Gene LRR8_l-1 (S.moellendorffii)

LRR8_l-1

Species: S.moellendorffii
Alias: LRR8_l-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_l-1.AA Protein None 1230 None Fasta, JSON
LRR8_l-1.NA RNA None 3693 None Fasta, JSON
LRR8_l-1.kin_dom Protein Kinase Domain None 210 None Fasta, JSON

Protein domain

Protein domains of LRR8_l-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_l-1.AA LRRNT_2 23-73 30 2.8e-11 39.53 Pfam 1-46 (46) Show / Hide 
Range on Protein: 23-73
Range on HMM: 1-46/46
Sequence Identity: 30% (16 aa)

SSPDLQWLLELKAGFQA-DP-LNATGDWIPPDRHRNGSTSSSDPCSWSGISCS
.. |.| ||..|....  || ...  .| | .        .||.|||.|..|.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSS-------DSDCCSWTGVTCD
LRR_1 LRR8_l-1.AA LRR_1 77-100 25 0.155692 9.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 77-100
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RVTAINLTS-T--SLTGSISSSAIAHL
. . ..| . .  .|||.|..|.. .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 102-124 33 0.000724 17.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 102-124
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLELLDLSN-N--SFSGPMPSE-IGRL
.|. ||||. |  ...|  |.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 126-148 33 0.066499 10.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 126-148
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLQVLRAGD-N--LFSGPIPDS-IAGL
.||.|  .. |   ..| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 150-172 37 0.052295 11.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 150-172
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQILGLANC---ELSGGIPRG-IGQL
.||.| | .|    |.| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 174-196 37 0.048375 11.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 174-196
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALESLMLHY-N--NLSGGIPPE-VTQC
 |..| | . |  ||.| |||.   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 198-220 40 0.005601 14.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 198-220
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLTVLGLSE-N--RLTGPIPRG-ISDL
.|..| ||  |  .||| || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 222-244 25 0.034963 11.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 222-244
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALQTLSIFN-N--SLSGSVPEE-VGQC
 ||.|.. . |  .|.|..|..   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 246-268 40 9.9e-05 20.95 Pfam 1-26 (26) Show / Hide 
Range on Protein: 246-268
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLVYLNLQG-N--DLTGQLPDS-LAKL
.| .|.|.| |   |||..|.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 270-292 37 0.000228 19.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 270-292
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALETLDLSE-N--SISGPIPDW-IGSL
 |..||||  |  ...| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 294-316 40 0.002362 16.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 294-316
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLENLALSM-N--QLSGEIPSS-IGGL
.|. | ||  |  .|.|.||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 318-340 29 0.006546 14.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 318-340
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLEQLFLGS-N--RLSGEIPGE-IGEC
.|. | |.. |  .|.|.|| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 342-364 51 9e-06 24.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 342-364
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

SLQRLDLSS-N--RLTGTIPAS-IGRL
.||.||||. |  .|||.|| | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 366-388 33 0.015227 13.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 366-388
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

MLTDLVLQS-N--SLTGSIPEE-IGSC
 |. | |.. |  .|||.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 390-412 40 0.039812 11.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 390-412
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLAVLALYE-N--QLNGSIPAS-IGSL
|| .| |   |  .| |.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 414-436 33 0.002047 16.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 414-436
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLDELYLYR-N--KLSGNIPAS-IGSC
.| .|.| . |  .|.|.|| | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 443-465 29 0.117759 10.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 443-465
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KMRKLDLAE-N--SLSGAIPQD-LTSA
. ..|||   |  .|.| || . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 468-490 37 0.162932 9.54 Pfam 1-26 (26) Show / Hide 
Range on Protein: 468-490
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

DLEMLLLYQ-N--NLTGAVPES-IASC
 |. | |   |  |||| .|.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 493-515 37 0.082391 10.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 493-515
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTTINLSD-N--LLGGKIPPL-LGSS
||....||. |   | |.|||  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 517-536 42 0.108226 10.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 517-536
Range on HMM: 1-26/26
Sequence Identity: 42% (11 aa)

ALQVLDLTD-N--GIGGNIPP---SL
 ||.||| . |   . |.|||   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR8_l-1.AA LRR_1 541-563 33 0.092008 10.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 541-563
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLWRLRLGG-N--KIEGLIPAE-LGNI
.| .| |.| |  ...| || . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 565-587 33 0.150718 9.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 565-587
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ALSFVDLSF-N--RLAGAIPSI-LASC
 |   |||  |  .| | ||.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 589-611 40 0.000227 19.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 589-611
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTHIKLNG-N--RLQGRIPEE-IGGL
||.|. |.| |  .|.| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 613-636 40 0.004887 14.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 613-636
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLGELDLSQ-N--ELIGEIPGSIISGC
.| .||||  |   | |.|| |.. ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 638-660 29 1.644349 5.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 638-660
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KISTLKLAE-N--RLSGRIPAA-LGIL
.. .| |   |  .|.| ||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 662-684 44 0.0006 18.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 662-684
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLQFLELQG-N--DLEGQIPAS-IGNC
.|| | |.| |   |.|.|| | . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 686-708 33 0.061513 11.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 686-708
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLLEVNLSR-N--SLQGGIPRE-LGKL
 | . .||. |  .|.| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 713-733 44 0.046225 11.48 Pfam 3-26 (26) Show / Hide 
Range on Protein: 713-733
Range on HMM: 3-26/26
Sequence Identity: 44% (11 aa)

TSLDLSF-N--RLNGSIPPE-LGML
..||||  |  .| |.|||. .  |
QHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 735-757 37 0.000169 20.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 735-757
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLEVLNLSS-N--AISGTIPES-LANN
.|..|.||. |   ..|.||.| . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_l-1.AA LRR_1 760-784 35 0.019237 12.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 760-784
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

SLLSLNLSS-N--NLSGPVPSGPVFDRM
.| .|.||. |  ||.| .|..  |  .
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_l-1.AA TKL 915-1190 21 1e-63 217.99 In-house 1-364 (364) Show / Hide 
Range on Protein: 915-1190
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

IGSGGFGTVYKAILPS---------GEVLAVKKVDVAG-----------------------DGDPTQDKSFLREVS-TLGKIRHRHLVRLVGFCSHKGV-
|||||||.|||...           |.. ||||  .                         | .. . . |..|.   . ..|| ..|...|.|   .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLVYDYMPNGSLFDRLHGSACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCA-----PRIVHRDIKSNNVLLDSRDE--------
              .|..|.|.|||...||              |. |.|.| .|| |..||| .       | |.|||.||.|.|.|.  .        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN

------PHLGDFGLAKIIDSSSSSH-----------------TLSVFAGSYGYIAPEYAYTM----------------RASEKTDIYSFGVVLMELVTGK
      . ..||||.. .. |...                  |..   |.... |||    .                 .|||.|.||||.|| |..|..
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

LPVDPTFPDGVDIVSWVRLRISQKASVDDLIDPLLQKVSRT------ERLEMLLVLKAALMCTSSSLGDRPSMREVVDKL
.| .   .. ...   . . . ..  .|.   |..  . ..      .   .  . | . .| ..   .|||. |....|
RPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_l-1.AA IRAK 910-1190 28 9.6e-60 204.79 In-house 2-317 (317) Show / Hide 
Range on Protein: 910-1190
Range on HMM: 2-317/317
Sequence Identity: 28% (92 aa)

SDLNIIGSGGFGTVYKAILPSGE-VLAVKKVDVAGDGDPTQ-DKSFLR---EVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPNGSLFDRLHGSACTE
.  | ||.||||.||.. .   . . ||||.    |  ... ...|.    |. .. ..|| ..| | |.|.  .   |||.|||||||.|||.   |. 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLW---CQD

KNNA-GVLDWESRHRIAVGIAEGIAYLHHDC-APRIVHRDIKSNNVLLDSRDEPHLGDFGLAKII--DSSSSSHTL-----SVFAGSYGYIAPEYAY--T
  ..   | |  |. |. |.| || .|| .  .  | |.|||| |.||| . .| ..||||.      |.. ..|.     |.. |.  | .||. .  .
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

MRASEKTDIYSFGVVLMELVTGKLPVDPTFPDGVDIVSWVRLRISQKAS-------------------------VDDLIDPLLQKVSRTERLEMLLVLKA
 . . |||.||||.||.|..||  .|.   |    ..  ..   .. ..                         . ..||..   . ... .||   . .
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEM---CQC

ALMCTSSSLGDRPSMREVVDKL
|. |.   .  |..|..|. .|
ACCCGHHRANRRCDMAWVMQQL
Pkinase LRR8_l-1.AA Pkinase 909-1118 26 8.6e-52 183.17 Pfam 1-211 (293) Show / Hide 
Range on Protein: 909-1118
Range on HMM: 1-211/293
Sequence Identity: 26% (60 aa)

LSDLNIIGSGGFGTVYKAILPSGEV-LAVKKVDVAGDGDPTQDKSFLR--EVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPNG----SLFDRLHGSA
.  . .||||.||.|||..  . .   |||....  . .. .|.. .|  |.. . ...| . ||| ...  |.   .| .|...|    .|||....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

CTEKNNAGVL--DWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEP----HLGDFGLAKIIDSSSSSHTLSVFAGSYGYIAPEYAY-TM
     . |..  ...   ...  |..|..|.|     .|.|||.|. |.|.|.....    ...|||||| .|   ... ...|.|...|.|||      
----WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQ

RASEKTDIYSFGVVLMELVTGKLP
  . | |..|.|..| |...|..|
YYGPKVDMWSCGCILYEMLCGRPP
Kinase LRR8_l-1.AA MLK 909-1118 28 1.9e-45 155.6 In-house 1-235 (291) Show / Hide 
Range on Protein: 909-1118
Range on HMM: 1-235/291
Sequence Identity: 28% (67 aa)

LSDLNIIGSGGFGTVYKAILPSGE----VLAVKKVDVAGDGDPTQ----DKSFLREVSTLGKIRHRH----LVRLVGFCSHKGVN-LLVYDYMPNGSLFD
.  . .||||.|| |.|.     .    ..|||.|.   . |  .    .. | .|.  | ...|.      ....| |.  . . ..|  |...|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLHG-------SACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDS------RDEPHLGDFGLAKIIDSSSSSHTLSVFAGS
 |||       ..  .| |..| | ..  ..|. .|.|..||| .  . |.|||.|| |.|.|        .     |||... . ..    .   .||.
VLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

YGYIAPEY---AYTMRASEKTDIYSFGVVLMELVTGKLP
| . |||    .   . ||| |..|.|||| |..|...|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_l-1.AA S_TKc 909-1171 22 3.6e-38 134.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 909-1171
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

LSDLNIIGSGGFGTVYKAILPS-GEVLAVKKVDVAGDGDPTQDKSFLREVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPN--GSLFDRLHGSACTEK
   |..||.|.||.|||..  . |.. |.|...          ....||.. | | .| ..|.| ... . .   .| .|...  |.|||...   .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

NNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKIIDSSSSSHTLSVFAGSYGYIAPEYAYTMRASE-KTDIYS
.   ...     ...  |.....|.|     .|.|||.|  |.|||.  .  ..|||||...         . | |.  |.|||       .  | |..|
R--FPFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGVVLMELVTGKLPVDPTFPDGVDIVSWVRLRISQKASVDDLIDPLLQKVSRTERLEMLLVLK-------AALM
.|..| |...|. | .    .   .   ..       .. |.|. .|||   ..|.    .|.          .
CGCILYEMLCGYPPFP----QMQMMFKKIG-----SPEAKDFIRKCLQKD-PEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_l-1.AA TKL-Unique 911-1118 32 4.3e-38 131.95 In-house 1-233 (290) Show / Hide 
Range on Protein: 911-1118
Range on HMM: 1-233/290
Sequence Identity: 32% (76 aa)

DLNIIGSGGFGTVYKAILPSGEVLAVKKVDVAGDGDPTQDKSFLREVSTLGKIR-HRHLVRLVGFCS----HKGVNLLVYDYMPNGSLFDRLHGSACTE-
..| ||.||.|.|||.. .. .| |.|.  .  |  ..  . | .||... |.. |  .|...|.|     . .   .| .|.| ||| | || .     
FWNKIGEGGYGQVYKGKWRGYPV-AIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-KNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSR-----DEPHLGDFGLAKIIDSSSSSHTL-------SVFAGSYGYIAPEYA
  ||   |... | ..|  || |  ||||  .| | |||.|| |.|.|..         . ||||.|. .... . .        ... ||. ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

YT--MRASEKTDIYSFGVVLMELVTGKL------P
       ||| |.||||.|| |..|.|.      |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_l-1.AA TK 909-1118 15 8.8e-38 123.7 In-house 1-394 (486) Show / Hide 
Range on Protein: 909-1118
Range on HMM: 1-394/486
Sequence Identity: 15% (61 aa)

LSDLNIIGSGGFG---TVYKAILPSG--------------------------EVLAVKKVDVAGDGDPTQDKS-----------FLREVSTLGKIR----
.  .. .|.| ||   .|||... ..                          .  ||| .    . .... .            ||.|.. . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRHLVRLVGFCSHK------------GVNLLVYDYMPNGS----LFDRLHGSACTEKN-----------------------------------------
 | ..|||.| |...            .  ..|  |||.|.    | | |. .  ....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------NAGVLDWESRHRIAVGIAEGIAYLHHD----CAPRIVHRDIKSNNVLLDSRDE-----------PHLGDFG--
                           . . |. . .. ... ||.| .|||        ...||||.   |.|.....              ..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKIIDSSSSSHTLSVFAGSYG------------------------YIAPEYAY---------TMRASEKTDIYSFGVVLMELVT-GKLP
      ||. |.|..  .. |   .. .                        . |||            . . ..|.|..||||.. |..| |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase LRR8_l-1.AA LRRK 909-1120 25 1.9e-37 130.03 In-house 1-284 (351) Show / Hide 
Range on Protein: 909-1120
Range on HMM: 1-284/351
Sequence Identity: 25% (75 aa)

LSDLNIIGSGGFG-TVYKAILPS---------------------------GEVLAVKKVDVA-------------------------------GDGDPTQ
|   . ||.|||| .||.|.. .                           ..  |.|| ..                                ... .. 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

DKSFLREVSTLGKIRHRHLVRLVGFCSHKGVNLLVYDYMPNGSLFDRLHGSACTE----KNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKS
  .| .||. . . .| ..| |.||| |     .| .|.|.|.| ..|| .. ..    |    ...|  ...||. ||.|..|| |.. | |.||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMK---AHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKS

NNVLLDSRDEPH----LGDFGLAKIIDSSSSS------HT-LSVFAGSYGYIAPEYAYTM---RASEKTDIYSFGVVLMELVTGK-LPVD
 |.|| | ...|    ....  |||.| . |.      .. .. . |  |. |||    .     .||.|.||||..| ||.|.. .| |
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_l-1.AA STE 909-1118 23 4.6e-36 124.87 In-house 1-267 (359) Show / Hide 
Range on Protein: 909-1118
Range on HMM: 1-267/359
Sequence Identity: 23% (64 aa)

LSDLNIIGSGGFGTVYKAILP----------------SGEVLAVKKVDVAGD--------------GDPTQDKSFLREVSTLGKIR--HRHLVRLVGFCS
. .. .||.|.|||||||.                  .||. |.|....  .               .... ...|.|.... | .  | . |.  | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HKG-------VNLLVYDYMPNGSLFDRLH---GSACTEKNNA---GVLDWESRHRIAVGIAEG-IAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFG
..|          ..  ||..||| | ..   |  .. ..|    .... .   .|.. | .|  .|||      |.|||||. |.||       | |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKIIDSS--------------SSSHTLSVFAGSYGYIAPEYAYTMR------ASEKTDIYSFGVVLMELVTGKLP
.......|              ...     |.|.  . |||    ..       ..| ||.|.| ...|..||| |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase LRR8_l-1.AA CAMK 914-1118 16 1.7e-33 104.78 In-house 1-333 (425) Show / Hide 
Range on Protein: 914-1118
Range on HMM: 1-333/425
Sequence Identity: 16% (57 aa)

IIGSGGFGTVYKAILP-SG------------EVLAVKKVDVA--------------------GDG-----DPTQDKSFLREVSTLGK-------IRHRHL
..|.|.||.|...|   ..            .  |.| .|                      ...     .|   |...||.. . |       ..|...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLVGFCSHKGV-------------------NLLVY---DYMPNG----SLFDRLH-GSACTEKNNA-------GVLDWESRHRIAVGIAEGIAYLHHDC
..|  .   . .                     .|    .|...|     |||..   . ..|.. .       | .. .  .|.   |.....|.|   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-DQFDIVERGRFTEREARRYFRQICSAVHYCHSH-

APRIVHRDIKSNNVLLDSRD-----------------EPHLGDFGLAKIIDSSSSSH---------------------TLSVFAGSYGYIA-PEYAYTMR
   |||||.|  |.|||...                    . |||.|...|......                      .. | |. .|.| ||     .
--NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

--------------ASEKTDIYSFGVVLMELVTGKLP
               ..|.|. | ||.|  ...|..|
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP
Kinase LRR8_l-1.AA Pkinase_Tyr 909-1118 26 2.1e-30 103.6 Pfam 1-214 (270) Show / Hide 
Range on Protein: 909-1118
Range on HMM: 1-214/270
Sequence Identity: 26% (60 aa)

LSDLNIIGSGGFGTVYKAILP-----SGEVLAVKKVDVAGDGDPTQ--DKSFLREVSTLGKI-RHRHLVRLVGFCS-HKGV--NLLVYDYMPNGSLFDRL
.. .  .|.| ||.|||...       .   |||..    . .. |   ..|.||.... .. .| ..|||.| |. ...    ..|  |||.|.| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HGSACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKII--DSSS-SSHT---LSVFAGSYGYIAPEYA
.       .. . |. .    ... ||.| .||.      ..|||.   |.|...      .|||||. |  |.    ...   | ..       |||  
RKHR----EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK-----WMAPECI

YTMRASEKTDIYSFGVVLMELVT-GKLP
 ... ..|.|..||||.. |..| |. |
NYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_l-1.AA Dicty4 909-1116 34 2.7e-29 95.01 In-house 1-214 (277) Show / Hide 
Range on Protein: 909-1116
Range on HMM: 1-214/277
Sequence Identity: 34% (74 aa)

LSDLNIIGSGGFGTVYKAILPSGEVLAVKKVDVAGDG-DPTQDKSFLREVSTLGKIRHRHLVRLVGFCS----HKGVNLLVYDYMPNGSLFDRLHGSACT
.   ..||.|.||.|||..    || ||||     .. |    ..|..||. ..|||| ... . | |     |.|  . |  ||| |.|.  || .   
INIEQRIGKGSFGEVYKGTWRGKEV-AVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH-DKPS

EKNNAGVLDWESRHR---IAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKIIDSSSSSHT-LSVFAGSYGYIAPEYAYTMRASEK
|.     |||. . |   .|  .| |...||  | |.|.|||.|| | | |       .||||....   ..  . ..  .|. .. |||     .  ||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

TDIYSFGVVLMELVTGK
 | |||| || |..|..
ADVYSFGIVLWEILTRQ
Kinase LRR8_l-1.AA LISK 914-1068 33 7.6e-28 87.39 In-house 1-156 (296) Show / Hide 
Range on Protein: 914-1068
Range on HMM: 1-156/296
Sequence Identity: 33% (55 aa)

IIGSGGFGTVYKAILP-SGEVLAVKKVDV--AGDGDPTQDKSFLREVSTLGKIRHRHLVRLVGFCSH-KGVNLLVYDYMPNGSLFDRLHGSACTEKNNAG
.||.|.|| |||  .  .|.| |.|.         ||   | .|||| .. ..||.. |. .| | | .|   .|  |.  | |...|. ..        
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK----HKI

VLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSR-DEPH---LGDFGLAKIID
.| |. | .||..||.| .|||  .   |.||| ||.|.|.. . ...    ..|||.|...|
PLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMD
Kinase LRR8_l-1.AA TyrKc 909-1190 21 8.5e-25 89.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 909-1190
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

LSDLNIIGSGGFGTVYKAILPSGEVLAVKKVDVAGDGDPTQDKSFLREVSTLGKI--RHRHLVRLVGFCSHK-------GVNLLVYDYMPNGSLFDRLHG
.. . ..|.| ||.|||...   .  |||..           . |.|| . . |.  .| ..|||.| |...       .  ..|  |||.|.| |.|. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SACTEKNNAGVLDWESRHRIAVGIAEGIAYLHHDCAPRIVHRDIKSNNVLLDSRDEPHLGDFGLAKIIDSS------SSSHT-----LSVFAGSYGYIAP
.  .       | ..  . ... ||.| .|||.    ...|||.   |.|....     .||||.. |..       ..  .      . .   .   ||
HRPK-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYAYTMRASEKTDIYSFGVVLMELVT-GKLPVDP-TF--PDGVDIVSWVRLRISQKASVDDLIDPLLQKVSRTERLEMLLVLKAALMCTSSSLGDRPSMR
|   . . ..|.|..||||.. |. | |. |    ..   .  ... .|. .   .   .|.  | .  |  .. . ..      ..|      |||...
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIM-----KQCWHEDPEDRPTFS

EVVDKL
|.....
EIHECF
Kinase LRR8_l-1.AA LISK 1097-1116 45 1e-05 14.39 In-house 217-236 (296) Show / Hide 
Range on Protein: 1097-1116
Range on HMM: 217-236/296
Sequence Identity: 45% (9 aa)

SEKTDIYSFGVVLMELVTGK
.|. |..|||.|| |..|..
DESCDVFSFGIVLCEIITRV
Kinase LRR8_l-1.AA LRRK 1172-1192 28 0.005924 6.27 In-house 331-351 (351) Show / Hide 
Range on Protein: 1172-1192
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CTSSSLGDRPSMREVVDKLKQ
| .    .||.. ..|..|.|
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_l-1.AA TK 1170-1190 23 0.01128 3.93 In-house 466-486 (486) Show / Hide 
Range on Protein: 1170-1190
Range on HMM: 466-486/486
Sequence Identity: 23% (5 aa)

LMCTSSSLGDRPSMREVVDKL
..| .    |||........|
QQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_l-1.AA MLK 1179-1190 50 0.034496 3.55 In-house 280-291 (291) Show / Hide 
Range on Protein: 1179-1190
Range on HMM: 280-291/291
Sequence Identity: 50% (6 aa)

DRPSMREVVDKL
.|||.|..| .|
KRPSFRQIVQHL
Kinase LRR8_l-1.AA Dicty4 1180-1192 33 0.130735 1.34 In-house 263-277 (277) Show / Hide 
Range on Protein: 1180-1192
Range on HMM: 263-277/277
Sequence Identity: 33% (5 aa)

RPSMREVVDK--LKQ
|||. |.. .  |  
RPSFEEIIQRRILEH
Kinase LRR8_l-1.AA Pkinase_Tyr 1179-1190 41 0.857441 3.31 Pfam 259-270 (270) Show / Hide 
Range on Protein: 1179-1190
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

DRPSMREVVDKL
|||...|.. .|
DRPTFSEIHEQL