Gene LRR8_o-1 (S.moellendorffii)

LRR8_o-1

Species: S.moellendorffii
Alias: LRR8_o-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_o-1.AA Protein None 1218 None Fasta, JSON
LRR8_o-1.NA RNA None 3657 None Fasta, JSON
LRR8_o-1.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of LRR8_o-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_o-1.AA LRRNT_2 39-78 40 2.2e-13 46.36 Pfam 1-46 (46) Show / Hide 
Range on Protein: 39-78
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

LSSDLQVLLEVKAAII--DR-NGSLASWN----ESRPCSQWIGVTCA
...|.| ||. |...   |. .|.|.|||     | .|| | |||| 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS-WTGVTCD
LRR_1 LRR8_o-1.AA LRR_1 112-134 29 0.001451 16.81 Pfam 1-26 (26) Show / Hide 
Range on Protein: 112-134
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLRFLNMSY-N--WLEGEIPGE-IGQC
.|. |..|. |   |.|.|| . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 136-159 40 2.1e-05 23.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 136-159
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLEQLDLSN-N-THITGRIPPE-LGDC
.|. ||||. | ...|| |||. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 161-183 37 0.207184 9.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 161-183
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NMTFIDLSV-N--QLEGGIPSS-ITRM
| . .|||  |  .|.| ||.| .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 185-207 44 0.000391 18.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 185-207
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

KLEILVLYQ-N--NLTGEIPPD-IGRL
.|..| |   |  ||||.|||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 209-231 33 0.072356 10.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 209-231
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

MLQNLHLYS-N--KMNGEIPAG-IGSL
 || |.| . |  .. |.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 233-255 37 0.034963 11.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 233-255
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

HLDVLILQE-N--QFTGGIPPS-LGRC
.| .| |.  |  ..|| |||| .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 257-279 44 0.036589 11.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 257-279
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLSTLLLGT-N--NLSGIIPRE-LGNL
|| .| |.  |  ||.| || . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 281-303 29 0.010863 13.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 281-303
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLQSLQLFD-N--GFSGELPAE-LANC
.||.| | . |   ..|..| . . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 305-327 37 0.001432 16.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 305-327
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLEHIDVNT-N--QLEGRIPPE-LGKL
.|.|.|..  |  .|.| |||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 329-351 25 0.026444 12.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 329-351
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLSVLQLAD-N--GFSGSIPAE-LGDC
.| .| | . |   ..|.|| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 353-375 40 0.004793 14.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 353-375
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTALVLNM-N--HLSGEIPRS-LSGL
||. | |.  |  .|.|.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 377-399 37 0.132361 9.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 377-399
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLVYVDISE-N--GLGGGIPRE-FGQL
.| . |.|  |   | | || . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 401-423 25 0.039554 11.72 Pfam 1-26 (26) Show / Hide 
Range on Protein: 401-423
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLETFQART-N--QLSGSIPEE-LGNC
.|..   .  |  .|.|.||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 425-447 40 0.020263 12.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 425-447
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLSVMDLSE-N--YLTGGIPSR-FGDM
.| . |||  |   ||| ||.. |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 448-470 25 1.530993 6.09 Pfam 1-26 (26) Show / Hide 
Range on Protein: 448-470
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

AWQRLYLQS-N--DLSGPLPQR-LGDN
  |.|.|.. |   |.| .| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 472-494 25 23.852725 1.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 472-494
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

MLTIVHSAN-N--SLEGTIPPG-LCSS
 |.. .  . |  .|.|.|||. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 496-518 29 0.117759 10.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 496-518
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLSAISLER-N--RLTGGIPVG-LAGC
.|  ..| . |  .||| || . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 520-542 29 0.102082 10.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 520-542
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLRRIFLGT-N--RLSGAIPRE-FGDN
.|... |.  |  .|.| || . |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 544-566 29 0.000494 18.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 544-566
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLTYMDVSD-N--SFNGSIPEE-LGKC
||.. |.|. |  .. |.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 568-590 33 0.020796 12.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 568-590
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

MLTALLVHD-N--QLSGSIPDS-LQHL
 |. | . . |  .|.|.||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 592-614 37 2.949811 5.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 592-614
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ELTLFNASG-N--HLTGPIFPT-VGRL
 |.  . || |  .||| | |     |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 616-638 44 0.004492 15.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 616-638
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ELIQLDLSR-N--NLSGAIPTG-ISNI
 |  ||||. |  ||.| || . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 640-662 33 23.545238 1.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 640-662
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

GLMDLILHG-N--ALEGELPTF-WMEL
 |  | | | |   |.|..|      |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 664-686 37 0.01237 13.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 664-686
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLITLDVAK-N--RLQGRIPVQ-VGSL
|| .||.   |  .|.| ||     .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 688-710 44 0.002047 16.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 688-710
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLSVLDLHG-N--ELAGTIPPQ-LAAL
.| .||| | |   | |.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 712-734 48 7.5e-05 21.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 712-734
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

RLQTLDLSY-N--MLTGVIPSQ-LDQL
.||.||||. |   ||| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-1.AA LRR_1 736-758 25 0.01221 13.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 736-758
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLEVLNVSF-N--QLSGPLPDG-WRSQ
.|..|..|  |  .|.| .|..   . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRR8_o-1.AA IRAK 852-1058 35 1.3e-55 191.07 In-house 1-225 (317) Show / Hide 
Range on Protein: 852-1058
Range on HMM: 1-225/317
Sequence Identity: 35% (80 aa)

FHSRFVIGQGAYGTVYKAKLPSGLE--FAVKKL---QLVQGERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLDDCDLLVYEFMANGSLGDMLYRRP-
||  ..||.|..|.||.... ....  .|||||     .. . . .  ..|. |||.     | ||| | ...   .|  |||..|.|||| | |  .  
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

SES---LSWQTRYEIALGTAQGLAYLHHDCSP-AIIHRDIKSNNILLDIEVKARIADFGLAKLV-EKQ-VETGSM-----SSIAGSYGYIAPEYAY--TL
. .   |||..| .|..||| |. .|| . .  .|||.|||| |||||    . |.||||.    ...  | ..      | . |.  | .||. .  . 
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

RVNEKSDVYSFGVVILELLLGKSPVD
.   |.||||||.|.||.| |  .|.
QLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase LRR8_o-1.AA TKL 858-1056 22 4.9e-52 179.2 In-house 1-288 (364) Show / Hide 
Range on Protein: 858-1056
Range on HMM: 1-288/364
Sequence Identity: 22% (68 aa)

IGQGAYGTVYKAKLPS---------GLEFAVKKLQLVQ-----------------------GERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLDDC-
||.|..|.|||.|.           | . ||||.   .                        . .        .|..   . .| |||.. .. .  .| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------DLLVYEFMANGS-LGDMLYRRPSESLSWQTRYEIALGTAQGLAYLHHDCS-----PAIIHRDIKSNNILLDIEVK-------------
              .|.|.. .|| | ...         |. |  .||..|.|..||| .       |.|||||.||.|||.|   .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-ARIADFGLAKLVEKQVETGSMSS-----------------IAGSYGYIAPEYA-----YT-----------LRVNEKSDVYSFGVVILELLLGKSP
 . |.||||.. ...  .   ...                 . |.... |||       ||           .  .||.||||||.|. |.| .. |
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase LRR8_o-1.AA Pkinase 852-1056 28 6e-44 156.48 Pfam 1-211 (293) Show / Hide 
Range on Protein: 852-1056
Range on HMM: 1-211/293
Sequence Identity: 28% (62 aa)

FHSRFVIGQGAYGTVYKAKLPSGLE-FAVKKLQLVQGERSAVDDRSSLR--ELKTAGQVKHRNIVKLHAFFKLDDCDLLVYEFMANG----SLGDMLYRR
.|   .||.|..|.|||..  .  . .|||.. ..  ...   |.. .|  |..    ..| |||.|. .|  .|   .| |.. .|    .| |.. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

PSESL--SWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKA----RIADFGLAKLVEKQVETGSMSSIAGSYGYIAPEYAY-TLRVNEK
 . ..  |...   ... ...||.|.|      |||||.|. |||.| .       .|.||||||...     . |....|...|.|||          |
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVYSFGVVILELLLGKSP
.|..|.|... |.|.|. |
VDMWSCGCILYEMLCGRPP
Kinase LRR8_o-1.AA S_TKc 852-1126 24 4.7e-38 133.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 852-1126
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

FHSRFVIGQGAYGTVYKAKLPS-GLEFAVKKLQLVQGERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLDDCDLLVYEFMAN--GSLGDMLYRRPSES
..   .||.||.|.|||..  . | ..|.|..            .. .||..   . .| |||||. .|   |.  .| |.. .  |.| |.. .|... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEKQVETGSMSSIAGSYGYIAPEYAYTLRVNE-KSDVYSF
    ..  .   ..  ....|.|.|      |||||.|  |||||      |.|||||...         ... |.  |.|||       .  |.|..|.
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVILELLLGKSPVDPLFLEKGENIVSWAKKCGSIEVLADPSVWEFASEGDRSEMSLLLR-VALFCTRERPGDRPTMKEAVE---------ML
|... |.| |. | .        ..    ||.|                      |  ..     | .  | .|||  || .          .
GCILYEMLCGYPPFP--------QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_o-1.AA MLK 852-1051 26 1.3e-36 124.52 In-house 1-230 (291) Show / Hide 
Range on Protein: 852-1051
Range on HMM: 1-230/291
Sequence Identity: 26% (61 aa)

FHSRFVIGQGAYGTVYKAKLPSGL----EFAVKKLQLVQGERSAVD---DRSSLRELKTAGQVKHRN----IVKLHAFFKLDDC-DLLVYEFMANGSLGD
.    .|| |..| |.|..    .    . |||.        ...    ..   .| . .  ..|.|    |... .  . . |  ..| |....||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

MLYR-RPSES-----------LSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDI------EVKARIADFGLAKLVEKQVETGS-MSSIAGS
 |.  |. ..            . .    .||  |.|..||| .  ..|||||.|| |||.|       . ...|.|||...  ...  . . | | ||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR--DWHQMC-TNMMSNAGT

YGYIAPEY---AYTLRVNEKSDVYSFGVVILELL
| . |||    .   ...||.||.|.|||. |.|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase LRR8_o-1.AA STE 852-1056 23 1.4e-32 112.45 In-house 1-267 (359) Show / Hide 
Range on Protein: 852-1056
Range on HMM: 1-267/359
Sequence Identity: 23% (64 aa)

FHSRFVIGQGAYGTVYKA--KLPS--------------GLEFAVKKLQLVQG--------ERSAV-------DDRSSLRELKTAGQVK--HRNIVKLHAF
.    .||.||.||||||  . ..              |  .|.|.. | .         . . .       .  . |.|.|.  . .  | |||| .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FKLD-------DCDLLVYEFMANGSLGDMLYR--RPSESLS----------WQTRYEIALGTAQG-LAYLHHDCSPAIIHRDIKSNNILLDIEVKARIAD
.  .       |   .. |.|..||| |.. .   . ..|.           .    |.  . .| |.|||      |||||||. ||||     . ..|
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCD

FGLAKLVEKQVE------------TGS-MS-SIAGSYGYIAPEYAYTLRVN------EKSDVYSFGVVILELLLGKSP
||... ... .             |.. .. ...|.  . |||     . .      .|.|..|.| .|.|.. || |
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase LRR8_o-1.AA RIPK 858-1056 29 9e-32 105.53 In-house 1-227 (290) Show / Hide 
Range on Protein: 858-1056
Range on HMM: 1-227/290
Sequence Identity: 29% (67 aa)

IGQGAYGTVYKAKLPSGLEFAVKKL---QLVQGERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLD----DCDL--LVYEFMANGSLGDMLYRRPS--
.| |. |.|.||   .  . ..||      .. .    .    ..| |   . ....||..  | .      || |  .| |.|.|||| . | ....  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-ESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEKQVETG---------SMSSIA--GSYGYIAPEYAY---T
   . |  |  .   .. |  || |.  | ||||| |  |||.| .  . |||||||.  .    ..         || |    |   |..||       
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

LR---VNEKSDVYSFGVVILELLLGKSP
 .   |..|.|||||..|. |.| .| |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR8_o-1.AA TKL-Unique 857-1051 31 3.6e-31 107.26 In-house 4-222 (290) Show / Hide 
Range on Protein: 857-1051
Range on HMM: 4-222/290
Sequence Identity: 31% (70 aa)

VIGQGAYGTVYKAKLPSGLEFAVKKLQLVQGERSAVDDRSSLRELKTAGQVK-HRNIVKLHAFFK----LDDCDLLVYEFMANGSLGDMLYR--------
.||.|.||.|||.| . | . |.|.. . . . |    .   .|...    . | |||.. .. .          .| |..  ||| | | .        
KIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

RPSESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIE-----VKARIADFGLAKLVEKQVETGSM-------SSIAGSYGYIAPEYAYT
...  |..| |. .|.  |||. ||||   | |||||.|| |.|.| .     ....|.||||.|.  |  .. .        ..  ||. ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--LRVNEKSDVYSFGVVILELL
     .|||||||||.|  |..
NFCQYSEKSDVYSFGIVLWEIA
Kinase LRR8_o-1.AA Ciliate-E2 852-1056 21 8.7e-31 102.89 In-house 1-295 (365) Show / Hide 
Range on Protein: 852-1056
Range on HMM: 1-295/365
Sequence Identity: 21% (66 aa)

FHSRFVIGQGAYGTVYKA--KLPSGLE-----------------FAVKK---LQLVQGERSAVDD-RSSLRELKTAG-----------QVKHRNIVKLHA
.    .||||..|.|||.  ..   ..                 ...|.    .. . .  ..    . .||..  .           |..| ||.|.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

FFK--LDDCDLLVYEFMANGSLGDMLY----RRPSE-----SLSWQTRYEIALGTAQ---------------GLAYLHHDCSPAIIHRDIKSNNILLDIE
.|.   |..  || |.   |.| | ..     |..|     ..... . .|    .|               .| |||   .  ||||||| .|||.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF---

VKARIADFGLAK-----------------LVEKQVETGSMSS-------------IAGSYGYIAPEYAYTLRVN---------EKSDVYSFGVVILELLL
    |.||||.|                 . . ...|  ...             |.|..|| |||       .         .|.|..|.||.. |.| 
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GKSP
|| |
GKPP
Kinase LRR8_o-1.AA TK 852-1051 15 5.4e-29 93.73 In-house 1-388 (486) Show / Hide 
Range on Protein: 852-1051
Range on HMM: 1-388/486
Sequence Identity: 15% (59 aa)

FHSRFVIGQGAYG---TVYKAKLPSGL--------------------------EFAVKKLQLV-QGERSAVDDR---------SSLRELKTAGQVK----
 .   ..|.|..|   .|||... ..                           . ||| | .    .  .  |.           |.|.  . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNIVKLHAFFKLDDCD------------LLVYEFMANGS----LGDMLY--RRPSES-----------------------------------------
 | |||.|..    ...             ..| |.|..|.    | | |   |..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWQTRYEIALGTAQGLAYLHHD-CSPA---IIHRDIKSNNILLDIEVK-----------ARIADFGLA
                               |. ...  ...  |.|..|||   |.     ..|||.   |.|.. . .           ..||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KLVE----KQVETGSMSSIAGSYG----------------------------YIAPEYAY---------TLRVNEKSDVYSFGVVILELL
.  .    . .. ..    ..|||                            . |||            . .  .||||.||||.. |..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase LRR8_o-1.AA Ciliate-E2-Unclassified 852-1056 21 1e-28 96.78 In-house 1-269 (352) Show / Hide 
Range on Protein: 852-1056
Range on HMM: 1-269/352
Sequence Identity: 21% (59 aa)

FHSRFVIGQGAYGTVYKAKLPSGLEFAVKKLQLVQGERSAVDDRSS---------LRELKTAGQVK--------------HRNIVKLHAFFKLDDCDLLV
..   .||||..|.|||..  .  .....|   .. ...    ...         . ..|   ...              | .|||..  |. ...  .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YEFMANGSLGDMLYRRPS---------------ESLSWQTRY-----EIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEV---KARIADFGLAKLV
.|.. .|.| ...  |..               . .. |         ..    ||| ||||     ||||||| .|||.| .    . .|.|||..|  
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

EKQVE-------------TGSMSSIAGSYGYI----APEYAYTLRVN----EKSDVYSFGVVILELLLGKSP
.....                |....|...|.    |||.      .    .|.|..|.||.. |.| |. |
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase LRR8_o-1.AA Pkinase_Tyr 852-1051 26 2.5e-25 86.38 Pfam 1-208 (270) Show / Hide 
Range on Protein: 852-1051
Range on HMM: 1-208/270
Sequence Identity: 26% (59 aa)

FHSRFVIGQGAYGTVYKAKLP-----SGLEFAVKKLQLVQGERSAVDD---RSSLRELKTAGQV-KHRNIVKLHAFFK-LDDC--DLLVYEFMANGSLGD
 .   ..|.||.|.|||...       ... |||.|     | .  ..   .. .||.|.  |  .| |||.|..     ..    ..| |.|..|.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

MLYRR--PSESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEK-----QVETGSMSSIAGSYGYIAPEYAYTL
 | ..  . ..|. ..  ....  |.|..||.      .||||.   |.|.. . ...|.|||||.....     .. .|..  |       |||   . 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYG

RVNEKSDVYSFGVVILELL
. ..||||.||||.. |..
KFTTKSDVWSFGVLMWEIF
Kinase LRR8_o-1.AA LRRK 927-1058 33 3.6e-24 82.39 In-house 132-284 (351) Show / Hide 
Range on Protein: 927-1058
Range on HMM: 132-284/351
Sequence Identity: 33% (52 aa)

LVYEFMANGSLGDMLY-RRPSE------SLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILL-DI-----------EVKARIADFGLAKLVEK
.| |.. .|.| . |  .. ..      ..||.....|||  | |..|| |...| ||||| || ||||  .           .|.| |||||.  .  .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-Q

QVETGSMSSIAGSYGYIAPEYAY---TLRVNEKSDVYSFGVVILELLLGK-SPVD
 . .|  .   |  |. |||      .   .||.|.||||... ||| ..  | |
CFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_o-1.AA TyrKc 852-1126 23 3.7e-17 54.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 852-1126
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FHSRFVIGQGAYGTVYKAKLPSGLEFAVKKLQLVQGERSAVDDRSSLRELKTAGQV--KHRNIVKLHAFFKLD-------DCDLLVYEFMANGSLGDML-
 .   ..| ||.|.|||...   .. |||.|.           .  .||..   ..  .| |||.|..    .       .  ..| |.|..|.| | | 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YRRPSESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEKQ-------VETGSM---SSIA-GSYGYIAPEYAY
..||   |....  ....  |.| .|||.     .||||.   |.|.. .  ..|.||||.. ..             ..   .. .   .   |||   
KHRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

TLRVNEKSDVYSFGVVILELL-LGKSPVDPLFL--EKGENIVSWAKKCGSIEVLADP---SVWEFASEGDRSEMSLLLRVALFCTRERPGDRPTMKEAVE
. . ..||||.||||.. |.. .|..|     .   . . .. . |. .  .  ...   |   |     .    .   . . | .| | ||||..| .|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---F----VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHE

ML
 .
CF
Kinase LRR8_o-1.AA LRRK 852-883 29 0.000274 11.06 In-house 1-37 (351) Show / Hide 
Range on Protein: 852-883
Range on HMM: 1-37/351
Sequence Identity: 29% (11 aa)

FHSRFVIGQGAYG-TVYKAKLPS----GLEFAVKKLQ
. .   ||.|..| .||.||. .      ... |.||
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQ
Kinase LRR8_o-1.AA TK 1108-1126 42 0.000575 8.34 In-house 468-486 (486) Show / Hide 
Range on Protein: 1108-1126
Range on HMM: 468-486/486
Sequence Identity: 42% (8 aa)

CTRERPGDRPTMKEAVEML
| .. | ||||... .|.|
CWHYDPEDRPTFSQLHEQL
Kinase LRR8_o-1.AA LRRK 1108-1128 33 0.001434 8.48 In-house 331-351 (351) Show / Hide 
Range on Protein: 1108-1128
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CTRERPGDRPTMKEAVEMLRQ
|  . | .||.. . |. | |
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_o-1.AA TKL 1108-1126 31 0.008861 5.85 In-house 346-364 (364) Show / Hide 
Range on Protein: 1108-1126
Range on HMM: 346-364/364
Sequence Identity: 31% (6 aa)

CTRERPGDRPTMKEAVEML
|  . | .||...| .. |
CWDHDPEKRPSFQEILKRL
Kinase LRR8_o-1.AA MLK 1113-1126 35 0.091534 2.06 In-house 278-291 (291) Show / Hide 
Range on Protein: 1113-1126
Range on HMM: 278-291/291
Sequence Identity: 35% (5 aa)

PGDRPTMKEAVEML
|..||.... |. |
PHKRPSFRQIVQHL
Kinase LRR8_o-1.AA IRAK 1101-1126 23 0.107884 1.98 In-house 292-317 (317) Show / Hide 
Range on Protein: 1101-1126
Range on HMM: 292-317/317
Sequence Identity: 23% (6 aa)

LLRVALFCTRERPGDRPTMKEAVEML
.. .|. |. .|   |..|..... |
MCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR8_o-1.AA Pkinase_Tyr 1110-1126 47 1.164311 2.86 Pfam 254-270 (270) Show / Hide 
Range on Protein: 1110-1126
Range on HMM: 254-270/270
Sequence Identity: 47% (8 aa)

RERPGDRPTMKEAVEML
.. | ||||..| .|.|
HYDPEDRPTFSEIHEQL