Gene LRR8_k-2 (S.moellendorffii)

LRR8_k-2

Species: S.moellendorffii
Alias: LRR8_k-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_k-2.AA Protein None 1108 None Fasta, JSON
LRR8_k-2.NA RNA None 3327 None Fasta, JSON
LRR8_k-2.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of LRR8_k-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_k-2.AA LRRNT_2 36-75 32 1.2e-10 37.51 Pfam 1-46 (46) Show / Hide 
Range on Protein: 36-75
Range on HMM: 1-46/46
Sequence Identity: 32% (15 aa)

DPPEQEALREFLLAAKG----SELLKSWSTSS--SSPCSWLGVSCS
.. . .|| .|  .  .    .  |.||..||  |..||| ||.|.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 LRR8_k-2.AA LRR_1 79-101 33 11.163455 3.03 Pfam 1-26 (26) Show / Hide 
Range on Protein: 79-101
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HVVELSLGG-L--PLYGRIPTV-FGFL
.  .|.|.|    .| | ||   |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 103-125 37 0.000222 19.7 Pfam 1-26 (26) Show / Hide 
Range on Protein: 103-125
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ELKVLNLSS-T--NLTGSIPEE-LGSC
 |..|.||. .  ||||.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 127-149 48 0.002888 15.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 127-149
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

KLQLLDLSV-N--SLTGRVPSS-IGRL
.|| ||||  |  .||| .|.| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 151-173 33 0.000127 20.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 151-173
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ELRSLNLQD-N--QLQGSIPKE-IGNC
 |..|.|.. |  .|.|.||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 175-197 37 0.001775 16.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 175-197
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLEELQLFD-N--QLNGSIPPE-IGQL
.|..| | . |  .| |.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 199-222 33 0.847894 7.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 199-222
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLQAFRAGG-N-MALSGPLPPE-LSNC
.||    .| |   |.| .||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 224-246 37 18.762087 2.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 224-246
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTVLGLAV-T--ALSGSIPGS-YGEL
||..| |   .   |.|.|| |    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 248-270 33 0.034963 11.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 248-270
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLESLILYG-A--GISGRIPPE-LGGC
||..| | |     ..| |||. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 272-294 40 0.000836 17.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 272-294
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLQSIYLYE-N--RLTGPIPPE-LGRL
.||...|   |  .||| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 296-318 22 0.428767 8.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 296-318
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

QLRSLLVWQ-N--AITGSVPRE-LSQC
.|..| .   |   .||..| . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 320-342 37 0.012532 13.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 320-342
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLEVIDFSS-N--DLSGDIPPE-IGML
 |...|.|. |   |.|.|||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 344-366 48 0.000118 20.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 344-366
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLQQFYLSQ-N--NITGIIPPE-LGNC
|||  .||  |  |.|| |||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 368-390 40 0.016039 13.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 368-390
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLTFLELDT-N--MLTGPIPPE-LGQL
.|. | |.  |   ||| |||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 392-414 40 0.002814 15.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 392-414
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLKLLHLWQ-N--KLTGNIPAS-LGRC
||. |.|   |  .|||.|| | .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 416-438 51 0.000688 17.96 Pfam 1-26 (26) Show / Hide 
Range on Protein: 416-438
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

LLEMLDLSM-N--QLTGTIPPE-IFNL
 |. ||||  |  .|||.|||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 440-462 33 0.501079 7.81 Pfam 1-26 (26) Show / Hide 
Range on Protein: 440-462
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLQRMLLLF-N--NLSGTLPNN-AGNC
.||.  |   |  ||.|..|..   |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 464-486 33 0.023375 12.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 464-486
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLLRLRLNN-N--MLSGSLPIS-LGQL
.| .| |.. |   |.|..| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 488-510 37 0.006632 14.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 488-510
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLNFLDLHD-N--MFSGPLPTG-ISNL
||  ||| . |   ..| .| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 512-534 37 0.00174 16.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 512-534
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQMLDVHD-N--QLSGPFPAE-FGSL
.|| ||. . |  .|.| .| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 536-558 40 0.000573 18.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 536-558
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLEILDASF-N--NLSGPIPAE-IGKM
||..|| |  |  ||.| || . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 560-582 37 0.024304 12.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 560-582
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLSQLNLSM-N--QLSGDIPPE-MGRC
 |  |.||  |  .|.|.|||.    .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 584-606 37 0.074744 10.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 584-606
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ELLLLDLSS-N--QLSGNLPPD-LGMI
 |  ||||. |  .|.|..||. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 612-631 37 3.492297 4.82 Pfam 4-26 (26) Show / Hide 
Range on Protein: 612-631
Range on HMM: 4-26/26
Sequence Identity: 37% (9 aa)

TLDLHK-N--RFMGLIPSA-FARL
.|||   |  .. | ||.  |  |
HLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 633-654 33 0.000989 17.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 633-654
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLERLDISS-N--ELTGNLDV--LGKL
.|..||.|. |   |||..    . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_k-2.AA LRR_1 656-680 21 1.909217 5.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 656-680
Range on HMM: 1-26/26
Sequence Identity: 21% (6 aa)

SLNFVNVSF-N--HFSGSLPGTQVFQTM
.|   ..|  |  ...|..|    |  .
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_k-2.AA TKL 785-1049 22 4.7e-66 225.77 In-house 1-364 (364) Show / Hide 
Range on Protein: 785-1049
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

IGQGRSGVVYKAAMPS---------GEVVAVKKLRRYD-------------------------RSEHNQSEFTAEINTLGKIRHRNIVRLLGYCTNKTIE
||.|..|.|||.             |..|||||... .                          ..... ..  ||. . ..|| |||...|||.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------LLMYDYMPNGSLADFLQEKKTANNWEIRYKIALGAAQGLSYLHHDCV-----PAILHRDIKPNNILLDSRYE--------------P
              . ..|.|.||| ..|.       |. | ..||..|.|..||| .       |.|.|||.|..|||.|. ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

YVADFGLAKLIGSSTSAADPMSK----------------VAGSYGYIAPEY-----SYT-----------LKISEKSDVYSYGVVLLELLTGREAVVQDI
 ..||||.. .  |..  | |..                . |.... |||       ||           .. |||.||||.|.|| |.||...   .. 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

HIV---------KWVQGALRGSNPSVE-----VLDPRLRGMPDLFIDEMLQILGVALMCVSQLPADRPSMKDVVAFL
..           ... ...|  | .      ..    . |     | . ..   . .| .. | .|||.....  |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH----K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_k-2.AA IRAK 780-1049 29 3.1e-57 196.45 In-house 2-317 (317) Show / Hide 
Range on Protein: 780-1049
Range on HMM: 2-317/317
Sequence Identity: 29% (94 aa)

VDTNIIGQGRSGVVYKAAMPSGE-VVAVKKLRRYDRSEHNQSE--FTA---EINTLGKIRHRNIVRLLGYCTNKTIELLMYDYMPNGSLADFLQEKKTAN
   | ||.|  |.||.. .   . ..|||||. .  .. |...  | .   |. .. ..|| ||| |.||||      | |.||||||| | |.  ....
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

N-----WEIRYKIALGAAQGLSYLHHDC-VPAILHRDIKPNNILLDSRYEPYVADFGLAKLI-GSSTSAADPM-----SKVAGSYGYIAPEYSY--TLKI
      | .| .|..|.| |. .|| .    .| |.|||. ||||| . .|  .||||.      | . . .      |.| |.  | .||. .  . ..
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

SEKSDVYSYGVVLLELLTGREAVVQDIHIVKWVQGALRGSNPSVEV-----------------------------LDPRLRGMPDLFIDEMLQILGVALM
. |.|||| |.||||.|||. ||. |   ..     ..    .  .                             .|.|  ..|  .  ||.|   .|. 
TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQ---CACC

CVSQLPADRPSMKDVVAFL
|. .  . |..|. |.. |
CGHHRANRRCDMAWVMQQL
Kinase LRR8_k-2.AA TKL-Unique 781-978 33 6.9e-47 162.09 In-house 1-224 (290) Show / Hide 
Range on Protein: 781-978
Range on HMM: 1-224/290
Sequence Identity: 33% (75 aa)

DTNIIGQGRSGVVYKAAMPSGEVVAVKKLRRYDRSEHNQ--SEFTAEINTLGKIR-HRNIVRLLGYCT--NKTIE--LLMYDYMPNGSLADFLQ------
. | ||.| .|.|||.  . |. ||.|..     . .|.   ||  |.|.. |.. | |||.. |||.    ..    .  .|.| ||| | |.      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---EKKTANNWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSR-----YEPYVADFGLAKLIGSSTSAADPMS------KVAGSYGYIAPEY
   .... .|.. |.|.|. .|||. ||||   | |.|||.|. |.|.|..     .   ..||||.|.  ...     ..       . ||. ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

SYT--LKISEKSDVYSYGVVLLELLTG
      ..||||||||.|.|| |..|.
LRMNFCQYSEKSDVYSFGIVLWEIATR
Pkinase LRR8_k-2.AA Pkinase 779-979 27 1.1e-46 166.16 Pfam 1-209 (293) Show / Hide 
Range on Protein: 779-979
Range on HMM: 1-209/293
Sequence Identity: 27% (59 aa)

LVDTNIIGQGRSGVVYKAAMPSGEV-VAVKKLRRYDRSEHNQSEFTA--EINTLGKIRHRNIVRLLGYCTNKTIELLMYDYMPNG----SLADFLQ-EKK
..   .||.| .|.|||.   . .  ||||.... ....  . . .   ||  . ...| |||||......|.   .  .|...|    .|.|... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TAN--NWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSRYEP----YVADFGLAKLIGSSTSAADPMSKVAGSYGYIAPEYSY-TLKISEKS
..    ..   ....  ..|| |.|      |.|||.|| |||.|.....     ..||||||..   .     |. ..|...|.|||      ... |.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSYGVVLLELLTGR
|..|.|..| |.|.||
DMWSCGCILYEMLCGR
Kinase LRR8_k-2.AA MLK 779-980 28 1.2e-39 135.27 In-house 1-234 (291) Show / Hide 
Range on Protein: 779-980
Range on HMM: 1-234/291
Sequence Identity: 28% (68 aa)

LVDTNIIGQGRSGVVYKAAMPSGE----VVAVKKLR---RYDRSEHN--QSEFTAEINTLGKIRHRN----IVRLLGYCTNKTIE--LLMYDYMPNGSLA
.    .|| | .|.|.|. .   .    .||||. |   . | |.    | .|  |.. | ...|.|    |....| |.. . .  ..|  |...|||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVM-EYCEGGSLY

DFLQEKKT-------------ANNWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDS------RYEPYVADFGLAKLIGSSTSAADPMSKVAG
..| ....                 .   ..||  |.|..||| . ...| |||.|. |||.|            ..|||... .  ...  . | . ||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW--HQMC-TNMMSNAG

SYGYIAPEY---SYTLKISEKSDVYSYGVVLLELLTGRE
.| . |||    .   | |||.||.|.|||| |.||...
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase LRR8_k-2.AA Dicty4 779-980 33 2.2e-39 129.13 In-house 1-215 (277) Show / Hide 
Range on Protein: 779-980
Range on HMM: 1-215/277
Sequence Identity: 33% (74 aa)

LVDTNIIGQGRSGVVYKAAMPSGEVVAVKKL--RRYDRSEHNQSEFTAEINTLGKIRHRNIVRLLGYCT----NK-TIELLMYDYMPNGSLADFLQE---
.. ...||.|  | |||.    |  ||||||  .  . .|   .|| .|.. ..|||| ||. ..|.||    .. ..   .  ||| |.|.  |     
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVT-EYMPKGNLYSLLHDKPS

---KKTANNWEIRYK---IALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSRYEPYVADFGLAKLIGSSTSAADPMSKVAGSYGYIAPE----YSYTLK
   ...   |. . .   .|. ||.|. .||  | | |.|||.|. |.| |  .   |.||||....   ..  | .. ..|. .. |||     .|.  
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN--

ISEKSDVYSYGVVLLELLTGRE
  ||.||||.| || |.||. |
--EKADVYSFGIVLWEILTRQE
Kinase LRR8_k-2.AA RIPK 785-981 29 4.5e-34 113.48 In-house 1-227 (290) Show / Hide 
Range on Protein: 785-981
Range on HMM: 1-227/290
Sequence Identity: 29% (68 aa)

IGQGRSGVVYKAAMPSGEVVAVKKLRR-YDRSEH----NQSEFTAEINTLGKIRHRNIVRLLGYCTNK----TIEL--LMYDYMPNGSLADFLQEKKTA-
.| | .| |.||   .  ....||      . .|     . .   |   . |.|...||...| |  .    . .|  .   ||.||||..||. |    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---NNWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSRYEPYVADFGLAKLIGSSTSAADPM---------SKVA-GSYGYIAPEYSY--TL
     |  |  .    . |  || |.  | |.||| || |||.|. .   .||||||.  . |.|  |           ||   |   |..||       
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

KI----SEKSDVYSYGVVLLELLTGREA
|     ..|.||||...|. |.||....
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR8_k-2.AA LRRK 779-979 25 2.4e-32 111.72 In-house 1-279 (351) Show / Hide 
Range on Protein: 779-979
Range on HMM: 1-279/351
Sequence Identity: 25% (73 aa)

LVDTNIIGQGRSG-VVYKAAMPS---------------------------GEVVAVKKLRR--------------------------------YDRSEHN
|.  . ||.| .| .||.| . .                           .. ||.||. |                                 . . ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QSEFTAEINTLGKIRHRNIVRLLGYCTNKTIELLMYDYMPNGSLADFLQEKK-TA------N-NWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNI
 .||  |.  . . .| ||| |.|.| .  .  .  .|.|.|.| .||..|| ..      . .| ...||||  | |. || |.. | |.||| |. ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LLDSRYEP----YVADFGLAKLI--GSST--SAADP--MSKVAGSYGYIAPEYSY---TLKISEKSDVYSYGVVLLELLTGR
|| |  ..    |....  ||..  | |.  ..  .   ... |  |. |||      .   .||.|.||.|..| ||||..
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase LRR8_k-2.AA STE 779-979 22 8e-32 109.69 In-house 1-265 (359) Show / Hide 
Range on Protein: 779-979
Range on HMM: 1-265/359
Sequence Identity: 22% (61 aa)

LVDTNIIGQGRSGVVYKAAMP----------------SGEVVAVKKLR--RYDRSEHN--------------QSEFTAEINTLGKIR--HRNIVRLLGYC
. .  .||.| .|.||||.                  .||..|.|...  . . .. .              . ..  ||... | .  | |||. .|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

TNK--------TIELLMYDYMPNGSLADFLQEKKTANN-------------WEIRYKIALGAAQG-LSYLHHDCVPAILHRDIKPNNILLDSRYEPYVAD
 ..        .. . |  ||..||| |....|.  ..              ..  .|.    .| |.|||      | |||||| ||||        .|
FKEGHNHKNDDELWICM-EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCD

FGLAK-LIGSST------------SAADPMSKVAGSYGYIAPEYSYT------LKISEKSDVYSYGVVLLELLTGR
||... |. |..            . .     ..|.  . |||           . ..|.|..| | ...|..||.
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase LRR8_k-2.AA DRK 801-977 34 1.3e-31 104.39 In-house 22-197 (258) Show / Hide 
Range on Protein: 801-977
Range on HMM: 22-197/258
Sequence Identity: 34% (63 aa)

GEVVAVKKLRRYDRS-EHNQSEFTAEINTLGKIRHRNIVRLLGYCTNKTIELLMYDYMPNGSLADFLQEKKTANNWEIRYKIALGAAQGLSYLHHDCVPA
|  ||||.|       |   .||  ||| . . || ||.  .| |.|    .    ||| |||.  | . .    |  . .... .| |. |||  | | 
GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CNPI

ILHRDIKPNNILLDSRYEPYVADFGLAK---LIGSSTSAADPMSKVAGSYGYIAPEYSYTLKISEKSDVYSYGVVLLELLT
|.||| |  | | |  .   ||||||.     . . . |  .     |  . .|||        || ||||...|| |..|
IIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC----GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase LRR8_k-2.AA TK 779-977 15 2.8e-31 101.51 In-house 1-389 (486) Show / Hide 
Range on Protein: 779-977
Range on HMM: 1-389/486
Sequence Identity: 15% (61 aa)

LVDTNIIGQGRSG---VVYKA--------------------------AMPSGEVVAVKKLRRYDRSEHN-QSE--------------FTAEINTLG--KI
..  . .|.|  |   .|||.                               . |||| |.  | .. . . .              . .|.  .   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRNIVRLLGYCTNK------------TIELLMYDYMPNGS----LADFLQ--EKKTANNWEIRYK----------------------------------
.| |||||.|.|| .               ...  |||.|.    | |.|.   .|. .. .  .                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------IALGAAQGLSYLHHD----CVPAILHRDIKPNNILLDSRYE-----------PYVADFG---
                                      ... .|.|..|||        . . |||.   |.|.....              .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLIGS--STSAADPMSKVAGSYG----------------------YIAPEYSY---------TLKISEKSDVYSYGVVLLELLT
     ||. |.|     .... ..  .                         . |||            . | ..||||.|.||.. |..|
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase LRR8_k-2.AA S_TKc 779-1049 21 4.4e-31 110.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 779-1049
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

LVDTNIIGQGRSGVVYKAAMPS-GEVVAVKKLRRYDRSEHNQSEFTAEINTLGKIRHRNIVRLLGYCTNKTIELLMYDYMPN--GSLADFLQEKKT----
    ..||.|  |.|||.   . |..||.|...           .  ||. | | .| |||.|.... . .   .  .|...  |.| |.......    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--ANNWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSRYEPYVADFGLAKLIGSSTSAADPMSKVAGSYGYIAPEYSYTLKISE-KSDVYSY
   .  ..|. ..   ...| |.|      |.|||.|| |||||.  .  ..|||||...          . . |.  |.|||     . .  |.|..| 
FPFPE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLLELLTGRE--AVVQDIHIVKWVQGALRGSNPSVEVLDPRLRGMPDLFIDEMLQILGVALMCVSQLPADRPSMKDVVA---------FL
|..| |.|.|.      |.  . | .                              . .     |    |..||.  .. .         ..
GCILYEMLCGYPPFP--QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_k-2.AA Pkinase_Tyr 779-977 28 4.6e-26 88.9 Pfam 1-209 (270) Show / Hide 
Range on Protein: 779-977
Range on HMM: 1-209/270
Sequence Identity: 28% (60 aa)

LVDTNIIGQGRSGVVYKAAMP-----SGEVVAVKKLRRYDRSEH-NQSEFTAEINTLGKI-RHRNIVRLLGYCTNKTIE---LLMYDYMPNGSLADFLQE
..    .|.|  |.|||. .       .  ||||.|. .  .|.  . .| .|.... .. .| |||||.| || .      ..   |||.|.| |.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---KTANNWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSRYEPYVADFGLAKLI-GSSTS-AADPMSKVAGSYGYIAPEYSYTLKISEKS
.   | . . .   ....  |.|..||.      . |||.   |.|...     ..|||||..|   ..   .   .|        |||   . | ..||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTTKS

DVYSYGVVLLELLT
||.|.||.. |..|
DVWSFGVLMWEIFT
Kinase LRR8_k-2.AA TyrKc 779-1049 24 1e-23 86.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 779-1049
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

LVDTNIIGQGRSGVVYKAAMPSGEVVAVKKLRRYDRSEHNQSEFTAEINTLGKI--RHRNIVRLLGYCTNK-------TIELLMYDYMPNGSLADFLQEK
..   ..| |  |.|||. .   . ||||.|. .      . .|  |.. . |.  .| |||||.|.|| .          ..   |||.|.| |.|...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KTANNWEIRYKIALGAAQGLSYLHHDCVPAILHRDIKPNNILLDSRYEPYVADFGLAKLIGSS------TSAADP----MSKVAGSYGYIAPEYSYTLKI
.   ...   .... .|.| .|||.     . |||.   |.|.....   ..||||.. |..       ..  ..     .|    .   |||   . | 
RPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SEKSDVYSYGVVLLELLTG----REAV----VQDIHIVKWVQGALRGSNPSVEVLDPRLRGMPDL----FIDEMLQILGVALMCVSQLPADRPSMKDVVA
..||||.|.||.. |..|      . .    . .......|.   |   |            | .      ||| ||    ..|    |.|||...... 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--------P-MSFVCCPDEMYQIM---KQCWHEDPEDRPTFSEIHE

FL
..
CF
Kinase LRR8_k-2.AA TK 1027-1049 26 0.000201 9.9 In-house 464-486 (486) Show / Hide 
Range on Protein: 1027-1049
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

VALMCVSQLPADRPSMKDVVAFL
. ..| .  |.|||...... .|
LMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_k-2.AA MLK 1030-1049 40 0.001497 8.34 In-house 272-291 (291) Show / Hide 
Range on Protein: 1030-1049
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

MCVSQLPADRPSMKDVVAFL
.| .| |..|||.. .| .|
QCWNQDPHKRPSFRQIVQHL
Kinase LRR8_k-2.AA LRRK 1031-1051 28 0.023242 4.14 In-house 331-351 (351) Show / Hide 
Range on Protein: 1031-1051
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CVSQLPADRPSMKDVVAFLQE
| .. | .||.. ..| .| .
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_k-2.AA Pkinase_Tyr 1036-1049 35 0.06387 7.13 Pfam 257-270 (270) Show / Hide 
Range on Protein: 1036-1049
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PADRPSMKDVVAFL
|.|||...... .|
PEDRPTFSEIHEQL
Kinase LRR8_k-2.AA DRK 1031-1051 33 0.111084 1.51 In-house 238-258 (258) Show / Hide 
Range on Protein: 1031-1051
Range on HMM: 238-258/258
Sequence Identity: 33% (7 aa)

CVSQLPADRPSMKDVVAFLQE
| .  |  |||| ...  |  
CWNEDPQHRPSMQECLERLEA
Kinase LRR8_k-2.AA TKL-Unique 1030-1049 30 0.209405 0.94 In-house 271-290 (290) Show / Hide 
Range on Protein: 1030-1049
Range on HMM: 271-290/290
Sequence Identity: 30% (6 aa)

MCVSQLPADRPSMKDVVAFL
.|  . | .|||  ...  |
QCWHHDPSQRPSFDEIIHRL