Gene PERK_a-1 (S.moellendorffii)

PERK_a-1

Species: S.moellendorffii
Alias: PERK_a-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: PERK

Sequence

Name Sequence Type Origin Length Description Download
PERK_a-1.AA Protein None 252 None Fasta, JSON
PERK_a-1.NA RNA None 759 None Fasta, JSON
PERK_a-1.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of PERK_a-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PERK_a-1.AA IRAK 34-239 40 9.3e-76 258.0 In-house 1-229 (317) Show / Hide 
Range on Protein: 34-239
Range on HMM: 1-229/317
Sequence Identity: 40% (92 aa)

FSRANMLGEGGFGCVYKGILPGGQ-EVAVKQLK----IGGGQGEREFRA---EVEIITRIHHRHLVTLVGYCISETQRLLVYEFVPNGTLEHHLHGKGR-
|...| .|||||||||.| . .    .||| ||    .  .. ...|..   |... .|..| ..| | |||. . .  |||.. |||.||  |.. .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-PL--LDWSLRMKIAVGSARGLAYLHEDCHPK--IIHRDIKSSNILLDSNFEAQVADFGLAK---LAS--DAHTH---VTTRVMGTFGYLAPEYAS--SG
 |.  | |  | .|. |.|.|. .||.. ||.  |||.||||.||||| .|..  .||||.     ||   ..|     | .| ||  |..||.    .|
CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

KLTDKSDVYSFGVVLLELITGRKPVDTSQP
.|| |.||||||.||||..||...|.. .|
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRP
Kinase PERK_a-1.AA TKL 40-233 25 9.9e-69 234.65 In-house 1-288 (364) Show / Hide 
Range on Protein: 40-233
Range on HMM: 1-288/364
Sequence Identity: 25% (76 aa)

LGEGGFGCVYKGILPG---------GQEVAVKQLKIGGGQGE---------------------------REFRAEVEIITRIHHRHLVTLVGYCISETQ-
.|.||||.||||.. |         |..||||..|.   . .                            ... |. .. |..| ..| ..|||..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFVPNGTLEHHLHGKGRPLLDWSLRMKIAVGSARGLAYLHEDCH-----PKIIHRDIKSSNILLDSNFE--------------
              .|.|..|.|.|.|.||        |..|...| . |||..||| .       |.|||||.||.|||.|.|..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AQVADFGLAKLA----SDAHTHVTTR--------------VMGTFGYLAPEYAS----------------SGKLTDKSDVYSFGVVLLELITGRKP
. ..||||..      .. .|  |..              . ||....|||                   ... . |.||||||.|| |..|...|
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase PERK_a-1.AA TKL-Unique 36-230 34 1.2e-52 181.28 In-house 1-224 (290) Show / Hide 
Range on Protein: 36-230
Range on HMM: 1-224/290
Sequence Identity: 34% (77 aa)

RANMLGEGGFGCVYKGILPGGQEVAVKQLKI---GGGQGEREFRAEVEIITRIH-HRHLVTLVGYCI----SETQRLLVYEFVPNGTLEHHLHG------
  | .||||.| ||||. . | .||.||...      . ..||. || .. ..| |  .|...|||.    .. .. .| |..| |.|  .||       
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--KGRPLLDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSN-----FEAQVADFGLAKLASDAHTHVTTRV--------MGTFGYLAPEYA
  .    |....|.|.|   |.|. |||    | |||||.||||.|.|.|     . ....||||.|..|   .  ...         .|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

SS--GKLTDKSDVYSFGVVLLELITG
..   . . ||||||||.|| |..|.
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase PERK_a-1.AA LRRK 34-235 28 2.3e-49 170.29 In-house 1-284 (351) Show / Hide 
Range on Protein: 34-235
Range on HMM: 1-284/351
Sequence Identity: 28% (83 aa)

FSRANMLGEGGFG-CVYKGILPG---------------------------GQEVAVKQLKIGG---------------------GQGE------------
. . ...|.||||  ||.... |                           .|.||.|......                     .|.|            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-REFRAEVEIITRIHHRHLVTLVGYCISETQRLLVYEFVPNGTLEHHLH---GKGR----PLLDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNI
 |||| || |. . .| ..| |.|.||.   . .| |..|.|.| |.||     |.    . ..|.|. |||.  |.|..||| ...|.||||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------SNFEAQVADFGLAK-LASDAHTHVTTRVMGTFGYLAPEYASSG---KLTDKSDVYSFGVVLLELITGR-KPVD
||   .          .  | .||||.     .  |. |. .. |..|..|||    .     |.|.|.||||..| ||.|..  | |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase PERK_a-1.AA Dicty4 34-233 35 6e-45 147.93 In-house 1-216 (277) Show / Hide 
Range on Protein: 34-233
Range on HMM: 1-216/277
Sequence Identity: 35% (78 aa)

FSRANMLGEGGFGCVYKGILPGGQEVAVKQL---KIGGGQGE-REFRAEVEIITRIHHRHLVTLVGYCI----SETQRLLVYEFVPNGTLEHHLHG----
  . . .|.|.|| ||||.   |.||||| |   ...  . .  |||.||.|   | | ..... |.|.         . | |..| |.|.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-KGRPLLDWSLRMK---IAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSNFEAQVADFGLAKLASDAHTHVT--TRVMGTFGYLAPEYASSGKLTDKS
 . .  |||.|. .   .|   |||...||. | | |||||.||.|.| | |. . |.||||...     .| .  . . || .. |||   .   . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELITGRKP
|||||| || |. |.  |
DVYSFGIVLWEILTRQEP
Kinase PERK_a-1.AA Pkinase_Tyr 34-233 31 2.6e-44 150.69 Pfam 1-214 (270) Show / Hide 
Range on Protein: 34-233
Range on HMM: 1-214/270
Sequence Identity: 31% (68 aa)

FSRANMLGEGGFGCVYKGILP-----GGQEVAVKQLKIGGGQGE---REFRAEVEIITRI-HHRHLVTLVGYCISETQR---LLVYEFVPNGTLEHHLHG
 .   .|||| || ||||..      ....|||| || |  . .   ..| .|..| . . || ..| |.| |... .    ..| |..|.| | ..|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K--GRPLLDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSNFEAQVADFGLAKLA-SDAHT-HVTTRVMGTFGYLAPEYASSGKLTDKSDV
.  ... |. .   ....  |.|..||..     .||||.   |.|...|. . ..|||||..  .|    ....  .     .|||  . || | ||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVVLLELIT-GRKP
.||||.. |..| |..|
WSFGVLMWEIFTYGEQP
Kinase PERK_a-1.AA TK 34-233 18 3e-43 142.36 In-house 1-394 (486) Show / Hide 
Range on Protein: 34-233
Range on HMM: 1-394/486
Sequence Identity: 18% (72 aa)

FSRANMLGEGGFG---CVYKGILPGG--------------------------QEVAVKQLKIGGGQGEREFRA--------------EVEIITRIH----
    . |||| ||    ||||.. |.                          ..||||.|| | .. ..||..              |.|..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRHLVTLVGYCISE------------TQRLLVYEFVPNGT----LEHHLH--GKGRPL-----------------------------------------
 | ..| |.|.|  .               ..| |..|.|     | ..|.   ...                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWSLRMKIAVGSARGLAYLHED----CHPKIIHRDIKSSNILLDSNFE-----------AQVADFGLA
                               |.   .. ...  |.|..|||.       ....|||.   |.|...|             . .|||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LASDAHTHVTTRVMGTFG----------------------------YLAPEYAS---------SGKLTDKSDVYSFGVVLLELIT-GRKP
.     || | . .   ..... |                            ..|||             || | ||||.||||.. |. | |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase PERK_a-1.AA Pkinase 34-231 28 3.6e-43 153.72 Pfam 1-209 (293) Show / Hide 
Range on Protein: 34-231
Range on HMM: 1-209/293
Sequence Identity: 28% (61 aa)

FSRANMLGEGGFGCVYKGILPGGQE-VAVKQLKIGGGQGEREFRA-----EVEIITRIHHRHLVTLVGYCISETQRLLVYEFVPNG----TLEHHLH-GK
. .   .|.|.||||||..  | .. ||||..|   .. . . ..     |..|  |..| . |.| ... ...   .| |....|     | ....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GRPL-LDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSNFEA----QVADFGLAKLASDAHTHVTTRVMGTFGYLAPEYAS-SGKLTDKSD
.... ...    ...   .|||.|.|.    .|||||.|..|||.|.| .      ..||||||...  . . .| . || .|.|||    . . . |.|
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGVVLLELITGR
..|.|..| |...||
MWSCGCILYEMLCGR
Kinase PERK_a-1.AA MLK 34-233 27 3.7e-43 147.57 In-house 1-235 (291) Show / Hide 
Range on Protein: 34-233
Range on HMM: 1-235/291
Sequence Identity: 27% (64 aa)

FSRANMLGEGGFGCVYKGILPGGQ----EVAVKQLK--IGGGQGE-----REFRAEVEIITRIHHRH----LVTLVGYCISETQ-RLLVYEFVPNGTLEH
.     .|.|.|| |.||   .      .||||. .  |    ..     ..|. |...  .. |.      . ..| |.....  ..| |....| | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHG-KGRPL-----------LDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDS------NFEAQVADFGLAKLASDAHTHVTTRVMGTFG
 ||| .. .             | .. |..|.  |||..|||..  ..|||||.||.|||.|       .  . ..|||...  .. .    .  .||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YLAPEY---ASSGKLTDKSDVYSFGVVLLELITGRKP
. |||    . ..| . |.||.|.|||| |..|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase PERK_a-1.AA Dicty4-Unclassified 37-233 35 1e-42 144.12 In-house 4-207 (263) Show / Hide 
Range on Protein: 37-233
Range on HMM: 4-207/263
Sequence Identity: 35% (74 aa)

ANMLGEGGFGCVYKGILPGGQEVAVKQLKIGGGQGE----REFRAEVEIITRIHHRHLVTLVGYCISE----TQRLLVYEFVPNGTLEHHLH----GKGR
   .|.| |  |.||.   | .|||| .  .  .       .|..||||   | |  ||.. ||||           | || . |.|    |     . .
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

PL-LDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSNFEAQVADFGLAKLASDAHTHVTTRVMGTFGYLAPEYASSGKLTDKSDVYSFGVV
|. ||  | .|.|   |.|...||      .|||||||||||.| .| . .||||..   .   .   | . ||    .||       . ||||||....
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LLELITGRKP
| ||.||  |
LYELATGDEP
Kinase PERK_a-1.AA TK-Unique 34-229 24 5.6e-36 121.6 In-house 1-234 (294) Show / Hide 
Range on Protein: 34-229
Range on HMM: 1-234/294
Sequence Identity: 24% (58 aa)

FSRANMLGEGGFGCVYKGILPG-------GQEVAVKQLKIGGGQGE-REFRAEVEIITRIH-HRHLVTLVGYCISET-QRLLVYEFVPNGTLEHHLHGKG
.   . .||| ||.|..| . |        . ||||.||..  . . ..|  | ..   .  | ..|...|.|.. . . ....|..|.|.|.|.|. ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

RP------------------------LLDWSLRMKIAVGSARGLAYLHE--DCHPKIIHRDIKSSNILLDSNFEAQVADFGLAKLASDAHTHVTTR--VM
..                         ..  .   .|.. |.|..||..  .   ||.|||. ..|.|| ..... ..|||.|.  .. . .....   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTFGYLAPEYAS--SGKL-TDKSDVYSFGVVLLELIT
    ..|||. .   |   | ||||.||||.. |. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase PERK_a-1.AA STE 34-231 21 1.1e-34 119.87 In-house 1-265 (359) Show / Hide 
Range on Protein: 34-231
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FSRANMLGEGGFGCVYKG--ILPG--------------GQEVAVKQLKIGGGQG-----------------EREFRAEVEIITRIH--HRHLVTLVGYCI
. .  ..|.|.|| |||.  . ..              |. .|.||...   .                  . ..  |..|  . .  | . |.  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SE-------TQRLLVYEFVPNGTLE---HHLHGKGRPL---------LDWSLRMKIAVGSARG-LAYLHEDCHPKIIHRDIKSSNILLDSNFEAQVADFG
 |       ..  .. |....|.|.   .| .|.|.||         .. |.  .|..   .| |.|||.     |||||||..||||     .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLASDAHT--------------H-VTTRVMGTFGYLAPEYASS------GKLTDKSDVYSFGVVLLELITGR
...  .| ..                 .. . ||  . |||  .       .. . |.|..|.| ...|..||.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase PERK_a-1.AA S_TKc 34-249 24 1.3e-30 108.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-249
Range on HMM: 1-231/231
Sequence Identity: 24% (63 aa)

FSRANMLGEGGFGCVYKGILPG-GQEVAVKQLKIGGGQGEREFRAEVEIITRIHHRHLVTLVGYCISETQRLLVYEFVPN--GTLEHHLHGKGRPL----
.   . .|.|.||.|||..  . |..||.|..|       . .| |..|  . || ..|.| ... . .   .| |....  |.| .... .||.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSNFEAQVADFGLAKLASDAHTHVTTRVMGTFGYLAPEYASSGKLTD-KSDVYSFGVVLL
..     ...   ...|.|.|.  | .|||||.| .|||||.  .  ..|||||..         | . ||  |.|||     . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHS--H-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGRKPVDTSQPLG----------------------------EESL-------VEWV
|...|. | .  |.                              |           .|.
EMLCGYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase PERK_a-1.AA TyrKc 34-249 24 1.5e-24 88.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-249
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FSRANMLGEGGFGCVYKGILPGGQEVAVKQLKIGGGQGEREFRAEVEIITRI--HHRHLVTLVGYCISE-------TQRLLVYEFVPNGTLEHHLHGKGR
 .   .|||| || ||||..   ..|||| || .    ...|. | .| ...  || ..| |.|.|...        . ..| |..|.| | ..|. ...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

PLLDWSLRMKIAVGSARGLAYLHEDCHPKIIHRDIKSSNILLDSNFEAQVADFGLAKLASDA--------HTHV----TTRVMGTFGYLAPEYASSGKLT
  | ..   ....  |.| .|||.    ..||||.   |.|...|. . ..||||..   |           ..     .. |     .|||    || |
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

DKSDVYSFGVVLLELIT-GRKPVDT---------------------SQPLG---------------------EE---------SLVEWV
 ||||.||||.. |. | | .|                         ||                       .|          ..|  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF