Gene PERK_b-2 (S.moellendorffii)

PERK_b-2

Species: S.moellendorffii
Alias: PERK_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: PERK

Sequence

Name Sequence Type Origin Length Description Download
PERK_b-2.AA Protein None 565 None Fasta, JSON
PERK_b-2.NA RNA None 1698 None Fasta, JSON
PERK_b-2.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of PERK_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PERK_b-2.AA IRAK 189-461 31 2.4e-82 279.89 In-house 1-317 (317) Show / Hide 
Range on Protein: 189-461
Range on HMM: 1-317/317
Sequence Identity: 31% (103 aa)

FSRANLLGEGGFGCVYKGFLHGGQ-VVAVKQLR----VGSRQGEREFRA---EVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPNGTLEHHLHGKGRP
|...|..|||||||||.| ...   ..||| |.    .   . ...|..   |... .| .| ..|.| |||..  .  |||.. |||.||  |.. .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VM----DWPTRLKIASGSARGLAYLHEDCHPR--IIHRDIKSSNILLDNNFDAQVSDFGLAKLA----SDTYTHV----TTRVMGTFGYLAPEYAS--TG
..     |..|..|..|.|.|. .||.. ||   |||.||||.||||| .| .  .||||.       .  .. .    | .| ||  |..||.    .|
CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

KLTEKSDVYSFGVVLLELLTGRRPVDTT--QPVGKESLVEWARPYLMQAIEN-----------------------GDLDGIVDERLANYNENEMLRMVEA
.|| |.||||||.||||.|||.|.|..    . ..  |.|    ..|.                            .    .|.| .  ..|. . |  .
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCE----EIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQC

AAACVRHSASERPRMAEVVPAL
|  |. | | .|. ||.|.  |
ACCCGHHRANRRCDMAWVMQQL
Kinase PERK_b-2.AA TKL 195-461 23 8.3e-71 241.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 195-461
Range on HMM: 1-364/364
Sequence Identity: 23% (87 aa)

LGEGGFGCVYKGFLHG---------GQVVAVKQLRVGSRQGE---------------------------REFRAEVEIISRVHHRHLVSLVGYCIADAQ-
.|.||||.|||| ..|         |..||||.... . . .                            ... |. ..|| .| ..|...|||..  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYDFVPNGTLEHHLHGKGRPVMDWPTRLKIASGSARGLAYLHEDCH-----PRIIHRDIKSSNILLDNNFD--------------
              .|....|.|.|.|.||        |. |...| . |||..||| .       | |||||.||.|||.|.|.               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AQVSDFGLAKLA----SDTYTHVTTR--------------VMGTFGYLAPEYAS----------------TGKLTEKSDVYSFGVVLLELLTGRRPVDTT
. ..||||..      ... |  |..              . ||....|||                    .. .||.||||||.|| |.||..|     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

QPVGKESLVEWARP----YLMQAIENGDLDGIVDERLAN-----YNENEMLRMVEAAAACVRHSASERPRMAEVVPAL
 |  ..   ..         .  . .  |   ....  |      ... . .| . .  |  | ...|| . |..  |
-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase PERK_b-2.AA LRRK 189-390 29 1.7e-50 174.09 In-house 1-284 (351) Show / Hide 
Range on Protein: 189-390
Range on HMM: 1-284/351
Sequence Identity: 29% (85 aa)

FSRANLLGEGGFG-CVYKGFLHG---------------------------GQVVAVKQLRVG---------------------SRQGE------------
. . ...|.||||  ||.. . |                           .| ||.|.. ..                     | |.|            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-REFRAEVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPNGTLEHHLH---GKGR----PVMDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNI
 |||| || |.|. .| ..|||.|.||    . .| ...|.|.| |.||     |.    ....| ..||||   |.|..||| ...| ||||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------NNFDAQVSDFGLAKLASDTYTH-VTTRVMGTFGYLAPEYASTG---KLTEKSDVYSFGVVLLELLTGR-RPVD
||   .         ..  | ..|||.  .   .... |. .. |..|..|||    .     |||.|.||||..| ||||.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase PERK_b-2.AA TKL-Unique 191-388 33 1.7e-50 174.09 In-house 1-233 (290) Show / Hide 
Range on Protein: 191-388
Range on HMM: 1-233/290
Sequence Identity: 33% (79 aa)

RANLLGEGGFGCVYKGFLHGGQVVAVKQLRV---GSRQGEREFRAEVEIISRVH-HRHLVSLVGYCI----ADAQRLLVYDFVPNGTLEHHLHG------
  |..||||.| ||||  . |  ||.||. .    | . ..||. || .... | |  .| ..|||.    . ... .| ...| |.|  .||       
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--KGRPVMDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNN-----FDAQVSDFGLAKLAS-DTYTHVT-------TRVMGTFGYLAPEYA
  .    ...  |.|.|   |.|. |||    | |||||.||||.|.|||     . ....||||.|..| .. . ..       . ..|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

ST--GKLTEKSDVYSFGVVLLELLTGRR------P
.    . .|||||||||.|| |..|. .      |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase PERK_b-2.AA TK 189-388 17 7.2e-45 147.88 In-house 1-394 (486) Show / Hide 
Range on Protein: 189-388
Range on HMM: 1-394/486
Sequence Identity: 17% (70 aa)

FSRANLLGEGGFG---CVYKGFLHGG--------------------------QVVAVKQLRVGSRQGEREFRA--------------EVEIISRVH----
    . |||| ||    |||| ..|.                          . ||||.|. |. . ..||..              |.|...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRHLVSLVGYCIADAQ------------RLLVYDFVPNGT----LEHHLH--GKGRPV-----------------------------------------
 | ..|.|.|.|  ..              ..|  ..|.|     | ..|.   ...                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MDWPTRLKIASGSARGLAYLHED----CHPRIIHRDIKSSNILLDNNFD-----------AQVSDFGLA
                               .. ...| ..   |.|..|||.       ....|||.   |.|...|             . ..||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LASDTYTHVTTRVMGTFG----------------------------YLAPEYAS---------TGKLTEKSDVYSFGVVLLELLT-GRRP
.     || | | .   ..... |                            ..|||            .|| |.||||.||||.. |..| |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase PERK_b-2.AA Pkinase_Tyr 189-388 30 3.8e-43 146.75 Pfam 1-214 (270) Show / Hide 
Range on Protein: 189-388
Range on HMM: 1-214/270
Sequence Identity: 30% (67 aa)

FSRANLLGEGGFGCVYKGFLH-----GGQVVAVKQLRVGSRQGE---REFRAEVEIISRV-HHRHLVSLVGYCI-ADAQ--RLLVYDFVPNGTLEHHLHG
 .    |||| || |||| ..     ... |||| |. |. . .   ..| .|..| .   || ..|.|.| |.  . .   ..|  ..|.| | ..|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K--GRPVMDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNNFDAQVSDFGLAKLA-SDTYT-HVTTRVMGTFGYLAPEYASTGKLTEKSDV
.  ...  . .. |...   |.|..||..     .||||.   |.|...|. . ..|||||..  .| |  ....  .     .|||  ..|| |.||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVVLLELLT-GRRP
.||||.. |..| |. |
WSFGVLMWEIFTYGEQP
Kinase PERK_b-2.AA Pkinase 189-386 29 7.2e-43 152.65 Pfam 1-209 (293) Show / Hide 
Range on Protein: 189-386
Range on HMM: 1-209/293
Sequence Identity: 29% (63 aa)

FSRANLLGEGGFGCVYKGFLHGGQV-VAVKQLRVGSRQG--EREFRA--EVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPNG----TLEHHLH-GKG
. .   .|.|.||||||.  .| .  ||||.... ..    ... |   |..|  |..| . | | ...  .    .| .....|     | ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPV-MDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNNFDA----QVSDFGLAKLA-SDTYTHVTTRVMGTFGYLAPEYAS-TGKLTEKSD
... ... .  ...   .|||.|.|.    .|||||.|..|||.||| .      ..||||||..    ..  ||.. || .|.|||      . . |.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKVD

VYSFGVVLLELLTGR
..|.|..| |.|.||
MWSCGCILYEMLCGR
Kinase PERK_b-2.AA Dicty4 189-388 34 1.2e-42 140.15 In-house 1-216 (277) Show / Hide 
Range on Protein: 189-388
Range on HMM: 1-216/277
Sequence Identity: 34% (75 aa)

FSRANLLGEGGFGCVYKGFLHGGQVVAVKQL---RVGSRQGE-REFRAEVEIISRVHHRHLVSLVGYCI----ADAQRLLVYDFVPNGTLEHHLHG----
  . ...|.|.|| ||||    |. |||| |    ..... .  |||.||.| .   | ... . |.|.    .    . |  ..| |.|.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-KGRPVMDWPTRLK---IASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNNFDAQVSDFGLAK-LASDTYTHV-TTRVMGTFGYLAPEYASTGKLTEKS
 . .  .|||....   .|   |||...||. | |.|||||.||.|.| | |. . |.||||..    ..     .. . || .. |||       .||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELLTGRRP
|||||| || |.||.  |
DVYSFGIVLWEILTRQEP
Kinase PERK_b-2.AA MLK 189-388 27 1.9e-41 141.58 In-house 1-235 (291) Show / Hide 
Range on Protein: 189-388
Range on HMM: 1-235/291
Sequence Identity: 27% (64 aa)

FSRANLLGEGGFGCVYKGFLHGGQ----VVAVKQLR------VGSRQGEREFRAEVEIISRVHHRH----LVSLVGYCIADAQ-RLLVYDFVPNGTLEHH
.     .|.|.|| |.||  ..      .||||. |      . .    ..|. |... ... |.      . ..| |. . .  ..|  ....| | . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHG-KGRPV-----------MDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDN------NFDAQVSDFGLAKLASDTYTHVTTRVMGTFGY
||| .. .            .|    ...|   |||..|||..  . |||||.||.|||.|.      . .. ..|||...  ...     .  .||. .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

LAPEY---ASTGKLTEKSDVYSFGVVLLELLTGRRP
 |||    .  .| .||.||.|.|||| |.||.. |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase PERK_b-2.AA TyrKc 189-461 24 1.8e-38 135.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 189-461
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

FSRANLLGEGGFGCVYKGFLHGGQVVAVKQLRVGSRQGEREFRAEVEIISRV--HHRHLVSLVGYCIAD-------AQRLLVYDFVPNGTLEHHLHGKGR
 .    |||| || |||| .   . |||| |. ..   ...|. | .| ...  || ..| |.|.|. .        . ..|  ..|.| | ..|. ...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

PVMDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNNFDAQVSDFGLAKLASDT--------YTHV----TTRVMGTFGYLAPEYASTGKLT
    ... |...   |.| .|||.    ..||||.   |.|...|. . .|||||..   |         | ..     .. |     .|||   .|| |
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKSDVYSFGVVLLELLTGRRPVDTTQPVGKESLVE-----WARPYLMQAIENGDLDGIVDERLANYNENEM------LRMVEAAAACVRHSASERPRMAE
.||||.||||.. |..|           |..   .          ... ...|.   . .. .      .|        | .    | .. ...||...|
TKSDVWSFGVCMWEIFTY----------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

VVPAL
..  .
IHECF
Kinase PERK_b-2.AA Dicty4-Unclassified 192-388 32 8.5e-38 127.01 In-house 4-207 (263) Show / Hide 
Range on Protein: 192-388
Range on HMM: 4-207/263
Sequence Identity: 32% (69 aa)

ANLLGEGGFGCVYKGFLHGGQVVAVKQLRVGSRQGE----REFRAEVEIISRVHHRHLVSLVGYCIAD----AQRLLVYDFVPNGTLEHHLH----GKGR
   .|.| |  |.||   |   |||| .  .. .       .|..||||   . |  || . ||||.     .    |  | . |.|    |     . .
DQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

PV-MDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNNFDAQVSDFGLAKLASDTYTHVTTRVMGTFGYLAPEYASTGKLTEKSDVYSFGVV
|. .|    .|.|   |.|...||      .|||||||||||.| .| . . |||..   . ...   | . ||    .||       . ||||||....
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN--MTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LLELLTGRRP
| ||.||  |
LYELATGDEP
Kinase PERK_b-2.AA S_TKc 189-461 22 1.2e-36 129.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 189-461
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FSRANLLGEGGFGCVYKGFLHG-GQVVAVKQLRVGSRQGEREFRAEVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPN--GTLEHHLHGKGRPV----
.   ...|.|.||.|||.  .. |..||.|...       . .| |..| .. || ..| | ...       .| .....  |.| .... .||.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDWPTRLKIASGSARGLAYLHEDCHPRIIHRDIKSSNILLDNNFDAQVSDFGLAKLASDTYTHVTTRVMGTFGYLAPEYASTGKLTE-KSDVYSFGVVLL
..  .  ...   ...|.|.|.  | .|||||.| .|||||.     ..|||||..         | . ||  |.|||     . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHS--H-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGRRPVDTTQPVGKESLVEWARPYLMQAIENGDLDGIVDERLANYNENEMLRMVEAAA----ACVRHSASERPRMAEVV---------PAL
|.|.|. | .                 ... |                         . |      | .   ..||   |.          | .
EMLCGYPPFP-------------QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PERK_b-2.AA TK-Unique 189-384 24 2.2e-36 123.04 In-house 1-234 (294) Show / Hide 
Range on Protein: 189-384
Range on HMM: 1-234/294
Sequence Identity: 24% (57 aa)

FSRANLLGEGGFGCVYKGFLHG-------GQVVAVKQLRVGSRQGE-REFRAEVEIISRVH-HRHLVSLVGYCIADA-QRLLVYDFVPNGTLEHHLHGKG
.   ...||| ||.|..| . |        ..||||.|. .... . ..|  | .. . .  | ..|...|.|. .  . .... ..|.|.|.|.|. ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

RP-----------------VMDWPTR-LK------IASGSARGLAYLHE--DCHPRIIHRDIKSSNILLDNNFDAQVSDFGLAKLASD--TYTHVTTRVM
..                  .. .|  ..      .| . |.|..||..  .   .|.|||. ..|.|| ... . ..|||.|.  ..   |   ... .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTFGYLAPEYAS--TGKL-TEKSDVYSFGVVLLELLT
    ..|||. .  .|   |.||||.||||.. |..|
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase PERK_b-2.AA STE 189-388 21 3.7e-34 118.03 In-house 1-267 (359) Show / Hide 
Range on Protein: 189-388
Range on HMM: 1-267/359
Sequence Identity: 21% (58 aa)

FSRANLLGEGGFGCVYKGFLHG----------------GQVVAVKQLRVGSRQG-----------------EREFRAEVEIISRVH--HRHLVSLVGYCI
. .   .|.|.|| |||.  |                 |...|.||... . .                  . ..  |..| .. .  | . |   |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ADA-------QRLLVYDFVPNGTLE---HHLHGKGRP---------VMDWPTRLKIASGSARG-LAYLHEDCHPRIIHRDIKSSNILLDNNFDAQVSDFG
 .        .  ..  ....|.|.   .| .|.|.|         ... .   .|.    .| |.|||.     |||||||..||||     .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLASD---------------TYTHVTTRVMGTFGYLAPEYAST------GKLTEKSDVYSFGVVLLELLTGRRP
...  .|               |    .. . ||  . |||  .       .. ..|.|..|.| ...|..||. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase PERK_b-2.AA TK 424-461 12 0.008325 4.38 In-house 450-486 (486) Show / Hide 
Range on Protein: 424-461
Range on HMM: 450-486/486
Sequence Identity: 12% (5 aa)

RLANYNENEMLRMVEA-AAACVRHSASERPRMAEVVPAL
|     ....  ...     | .. ...||...... .|
RM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase PERK_b-2.AA MLK 448-461 28 0.309438 0.2 In-house 278-291 (291) Show / Hide 
Range on Protein: 448-461
Range on HMM: 278-291/291
Sequence Identity: 28% (4 aa)

ASERPRMAEVVPAL
...|| ....|. |
PHKRPSFRQIVQHL
Kinase PERK_b-2.AA Pkinase_Tyr 443-461 26 3.362372 1.3 Pfam 252-270 (270) Show / Hide 
Range on Protein: 443-461
Range on HMM: 252-270/270
Sequence Identity: 26% (5 aa)

CVRHSASERPRMAEVVPAL
| .. ...||...|..  |
CWHYDPEDRPTFSEIHEQL