Gene LRR8_r-2 (S.moellendorffii)

LRR8_r-2

Species: S.moellendorffii
Alias: LRR8_r-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_r-2.AA Protein None 1105 None Fasta, JSON
LRR8_r-2.NA RNA None 3318 None Fasta, JSON
LRR8_r-2.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of LRR8_r-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_r-2.AA LRRNT_2 48-88 39 4.6e-13 45.33 Pfam 1-46 (46) Show / Hide 
Range on Protein: 48-88
Range on HMM: 1-46/46
Sequence Identity: 39% (18 aa)

LRNEVASLIAIKSSLH--DP-SRSLSTWNASD--ACPCAWTGIKCH
. .....|.|.||||.  || . .|| ||.|.  ...| |||. | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 LRR8_r-2.AA LRR_1 117-139 44 0.000243 19.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 117-139
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

QLVYLDLSL-N--DLSGEIPPE-LGNC
.| .||||  |   |.|.|||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 141-164 37 0.005601 14.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 141-164
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RMRYLDLGT-N--SFSGSIPPQVFTRL
. ..|||.  |  ...|.|||  |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 166-188 22 47.430227 0.8 Pfam 1-26 (26) Show / Hide 
Range on Protein: 166-188
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

RIQSFYANT-N--NLSGDLASV-FTRV
..|. . .  |  ||.|.. .  |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 215-238 37 0.016785 13.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 215-238
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTSLHLST-N--LFHGTLPRDGFSSL
||..|.||  |   . |..| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 191-214 37 0.688805 7.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 191-214
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

DLSDLWLYE-N--SLSGEIPPVIFTSA
 |  | |   |  .|.|.||| .| . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 240-262 48 0.000588 18.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 240-262
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

QLQQLGLSQ-N--NLSGEIPPS-LGRC
.|| | ||  |  ||.|.|||| .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 264-286 33 0.000243 19.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 264-286
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ALERIDLSR-N--SFSGPIPPE-LGGC
 |...|||. |  ...| |||. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 288-310 37 0.000892 17.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 288-310
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLTSLYLFY-N--HLSGRIPSS-LGAL
.|..|.| . |  .|.| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 312-335 33 0.105451 10.21 Pfam 1-26 (26) Show / Hide 
Range on Protein: 312-335
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LVTIMDLSY-N--QLTGEFPPEIAAGC
  .. |||. |  .|||..||..  ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 337-359 37 0.001528 16.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 337-359
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLAYLSVSS-N--RLNGSIPRE-FGRL
.| .|..|. |  .| |.|| . |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 361-383 40 0.006462 14.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 361-383
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLQTLRMES-N--TLTGEIPPE-LGNS
.||.| . . |   |||.|||. . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 385-407 37 0.013547 13.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 385-407
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLLELRLAD-N--QLTGRIPRQ-LCEL
.| .| | . |  .||| ||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 409-431 40 0.007454 14.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 409-431
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

HLQVLYLDA-N--RLHGEIPPS-LGAT
.||.|.|.  |  .| |.|||| . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 433-456 37 0.013994 13.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 433-456
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTEVELSN-N--LLTGKIPAKSLCSS
||..  ||. |   |||.||  .. . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 482-504 33 0.041663 11.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 482-504
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RIQRLRLSN-N--LFDGSIPVD-FAKN
..|.| ||. |   . |.|| . | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 506-528 37 0.149742 9.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 506-528
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALYFLDLAG-N--DLRGPVPPE-LGSC
 |  ||| | |   | | .||. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 530-552 29 0.005786 14.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 530-552
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLSRIELQR-N--RLSGPLPDE-LGRL
|| .. |.. |  .|.| .|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 554-576 40 0.034288 11.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 554-576
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLGYLDVSS-N--FLNGTIPAT-FWNS
.| .||.|. |   | |.||   | | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 602-624 37 0.000903 17.54 Pfam 1-26 (26) Show / Hide 
Range on Protein: 602-624
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLNYLRLQR-N--ELTGVIPDE-ISSL
.| .| |.. |   ||| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 578-601 25 0.101421 10.27 Pfam 1-26 (26) Show / Hide 
Range on Protein: 578-601
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLTTLDLSS-N--SIHGELSMAATSSS
.|..||||. |  .. |...  .  . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 626-648 33 2.159911 5.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 626-648
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

GLMEFNLAE-N--KLRGAIPPA-LGQL
 | . .|   |  .| | |||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 655-673 43 0.13762 9.8 Pfam 5-26 (26) Show / Hide 
Range on Protein: 655-673
Range on HMM: 5-26/26
Sequence Identity: 43% (10 aa)

LNLSW-N--SLTGPIPQA-LSSL
|.||  |  .||| ||   . .|
LDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 675-697 40 0.000404 18.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 675-697
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

MLQSLDLSH-N--SLEGSLPQL-LSNM
 ||.||||. |  .|.|..|   . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_r-2.AA LRR_1 699-719 30 0.030506 12.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 699-719
Range on HMM: 1-26/26
Sequence Identity: 30% (8 aa)

SLISVNLSY-N--QLSGKLPSG--QL
.| . .||. |  .|.|..|..  .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
Kinase LRR8_r-2.AA TKL 831-1101 22 9.1e-61 208.19 In-house 1-364 (364) Show / Hide 
Range on Protein: 831-1101
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

IGRGAHGVVYCVTTSS---------GHVFAVKKLTYRS----------------------QDDDTNQSFEREIVTA---GSFRHRHVVKLVAYRRSQPD-
||.|. |.||  .            | . ||||.  ..                       |... . ...|.. .    ..|| ..|....|  . |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SNMIVYEFMPNGSLDTALHKNGDQLDWPTRWKIALGAAHGLAYLHHDCV-----PSVIHRDVKASNILLDADME--------------A
             .||.|..|.|||   ||       |. | ..||..| |..||| .       | .|||| | .|||.| ...              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLTDFGIAKLTYERDPQTASA------------------IVGTLGYMAPEY-----GYT-----------MRLSDKVDVYGFGVVLLELATRKSPFD--R
|..|||...   ..  .....                  ..||...||||       ||              | |.||| ||.|| |..||. |..   
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NFPAEGMDLVSWVRAQVLLSSETLRIEEFVDNVLLETGASVE--VMMQFVKLGLLCTTLDPKERPSMREVVQML
..| ...|.. .  ..| . .. . | .   |.. . . . .  .. .. ||   |   ||..|||. |... |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_r-2.AA IRAK 826-1022 32 4.3e-51 176.05 In-house 2-219 (317) Show / Hide 
Range on Protein: 826-1022
Range on HMM: 2-219/317
Sequence Identity: 32% (72 aa)

SDDNIIGRGAHGVVYCVTTSSGH-VFAVKKL--TYRSQDDDTNQSFER---EIVTAGSFRHRHVVKLVAYRRSQPDSNMIVYEFMPNGSLDTALH--KNG
. || || |. |.|| .  .    ..|||||  .  .. .   |.|     |. .  ..|| ..| | .|  ....    ||..||||||   |.  .. 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGY-CTERQCHCLVYPYMPNGSLEDRLWCQDGQ

DQ---LDWPTRWKIALGAAHGLAYLHHDC-VPSVIHRDVKASNILLDADMEAKLTDFGIAKL-----TYERDPQ---TASAIVGTLGYMAPEYGY--TMR
.    | |..| .|..|.| |. .|| .    ..||.|.| .|||||.....|..||| .         |. .     .| ..||. ||.||. .  . .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSDKVDVYGFGVVLLELAT
|. |.||| ||.||||..|
LTKKTDVYSFGIVLLEVLT
Pkinase LRR8_r-2.AA Pkinase 825-1028 27 1.6e-41 147.93 Pfam 1-213 (293) Show / Hide 
Range on Protein: 825-1028
Range on HMM: 1-213/293
Sequence Identity: 27% (60 aa)

VSDDNIIGRGAHGVVY-CVTTSSGHVFAVKKLTYRSQDDDTNQSFER--EIVTAGSFRHRHVVKLVAYRRSQPDSNMIVYEFMPNG----SLDTALH-KN
     .||.|. |.|| |.  ..|...|||.. .|..... .|.  |  ||    ...| ..|.|  . .. .|.  .| |....|    .| . .. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

GDQL--DWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLDADMEA----KLTDFGIAKLT-YERDPQTASAIVGTLGYMAPEY--GYTMRLSDK
.  .  .. .  ....  . ||.|.|     ..||||.| .|||.| ...     |..|||.||.  | ...  .. ..||..|||||   |...  . |
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGP-K

VDVYGFGVVLLELATRKSPFD
||....|..| |..... ||.
VDMWSCGCILYEMLCGRPPFP
S_TKc LRR8_r-2.AA S_TKc 825-1101 22 4.9e-39 136.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 825-1101
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

VSDDNIIGRGAHGVVYCVTTSS-GHVFAVKKLTYRSQDDDTNQSFEREIVTAGSFRHRHVVKLVAYRRSQPDSNMIVYEFMPN--GSLDTALHKNGDQ--
    ..||.|| |.||...  . |...|.|..          ....|||    . .| ..|||  . ..  |.  .| |....  |.| . ..|.| .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLDADMEAKLTDFGIAKLTYERDPQTASAIVGTLGYMAPEYGYTMRLSD-KVDVYGFGV
   ..  . ....   . .|.|.|      .||||.| .|||||   . |..|||.|..         . ..||. |||||       .  |.|.. .|.
RFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLLELATRKSPFDRNFPAEGMDLVSWVRAQVLLSSETLRIEEFVDNVLLETGASVEVMMQFVKLGLLCTTLDPKERPSMREVVQ---------ML
.| |..... ||.   ... ....                             | |.   |..    | . ||..||.  |. |          .
ILYEMLCGYPPFP--QMQMMFKKIG----------------------------SPEAKD-FIR---KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_r-2.AA Dicty4 891-1027 36 1.3e-38 126.56 In-house 71-217 (277) Show / Hide 
Range on Protein: 891-1027
Range on HMM: 71-217/277
Sequence Identity: 36% (54 aa)

RSQPDSNMIVYEFMPNGSLDTALHK------NGDQLDWPTRWK---IALGAAHGLAYLHH-DCVPSVIHRDVKASNILLDADMEAKLTDFGIAK-LTYER
||.| . .|| |.|| |.| . ||.        ..||||.. .   .|. || |...||  ..|  .|||| |..|.| |... .| .|||...    . 
RSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHE

DPQT-ASAIVGTLGYMAPEYGYTMRLSDKVDVYGFGVVLLELATRKSPF
| .. ... .|| ..||||     .   |.||| || || |..||. |.
DHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPY
Kinase LRR8_r-2.AA MLK 825-1034 25 1e-37 128.42 In-house 1-244 (291) Show / Hide 
Range on Protein: 825-1034
Range on HMM: 1-244/291
Sequence Identity: 25% (63 aa)

VSDDNIIGRGAHGVVYCVTTSSGH----VFAVKKLTYRSQDDDTN-----QSFEREIVTAGSFRHRH----VVKLVAYRRSQPDSNMIVYEFMPNGSLDT
     .|| |. |.|.  .         . |||. . |   |        . ||.|.  .  ..|.     ......   ..|    || |....||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALHK---------NGDQ----LDWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLDA------DMEAKLTDFGIAKLTYERDPQTASAIVGTLG
 ||          ....     |     ..||  |.|..||| . .. .|||| | .|||.|.      .. .| .|||...  .... ..     ||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YMAPEY---GYTMRLSDKVDVYGFGVVLLELATRKSPFD-RNFPAE
.||||        . | |.||. .|||| |. ||. |..  . |..
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMA
Kinase LRR8_r-2.AA STE 825-1027 23 4.5e-33 114.15 In-house 1-268 (359) Show / Hide 
Range on Protein: 825-1027
Range on HMM: 1-268/359
Sequence Identity: 23% (64 aa)

VSDDNIIGRGAHGVVYCVTTS----------------SGHVFAVKKLTYRSQD---------------DDTNQSFEREIVTAGSFR--HRHVVKLVAYRR
  .  .||.|| |.||.                    .| ..|.|.. .....               ..  |....|| .   ..  | ..||   .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SQP------DSNMIVYEFMPNGSLDTALH-KNGDQLD------------WPTRWKIALGAAHG-LAYLHHDCVPSVIHRDVKASNILLDADMEAKLTDFG
         |.  |. |.|..||||  .. | | . .             .   .|.    .| |.|||      .||||.|..||||     .||.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

IAK-LTYERD--------------PQTASAIVGTLGYMAPEYGYTMR------LSDKVDVYGFGVVLLELATRKSPF
... || . .               |    .|||  .||||    ..       . |.|.. .| ...|.|| | |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase LRR8_r-2.AA LISK 830-1026 27 7.7e-33 103.88 In-house 1-238 (296) Show / Hide 
Range on Protein: 830-1026
Range on HMM: 1-238/296
Sequence Identity: 27% (66 aa)

IIGRGAHGVVYCVTTS-SGHVFAVKKLTY---RSQDDDTNQSFEREIVTAGSFRHRHVVKL--VAYRRSQPDSNMIVYEFMPNGSLDTALHKNGD---QL
.||.|. | || .|   .| | |.|...     . |...   ..||. .  ..||...|.   | |.    .. .|| |..  | |   |....    .|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYH--NDGQLHIVTEYINGGDLHQYLKDMDKHKIPL

DWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLD----ADMEAKLTDFGIAKLTYERDPQ------------------------------TAS-
 || | ||||. | |..|||  .   .|||| |. |.|..     . ..|..||| |..  ... .                              ..  
PWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKR

--AIVGTLGYMAPEYGYTMRLSDKVDVYGFGVVLLELATRKSP
  .|.||   ||||    .  ....||. ||.||.|. ||. .
RMTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase LRR8_r-2.AA LRRK 825-1028 25 1e-32 113.06 In-house 1-284 (351) Show / Hide 
Range on Protein: 825-1028
Range on HMM: 1-284/351
Sequence Identity: 25% (75 aa)

VSDDNIIGRGAHG-VVYCVTTSS---------------------------GHVFAVKKLTYR----------------------SQDDDTN---------
.   . ||||. | .||  .  .                           .   |.||..                        .| .| .         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

--QSFEREIVTAGSFRHRHVVKLVAYRRSQPDSNMIVYEFMPNGSLDTALHKNG-DQ-------LDWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKAS
  ..| .|..   ...| ..|.|. .  . .   ..| |..|.|.|.. ||..  |.       ..| .. ||||  | |..|| |.. |..|||| |  
AFREFRHEVWIMSHLNHPNIVSLKGFCIHPL---CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSP

NILL---D---------ADMEAKLTDFGIAKLTYERDPQT-ASAIVGTLGYMAPE-YGYT--MRLSDKVDVYGFGVVLLELATRK-SPFD
||||   .         |.. ||. ||||    .  .. . |.  ||. |.||||  .|.     ..|||.| ||..| || ||.  |||
NILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_r-2.AA TKL-Unique 827-1028 30 2.4e-32 111.42 In-house 1-235 (290) Show / Hide 
Range on Protein: 827-1028
Range on HMM: 1-235/290
Sequence Identity: 30% (74 aa)

DDNIIGRGAHGVVYCVTTSSGHVFAVKKLTY-RSQDDDTNQSFEREIVTAGSFR-HRHVVKLVAYRR-SQPDSN--MIVYEFMPNGSLDTALH-------
. | ||.|. |.|| ..  .  | |.|..    ..  .  | ||.|. .   .. |  .|....|    |.. .   || |..| |||.  ||       
FWNKIGEGGYGQVYKGKWRGYPV-AIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--KNGDQLDWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLDAD-----MEAKLTDFGIAKLTYERDPQTASAI--------VGTLGYMAPEYG
  .|   |..  | |.|. .| |. ||||   | .|||| | ||.|.| .     . .|. |||..|.   ..  |.. .        .|.. .||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE--

YTMRL----SDKVDVYGFGVVLLELATRKS------PFD
 ....    | |.||| ||.|| |.||||       |..
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQ
Kinase LRR8_r-2.AA TK 825-1023 14 6.8e-30 96.79 In-house 1-390 (486) Show / Hide 
Range on Protein: 825-1023
Range on HMM: 1-390/486
Sequence Identity: 14% (57 aa)

VSDDNIIGRGAHG---VVYCV--------------------------TTSSGHVFAVKKLT-YRSQDDDTNQS--------------FEREIVTAGS--F
.   . .|.|. |   .||                            ..   .  ||| |.   .....  .               . .|.    .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHVVKLVA-YRRSQP----------DSNMIVYEFMPNGS----LDTALHKNGD---------------------------------------------
.| ..|.|..   ...|             ||| |.||.|.    |.. |.|. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLDWPTRWKIALGAAHGLAYLHHD----CVPSVIHRDVKASNILLDADME-----------AKLTDFGIA
                              ||. ...  ... .| |..|||        . ..|||. | |.|.. ..            .|..||| .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------KLTYERDPQTASAIVGTLG-------------------------YMAPEYGY---------TMRLSDKVDVYGFGVVLLELATR
        .  |..|  ...   || .                         .||||            . . . | ||. |||.. |. |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Kinase LRR8_r-2.AA DRK 894-1027 37 9.7e-28 91.05 In-house 69-202 (258) Show / Hide 
Range on Protein: 894-1027
Range on HMM: 69-202/258
Sequence Identity: 37% (50 aa)

PDSNMIVYEFMPNGSLDTALHKNGDQLDWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLDADMEAKLTDFGIAK-LTYERDPQTASAIVGTLG
| .  |. |.|| |||   ||    ..||| . .... .| |. |||  | | .|||| |  | | |     |  ||| .      ..  .|   .|| .
PPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPC

YMAPEYGYTMRLSDKVDVYGFGVVLLELATRKSPF
  |||     |   | ||| |..|| |..||. |.
WTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPY
Kinase LRR8_r-2.AA Pkinase_Tyr 851-980 28 1.4e-22 77.11 Pfam 32-165 (270) Show / Hide 
Range on Protein: 851-980
Range on HMM: 32-165/270
Sequence Identity: 28% (39 aa)

AVKKLTYRSQDDDTN---QSFEREIVTAGSF-RHRHVVKLVAYRRSQPDS--NMIVYEFMPNGSLDTALHKN---GDQLDWPTRWKIALGAAHGLAYLHH
|||.|  . . .. .   ..| ||. .  .. .| ..|.|..   .| ..   .|| |.||.|.|.. |.|.   ...|. ..  ....  | |..||. 
AVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES

DCVPSVIHRDVKASNILLDADMEAKLTDFGIAKLTYERD
      ||||. | |.|.. .. .| .||| |.. |. |
KN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase LRR8_r-2.AA TyrKc 825-1101 22 9.7e-18 64.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 825-1101
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

VSDDNIIGRGAHGVVYCVTTSSGHVFAVKKLTYRSQDDDTNQSFEREIVTAGSF--RHRHVVKLVAYRRSQP------DSNMIVYEFMPNGSLDTALHKN
.. . ..|.|| |.||  | .     |||.|   .      . | ||.    ..  .| ..|.|... ..|       .  ||| |.||.|.|.  |.|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GDQLDWPTRWKIALGAAHGLAYLHHDCVPSVIHRDVKASNILLDADMEAKLTDFGIAKLTYER-------DPQTA----SAI-VGTLGYMAPEYGYTMRL
...| ...  .... .| | .|||.     .||||  | |.|....  .| .||| ..  |.        |  ..    ..  .  .  ||||   . . 
RPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SDKVDVYGFGVVLLELATR-KSPFDR---NFPAEGMDLVSWVRAQVLLSSETL----RIEEFVDNVLLETGASVEVMMQFVKLGLLCTTLDPKERPSMRE
. | ||. |||.. |. |. ..|      . . .  ... .|..   .                        .|.      .. . |   ||..||...|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS--------------FVCCPDEMYQIMKQCWHEDPEDRPTFSE

VVQML
... .
IHECF
Kinase LRR8_r-2.AA LISK 1075-1101 48 7e-06 14.97 In-house 270-296 (296) Show / Hide 
Range on Protein: 1075-1101
Range on HMM: 270-296/296
Sequence Identity: 48% (13 aa)

QFVKLGLLCTTLDPKERPSMREVVQML
.|..| . |. .|||.|||  |.|| |
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_r-2.AA TK 1081-1101 28 2e-05 13.35 In-house 466-486 (486) Show / Hide 
Range on Protein: 1081-1101
Range on HMM: 466-486/486
Sequence Identity: 28% (6 aa)

LLCTTLDPKERPSMREVVQML
. |  .||..||........|
QQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_r-2.AA LRRK 1082-1103 36 0.000216 11.43 In-house 330-351 (351) Show / Hide 
Range on Protein: 1082-1103
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

LCTTLDPKERPSMREVVQMLQS
.| . |||.||.. ..|. | .
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_r-2.AA MLK 1087-1101 60 0.00035 10.56 In-house 277-291 (291) Show / Hide 
Range on Protein: 1087-1101
Range on HMM: 277-291/291
Sequence Identity: 60% (9 aa)

DPKERPSMREVVQML
||..|||.|..|| |
DPHKRPSFRQIVQHL
Kinase LRR8_r-2.AA Dicty4 1087-1103 42 0.000375 9.94 In-house 259-277 (277) Show / Hide 
Range on Protein: 1087-1103
Range on HMM: 259-277/277
Sequence Identity: 42% (8 aa)

DPKERPSMREVVQM--LQS
||. |||. |..|   | .
DPQHRPSFEEIIQRRILEH
Kinase LRR8_r-2.AA DRK 1087-1103 47 0.000383 9.97 In-house 242-258 (258) Show / Hide 
Range on Protein: 1087-1103
Range on HMM: 242-258/258
Sequence Identity: 47% (8 aa)

DPKERPSMREVVQMLQS
||  |||| |... | .
DPQHRPSMQECLERLEA
Kinase LRR8_r-2.AA Pkinase_Tyr 1087-1101 40 0.012408 9.54 Pfam 256-270 (270) Show / Hide 
Range on Protein: 1087-1101
Range on HMM: 256-270/270
Sequence Identity: 40% (6 aa)

DPKERPSMREVVQML
||..||...|....|
DPEDRPTFSEIHEQL
Kinase LRR8_r-2.AA IRAK 1089-1101 38 0.036487 3.67 In-house 305-317 (317) Show / Hide 
Range on Protein: 1089-1101
Range on HMM: 305-317/317
Sequence Identity: 38% (5 aa)

KERPSMREVVQML
..|..|..|.| |
NRRCDMAWVMQQL
Kinase LRR8_r-2.AA TKL-Unique 1083-1101 42 0.096612 2.14 In-house 272-290 (290) Show / Hide 
Range on Protein: 1083-1101
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CTTLDPKERPSMREVVQML
| . || .|||  |..  |
CWHHDPSQRPSFDEIIHRL
Kinase LRR8_r-2.AA Pkinase 1085-1101 31 0.961821 3.71 Pfam 275-293 (293) Show / Hide 
Range on Protein: 1085-1101
Range on HMM: 275-293/293
Sequence Identity: 31% (6 aa)

TLDPKERPSMREVVQM--L
..|||.||. ....|   .
CKDPKKRPTAEQILQHPWF
Kinase LRR8_r-2.AA Pkinase_Tyr 994-1023 40 3.455054 1.26 Pfam 181-210 (270) Show / Hide 
Range on Protein: 994-1023
Range on HMM: 181-210/270
Sequence Identity: 40% (12 aa)

MAPEYGYTMRLSDKVDVYGFGVVLLELATR
||||   ... . | ||. |||.. |. |.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY