Gene SD-2b_a-1 (S.moellendorffii)

SD-2b_a-1

Species: S.moellendorffii
Alias: SD-2b_a-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD2b2

Sequence

Name Sequence Type Origin Length Description Download
SD-2b_a-1.AA Protein None 185 None Fasta, JSON
SD-2b_a-1.NA RNA None 558 None Fasta, JSON
SD-2b_a-1.kin_dom Protein Kinase Domain None 147 None Fasta, JSON

Protein domain

Protein domains of SD-2b_a-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SD-2b_a-1.AA TKL 23-184 24 1e-40 141.56 In-house 1-240 (364) Show / Hide 
Range on Protein: 23-184
Range on HMM: 1-240/364
Sequence Identity: 24% (60 aa)

IASGGFGTVFEGILSD---------GSKVPVKRLET---------------------------FSSQGYKQFKAEVGAIRSIHHKNLVRLKGFCSQESH-
| |||||.|. |..           |  | ||.. .                           ..|.  .... |.  .....| |.|...|.| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HFLVYEYVPNGLLDKWIYKPLEELNWDTRFRIVEEIAQGIRYLHEECS-----TRVLHLDIKPQNILLDENFG--------------V
            ...|.||.|.| |   .        |. |.|.. .||.|. ||| .         ..| |.|..|||.|||.               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIADFGLSR-MVEQGDLSDVMTM----------------IRGTPGHM
||.|||||| | . |. .| ||.                ..|||..|
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWM
Pkinase SD-2b_a-1.AA Pkinase 17-184 26 2.1e-37 133.34 Pfam 1-178 (293) Show / Hide 
Range on Protein: 17-184
Range on HMM: 1-178/293
Sequence Identity: 26% (49 aa)

KAFSKKIASGGFGTVFEGILSDGSK-VPVKRLETFSSQGYKQFKA-----EVGAIRSIHHKNLVRLKGFCSQESHHFLVYEYVPNG----LLDKWIY---
  . .|| ||.||.|....  . .| | ||...   ..  .. ..     |.   ....|.| |||....  ..|  .| ||...|     |  .|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

-KPLEELNWDTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDENFGV----KIADFGLSRMVEQGDLSDVMTMIRGTPGHM
 ...  . ...  ... .|..|. |.|..   ...| |.||.|||.|.|  .    ||.||||.. ..    .  || . |||. |
HGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYM
Kinase SD-2b_a-1.AA TKL-Unique 19-163 30 5.7e-33 113.68 In-house 1-165 (290) Show / Hide 
Range on Protein: 19-163
Range on HMM: 1-165/290
Sequence Identity: 30% (51 aa)

FSKKIASGGFGTVFEGILSDGSKVPVKRLET---FSSQGYKQFKAEVGAIRSIH-HKNLVRLKGFCS----QESHHFLVYEYVPNGLLDKWIY-------
|..|| .||.|.|. |.   |..| .|...    .|..  . |. ||  .  .| |.|.|.. |.|     .... ..| ||.| | |.. .        
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--KPLEELNWDTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDEN-----FGVKIADFGLSR
  ..  .||.  | .... ||||  ||| .  . ..|.|.|..|.|.|.|     . .||.|||||.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK
Kinase SD-2b_a-1.AA Ciliate-E2 19-185 21 1.5e-29 98.64 In-house 3-236 (365) Show / Hide 
Range on Protein: 19-185
Range on HMM: 3-236/365
Sequence Identity: 21% (52 aa)

FSKKIASGGFGTVFEGIL-SDGS------------------KVPVKR--LETFSSQGYKQFKAEVGAIRSIH----------------HKNLVRLKGFCS
| ||| .|.||.|...   ...                   || .|   ..... .. .|.| |   .| |.                |.|..... .  
FIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ

--QESHHFLVYEYVPNGLLDKWIY----KPLEELN------WDTRFRIVEEIAQ---------------GIRYLHEECSTRVLHLDIKPQNILLDENFGV
  .... .|| ||.  | | ..|.    | ..|..      .  . .| ..|.|               ...|||.. .  ..| ||||.|||.     .
EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF-----I

KIADFGLSR-----------MVEQGDLSDVMTMIRGTPGHMR
||.|||||.           ..... . .   .. .||| |.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD
Kinase SD-2b_a-1.AA CAMK 22-184 17 1e-28 89.09 In-house 1-286 (425) Show / Hide 
Range on Protein: 22-184
Range on HMM: 1-286/425
Sequence Identity: 17% (50 aa)

KIASGGFGTVFEGILS-DG------------SKVPVKRLETF----------------------------SSQGYKQFKAEVGAIRS-------IHHKNL
.. .|.||.|...|   ..             || .| ...                             . .  |... |.   ..       ..|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLKG--------------------FCSQESHHFLVY---EYVPNG----LLDKWI--YKPLEELNWD-------TRF------RIVEEIAQGIRYLHEE
..|                      | ....| ..|    ||...|     |  .|   ..  | . |        ||      |..  |.....|.|. 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-DQFDIVERGRFTEREARRYFRQICSAVHYCHSH

CSTRVLHLDIKPQNILLDENF----------------G-VKIADFGLSRMVEQGDL---------------------SDVMTMIRGTPGHM
    . |.|.|| |||||.|.                . .||.|||.......|.                       . |.   |||. |
---NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM
Kinase SD-2b_a-1.AA RIPK 23-162 30 4.5e-28 92.73 In-house 1-156 (290) Show / Hide 
Range on Protein: 23-162
Range on HMM: 1-156/290
Sequence Identity: 30% (49 aa)

IASGGFGTVFEGILSDGSKVPVKRL-------ETFSSQGYKQFKAEVGAIRSIHHKNLVRLKGFCSQE-----SH-HFLVYEYVPNGLLDKWIYKPLEE-
...||||.||     .   . .|         ... .|  .. | |. .  .. ... |...||| .|     .    .| || .|| | .      .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LNWDTRFRIVEEIAQGIRYLHEECSTR--VLHLDIKPQNILLDENFGVKIADFGLS
   . |. |.|.. ||. |  |||   |    ..|.| ||.|||.| || ||||||||.
HHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLA
Kinase SD-2b_a-1.AA Pkinase_Tyr 18-169 31 9.1e-28 94.67 Pfam 2-165 (270) Show / Hide 
Range on Protein: 18-169
Range on HMM: 2-165/270
Sequence Identity: 31% (52 aa)

AFSKKIASGGFGTVFEGILS-----DGSKVPVKRL-ETFSSQG--YKQFKAEVGAIRSI-HHKNLVRLKGFCS-QESH--HFLVYEYVPNGLLDKWIYKP
 | ||. .| ||.|..|..      .. .| || | |. ...    . | .|.   ... ||.|.||| | |. |. .  ...| ||.|.| |..   |.
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

---LEELNWDTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDENFGVKIADFGLSRMVEQGD
    . |.  .   .  .||.|  ||..       | |.   |.|..||. |||.||||.| ..  |
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase SD-2b_a-1.AA Dicty4 18-184 30 1.3e-27 89.27 In-house 2-184 (277) Show / Hide 
Range on Protein: 18-184
Range on HMM: 2-184/277
Sequence Identity: 30% (57 aa)

AFSKKIASGGFGTVFEGILSDGSKVPVKRL----ETFSSQGYKQFKAEVGAIRSIHHKNLVRLKGFCS----QESHHFLVYEYVPNGLLDKWIYK-----
.. ..| .|.||.|. |.   |..| || |    ..|..   . |..||    .| | |.. ..| |     . .    | ||.| | | . . .     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-PLEELNWDTRFR---IVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDENFGVKIADFGLSR-MVEQGDLSD-VMTMIRGTPGHM
 .  .| | .. |   .   .|.|. .||. | ....|.|.|. |.| |.|. ||..|||||. | .  |..|  ||.. |||. |
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC-GTPCWM
Kinase SD-2b_a-1.AA IRAK 18-163 35 1e-26 91.8 In-house 2-161 (317) Show / Hide 
Range on Protein: 18-163
Range on HMM: 2-161/317
Sequence Identity: 35% (57 aa)

AFSKKIASGGFGTVFEGILSDGS-KVPVKRL----ETFSSQGYKQFKA---EVGAIRSIHHKNLVRLKGFCSQESHHFLVYEYVPNG-LLDK-WIYK---
. . .| .||||.|. | ..     . ||.|    ..   .  ..| .   |. .  ...|.|.| | |.|.... | |||.| ||| | |  |  .   
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

PLEELNWDTRFRIVEEIAQGIRYLHEEC-STRVLHLDIKPQNILLDENFGVKIADFGLSR
|.  | | .|. | . .| ||..||.    | . | |||. |||||..|  ||.|||| |
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR
Kinase SD-2b_a-1.AA STE 17-184 20 5.8e-26 88.74 In-house 1-229 (359) Show / Hide 
Range on Protein: 17-184
Range on HMM: 1-229/359
Sequence Identity: 20% (48 aa)

KAFSKKIASGGFGTVFEGILSD----------------GSKVPVKRLETFSSQG-----------------YKQFKAEVGAIRSIH--HKNLVRLKGFCS
  . .|| .|.||||. ..  .                |  . .|...  ...                   .|.. |.   .  .  |.| |.  | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QE-------SHHFLVYEYVPNGLLDKWIY---KPLEELN----------WDTRFRIVEEIAQG-IRYLHEECSTRVLHLDIKPQNILLDENFGVKIADFG
.|       .. ... ||...| ||. |    .....||           .   .|. .| .|   |||.     . | ||||.||||     ||..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSRMVEQG--------------DLSDVMTMIRGTPGHM
..  ...               . .   . . ||| .|
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WM
Kinase SD-2b_a-1.AA LISK 22-171 27 7.1e-24 74.28 In-house 1-161 (296) Show / Hide 
Range on Protein: 22-171
Range on HMM: 1-161/296
Sequence Identity: 27% (45 aa)

KIASGGFGTVFEGILS-DGSKVPVKRLET-----FSSQGYKQFKAEVGAIRSIHHKNLVRLKGFCSQ-ESHHFLVYEYVPNGLLDKWIYKPLE---ELNW
.| .|.|| |. | .  .|. . .| ...     .     | .. ||  .... |.| |.  | | . ... ..| ||.  | |   . .. .    | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

DTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDEN----FGVKIADFGLSRMVEQGDLS
. | .|   ||.| .|||. .   ..| | | .|.|..||    . .|..|||. ||... . |
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNS
Kinase SD-2b_a-1.AA MLK 17-181 25 1.5e-22 75.1 In-house 1-197 (291) Show / Hide 
Range on Protein: 17-181
Range on HMM: 1-197/291
Sequence Identity: 25% (52 aa)

KAFSKKIASGGFGTVFEGILSDGSK-----VPVKRLE--TFSSQGY-----KQFKAEVGAIRSIHHKN----LVRLKGFCSQE-SHHFLVYEYVPNGLLD
  |...| ||.|| |. |    .       | ||| .  .| . .      ..|. |.   | . |.|     ....| |.|. .| ..| ||...| | 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

KWIYK--PLEE-----------LNWDTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDE------NFGVKIADFGLSRMVEQGDLSDVMTMIRGT
  ..   . ..              |  ...   .|.|. |||..    . | |.|..|||.||      .  .||.|||.||.. | .  . |.  .||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

P
.
Y
Kinase SD-2b_a-1.AA TyrKc 17-184 19 1.8e-11 -37.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-184
Range on HMM: 1-280/280
Sequence Identity: 19% (55 aa)

KAFSKKIASGGFGTVFEGILSDGSKVPVKRLETFSSQGYKQFKAEVGAIRSI--HHKNLVRLKGFCSQE-------SHHFLVYEYVPNGLLDKWIYKPLE
  . ||. .| ||.|..|...   .| || |   .    . |  |    ...  ||.|.||| | |.|.         ...| ||.|.| |.. . |. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

ELNWDTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDENFGVKIADFGLSRMVEQG-------DLSDV----MTM------------IRGT----
.|....   .   ||.| .|||.    .. | |.   |.|..||. |||.|||||| .. .       |  ..     .             |.      
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

----------------------PG-------------------------H-------------------------------------M
                      ||                         .                                     .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SD-2b_a-1.AA S_TKc 17-185 20 8.2e-10 -33.04 SMART 1-220 (231) Show / Hide 
Range on Protein: 17-185
Range on HMM: 1-220/231
Sequence Identity: 20% (48 aa)

KAFSKKIASGGFGTVFEGILSD-GSKVPVKRLETFSSQGYKQFKAEVGAIRSIHHKNLVRLKGFCSQESHHFLVYEYVPN--GLLDKWIYKPLEE-----
  . .|| .|.||.|. ..  . | .| .|..        .... |.   .. ||.|.|.|....   .| ..| ||...  | | . | |   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LNWDTRFRIVEEIAQGIRYLHEECSTRVLHLDIKPQNILLDENFGVKIADFGLSRMVEQ----------------GD-LSDV-------MTMIRGTP---
..  .  ... .|.... |.|.     ..| |.||.||||||   .||.||||.| .                  |   .|.         |. | |   
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP

--------------------------------GHMR
                                  ..
QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ