Gene SD2b2_c-2 (S.moellendorffii)

SD2b2_c-2

Species: S.moellendorffii
Alias: SD2b2_c-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD2b2

Sequence

Name Sequence Type Origin Length Description Download
SD2b2_c-2.AA Protein None 643 None Fasta, JSON
SD2b2_c-2.NA RNA None 1932 None Fasta, JSON
SD2b2_c-2.kin_dom Protein Kinase Domain None 122 None Fasta, JSON

Protein domain

Protein domains of SD2b2_c-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin SD2b2_c-2.AA B_lectin 100-201 35 5.7e-33 114.87 Pfam 1-137 (137) Show / Hide 
Range on Protein: 100-201
Range on HMM: 1-137/137
Sequence Identity: 35% (49 aa)

TQRIIWEANRE---DPV-----GLNATLSLAS-DGDLVLRDRD-G-RL--VWST--GTANRG--ATRVEVVRETGNLVVF--RN--NTILWQS--FDRPT
 | . | |||.   .||     . |.||.. . ||.||| | . | .   ||||  .|...|  .  . .  ..||||..   |  |..||||  || ||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTLMAGQVLRP------GMR----LQSRRSRT--DPS
||.  |. |.       .|.    | |..| |  |||
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin SD2b2_c-2.AA B_lectin 56-175 25 2.1e-20 75.0 SMART 1-126 (126) Show / Hide 
Range on Protein: 56-175
Range on HMM: 1-126/126
Sequence Identity: 25% (34 aa)

QDVYGATTRMTGFFSGV-YNLGFVNSTPDRYTLAVLMNVDSGFPTTQRIIWEA--NREDPVGL---NATLSLASDGDLVLRDRDGRLVWSTGTANRGATR
. . .   .  .. |    .|||.. ..   .. .. .  |.   .....| |  ||. ||     ...|.. ||| ||. |  .| |||..|...    
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ-WCNGIWYKNISNK--QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNY

VEVVRETGNLVVFRNN-----TILWQSFDRP
| |....||.|.....      ..||||| |
VAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP SD2b2_c-2.AA PAN_AP 383-460 19 0.000412 18.87 SMART 1-85 (85) Show / Hide 
Range on Protein: 383-460
Range on HMM: 1-85/85
Sequence Identity: 19% (17 aa)

IESLEFVPVPGVEHFSSKY----VNGSQVTIDECRDRCLRNCSCSAFFFWEESNSCFTVDNTSTLQRVS------TQSHVGYIKAVDY
 . . || .|...  .|          .....||...||.|||| .| . . . .|   ...| |....      ..  .|..     
CCDDCFVRMPNMKL-FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase SD2b2_c-2.AA Pkinase_Tyr 488-603 31 1.5e-25 87.17 Pfam 2-129 (270) Show / Hide 
Range on Protein: 488-603
Range on HMM: 2-129/270
Sequence Identity: 31% (40 aa)

NFSKLLGTGGFGGVYEGTLP-----DGRTVAVKKL-EGTGQG---KKEFYAEVAVLGSL-HHWNLVKLLGFCS-EGSN--RLLVYEHMTNGSLDKWIYQD
 | | || | || ||.||.      .. .||||.| ||. .    ...| .|.... .| || |.|.|.| |. .|     ..| |.| .|.|..   . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

SEKNLMVLCWKQRIEIVLGMARGLAYLHE
.  .   |. |. ... .  |.|..||..
R-EDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase SD2b2_c-2.AA IRAK 488-603 35 3.9e-23 78.92 In-house 2-127 (317) Show / Hide 
Range on Protein: 488-603
Range on HMM: 2-127/317
Sequence Identity: 35% (45 aa)

NFSKLLGTGGFGGVYEGTLPDGRT--VAVKKLE-----GTGQGKKEFYA---EVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNGSL-DKWIYQDSE
. . ..| |||| || | . .. |  .|||||       ... ...| .   |. |. ...| |.| |.|.|.|...  |||. |.|||| |    ||  
HKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

KNLMVLCWKQRIEIVLGMARGLAYLHE
  .  | | ||..| .| |.|. .||.
CPPKPLSWHQRCSICWGTACGIQFLHQ
Pkinase SD2b2_c-2.AA Pkinase 487-604 20 7.1e-23 81.97 Pfam 1-127 (293) Show / Hide 
Range on Protein: 487-604
Range on HMM: 1-127/293
Sequence Identity: 20% (26 aa)

GNFSKLLGTGGFGGVYEGTLPDGRT-VAVKKLEGTGQGKKEFYA-----EVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNG----SLDKWIYQDSE
  . . .| |.|| ||...  . .  ||||...  .. ... ..     |.... .|.| | |.|.... ....  .| |.. .|    .|  .|  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KNLMVLCWKQRIEIVLGMARGLAYLHEE
.... . ... . ... ..|||.|.|..
GCFY-FSEWECKFYMYQILRGLEYCHSM
Kinase SD2b2_c-2.AA TKL 493-604 22 5e-22 76.12 In-house 1-151 (364) Show / Hide 
Range on Protein: 493-604
Range on HMM: 1-151/364
Sequence Identity: 22% (37 aa)

LGTGGFGGVYEGTLPD---------GRTVAVKKLEG---TGQGK-------------------------KEFYAEVAVLGSLHHWNLVKLLGFCSEGSN-
.| |||| || |..           |..|||||.         |                         ...  |. .. .|.| |.|...|.| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEHMTNGSLDKWIYQDSEKNLMVLCWKQRIEIVLGMARGLAYLHEE
              .|.| . .|||   .            | ||. ..|..|||..||| .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSM
Kinase SD2b2_c-2.AA TKL-Unique 489-602 30 1.3e-19 66.0 In-house 1-127 (290) Show / Hide 
Range on Protein: 489-602
Range on HMM: 1-127/290
Sequence Identity: 30% (39 aa)

FSKLLGTGGFGGVYEGTLPDGRTVAVKKLE----GTGQGKKEFYAEVAVLGSLH-HWNLVKLLGFCS----EGSNRLLVYEHMTNGSLDKWIYQ-----D
|....|.||.| || |. . |  ||.|...       . ..||. || ..  || | |.|.. |.|       .|. .| | .  |||.. . |      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

SEKNLMVLCWKQRIEIVLGMARGLAYLH
  .| . | ..||. ... .|.|. |||
NNNNNCKLNMQQRVKMAIDIAQGMYYLH
Kinase SD2b2_c-2.AA TK 487-603 15 4.7e-18 56.4 In-house 1-252 (486) Show / Hide 
Range on Protein: 487-603
Range on HMM: 1-252/486
Sequence Identity: 15% (39 aa)

GNFSKLLGTGGFG---GVYEGTLPDGR--------------------------TVAVKKLE-GTGQGKKEFYA-----------------EVAVLGS--L
  . | || | ||    ||.|.. ...                          .|||| |  |... ..|| .                 | ... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHWNLVKLLGFCSEGSN------------RLLVYEHMTNGS----LDKWIYQDSEKNLM-----------------------------------------
|| |.|.|.| |..| .             ..| |.| .|.    |...  . ..|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------VLCWKQRIEIVLGMARGLAYLHE
                               |. .|.. . .  |.|..|||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS
Kinase SD2b2_c-2.AA LRRK 487-602 18 1.1e-14 48.33 In-house 1-181 (351) Show / Hide 
Range on Protein: 487-602
Range on HMM: 1-181/351
Sequence Identity: 18% (33 aa)

GNFSKLLGTGGFG-GVYEGTLPD---------------------------GRTVAVKKLEGT-------------------------------GQGKKEF
  . ...| ||||  || ... .                           . .||.||.. .                               .... . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YA----EVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNGSLDKWIYQDSEKNL----MVLCWKQRIEIVLGMARGLAYLH
.     ||... .|.| |.|.|.||| .   . .| | ...|.|.. .   ..  .     .. |  ...|.|  |.|..|||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH
Kinase SD2b2_c-2.AA Src 487-601 30 1.6e-14 45.75 In-house 1-113 (255) Show / Hide 
Range on Protein: 487-601
Range on HMM: 1-113/255
Sequence Identity: 30% (35 aa)

GNFSKLLGTGGFGGVYEGTLPDGRTVAVKKLEGTGQGKKEFYAEVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNGSLDKWIY-QDSEKNLMVLCWK
  . . ||.| || |..|.  .   |||| |       . | .|  .. .| | .||.|.  ||..   . | | |..||| ..   .. ...| .    
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLP---

QRIEIVLGMARGLAYL
| |..    |.| |||
QLIDMAAQVAEGMAYL
Kinase SD2b2_c-2.AA Frk 488-604 27 2.3e-14 45.85 In-house 2-117 (260) Show / Hide 
Range on Protein: 488-604
Range on HMM: 2-117/260
Sequence Identity: 27% (32 aa)

NFSKLLGTGGFGGVYEGTLPDGRTVAVKKLEGTGQGKKEFYAEVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNGSLDKWIYQDSEKNLMVLCWKQR
 . . ||.| || |.||       ||||.|       ..| .|  .. .| |  |..|   |      ... | | .||| ... |  ...   .  .| 
QLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYL-QAINDKGRQCQMQQL

IEIVLGMARGLAYLHEE
...   .| |.||| ..
VDMAAQVAAGMAYLESQ
Kinase SD2b2_c-2.AA Abl 488-579 33 2.5e-14 43.7 In-house 2-94 (252) Show / Hide 
Range on Protein: 488-579
Range on HMM: 2-94/252
Sequence Identity: 33% (31 aa)

NFSKLLGTGGFGGVYEGTLPD-GRTVAVKKLEGTGQGKKEFYAEVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNGSLDKWIYQDSEKNL
   . || | .| ||||     . ||||| |       .|| .| |..  ..| |||.||| |   .   .. |.|..| |  .. . ....|
MMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL
Kinase SD2b2_c-2.AA Dicty4-Unclassified 488-602 30 4.1e-14 44.71 In-house 2-126 (263) Show / Hide 
Range on Protein: 488-602
Range on HMM: 2-126/263
Sequence Identity: 30% (39 aa)

NFSKLLGTGGFGGVYEGTLPDGRTVAVKKL-EGTGQGK----KEFYAEVAVLGSLHHWNLVKLLGFCSEG----SNRLLVYEHMTNGSLDKWIY-QDSEK
   . .| | |  |. |    |. |||||. |.  .      ..| .||..|||. | ||||. | |       |    | | |  | |   |  . ||.
QIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

NLMVLCWK-QRIEIVLGMARGLAYLH
.  .       | . .  |.|...||
QQPIKLDDTLIIKYAFDIAQGMQHLH
Kinase SD2b2_c-2.AA RTKE 488-570 31 9.2e-14 43.28 In-house 2-102 (293) Show / Hide 
Range on Protein: 488-570
Range on HMM: 2-102/293
Sequence Identity: 31% (32 aa)

NFSKLLGTGGFGGVYEGTLP----------------DGRT---VAVKKLEGTGQGKKEFYAEVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTNGSLD
 |  .||.| || |   |.|                ..|    |||| |.   . ..|| .|.. .  ||| |.|.||.  ... ....||| |  |.|.
TFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNH-ECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQLE

KW
 |
DW
Kinase SD2b2_c-2.AA TyrKc 487-638 14 2.7e-09 -72.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 487-638
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

GNFSKLLGTGGFGGVYEGTLPDGRTVAVKKLEGTGQGKKEFYAEVAVLGSL--HHWNLVKLLGFCSEG-------SNRLLVYEHMTNGSLDKWIYQDSEK
  . | || | || ||.||.   ..||||.|      ...|. |  .. .|  || |.|.|.| |...          ..| |.| .|.|.. .    .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

NLMVLCWKQRIEIVLGMARGLAYLHEECM--------------QR------------------------IIST----SSR--RTYSWTS-----------
    ||.|. ... .  |.| .|||. .               ..                         ...    ...    . |..           
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

-----------------------------------LSWLKSR-TLDSPGS------------------------------------CL
                                   . ..|..  .. | .                                    |.
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SD2b2_c-2.AA S_TKc 487-643 12 3e-06 -86.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 487-643
Range on HMM: 1-231/231
Sequence Identity: 12% (31 aa)

GNFSKLLGTGGFGGVYEGTLPD-GRTVAVKKLEGTGQGKKEFYAEVAVLGSLHHWNLVKLLGFCSEGSNRLLVYEHMTN--GSLDKWIYQDSEKNL-MVL
  . ...| |.|| || ..  . || ||.|..       . .. |...| . || |.|||.... . ..  .| |.. .  |.| . | .   . |  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CWKQRIEIVLGMARGLAYLHE------------------------------------------ECMQRIIST----------------SSRRTYSWTSLS
   .   ..  ....|.|.|.                                          | .    ..                . .  ..   . 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQ

W------------LKSRTLD-------SPGSCLA-------TKAT
             . .. |.       .   .|.           
MMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF