8_l-2.AA LRRK 1261-1281 28 0.005924 6.27 In-house 331-351 (351) Show / Hide 
Range on Protein: 1261-1281
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CTSSSLGDRPSMREVVDKLKQ
| .    .||.. ..|..|.|
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_l-2.AA TK 1259-1279 23 0.01128 3.93 In-house 466-486 (486) Show / Hide 
Range on Protein: 1259-1279
Range on HMM: 466-486/486
Sequence Identity: 23% (5 aa)

LMCTSSSLGDRPSMREVVDKL
..| .    |||........|
QQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_l-2.AA MLK 1268-1279 50 0.034496 3.55 In-house 280-291 (291) Show / Hide 
Range on Protein: 1268-1279
Range on HMM: 280-291/291
Sequence Identity: 50% (6 aa)

DRPSMREVVDKL
.|||.|..| .|
KRPSFRQIVQHL
Kinase LRR8_l-2.AA Dicty4 1269-1281 33 0.130735 1.34 In-house 263-277 (277) Show / Hide 
Range on Protein: 1269-1281
Range on HMM: 263-277/277
Sequence Identity: 33% (5 aa)

RPSMREVVDK--LKQ
|||. |.. .  |  
RPSFEEIIQRRILEH
Kinase LRR8_l-2.AA Pkinase_Tyr 1268-1279 41 0.857441 3.31 Pfam 259-270 (270) Show / Hide 
Range on Protein: 1268-1279
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

DRPSMREVVDKL
|||...|.. .|
DRPTFSEIHEQL