Gene LRR8_i-2 (S.moellendorffii)

LRR8_i-2

Species: S.moellendorffii
Alias: LRR8_i-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_i-2.AA Protein None 1132 None Fasta, JSON
LRR8_i-2.NA RNA None 3399 None Fasta, JSON
LRR8_i-2.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of LRR8_i-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_i-2.AA LRRNT_2 24-74 33 0.000396 16.31 Pfam 3-46 (46) Show / Hide 
Range on Protein: 24-74
Range on HMM: 3-46/46
Sequence Identity: 33% (18 aa)

DDAAVLAEVKRSWV--LP-GDALRSWSWSSASASKYSSGSGNGTVCSWKGVTCA
||.. | . | |..   | ...|.||. ||            .. |||.|||| 
DDGQALLAFKSSLNDSDPHHGVLSSWNPSSS----------DSDCCSWTGVTCD
LRR_1 LRR8_i-2.AA LRR_1 79-101 33 0.940728 6.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 79-101
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RVAVLDLDA-H--NISGTLPAS-IGNL
.  .|||.     |..|..| | . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 103-125 33 0.007801 14.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 103-125
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLETLVLSK-N--KLHGSIPWQ-LSRC
.|..| ||  |  .| |.||   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 127-149 40 0.004463 15.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 127-149
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLQTLDLSS-N--AFGGPIPAE-LGSL
.||.||||. |   . | || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 151-173 40 0.000428 18.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 151-173
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLRQLFLYN-N--FLTDNIPDS-FGGL
.|. | | . |   ||..||.| | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 175-197 48 0.00694 14.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 175-197
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

SLQQLVLYT-N--NLTGPIPAS-LGRL
.|| | |   |  |||| || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 199-221 29 0.011295 13.65 Pfam 1-26 (26) Show / Hide 
Range on Protein: 199-221
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLEIIRAGQ-N--SFSGSIPPE-ISNC
||...  .  |  ...|.|||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 223-245 25 2.443519 5.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 223-245
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SMTFLGLAQ-N--SISGAIPPQ-IGSM
. . | |   |  ...| |||  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 247-269 48 0.00088 17.58 Pfam 1-26 (26) Show / Hide 
Range on Protein: 247-269
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLQSLVLWQ-N--CLTGSIPPQ-LGQL
|||.| |   |  .|||.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 271-293 44 0.004793 14.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 271-293
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLTMLALYK-N--QLQGSIPPS-LGKL
||. | |   |  .|.|.|||| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 295-317 33 0.000115 20.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 295-317
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLEYLYIYS-N--SLTGSIPAE-LGNC
.|..|.. . |  .|||.|| . . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 319-341 29 2.33494 5.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 319-341
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

MAKEIDVSE-N--QLTGAIPGD-LARI
  ...|.|  |  .||| || . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 343-365 29 0.156706 9.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 343-365
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

TLELLHLFE-N--RLSGPVPAE-FGQF
.|. |.|   |  .|.| .| . | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 367-389 37 0.012945 13.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 367-389
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLKVLDFSM-N--SLSGDIPPV-LQDI
.|..||.|  |  .|.|.|||  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 391-413 33 0.301946 8.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 391-413
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLERFHLFE-N--NITGSIPPL-MGKN
.|.. .|   |  |.||.|||    . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 439-461 29 0.14402 9.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 439-461
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLIWLNLYS-N--GLSGQIPWA-VRSC
 |  |.| . |   |.|.||     ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 415-438 44 0.17162 9.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 415-438
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLAVLDLSE-N--NLVGGIPKYVCWNG
.| .||||  |  ||.| ||.  . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 463-485 25 0.628946 7.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 463-485
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLVQLRLGD-N--MFKGTIPVE-LSRF
.|  | |.. |   . |.|| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 487-504 47 0.311911 8.54 Pfam 1-21 (26) Show / Hide 
Range on Protein: 487-504
Range on HMM: 1-21/26
Sequence Identity: 47% (10 aa)

NLTSLELYG-N--RFTGGIPS
||..| | | |  ..|| ||.
NLQHLDLSGCNCCNLTGHIPP
LRR_1 LRR8_i-2.AA LRR_1 508-530 33 0.034512 11.93 Pfam 1-26 (26) Show / Hide 
Range on Protein: 508-530
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLSRLLLNN-N--DLMGTLPPD-IGRL
.| .| |.. |   | |..||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 532-554 40 0.000148 20.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 532-554
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLVVLNVSS-N--RLTGEIPAS-ITNC
.| .|..|. |  .|||.|| | . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 556-578 48 0.001969 16.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 556-578
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLQLLDLSK-N--LFTGGIPDR-IGSL
||| ||||  |   .|| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 580-602 29 0.037309 11.81 Pfam 1-26 (26) Show / Hide 
Range on Protein: 580-602
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLDRLRLSD-N--QLQGQVPAA-LGGS
.| .| ||. |  .|.|..|   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 604-626 40 0.000674 17.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 604-626
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLTEVHLGG-N--RLSGLIPPE-LGNL
.|.. .|.| |  .|.| |||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 633-651 43 0.016568 13.06 Pfam 5-26 (26) Show / Hide 
Range on Protein: 633-651
Range on HMM: 5-26/26
Sequence Identity: 43% (10 aa)

LNLSH-N--YLSGPIPEE-LGNL
|.||. |   |.| ||.. . ||
LDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 653-675 44 0.000118 20.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 653-675
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

LLEYLYLSN-N--MLSGSIPAS-FVRL
 |..|.||. |   |.|.|| | |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_i-2.AA LRR_1 677-701 28 0.061914 11.03 Pfam 1-26 (26) Show / Hide 
Range on Protein: 677-701
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

SLIVFNVSH-N--QLAGPLPGAPAFANM
.| . ..|. |  .| | .|   .| |.
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_i-2.AA TKL 829-1095 23 5.4e-64 218.91 In-house 1-364 (364) Show / Hide 
Range on Protein: 829-1095
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

LGSGASGTVYKAVVPG--------TGEVVAVKKIMTQS-----------------------DGAHSSFLNSFNTELSTLGQVRHCNIVKLMGFCRHQGC-
.|||..|.|||..  |        ||..|||||. ...                       |   | |   .. |.  . . || |||..||.|   .| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLLYEYMSNGSLGELLHRSDCPLDWNRRYNIAVGAAEGLAYLHH-DC----KPLVVHRDIKSNNILLDENFE--------------A
              . .||...||| ..||       |..| ..| ..| |..|||  .     || ..|||.||.|||.|||..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

HVGDFGLAKLLDEPEGRSTTA------------------VAGSYGYIAPEFAYTM----------------IVTEKCDIYSFGVVLLELVTGRRPIQ-PL
 ..||||.. ... .. . |.                  . |.... |||    .                  .||||.||||.|| |..|..|| . . 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

ELGGDLVTWVRRGTQCSAAELLDTRLDLSDQSV--------VDEMVLVLKVALFCTNFQPLERPSMRQVVRML
.   ..   .      . . .   |. . ..           | .  . | .  | .  | .|||. ...  |
YMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_i-2.AA IRAK 823-1026 36 7.2e-60 205.21 In-house 1-223 (317) Show / Hide 
Range on Protein: 823-1026
Range on HMM: 1-223/317
Sequence Identity: 36% (81 aa)

FAESYVLGSGASGTVYKAVVPGTGEVVAVKKIMTQSDGAHSSFLNSFNT---ELSTLGQVRHCNIVKLMGFCRHQGCNLLLYEYMSNGSLGELLHRSD--
|... ..|.|. |.||...  .|. ..||||..   |    .   .|..   || ..   || ||| | |.|   .|  | |.||.||||   |.  |  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

CP---LDWNRRYNIAVGAAEGLAYLHHDC-KPLVVHRDIKSNNILLDENFEAHVGDFGLAKLL----DEPEGRS----TTAVAGSYGYIAPEFAY--TMI
||   | | .|  |. |.| |. .|| .  .  . |.|||| |||||..|..  .||||.       .   . .    |  | |.  | .||| .  . .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTEKCDIYSFGVVLLELVTGRRP
 | | |.||||.||||..||.|.
LTKKTDVYSFGIVLLEVLTGCRA
Kinase LRR8_i-2.AA LISK 828-1026 29 3.3e-47 151.33 In-house 1-238 (296) Show / Hide 
Range on Protein: 828-1026
Range on HMM: 1-238/296
Sequence Identity: 29% (71 aa)

VLGSGASGTVYKAVVPGTGEVVAVKKIMTQ-SDGAHSSFLNSFNTELSTLGQVRHCNIVKLMGFCRH-QGCNLLLYEYMSNGSLGELLHRSDC---PLDW
..|.|. | |||     ||.|.|.|.| .|  |    ...  .. |. ..   || |||. || |.| .|   .. ||.. | | ..|...|    || |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

NRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDEN----FEAHVGDFGLAKLLDEPE---------------------------------GRSTT
  | .||.. |.|..|||  .   ..||| ||.|.|..||    ... |.|||.|...|...                                 .... 
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

AVAGSYGYIAPEFAYTMIVTEKCDIYSFGVVLLELVTGRRP
.. |.    |||    .  .|.||..|||.||.|..|....
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase LRR8_i-2.AA TKL-Unique 826-1026 28 8.6e-46 158.45 In-house 2-233 (290) Show / Hide 
Range on Protein: 826-1026
Range on HMM: 2-233/290
Sequence Identity: 28% (68 aa)

SYVLGSGASGTVYKAVVPGTGEVVAVKKIMTQSDGAHSSFLNSFNTELSTLGQVR-HCNIVKLMGFCR----HQGCNLLLYEYMSNGSLGELLH------
. ..|.|..|.|||..  . |. ||.|..     . .....  |. |....   . | |||..||.|     ...   .  ||.. ||| ..||      
WNKIGEGGYGQVYKGK--WRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---RSDCPLDWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDEN-----FEAHVGDFGLAKLLDEPEGRSTT--------AVAGSYGYIAPEF
   .. |.|....|...|  .| |. ||||  .| . |||.|| |.|.|.|     . . . ||||.|...     ...         . ||. ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

AYT--MIVTEKCDIYSFGVVLLELVTGRR------P
        .||.|.||||.|| |..|. .      |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_i-2.AA Pkinase 823-1024 27 4.2e-44 157.03 Pfam 1-209 (293) Show / Hide 
Range on Protein: 823-1024
Range on HMM: 1-209/293
Sequence Identity: 27% (61 aa)

FAESYVLGSGASGTVYKAVVPGTGEVVAVKKIMTQSDGAHSSFL-NSFN-TELSTLGQVRHCNIVKLMGFCRHQGCNLLLYEYMSNG----SLGELLH-R
.    ..|||..|.|||..  |||..||||.|  .  ...|... . .. .|.. .  ..|.|||.| ....  .   .  ||. .|    .| .... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

SDCPL--DWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDENFEA----HVGDFGLAKLLDEPEGRSTTAVAGSYGYIAPEFAYTMIV-----
.....  ...   ...   ..||.|.|      ..|||.|. |||.|.| .     ...||||||..|.  .. .| ..|...|.|||     |      
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IRGGQYY

TEKCDIYSFGVVLLELVTGR
. |.|..|.|..| |...||
GPKVDMWSCGCILYEMLCGR
Kinase LRR8_i-2.AA Dicty4 829-1026 35 2.5e-42 139.09 In-house 7-216 (277) Show / Hide 
Range on Protein: 829-1026
Range on HMM: 7-216/277
Sequence Identity: 35% (75 aa)

LGSGASGTVYKAVVPGTGEVVAVKKIMTQSDGAHSSFLNSFNTELSTLGQVRHCNIVKLMGFCR----HQGCNLLLYEYMSNGSLGELLHR------SDC
.|.|. |.|||. . |.   |||||     ... ...||.|  | . ... || ||...|| |     | |  .   |||. |.| .|||       .  
IGKGSFGEVYKGTWRGK--EVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSI

PLDWNRRYN---IAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDENFEAHVGDFGLAKLLDEPEGRST--TAVAGSYGYIAPEFAYTMIVTEKCDIYSF
.||| ..     .|  || |...||  | | ..|||.|| |.| |.|. . |.||||...  . |  ..  ....|. .. |||       .|| | |||
KLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSF

GVVLLELVTGRRP
| || |..|.  |
GIVLWEILTRQEP
Kinase LRR8_i-2.AA MLK 823-1026 28 4.5e-42 143.77 In-house 1-235 (291) Show / Hide 
Range on Protein: 823-1026
Range on HMM: 1-235/291
Sequence Identity: 28% (67 aa)

FAESYVLGSGASGTVYKAVVPGTG---EVVAVKKIMTQSDGAHSSF---LNSFNTELSTLGQVRHCN----IVKLMGFCRHQGCN-LLLYEYMSNGSLGE
. .. ..|||..| |.|..  ..     .||||.. .  . . |.       |..|   |  ..| |    |....| |  ..|. ... ||...||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHR-------------SDCPLDWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDE------NFEAHVGDFGLAKLLDEPEGRSTTAVAGSYG
.||              .|   |     |.|.  |.|..||| . .....|||.|| |||.||      .  . . |||... . . .    .  ||.| 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YIAPEF---AYTMIVTEKCDIYSFGVVLLELVTGRRP
. |||    .    ..||||..|.|||| |..|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_i-2.AA LRRK 823-1026 24 3.9e-38 132.52 In-house 1-282 (351) Show / Hide 
Range on Protein: 823-1026
Range on HMM: 1-282/351
Sequence Identity: 24% (71 aa)

FAESYVLGSGASG-TVYKAVVPG--------------------------TGEVVAVKKIMT----------QSDG-----------------AHSSFLNS
. .   .|.|..| .||.| . |                           .. ||.||. .           |..                  |......
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FNT---ELSTLGQVRHCNIVKLMGFCRHQGCNLLLYEYMSNGSLGELLH---RSD-----CPLDWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNI
|..   |.. .   .| |||.|.||| |  |  .  ||...|.| ..||   ..        ..|. .. ||.  |.|..|| |...| ..||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------ENFEAHVGDFGLAKLLDEPEGRS-TTAVAGSYGYIAPEFAYTM---IVTEKCDIYSFGVVLLELVTGR-RP
||   .         ..  |...|||.  .   . . . .  . |  |. |||    .     ||| |.||||..| ||.|.. .|
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR8_i-2.AA S_TKc 823-1097 21 1.6e-36 128.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 823-1097
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

FAESYVLGSGASGTVYKAVVPGTGEVVAVKKIMTQSDGAHSSFLNSFNTELSTLGQVRHCNIVKLMGFCRHQGCNLLLYEYMSN--GSLGELLHRSDCP-
.    ..|.|| |.|||..  .||..||.|.|            ...  |.. | . .| ||||| ..... ..  .  ||...  |.| .....  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LDWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDENFEAHVGDFGLAKLLDEPEGRSTTAVAGSYGYIAPEFAYTMIVTE-KCDIYSFG
    ..  .   ..   ...|.|.|      ..|||.|  ||||||  .  ..|||||..|        | . |.  |.|||       .  |||..|.|
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VVLLELVTGRRPIQPLELGGDLVTWVRRGTQCSAAELLDTRLDLSDQSVVDEMVLVLKVALFCTNFQPLERPSMRQVVR-------MLLS
..| |...|. | .      .. .  ..                           ..     | .. | .||.  .. .       .   
CILYEMLCGYPPFP------QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_i-2.AA TK 828-1095 15 8.1e-36 117.0 In-house 6-486 (486) Show / Hide 
Range on Protein: 828-1095
Range on HMM: 6-486/486
Sequence Identity: 15% (76 aa)

VLGSGASG---TVYKAVVPGTG-------------------------EVVAVKKIMTQSDGAHSSFLN-------------SFNTELSTLGQ--VRHCNI
.||.|. |   .|||. . | .                         . |||| ..  .. .   |.              ..  |.. . .   .| ||
KLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNI

VKLMGFCRHQGC------------NLLLYEYMSNGS----LGELLHRSDCP-------------------------------------------------
|.| | | ....             ... |||..|.    | . |.... .                                                 
VRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLI

--------------------------LDWNRRYNIAVGAAEGLAYLHHD-CKPL---VVHRDIKSNNILLDENFE-----------AHVGDFGLAK----
                          |.  ..  ... .|.|..|||   |. .   .||||.   |.|..||             . ..||||..    
KDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG

-LLDEPEGRSTTAVAGSYG----------------------------YIAPEFAY---------TMIVTEKCDIYSFGVVLLELVT-GRRPIQPLELG--
 |  . . ..   ...|||                            . |||            . . |.| |..||||.. |..| |. |  .      
VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQD

-------GDLVTWVRRG--------------TQCSAAELLD----TRLDLSDQSVVDEMVLVLKVALFCTNFQPLERPSMRQVVRML
        ...  .|||               .. . ..      .|  . .... .|..  |   . | ...| .||...|....|
VWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDL--MQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_i-2.AA STE 823-1030 22 1.3e-35 123.24 In-house 1-274 (359) Show / Hide 
Range on Protein: 823-1030
Range on HMM: 1-274/359
Sequence Identity: 22% (64 aa)

FAESYVLGSGASGTVYKA--VVPG-------------TGEVVAVKKIMTQSDG-------------AHSSFLNSFNTELSTLGQVR--HCNIVKLMGFCR
.    ..|.||.||||||  . ..             |||..|.|..  ...               ... ....  |.... . .  | ||||  | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HQG-------CNLLLYEYMSNGSLGELLH---RSDCPLD----------WNRRYNIAVGAAEG-LAYLHHDCKPLVVHRDIKSNNILLDENFEAHVGDFG
. |          .  |||..||| ....      .||.           .    |..   .| |.|||      ..|||||. ||||     .   |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLLDE---------------PEGRSTTAVAGSYGYIAPEFAYTMI------VTEKCDIYSFGVVLLELVTGRRPI---QPL
... |..                 .  .. ..|.  . |||    .        ..||||.|.| ...|..||. |    .|.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM
Kinase LRR8_i-2.AA DRK 846-1022 36 9.3e-35 115.17 In-house 22-197 (258) Show / Hide 
Range on Protein: 846-1022
Range on HMM: 22-197/258
Sequence Identity: 36% (66 aa)

GEVVAVKKIMTQSDGAH-SSFLNSFNTELSTLGQVRHCNIVKLMGFCRHQGCNLLLYEYMSNGSLGELLHRSDCPLDWNRRYNIAVGAAEGLAYLHHDCK
|  ||||.     .      ||| |  |   . | || ||.  || |      .   |||. |||   ||     .|| ..  ..  .| |. |||  | 
GTQVAVKMLFN--HNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CN

PLVVHRDIKSNNILLDENFEAHVGDFGLAK----LLDEPEGRSTTAVAGSYGYIAPEFAYTMIVTEKCDIYSFGVVLLELVT
| ..||| || | | ||..   | ||||.      ..   .   |.. |  . .|||       ||| |.|||..|| |.||
PIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQ--HKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase LRR8_i-2.AA Pkinase_Tyr 823-1026 29 2.8e-34 116.73 Pfam 1-214 (270) Show / Hide 
Range on Protein: 823-1026
Range on HMM: 1-214/270
Sequence Identity: 29% (64 aa)

FAESYVLGSGASGTVYKAVVP----GTGEVVAVKKIMTQSDGAHSS--FLNSFNTELSTLGQV-RHCNIVKLMGFCR-HQGC--NLLLYEYMSNGSLGEL
     .||.|| |.|||..      .|.  ||||..    .||...  .. .|  |.... |  .| |||.|.| |  ...    ..  ||| .|.| . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LHRS---DCPLDWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDENFEAHVGDFGLAKLL-DEPEG-RSTTAVAGSYGYIAPEFAYTMIVTEK
|..    . ||.  .  ....  |.|..||.       .|||.   |.|..||. . ..|||||... .. .  |...         |||   ... |.|
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

CDIYSFGVVLLELVT-GRRP
 |..||||.. |..| |. |
SDVWSFGVLMWEIFTYGEQP
Kinase LRR8_i-2.AA TyrKc 823-1095 22 2.8e-19 71.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 823-1095
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FAESYVLGSGASGTVYKAVVPGTGEVVAVKKIMTQSDGAHSSFLNSFNTELSTLGQV--RHCNIVKLMGFCRHQ-------GCNLLLYEYMSNGSLGELL
     .||.|| |.|||..     . ||||..   .       .  |  |.. . ..  .| |||.| | |..|       .  ... |||..|.| . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

HRSDCPLDWNRRYNIAVGAAEGLAYLHHDCKPLVVHRDIKSNNILLDENFEAHVGDFGLAKLLDEP--------EGRSTT--AVA--GSYGYIAPEFAYT
...   | .    .... .|.| .|||.     ..|||.   |.|..||. . ..||||.. ...           |...         .   |||   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

MIVTEKCDIYSFGVVLLELVT-GRRPIQPL----ELGGDLVTWVRRGTQCSAAEL----LDTRLDLSDQSVVDEMVLVLKVALFCTNFQPLERPSMRQVV
 . |.| |..||||.. |. | |  |            ... .|..|      .               .|     .   . . | ...| .||......
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------FVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIH

RML
. .
ECF
Kinase LRR8_i-2.AA LISK 1071-1095 32 0.00809 4.76 In-house 272-296 (296) Show / Hide 
Range on Protein: 1071-1095
Range on HMM: 272-296/296
Sequence Identity: 32% (8 aa)

LKVALFCTNFQPLERPSMRQVVRML
|.... |.. .| .|||   .|. |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_i-2.AA LRRK 1077-1097 33 0.011474 5.24 In-house 331-351 (351) Show / Hide 
Range on Protein: 1077-1097
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CTNFQPLERPSMRQVVRMLLS
| . .|..||.. |.|  | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_i-2.AA DRK 1077-1097 38 0.013639 4.64 In-house 238-258 (258) Show / Hide 
Range on Protein: 1077-1097
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CTNFQPLERPSMRQVVRMLLS
| |  |  |||| ...  | .
CWNEDPQHRPSMQECLERLEA
Kinase LRR8_i-2.AA MLK 1082-1095 57 0.046017 3.11 In-house 278-291 (291) Show / Hide 
Range on Protein: 1082-1095
Range on HMM: 278-291/291
Sequence Identity: 57% (8 aa)

PLERPSMRQVVRML
| .|||.||.|  |
PHKRPSFRQIVQHL
Kinase LRR8_i-2.AA Pkinase_Tyr 1079-1095 23 0.114611 6.27 Pfam 254-270 (270) Show / Hide 
Range on Protein: 1079-1095
Range on HMM: 254-270/270
Sequence Identity: 23% (4 aa)

NFQPLERPSMRQVVRML
...| .||........|
HYDPEDRPTFSEIHEQL