Gene LRR8_aa (S.moellendorffii)

LRR8_aa

Species: S.moellendorffii
Alias: LRR8_aa
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_aa.AA Protein None 1034 None Fasta, JSON
LRR8_aa.NA RNA None 3105 None Fasta, JSON
LRR8_aa.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of LRR8_aa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_aa.AA LRRNT_2 22-62 41 3.8e-14 48.88 Pfam 1-46 (46) Show / Hide 
Range on Protein: 22-62
Range on HMM: 1-46/46
Sequence Identity: 41% (19 aa)

GFQDKSALLALKASMI--DS-SGSLDDWTETD-D-TPCLWTGITCD
  .|. ||||.|.|.   |. .|.| .|. .. | ..| |||.|||
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 LRR8_aa.AA LRR_1 67-89 33 6.264471 3.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 67-89
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RVVALDLSN-K--NLSGIVSSS-IGRL
.   ||||.    ||.| ...| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 91-113 33 1.204008 6.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 91-113
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ELINLTLDV-N--NFTGNLPGE-LATL
 |  | |.  |  |.||..| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 115-137 37 0.004264 15.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 115-137
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

DLHFLNVSH-N--AFTGDFPGR-FSNL
 |  |..|. |   .||..| . | ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 139-161 29 0.025434 12.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 139-161
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

LLEVLDAYN-N--NFSGPLPIE-LSRL
 |..||  . |  |..| .| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 163-185 44 0.005081 14.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 163-185
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLRHLHLGG-S--YFEGEIPPS-YGNM
||.||.|.|     ..|.||||   |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 187-209 40 0.030112 12.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 187-209
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLSYLALCG-N--CLVGPIPPE-LGYL
.| .| | | |  .|.| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 211-234 37 0.018263 12.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 211-234
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

GLEELYLGYFN--HFTGGIPPE-LGRL
 |..|.|...|  ..|| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 236-258 44 0.000296 19.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 236-258
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLQKLDIASC---GLEGVIPAE-LGNL
|||.||. .|    |.| || . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 260-282 40 0.162932 9.54 Pfam 1-26 (26) Show / Hide 
Range on Protein: 260-282
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLDSLFLQI-N--HLSGPIPPQ-LGDL
|| .| |.  |  .|.| |||  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 284-306 51 1.1e-05 24.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 284-306
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

NLKSLDLSN-N--NLTGAIPIE-LRKL
||..||||. |  |||| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 308-330 37 1.416225 6.21 Pfam 1-26 (26) Show / Hide 
Range on Protein: 308-330
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLELLSLFL-N--GLSGEIPAF-VADL
||. |.|   |   |.|.||      |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 332-354 37 0.231366 9.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 332-354
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLQALLLWT-N--NFTGELPQR-LGEN
||| | |   |  |.||..| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 356-375 50 0.001112 17.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 356-375
Range on HMM: 1-26/26
Sequence Identity: 50% (13 aa)

NLTELDVSS-N--PLTGPLPP---NL
||..||.|. |  .||| .||   ||
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR8_aa.AA LRR_1 380-402 33 0.008433 14.1 Pfam 1-26 (26) Show / Hide 
Range on Protein: 380-402
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLEVLVLIE-N--GITGTIPPA-LGHC
.|..| |   |   .||.|||  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 404-426 37 0.009855 13.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 404-426
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLIKVRLAG-N--HLTGPIPEG-LLGL
.| .  | | |  .||| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 428-449 33 24.479786 1.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 428-449
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

MLEMLELLD-N--RLTGMIPA--IVDA
 |. | | . |  .||| ||   .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 451-473 40 0.052295 11.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 451-473
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

LLDFLDLSQ-N--ELQGSIPAG-VARL
 |  ||||  |   |.|.|| .    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 475-497 33 0.016568 13.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 475-497
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQKLFLHS-N--RFVGGIPVE-LGQL
.||.| | . |  ...| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 499-521 37 0.001119 17.21 Pfam 1-26 (26) Show / Hide 
Range on Protein: 499-521
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

HLLHLDLHS-N--RLSGAIPAE-LAQC
.| |||| . |  .|.| || . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 523-545 37 0.000352 18.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 523-545
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLNYLDVSD-N--RLTGPIPAE-LGSM
.| .||.|. |  .||| || . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 547-569 33 0.633044 7.45 Pfam 1-26 (26) Show / Hide 
Range on Protein: 547-569
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

VLELLNVSR-N--RLSGGIPPQ-ILGQ
 |. |..|. |  .|.| |||  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_aa.AA LRR_1 571-595 28 0.299992 8.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 571-595
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

SLTSADFSY-N--DFSGTVPSDGHFGSL
.|.. |.|. |   ..|..|..  | .|
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR8_aa.AA TKL 708-983 22 1e-64 221.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 708-983
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

IGRGGSGTVYRAEMPN---------GEVVAVKRLCKATSDETGSGSHD---------------------HGFSAEIQTLGKIRHRNIVKLLGCCSNEET-
||.||.|.||...  .         |..||||.. .  .||. . | .                       .  ||  . ..|| |||...|.| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLVYEYMPNGSLGELLHSKKRNLLDWTTRYNIAVQSAFGLCYLHHDCS-----PLIVHRDVKSNNILLDSGFE--------------
              .|.||.|.||| ..||        |  | ..| . | |..||| .       | |.||| ||.|||.|. ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AHVADFGLAKFFQASSAGKCES---------------MSSIAGSYGYIAPEYA-----YT-----------LKVSEKADIFSFGVVLLELITGRKPTEQE
. ..||||..|.. |.  .. .                ... |.... |||       ||           .. |||.|..|||.|| |..|...| ...
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

FRDSGLGIVKWVKKVMDEAKDGVLSIVDSTLRSS----QLPVHEVTSLVGVALICCEEYPSDRPTMRDVVQML
  .. ..    ..  .  . |  |     .  ..    . . .  .|.   .  |... |..||.. .... |
PYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_aa.AA IRAK 704-983 28 6.9e-57 195.3 In-house 3-317 (317) Show / Hide 
Range on Protein: 704-983
Range on HMM: 3-317/317
Sequence Identity: 28% (92 aa)

EDNIIGRGGSGTVYRAEMPNGE-VVAVKRLCKATSDETGSGSHDHGFSA---EIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPNGSLGELLHSKK-R
.|| || || |.|||... | . ..|||.| .  . ..  ..|.  | .   |.... ..|| ||| |.| |. ..   |||.|||||||   |.  .  
KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSW--NEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

NL---LDWTTRYNIAVQSAFGLCYLHHDCS--PLIVHRDVKSNNILLDSGFEAHVADFGLAKFF---QASSAGKC--ESMSSIAGSYGYIAPEYAY--TL
.    | | .|  |.  .| |. .|| . .  |.| |.|.|| |||||  |..  .||||. |    ... ....     | . |.  | .||. .  . 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPII-HGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

KVSEKADIFSFGVVLLELITGRKPTEQEFRDSGLGIVKWVKKVMDEAK--DGVLS----------------I------VDSTLRSSQLPVHEVTSLVGVA
. . | |..|||.||||..||...   . .   . ..  .  .|.|..  |  .|                .      .|.  | . .|  .. ..  .|
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYY-LKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDH--RMPPCPPNMEKEMCQCA

LICCEEYPSDRPTMRDVVQML
. | ..    |..|. |.| |
CCCGHHRANRRCDMAWVMQQL
Kinase LRR8_aa.AA MLK 702-910 29 1.6e-47 162.92 In-house 1-235 (291) Show / Hide 
Range on Protein: 702-910
Range on HMM: 1-235/291
Sequence Identity: 29% (72 aa)

LIEDNIIGRGGSGTVYRAEMPNGE----VVAVKRLC-KATSDETGSGSHDHGFSAEIQTLGKIRHRN----IVKLLGCCSNEETN-LLVYEYMPNGSLGE
. .  .|| |..| |..... | .    .|||||    .  |   ... .  |  |.  | ...|.|    |....|.|.... . ..| ||...||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHS-KKRNL-----------LDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDS------GFEAHVADFGLAKFFQASSAGKCES-MSSIA
.||. ..               |     |.|.| | |. ||| .  ..|.||| || |||.|       .  . ..|||...... .    | . | | |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQM----C-TNMMSNA

GSYGYIAPEY---AYTLKVSEKADIFSFGVVLLELITGRKP
|.| . |||    .   |.|||.|..|.|||| |..|.. |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_aa.AA Pkinase 702-908 25 2.5e-41 147.2 Pfam 1-209 (293) Show / Hide 
Range on Protein: 702-908
Range on HMM: 1-209/293
Sequence Identity: 25% (59 aa)

LIEDNIIGRGGSGTVYRAEMPNGEV-VAVKRLCKATSDE--------TGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPNG----S
.    .||.|..|.||..   . .  ||||...| . ..        .          .||| . ...| |||.|.... ..    .| ||...|    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMD

LGELLH-SKKRNL-LDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEA----HVADFGLAKFFQASSAGKCESMSSIAGSYGYIAPEY
| .... ...... ... .  ... | . || |.|      |.|||.|. |||.|.  .     ...||||||.|.     . . |....|...|.||| 
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEV

AY-TLKVSEKADIFSFGVVLLELITGR
     . . |.|..|.|..| |...||
IRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase LRR8_aa.AA TKL-Unique 706-907 31 3.3e-41 143.09 In-house 3-224 (290) Show / Hide 
Range on Protein: 706-907
Range on HMM: 3-224/290
Sequence Identity: 31% (72 aa)

NIIGRGGSGTVYRAEMPNGEVVAVKRLCKATSDETGSGSHDHGFSAEIQTLGKIR-HRNIVKLLGCCS----NEETNLLVYEYMPNGSLGELLHS-----
| ||.||.|.||...  .|. ||.|.. .  .|   . . .  |. |. .. |.. | |||.. | |      .    .| ||.| ||| ..||      
NKIGEGGYGQVYKGKW-RGYPVAIKQFHP-NEDSSNEMMQE--FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KKRNLLDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSG-----FEAHVADFGLAKFFQASSAGKCESM-----SSIAGSYGYIAPEY
   .. . |..  |...| . | |..||||   | | ||| || |.|.|..     . . ..||||.||   .....         ..  ||. ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

AYT--LKVSEKADIFSFGVVLLELITG
      . |||.|..|||.|| |..|.
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase LRR8_aa.AA RIPK 708-915 30 4.2e-40 134.35 In-house 1-232 (290) Show / Hide 
Range on Protein: 708-915
Range on HMM: 1-232/290
Sequence Identity: 30% (71 aa)

IGRGGSGTVYRAEMPNGEVVAVKRL--CKATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSNEET------NLLVYEYMPNGSLGELLHSKKR-
.|.||.|.|..|      ....|    ||    .    .     . | . . |.|...||...| |  ||         .| |||.|||| ..||.| . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY

----NLLDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQASSAGK--C-----ESMSSIA--GSYGYIAPEYAY-
     ... . |  . .. . | ||| |.  | | ||| |  |||.|. | . .||||||.. . |. ..  |      || |    |   |..||    
QHHPDPWPLRCR--MIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

-TLKV----SEKADIFSFGVVLLELITGRKPTEQEF
   |     ..| |. ||..|. |. |...| | ..
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRK
Kinase LRR8_aa.AA S_TKc 702-983 22 2.1e-38 134.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 702-983
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

LIEDNIIGRGGSGTVYRAEMPN-GEVVAVKRLCKATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPN--GSLGELLHSKKR
    ..||.|. |.||..   . |..||.|..                .  ||| | | .| |||||.... . .   .| ||...  |.| .......|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

N-----LLDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQASSAGKCESMSSIAGSYGYIAPEYAYTLKVSE-KA
.     .   ..|. .. | . .| |.|      |.|||.|  |||||.  .  ..|||||...           ... |.  |.|||     . .  |.
HGLRFPFPE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKC

DIFSFGVVLLELITGRKPTEQEFRDSGLGIVKWVKKVMDEAKDGVLSIVDSTLRSSQLPVHEVTSLVGVALICCEEYPSDRPTMRDVVQ---------ML
|. |.|..| |...|. | .         . .  ||..                          ..      |..  |..|||  .. |          .
DWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_aa.AA LISK 707-922 26 8.9e-36 113.57 In-house 1-253 (296) Show / Hide 
Range on Protein: 707-922
Range on HMM: 1-253/296
Sequence Identity: 26% (70 aa)

IIGRGGSGTVYRAEMP-NGEVVAVKRLCK----ATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCSN-EETNLLVYEYMPNGSLGELLHSK--KR
.||.|. | ||. .    |.|.|.| . .    .  .|.      . .  |.|.. ..||.|||.  | | . .    .| ||.  | | ..|...  . 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEY-----QKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHK

NLLDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLD----SGFEAHVADFGLAKFFQASSAGKC-----------------------------
  | |. | .||.  | |. |||  .   |.||| ||.|.|..    ..... |.|||.|. .. .. . |                             
IPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQ

--ESMSSIAGSYGYIAPEYAYTLKVSEKADIFSFGVVLLELITGRKPTE-QEFRDS--GLGI
  ..| .| |.    |||     . .|..|.||||.||.|.||..|... .  |..  ..|.
RKRRM-TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGL
Kinase LRR8_aa.AA STE 703-908 24 8.9e-35 120.26 In-house 1-265 (359) Show / Hide 
Range on Protein: 703-908
Range on HMM: 1-265/359
Sequence Identity: 24% (66 aa)

IED-NIIGRGGSGTVYRA--------EMPNGEV---------VAVKRLCKATSD-----------ETGSGSHDHGFSAEIQTLGKIR--HRNIVKLLGCC
 |.  .||.|..||||.|        . ..|||         .|.|.. . ...           |.   .    .  ||... | .  | |||| .||.
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

SNE-------ETNLLVYEYMPNGSLGELLH---SKKRNL---------LDWTTRYNIAVQSAFG-LCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADF
 .|       ..  .. |||..||| ....   .....|         .. .    |..|   | | |||      |.|||.|. ||||     .  .||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GLAKFFQASSAGK------------CESMSSIAGSYGYIAPEYAYT------LKVSEKADIFSFGVVLLELITGR
|... .. |.|..             .   ...|.  . |||           . ..|.|| |.| ...|..||.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase LRR8_aa.AA Dicty4 702-910 33 2.7e-33 108.54 In-house 1-216 (277) Show / Hide 
Range on Protein: 702-910
Range on HMM: 1-216/277
Sequence Identity: 33% (75 aa)

LIEDNIIGRGGSGTVYRAEMPNGEVVAVKRL--CKATSDETGSGSHDHGFSAEIQTLGKIRHRNIVKLLGCCS----NEETNLLVYEYMPNGSLGELLHS
.  ...||.|. |.||..    |  |||| |   . ..||    .    | .|.  ..|||| ||....| |     . .. . | |||| |.| .|||.
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNE----FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHD

-----KKRNLLDWTTRYN---IAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQASSAGKCESMSSIAGSYGYIAPEYAYTLK
     ...  |||...     .|   | |. .||  | | |.||| || |.| |  . . |.||||.. ..  .  |   ... .|. .. |||      
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDN-QMTACGTPCWMAPEVMMHQP

VSEKADIFSFGVVLLELITGRKP
  |||| .||| || |. |.  |
YNEKADVYSFGIVLWEILTRQEP
Kinase LRR8_aa.AA LRRK 702-910 26 6.7e-33 113.71 In-house 1-282 (351) Show / Hide 
Range on Protein: 702-910
Range on HMM: 1-282/351
Sequence Identity: 26% (77 aa)

LIEDNIIGRGGSG-TVYRAEMPN---------------------------GEVVAVKRLCK---------------------------ATSDETGSGSHD
|.. . |||||.| .||||.. .                           .. ||.| . .                           . .|  ..... 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

--HGFSAEIQTLGKIRHRNIVKLLGCCSNEETNLLVYEYMPNGSLGELLHSKKRN-L------LDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNN
  . |  |.  . . .| |||.|.| | .  .  .| ||.|.|.| ..||.||.. .      ..|.... ||.| | |. || |...| |.||| || |
AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPN

ILL---D---------SGFEAHVADFGLAK-FFQASSAGKCES--MSSIAGSYGYIAPEYAY---TLKVSEKADIFSFGVVLLELITGR-KP
|||   .             |..||||.   | |.     . .   .   |  |. |||      .   .||.|..|||..| ||.|..  |
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QC-----FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR8_aa.AA TK 702-910 17 6.8e-32 103.62 In-house 1-394 (486) Show / Hide 
Range on Protein: 702-910
Range on HMM: 1-394/486
Sequence Identity: 17% (69 aa)

LIEDNIIGRGGSG---TVYRAEMPNG--------------------------EVVAVKRLCK--ATSDET----------GSGSHDHG-----FSAEIQT
..  . .|.|  |   .||..|. ..                          . |||| | .  |.|.|           |      |     . .|.. 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG------GEDFLEEAEEMKM

LG--KIRHRNIVKLLGCCSNEET------------NLLVYEYMPNGS----LGELLHSKKRN--------------------------------------
.   . .| |||.|.|.|. .|.             ..| ||||.|.    | . |......                                      
MCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC

------------------------------------LLDWTTRYNIAVQSAFGLCYLHHD-CSPL---IVHRDVKSNNILLDSGFE-----------AHV
                                     |.  ..  ...| | |. |||   |. .   .||||.   |.|....             . .
PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKI

ADFGLAKFFQ--ASSAGKCESMSSIAGSYG----------------------------YIAPEYAY---------TLKVSEKADIFSFGVVLLELIT-GR
|||||..      . .   ..    ..|||                            . |||            . | ..| |..||||.. |. | |.
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQ

KP
.|
EP
Kinase LRR8_aa.AA Pkinase_Tyr 702-855 27 9.4e-32 108.16 Pfam 1-159 (270) Show / Hide 
Range on Protein: 702-855
Range on HMM: 1-159/270
Sequence Identity: 27% (46 aa)

LIEDNIIGRGGSGTVYRAEMP-----NGEVVAVKRLCKATSDETGSGSHD---HGFSAEIQTLGKI-RHRNIVKLLGCCS-NEET--NLLVYEYMPNGSL
.. .  .|.|  |.||....      ..  |||| | |      |. ...     | .|.... .. .| |||.|.|.|.  .|    ..| ||||.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

GELLHSK--KRNLLDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAK
 . |...   .. |.  .  ....| | |. ||.      ..|||.   |.|..... . ..|||||.
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase LRR8_aa.AA TyrKc 702-983 23 3.6e-26 94.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 702-983
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

LIEDNIIGRGGSGTVYRAEMPNGEVVAVKRLCKATSDETGSGSHDHGFSAEIQTLGKI--RHRNIVKLLGCCSNE-------ETNLLVYEYMPNGSLGEL
.  . ..|.|  |.||....   . |||| | . .            |  |.. . |.  .| |||.|.|.|. .       |  ..| ||||.|.| . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LHSKKRNLLDWTTRYNIAVQSAFGLCYLHHDCSPLIVHRDVKSNNILLDSGFEAHVADFGLAKFFQAS-------SAGKC----ESM--SSIAGSYGYIA
|...... | . .  ....| | |  |||.     ..|||    |.|..... . ..||||...           .  .      .     |       |
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR----WMA

PEYAYTLKVSEKADIFSFGVVLLELIT-GRKPTEQEFR--DSGLGIVKWVKKV-MDEAKDGVL--SIVDSTLRSSQLPVHEVTSLVGVALICCEEYPSDR
||   . | ..| |..||||.. |. | | .| . .     |   ....||.  . .  . ..  |        .   |.  . .  . . |..| |.||
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------F---VCCPDEMYQIMKQCWHEDPEDR

PTMRDVVQML
||...... .
PTFSEIHECF
Kinase LRR8_aa.AA TK 965-983 36 5.2e-05 11.91 In-house 468-486 (486) Show / Hide 
Range on Protein: 965-983
Range on HMM: 468-486/486
Sequence Identity: 36% (7 aa)

CCEEYPSDRPTMRDVVQML
|... |.||||.......|
CWHYDPEDRPTFSQLHEQL
Kinase LRR8_aa.AA Pkinase_Tyr 965-983 36 0.002976 11.64 Pfam 252-270 (270) Show / Hide 
Range on Protein: 965-983
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CCEEYPSDRPTMRDVVQML
| .. |.||||.......|
CWHYDPEDRPTFSEIHEQL
Kinase LRR8_aa.AA MLK 964-983 40 0.005584 6.33 In-house 272-291 (291) Show / Hide 
Range on Protein: 964-983
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

ICCEEYPSDRPTMRDVVQML
.| .. |..||..| .|| |
QCWNQDPHKRPSFRQIVQHL
Kinase LRR8_aa.AA LISK 961-983 34 0.009904 4.47 In-house 274-296 (296) Show / Hide 
Range on Protein: 961-983
Range on HMM: 274-296/296
Sequence Identity: 34% (8 aa)

VALICCEEYPSDRPTMRDVVQML
... ||.  |..||.  ..|| |
LCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_aa.AA Pkinase_Tyr 889-910 43 0.019303 8.89 Pfam 192-214 (270) Show / Hide 
Range on Protein: 889-910
Range on HMM: 192-214/270
Sequence Identity: 43% (10 aa)

SEKADIFSFGVVLLELIT-GRKP
..| |. ||||.. |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_aa.AA Dicty4 965-985 26 0.024171 3.82 In-house 255-277 (277) Show / Hide 
Range on Protein: 965-985
Range on HMM: 255-277/277
Sequence Identity: 26% (6 aa)

CCEEYPSDRPTMRDVVQM--LVD
| ...|. ||..  ..|   |  
CWDHDPQHRPSFEEIIQRRILEH
Kinase LRR8_aa.AA TKL-Unique 965-983 31 0.096612 2.14 In-house 272-290 (290) Show / Hide 
Range on Protein: 965-983
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CCEEYPSDRPTMRDVVQML
|.   ||.||.  ...  |
CWHHDPSQRPSFDEIIHRL
Kinase LRR8_aa.AA LRRK 965-985 28 0.147534 1.26 In-house 331-351 (351) Show / Hide 
Range on Protein: 965-985
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CCEEYPSDRPTMRDVVQMLVD
| .. | .||.. ..|. | .
CWQHDPKKRPHFSQIVKRLSQ