Gene LRR8_o-2 (S.moellendorffii)

LRR8_o-2

Species: S.moellendorffii
Alias: LRR8_o-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_o-2.AA Protein None 1109 None Fasta, JSON
LRR8_o-2.NA RNA None 3330 None Fasta, JSON
LRR8_o-2.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of LRR8_o-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_o-2.AA LRRNT_2 39-78 42 2.7e-14 49.32 Pfam 1-46 (46) Show / Hide 
Range on Protein: 39-78
Range on HMM: 1-46/46
Sequence Identity: 42% (20 aa)

LSSDLQALLEVKAAII--DR-NGSLASWN----ESRPCSQWIGVTCA
...|.||||. |...   |. .|.|.|||     | .|| | |||| 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS-WTGVTCD
LRR_1 LRR8_o-2.AA LRR_1 112-134 29 0.02915 12.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 112-134
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLRFLNMSY-N--WLDGEIPGE-IGQM
.|. |..|. |   | |.|| . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 136-158 44 0.000391 18.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 136-158
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

KLEILVLYQ-N--NLTGEIPPD-IGRL
.|..| |   |  ||||.|||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 160-182 33 0.178439 9.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 160-182
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

MLQNLHLFS-N--KMNGEIPAG-IGSL
 || |.| . |  .. |.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 184-206 37 0.034963 11.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 184-206
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

HLDVLILQE-N--QFTGGIPPS-LGRC
.| .| |.  |  ..|| |||| .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 208-230 44 0.036589 11.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 208-230
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLSTLLLGT-N--NLSGIIPRE-LGNL
|| .| |.  |  ||.| || . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 232-254 29 0.010863 13.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 232-254
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLQSLQLFD-N--GFSGELPAE-LANC
.||.| | . |   ..|..| . . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 256-278 37 0.001432 16.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 256-278
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLEHIDVNT-N--QLEGRIPPE-LGKL
.|.|.|..  |  .|.| |||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 280-302 25 0.026444 12.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 280-302
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLSVLQLAD-N--GFSGSIPAE-LGDC
.| .| | . |   ..|.|| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 304-326 40 0.004793 14.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 304-326
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTALVLNM-N--HLSGEIPRS-LSGL
||. | |.  |  .|.|.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 328-350 37 0.132361 9.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 328-350
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLVYVDISE-N--GLGGGIPRE-FGQL
.| . |.|  |   | | || . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 352-374 25 0.039554 11.72 Pfam 1-26 (26) Show / Hide 
Range on Protein: 352-374
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLETFQART-N--QLSGSIPEE-LGNC
.|..   .  |  .|.|.||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 376-398 40 0.020263 12.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 376-398
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLSVMDLSE-N--YLTGGIPSR-FGDM
.| . |||  |   ||| ||.. |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 399-421 25 1.530993 6.09 Pfam 1-26 (26) Show / Hide 
Range on Protein: 399-421
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

AWQRLYLQS-N--DLSGPLPQR-LGDN
  |.|.|.. |   |.| .| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 423-445 25 23.852725 1.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 423-445
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

MLTIVHSAN-N--SLEGTIPPG-LCSS
 |.. .  . |  .|.|.|||. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 447-469 29 0.117759 10.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 447-469
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLSAISLER-N--RLTGGIPVG-LAGC
.|  ..| . |  .||| || . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 471-493 29 0.102082 10.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 471-493
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLRRIFLGT-N--RLSGAIPRE-FGDN
.|... |.  |  .|.| || . |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 495-517 29 0.000494 18.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 495-517
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLTYMDVSD-N--SFNGSIPEE-LGKC
||.. |.|. |  .. |.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 519-541 33 0.006134 14.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 519-541
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLTALLVHD-N--QLSGSIPDS-LQHL
.|. | . . |  .|.|.||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 543-565 37 1.128309 6.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 543-565
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ELTLFNASG-N--HLTGSIFPT-VGRL
 |.  . || |  .|||.| |     |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 567-589 48 0.001775 16.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 567-589
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

ELLQLDLSR-N--NLSGAIPTG-ISNL
 |  ||||. |  ||.| || . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 591-613 33 23.545238 1.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 591-613
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

GLMDLILHG-N--ALEGELPTF-WMEL
 |  | | | |   |.|..|      |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 615-637 37 0.003143 15.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 615-637
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLITLDVAK-N--RLQGRIPVQ-LGSL
|| .||.   |  .|.| ||   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 639-661 44 0.002047 16.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 639-661
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLSVLDLHG-N--ELAGTIPPQ-LAAL
.| .||| | |   | |.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 663-685 48 7.5e-05 21.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 663-685
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

RLQTLDLSY-N--MLTGVIPSQ-LDQL
.||.||||. |   ||| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_o-2.AA LRR_1 687-709 25 0.009984 13.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 687-709
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLEVLNVSF-N--QLSGRLPDG-WRSQ
.|..|..|  |  .|.| .|..   . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRR8_o-2.AA IRAK 803-1009 35 4.7e-56 192.55 In-house 1-225 (317) Show / Hide 
Range on Protein: 803-1009
Range on HMM: 1-225/317
Sequence Identity: 35% (80 aa)

FHSRFVIGQGAYGTVYKAKLPSGLE--FAVKKL---QLVQGERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLDDCDLLVYEFMANGSLGDMLYRRP-
||  ..||.|..|.||.... ....  .|||||     .. . . .  ..|. |||.     | ||| | ...   .|  |||..|.|||| | |  .  
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

SES---LSWQTRYEIALGTAQGLAYLHHDCSP-AIIHRDIKSNNILLDIEVKARIADFGLAKLV-EKQ-VETGSM-----SSIAGSYGYIAPEYAY--TL
. .   |||..| .|..||| |. .|| . .  .|||.|||| |||||    . |.||||.    ...  | ..      | . |.  | .||. .  . 
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

RVNEKSDVYSFGVVILELLVGKSPVD
.   |.||||||.|.||.| |  .|.
QLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase LRR8_o-2.AA TKL 809-1007 22 3.5e-52 179.68 In-house 1-288 (364) Show / Hide 
Range on Protein: 809-1007
Range on HMM: 1-288/364
Sequence Identity: 22% (68 aa)

IGQGAYGTVYKAKLPS---------GLEFAVKKLQLVQ-----------------------GERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLDDC-
||.|..|.|||.|.           | . ||||.   .                        . .        .|..   . .| |||.. .. .  .| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------DLLVYEFMANGS-LGDMLYRRPSESLSWQTRYEIALGTAQGLAYLHHDCS-----PAIIHRDIKSNNILLDIEVK-------------
              .|.|.. .|| | ...         |. |  .||..|.|..||| .       |.|||||.||.|||.|   .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-ARIADFGLAKLVEKQVETGSMSS-----------------IAGSYGYIAPEYA-----YT-----------LRVNEKSDVYSFGVVILELLVGKSP
 . |.||||.. ...  .   ...                 . |.... |||       ||           .  .||.||||||.|. |.| .. |
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase LRR8_o-2.AA Pkinase 803-1007 28 1.4e-43 155.12 Pfam 1-211 (293) Show / Hide 
Range on Protein: 803-1007
Range on HMM: 1-211/293
Sequence Identity: 28% (62 aa)

FHSRFVIGQGAYGTVYKAKLPSGLE-FAVKKLQLVQGERSAVDDRSSLR--ELKTAGQVKHRNIVKLHAFFKLDDCDLLVYEFMANG----SLGDMLYRR
.|   .||.|..|.|||..  .  . .|||.. ..  ...   |.. .|  |..    ..| |||.|. .|  .|   .| |.. .|    .| |.. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

PSESL--SWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKA----RIADFGLAKLVEKQVETGSMSSIAGSYGYIAPEYAY-TLRVNEK
 . ..  |...   ... ...||.|.|      |||||.|. |||.| .       .|.||||||...     . |....|...|.|||          |
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVYSFGVVILELLVGKSP
.|..|.|... |.| |. |
VDMWSCGCILYEMLCGRPP
Kinase LRR8_o-2.AA S_TKc 803-1077 24 2.9e-38 134.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 803-1077
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

FHSRFVIGQGAYGTVYKAKLPS-GLEFAVKKLQLVQGERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLDDCDLLVYEFMAN--GSLGDMLYRRPSES
..   .||.||.|.|||..  . | ..|.|..            .. .||..   . .| |||||. .|   |.  .| |.. .  |.| |.. .|... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEKQVETGSMSSIAGSYGYIAPEYAYTLRVNE-KSDVYSF
    ..  .   ..  ....|.|.|      |||||.|  |||||      |.|||||...         ... |.  |.|||       .  |.|..|.
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVILELLVGKSPVDPLFLERGQNIVSWAKKCGSIEVLADPSVWEFASEGDRSEMSLLLR-VALFCTRERPGDRPTMKEAVE---------ML
|... |.|.|. | .        ..    ||.|                      |  ..     | .  | .|||  || .          .
GCILYEMLCGYPPFP--------QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_o-2.AA MLK 803-1007 25 1e-36 124.96 In-house 1-235 (291) Show / Hide 
Range on Protein: 803-1007
Range on HMM: 1-235/291
Sequence Identity: 25% (62 aa)

FHSRFVIGQGAYGTVYKAKLPSGL----EFAVKKLQLVQGERSAVD---DRSSLRELKTAGQVKHRN----IVKLHAFFKLDDC-DLLVYEFMANGSLGD
.    .|| |..| |.|..    .    . |||.        ...    ..   .| . .  ..|.|    |... .  . . |  ..| |....||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

MLYR-RPSES-----------LSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDI------EVKARIADFGLAKLVEKQVETGS-MSSIAGS
 |.  |. ..            . .    .||  |.|..||| .  ..|||||.|| |||.|       . ...|.|||...  ...  . . | | ||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR--DWHQMC-TNMMSNAGT

YGYIAPEY---AYTLRVNEKSDVYSFGVVILELLVGKSP
| . |||    .   ...||.||.|.|||. |.| .. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_o-2.AA STE 803-1007 23 1.1e-32 112.78 In-house 1-267 (359) Show / Hide 
Range on Protein: 803-1007
Range on HMM: 1-267/359
Sequence Identity: 23% (64 aa)

FHSRFVIGQGAYGTVYKA--KLPS--------------GLEFAVKKLQLVQG--------ERSAV-------DDRSSLRELKTAGQVK--HRNIVKLHAF
.    .||.||.||||||  . ..              |  .|.|.. | .         . . .       .  . |.|.|.  . .  | |||| .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FKLD-------DCDLLVYEFMANGSLGDMLYR--RPSESLS----------WQTRYEIALGTAQG-LAYLHHDCSPAIIHRDIKSNNILLDIEVKARIAD
.  .       |   .. |.|..||| |.. .   . ..|.           .    |.  . .| |.|||      |||||||. ||||     . ..|
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCD

FGLAKLVEKQVE------------TGS-MS-SIAGSYGYIAPEYAYTLRVN------EKSDVYSFGVVILELLVGKSP
||... ... .             |.. .. ...|.  . |||     . .      .|.|..|.| .|.|.. || |
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase LRR8_o-2.AA RIPK 809-1007 29 5.3e-32 106.34 In-house 1-227 (290) Show / Hide 
Range on Protein: 809-1007
Range on HMM: 1-227/290
Sequence Identity: 29% (67 aa)

IGQGAYGTVYKAKLPSGLEFAVKKL---QLVQGERSAVDDRSSLRELKTAGQVKHRNIVKLHAFFKLD----DCDL--LVYEFMANGSLGDMLYRRPS--
.| |. |.|.||   .  . ..||      .. .    .    ..| |   . ....||..  | .      || |  .| |.|.|||| . | ....  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-ESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEKQVETG---------SMSSIA--GSYGYIAPEYAY---T
   . |  |  .   .. |  || |.  | ||||| |  |||.| .  . |||||||.  .    ..         || |    |   |..||       
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

LR---VNEKSDVYSFGVVILELLVGKSP
 .   |..|.|||||..|. |.| .| |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR8_o-2.AA TKL-Unique 808-1007 30 2.5e-31 107.79 In-house 4-233 (290) Show / Hide 
Range on Protein: 808-1007
Range on HMM: 4-233/290
Sequence Identity: 30% (72 aa)

VIGQGAYGTVYKAKLPSGLEFAVKKLQLVQGERSAVDDRSSLRELKTAGQVK-HRNIVKLHAFFK----LDDCDLLVYEFMANGSLGDMLYR--------
.||.|.||.|||.| . | . |.|.. . . . |    .   .|...    . | |||.. .. .          .| |..  ||| | | .        
KIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

RPSESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIE-----VKARIADFGLAKLVEKQVETGSM-------SSIAGSYGYIAPEYAYT
...  |..| |. .|.  |||. ||||   | |||||.|| |.|.| .     ....|.||||.|.  |  .. .        ..  ||. ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--LRVNEKSDVYSFGVVILELLVGKS------P
     .|||||||||.|  |.. .|       |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_o-2.AA Ciliate-E2 803-1007 21 4.9e-31 103.78 In-house 1-295 (365) Show / Hide 
Range on Protein: 803-1007
Range on HMM: 1-295/365
Sequence Identity: 21% (66 aa)

FHSRFVIGQGAYGTVYKA--KLPSGLE-----------------FAVKK---LQLVQGERSAVDD-RSSLRELKTAG-----------QVKHRNIVKLHA
.    .||||..|.|||.  ..   ..                 ...|.    .. . .  ..    . .||..  .           |..| ||.|.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

FFK--LDDCDLLVYEFMANGSLGDMLY----RRPSE-----SLSWQTRYEIALGTAQ---------------GLAYLHHDCSPAIIHRDIKSNNILLDIE
.|.   |..  || |.   |.| | ..     |..|     ..... . .|    .|               .| |||   .  ||||||| .|||.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF---

VKARIADFGLAK-----------------LVEKQVETGSMSS-------------IAGSYGYIAPEYAYTLRVN---------EKSDVYSFGVVILELLV
    |.||||.|                 . . ...|  ...             |.|..|| |||       .         .|.|..|.||.. |.| 
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GKSP
|| |
GKPP
Kinase LRR8_o-2.AA TK 803-1002 15 5.4e-29 93.73 In-house 1-388 (486) Show / Hide 
Range on Protein: 803-1002
Range on HMM: 1-388/486
Sequence Identity: 15% (59 aa)

FHSRFVIGQGAYG---TVYKAKLPSGL--------------------------EFAVKKLQLV-QGERSAVDDR---------SSLRELKTAGQVK----
 .   ..|.|..|   .|||... ..                           . ||| | .    .  .  |.           |.|.  . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNIVKLHAFFKLDDCD------------LLVYEFMANGS----LGDMLY--RRPSES-----------------------------------------
 | |||.|..    ...             ..| |.|..|.    | | |   |..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWQTRYEIALGTAQGLAYLHHD-CSPA---IIHRDIKSNNILLDIEVK-----------ARIADFGLA
                               |. ...  ...  |.|..|||   |.     ..|||.   |.|.. . .           ..||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KLVE----KQVETGSMSSIAGSYG----------------------------YIAPEYAY---------TLRVNEKSDVYSFGVVILELL
.  .    . .. ..    ..|||                            . |||            . .  .||||.||||.. |..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase LRR8_o-2.AA Ciliate-E2-Unclassified 803-1007 21 8e-29 97.12 In-house 1-269 (352) Show / Hide 
Range on Protein: 803-1007
Range on HMM: 1-269/352
Sequence Identity: 21% (59 aa)

FHSRFVIGQGAYGTVYKAKLPSGLEFAVKKLQLVQGERSAVDDRSS---------LRELKTAGQVK--------------HRNIVKLHAFFKLDDCDLLV
..   .||||..|.|||..  .  .....|   .. ...    ...         . ..|   ...              | .|||..  |. ...  .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YEFMANGSLGDMLYRRPS---------------ESLSWQTRY-----EIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEV---KARIADFGLAKLV
.|.. .|.| ...  |..               . .. |         ..    ||| ||||     ||||||| .|||.| .    . .|.|||..|  
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

EKQVE-------------TGSMSSIAGSYGYI----APEYAYTLRVN----EKSDVYSFGVVILELLVGKSP
.....                |....|...|.    |||.      .    .|.|..|.||.. |.| |. |
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase LRR8_o-2.AA Pkinase_Tyr 803-1007 27 2.3e-25 86.54 Pfam 1-214 (270) Show / Hide 
Range on Protein: 803-1007
Range on HMM: 1-214/270
Sequence Identity: 27% (61 aa)

FHSRFVIGQGAYGTVYKAKLP-----SGLEFAVKKLQLVQGERSAVDD---RSSLRELKTAGQV-KHRNIVKLHAFFK-LDDC--DLLVYEFMANGSLGD
 .   ..|.||.|.|||...       ... |||.|     | .  ..   .. .||.|.  |  .| |||.|..     ..    ..| |.|..|.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

MLYRR--PSESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEK-----QVETGSMSSIAGSYGYIAPEYAYTL
 | ..  . ..|. ..  ....  |.|..||.      .||||.   |.|.. . ...|.|||||.....     .. .|..  |       |||   . 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYG

RVNEKSDVYSFGVVILELLV-GKSP
. ..||||.||||.. |..  |..|
KFTTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_o-2.AA LRRK 878-1009 33 1.5e-24 83.78 In-house 132-284 (351) Show / Hide 
Range on Protein: 878-1009
Range on HMM: 132-284/351
Sequence Identity: 33% (52 aa)

LVYEFMANGSLGDMLY-RRPSE------SLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILL-DI-----------EVKARIADFGLAKLVEK
.| |.. .|.| . |  .. ..      ..||.....|||  | |..|| |...| ||||| || ||||  .           .|.| |||||.  .  .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-Q

QVETGSMSSIAGSYGYIAPEYAY---TLRVNEKSDVYSFGVVILELLVGK-SPVD
 . .|  .   |  |. |||      .   .||.|.||||... ||| ..  | |
CFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_o-2.AA TyrKc 803-1077 22 7.5e-17 49.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 803-1077
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

FHSRFVIGQGAYGTVYKAKLPSGLEFAVKKLQLVQGERSAVDDRSSLRELKTAGQV--KHRNIVKLHAFFKLD-------DCDLLVYEFMANGSLGDML-
 .   ..| ||.|.|||...   .. |||.|.           .  .||..   ..  .| |||.|..    .       .  ..| |.|..|.| | | 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YRRPSESLSWQTRYEIALGTAQGLAYLHHDCSPAIIHRDIKSNNILLDIEVKARIADFGLAKLVEKQ-------VETGSM---SSIA-GSYGYIAPEYAY
..||   |....  ....  |.| .|||.     .||||.   |.|.. .  ..|.||||.. ..             ..   .. .   .   |||   
KHRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

TLRVNEKSDVYSFGVVILELLVGKSPVDPLFLERGQNIVSW-AKKCGSIEVLADPSVWEFASEGDRSEMSLL-------------LRVALFCTRERPGDR
. . ..||||.||||.. |.           . .||   .  ...     .. .  | |.  .|.| .                  .. . | .| | ||
YGKFTTKSDVWSFGVCMWEI-----------FTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

PTMKEAVEML
||..| .| .
PTFSEIHECF
Kinase LRR8_o-2.AA LRRK 803-834 29 0.000274 11.06 In-house 1-37 (351) Show / Hide 
Range on Protein: 803-834
Range on HMM: 1-37/351
Sequence Identity: 29% (11 aa)

FHSRFVIGQGAYG-TVYKAKLPS----GLEFAVKKLQ
. .   ||.|..| .||.||. .      ... |.||
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQ
Kinase LRR8_o-2.AA TK 1059-1077 42 0.000575 8.34 In-house 468-486 (486) Show / Hide 
Range on Protein: 1059-1077
Range on HMM: 468-486/486
Sequence Identity: 42% (8 aa)

CTRERPGDRPTMKEAVEML
| .. | ||||... .|.|
CWHYDPEDRPTFSQLHEQL
Kinase LRR8_o-2.AA LRRK 1059-1079 33 0.001434 8.48 In-house 331-351 (351) Show / Hide 
Range on Protein: 1059-1079
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CTRERPGDRPTMKEAVEMLRQ
|  . | .||.. . |. | |
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_o-2.AA TKL 1059-1077 31 0.008861 5.85 In-house 346-364 (364) Show / Hide 
Range on Protein: 1059-1077
Range on HMM: 346-364/364
Sequence Identity: 31% (6 aa)

CTRERPGDRPTMKEAVEML
|  . | .||...| .. |
CWDHDPEKRPSFQEILKRL
Kinase LRR8_o-2.AA MLK 1064-1077 35 0.091534 2.06 In-house 278-291 (291) Show / Hide 
Range on Protein: 1064-1077
Range on HMM: 278-291/291
Sequence Identity: 35% (5 aa)

PGDRPTMKEAVEML
|..||.... |. |
PHKRPSFRQIVQHL
Kinase LRR8_o-2.AA IRAK 1052-1077 23 0.107884 1.98 In-house 292-317 (317) Show / Hide 
Range on Protein: 1052-1077
Range on HMM: 292-317/317
Sequence Identity: 23% (6 aa)

LLRVALFCTRERPGDRPTMKEAVEML
.. .|. |. .|   |..|..... |
MCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR8_o-2.AA Pkinase_Tyr 1061-1077 47 1.164311 2.86 Pfam 254-270 (270) Show / Hide 
Range on Protein: 1061-1077
Range on HMM: 254-270/270
Sequence Identity: 47% (8 aa)

RERPGDRPTMKEAVEML
.. | ||||..| .|.|
HYDPEDRPTFSEIHEQL