Gene RLCK34_f (S.moellendorffii)

RLCK34_f

Species: S.moellendorffii
Alias: RLCK34_f
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: RLCK34

Sequence

Name Sequence Type Origin Length Description Download
RLCK34_f.AA Protein None 281 None Fasta, JSON
RLCK34_f.NA RNA None 846 None Fasta, JSON
RLCK34_f.kin_dom Protein Kinase Domain None 181 None Fasta, JSON

Protein domain

Protein domains of RLCK34_f.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RLCK34_f.AA TKL 54-233 24 8.7e-45 155.11 In-house 80-288 (364) Show / Hide 
Range on Protein: 54-233
Range on HMM: 80-288/364
Sequence Identity: 24% (60 aa)

SRLKHENMVELLGYCIDGPL-------------RVLAFEFAEMGSLHDILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAAR
|||.|.| | ..|||...|                .  |... |||...||                                    | ||...| ..||
SRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------------------WHQRCRWALDIAR

GLEYLHEKA-----QPPVVHRDIKSSNVLLFENYA--------------AKIGDY------NPSNQAPDMASRLH-----------STRVLGSFGYHAPE
|..||| .       ||..|||.||.|.|..||.               .||.|.      ..|..  |...              . .. |.... |||
GMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPE

YAM----------------TGQLTQKSDVYSFGVVLLELLTGRRP
  .                 .. ..|.||||||.|| |.||..||
VLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase RLCK34_f.AA IRAK 119-235 38 4.8e-34 118.09 In-house 99-225 (317) Show / Hide 
Range on Protein: 119-235
Range on HMM: 99-225/317
Sequence Identity: 38% (49 aa)

GSRPGPVLDWMQRVKIAVGAARGLEYLHEKA-QPPVVHRDIKSSNVLLFENYAAKIGDYNPSNQA----PDMASRL---HSTRVLGSFGYHAPEYAM--T
|. | . | | ||..|. |.|.|...||..    |. |.||||.|.|| ..  .||.|              .. .   .  .| |.  | .||.    .
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

GQLTQKSDVYSFGVVLLELLTGRRPVD
|||| |.||||||.||||.|||.|.|.
GQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase RLCK34_f.AA LRRK 54-235 32 2.6e-33 115.17 In-house 112-284 (351) Show / Hide 
Range on Protein: 54-235
Range on HMM: 112-284/351
Sequence Identity: 32% (66 aa)

SRLKHENMVELLGYCIDGPLRVLAFEFAEMGSLHDILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAARGLEYLHEKAQPPV
|.|.| | | |.|.||. ||. .. |.|  |.|.. || .|. .|. .                      ....|| . |||.  |.|.|||| .. ||.
SHLNHPNIVSLKGFCIH-PLC-MVMEYAPHGDLYHFLHNKKQDGFHFMK---------------------AHISWMLKLKIALQIAKGMEYLH-SHNPPI

VHRDIKSSNVLL--F----------ENYAAKIGDYNPSN--QAPDMASRLHST---RVLGSFGYHAPEYAMTG---QLTQKSDVYSFGVVLLELLTGR-R
.||| || |.||  .          ... |||.|.  |   |.      .|..   ...| .|..|||    .   . |.|.|.||||..| ||||.. .
IHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC------FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH

PVD
| |
PFD
Kinase RLCK34_f.AA MLK 54-233 26 2e-27 92.27 In-house 60-235 (291) Show / Hide 
Range on Protein: 54-233
Range on HMM: 60-235/291
Sequence Identity: 26% (53 aa)

SRLKHEN----MVELLGYCIDGPL-RVLAFEFAEMGSLHDILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGP---VLDWMQRVKIAVGAARGLEYL
..|.|.|     ....| |.. |   ..  |..| |||...|||... ..                       ...   | |  . ...|.  |||..||
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDAN-------------------HNQKNDRVYDHDHAMNWALQCARGMHYL

HEKAQPPVVHRDIKSSNVLLFE------NYAAKIGDYNPSNQAPDMASRLHST-----RVLGSFGYHAPEY---AMTGQLTQKSDVYSFGVVLLELLTGR
|..|..|..|||.||.|.|. |      .  .|| |        . .  .|..        |.. . |||    .  .. . |.||.|.|||| |.||..
HSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF-------GTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE

RP
 |
VP
Kinase RLCK34_f.AA TK 54-233 18 6.2e-24 76.46 In-house 98-394 (486) Show / Hide 
Range on Protein: 54-233
Range on HMM: 98-394/486
Sequence Identity: 18% (57 aa)

SRLKHENMVELLGYCIDG------------PLRVLAFEFAEMGS----LHDILHGRKN------------------------------------------
| ..|.| | |.|.| .|            .   .  |... |.    |.| |. ...                                          
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE

--------------LSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAARGLEYLHEK----AQPPVVHRDIKSSNVLLFENYA-------
              |...    .  ..   |         .   |.  |.. ... .|.|.||||.|      . .||||.   |.|..||.        
QDYDDDLIKDHPPPLTTKDLLQMAWQWC-LT---------CKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDG

----AKIGDYNPSN-----QAPDMASRLHSTRVLGSFG---------------------------YHAPEYAM---------TGQLTQKSDVYSFGVVLL
    .||.|.  |       | |. |.   .|. .  .                           . |||  .         .|  | ||||.||||.. 
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

ELLT-GRRP
|..| |. |
EIFTYGQEP
Kinase RLCK34_f.AA Pkinase 55-231 23 6.2e-24 85.71 Pfam 56-209 (293) Show / Hide 
Range on Protein: 55-231
Range on HMM: 56-209/293
Sequence Identity: 23% (44 aa)

RLKHENMVELLGYCIDGPLRVLAFEFAEMG----SLHDILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGPVL--DWMQRVKIAVGAARGLEYLHEK
||.|.| |.|.... |..   . .|..|.|    .|.|....                            . . ..  .. .  ...   .|||||.|..
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM

AQPPVVHRDIKSSNVLLFENYAA----KIGDYNPSNQAPDMASRLHSTRVLGSFGYHAPEYAM-TGQLTQKSDVYSFGVVLLELLTGR
    ..|||.|..|.|. .|.      ||.|   . |.    .    | . |. .| |||  .     ..|.|..|.|..| |.|.||
---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase RLCK34_f.AA TKL-Unique 126-233 34 8.4e-22 73.78 In-house 107-233 (290) Show / Hide 
Range on Protein: 126-233
Range on HMM: 107-233/290
Sequence Identity: 34% (44 aa)

LDWMQRVKIAVGAARGLEYLHEKAQPPVVHRDIKSSNVLLFEN-----YAAKIGDYN-PSNQAPDMASRLH------STRVLGSFGYHAPEYAMT--GQL
|.. ||||.|  .|.|..||| .  | . |||.||||.|. .|     . .|| | . . ... .... .        . ..||| . |||  .    | 
LNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY

TQKSDVYSFGVVLLELLTGRR------P
..||||||||.|| |..|. .      |
SEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase RLCK34_f.AA CZAK 131-233 32 7e-21 72.66 In-house 107-221 (279) Show / Hide 
Range on Protein: 131-233
Range on HMM: 107-221/279
Sequence Identity: 32% (39 aa)

RVKIAVGAARGLEYLHEKAQP-PVVHRDIKSSNVLLFENYA-------------AKIGDYNPS----NQAPDMASRLHSTRVLGSFGYHAPEYAMTGQLT
. ..|.  |||  |||    | |..|||  |.|.|| ..|              .|| |.  |     |. .|      |   |.  . |||       |
QWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEM------TQTMGCLCWMAPECFKGENYT

QKSDVYSFGVVLLELLTGRRP
 |.|||||| .| ...|.. |
EKVDVYSFGMILWCIITCDQP
Kinase RLCK34_f.AA Dicty5 130-229 36 1.1e-19 64.37 In-house 105-198 (260) Show / Hide 
Range on Protein: 130-229
Range on HMM: 105-198/260
Sequence Identity: 36% (36 aa)

QRVKIAVGAARGLEYLHEKAQPPVVHRDIKSSNVLLFENYAAKIGDYNPSNQAPDMASRLHSTRVLGSFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT
|.. .|...|.....|| .    ..|||.|| |.|. ||. .|| |.  |      . |.| |  .|   . |.|       .|| ||||||.|| |..|
QQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITENWKIKIIDFGTSRF---VDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFT
Kinase RLCK34_f.AA TKL-ciliate1 126-227 25 3e-19 62.54 In-house 100-212 (279) Show / Hide 
Range on Protein: 126-227
Range on HMM: 100-212/279
Sequence Identity: 25% (29 aa)

LDWMQRVKIAVGAARGLEYLHEKAQPPVVHRDIKSSNVLLFENYAAKIGDY----N---PSNQAPDMASRLHSTRVLGSFGYHAPEYAM-----TGQLTQ
. | .|...    |.|. ||| . |.| .|||.|. | |. | |  || ..    .   .  .  . ..    . ... |.. |||          . . 
IKWQHRMRWCKDIAQGMQYLH-MRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINE

KSDVYSFGVVLLEL
| |.|..|.|. .|
KIDIYAYGIVMYIL
Kinase RLCK34_f.AA MLK 56-168 32 5e-19 59.33 In-house 58-139 (280) Show / Hide 
Range on Protein: 56-168
Range on HMM: 58-139/280
Sequence Identity: 32% (37 aa)

LKHENMVELLGYCIDGPLRVLAFEFAEMGSLHDILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAARGLEYLHEKAQPPVVH
|||.| ..|.| |.  |   |  |... |||  .. |.                            |  ||     |  ||  |||..|||. |  |..|
LKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK--------------------------RIPPHVL-----VNWAVQIARGMNYLHNEAPVPIIH

RDIKSSNVLLFEN
||.||||.|. |.
RDLKSSNILILEK
Kinase RLCK34_f.AA Pkinase_Tyr 54-175 23 4.6e-16 55.02 Pfam 58-154 (270) Show / Hide 
Range on Protein: 54-175
Range on HMM: 58-154/270
Sequence Identity: 23% (30 aa)

SRL-KHENMVELLGYCI-DGPL--RVLAFEFAEMGSLHDILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAARGLEYLHEKA
. | .|.| | |.| |. .|      . .|... |.|.| |. ..                           ... |.  . .....  |.|.|||..| 
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKN

QPPVVHRDIKSSNVLLFENYAAKIGD
    .|||.   |.|. ||  .||.|
---CIHRDLAARNCLVTENNVVKICD
TyrKc RLCK34_f.AA TyrKc 16-280 18 3.6e-11 -42.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-280
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

LSRSSI----------RARNRMRTSSLRYAPVLPKELFGDLSSKVSRQ---------SRL--KHENMVELLGYCIDG-------PLRVLAFEFAEMGSLH
..   .          ... .         .|  | |  |      |.         ..|  .|.| | |.|.|...       .   . .|... |.|.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

DILHGRKNLSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAARGLEYLHEKAQPPVVHRDIKSSNVLLFENYAAKIGDYNPSNQAPDM--
| |. ...                              | . . ..... .|.| ||||.|   ...|||.   |.|. ||. .||.|   |    |   
DYLRKHRPK-----------------------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQ

---ASRLHSTRV--LGS--FGYH--APEYAMTGQLTQKSDVYSFGVVLLELLT-GRRPVDP---TMPRGQQSLVTWVGFFFFVPFLFS--------FPLV
   ..   ...    |   . .   |||  ..|  | ||||.||||.. |..| |  |        .   | .. .|   .  |   .         |  
QGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE

THSLAGLF----------FLCLRQRR
 ...              |  .... 
MYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc RLCK34_f.AA S_TKc 4-269 16 5.5e-10 -30.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-269
Range on HMM: 1-231/231
Sequence Identity: 16% (48 aa)

FILQSC----AMGSPWLSRSSIRARNRMRTSSLRYAPVLPKELFGDLSSKVSRQSRLKHENMVELLGYCIDGPLRVLAFEFAEM--GSLHDILHGRKN--
. .       |.|. .. |          |  .    ...     .. . ..  .. .|.| | |.... |     . .|...   |.|.|... |.   
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSFSCVFLLRSCLKSVTGRKGVLGSRPGPVLDWMQRVKIAVGAARGLEYLHEKAQPPVVHRDIKSSNVLLFENYAAKIGDYNPSNQAPDMASRLHS
    ..   .                               ...   ...|||.|.. .  ..|||.| .|.|| |    ||.|   . |          
LRFPFPE-HA------------------------------RFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL---------

TRVLGSFGYHAPEYAMTGQLTQ-KSDVYSFGVVLLELLTGRRPVDPTMPRGQQSLVTWVGFFFFVPFLFSF--------PLVT-------HSLA
| . |.  | |||     . .  |.|..|.|..| |.|.|. | . .| .  . ..    .  |.  .. .         . .       |   
TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase RLCK34_f.AA IRAK 54-95 33 2.4e-07 22.24 In-house 58-99 (317) Show / Hide 
Range on Protein: 54-95
Range on HMM: 58-99/317
Sequence Identity: 33% (14 aa)

SRLKHENMVELLGYCIDGPLRVLAFEFAEMGSLHDILHGRKN
.|. |.| |.|.|||....   | ...   |||.| |.....
CRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG
Kinase RLCK34_f.AA TKL-Unique 54-99 27 3.7e-07 21.47 In-house 50-108 (290) Show / Hide 
Range on Protein: 54-99
Range on HMM: 50-108/290
Sequence Identity: 27% (16 aa)

SRLK-HENMVELLGYCI----DGPLRVLAFEFAEMGSLHDILHG--------RKNLSFS
..|. |.| | . |||.    . | . .  |. ..|||.| ||         ..|. ..
KKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLN
Kinase RLCK34_f.AA Pkinase_Tyr 202-233 51 4.8e-07 24.48 Pfam 182-214 (270) Show / Hide 
Range on Protein: 202-233
Range on HMM: 182-214/270
Sequence Identity: 51% (17 aa)

APEYAMTGQLTQKSDVYSFGVVLLELLT-GRRP
|||  ..|  | ||||.||||.. |..| |. |
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase RLCK34_f.AA MLK 202-233 50 2e-06 16.82 In-house 194-225 (280) Show / Hide 
Range on Protein: 202-233
Range on HMM: 194-225/280
Sequence Identity: 50% (16 aa)

APEYAMTGQLTQKSDVYSFGVVLLELLTGRRP
|||    .   . ||| |.||.| |||||  |
APEVIKESTWSKGSDVWSYGVLLWELLTGEVP