Gene WAKc-23_c (S.moellendorffii)

WAKc-23_c

Species: S.moellendorffii
Alias: WAKc-23_c
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: WAKc23

Sequence

Name Sequence Type Origin Length Description Download
WAKc-23_c.AA Protein None 732 None Fasta, JSON
WAKc-23_c.NA RNA None 2199 None Fasta, JSON
WAKc-23_c.kin_dom Protein Kinase Domain None 103 None Fasta, JSON

Protein domain

Protein domains of WAKc-23_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin WAKc-23_c.AA B_lectin 81-195 27 1.2e-21 75.95 Pfam 1-137 (137) Show / Hide 
Range on Protein: 81-195
Range on HMM: 1-137/137
Sequence Identity: 27% (40 aa)

PLDTIWMANRD---DPF-RAT----PELLFS---GSLLVTIHQN----V--QWNSSSSTTSPSSSSSGDFLELLDSGNLRVV-SRSSSSSPPSDDQAGVV
.  . | ||||   .|    .      | ..   |.| .. ...    |   |.. ...||.|.|... .....||||| .  . ...          |.
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLY-DGGNGGSVRPVWST-NNNTSGSGSANNCRAQMQDSGNLVLYDD-NND-------SNNVL

WQS--FDHPTDTLLQGQNFTQ------AMR----LVSSISNQ--DPR
|||  |||||||.| |....        |.    |.|. ||   ||.
WQSNTFDHPTDTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin WAKc-23_c.AA B_lectin 47-169 20 1.9e-05 10.94 SMART 1-126 (126) Show / Hide 
Range on Protein: 47-169
Range on HMM: 1-126/126
Sequence Identity: 20% (28 aa)

FLVSSNRDFAAGFSRDPA--AGYFALAVA---GMNANSQ---PLDTIWMA--NRDDPFRAT---PELLFS--GSLLVTIHQNVQWNSSSSTTSPSSSSSG
 .. |.  .  ....     .| | .      |.  ..    .   .| |  ||| | . .     | ..  | | .   ... | |...     . ...
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQWCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNTT-----RNNGN

DFLELLDSGNLRVVSRSSSSSPPSDDQAGVVWQSFDHP
  ..|.|.||. ..      .|...|. ...|||||||
YVAVLQDDGNFVIY------DPDDNDSGNFIWQSFDHP
PAN_1 WAKc-23_c.AA PAN_1 367-429 17 1.1e-05 20.45 Pfam 1-58 (84) Show / Hide 
Range on Protein: 367-429
Range on HMM: 1-58/84
Sequence Identity: 17% (12 aa)

KNSSEDDFLMIQGVDYFAIRFVVAAFGVS-TV-TLEECRALCLGNCS--CKAFFFRNDSSVCFHTDS
 ..  ..|  ......       .   |  .| ..|||...|..| .  |..| . ...  |.. |.
CHR--WHFERHPNYIL-G-----H-IWVMKNVDSAEECQQKCQNNPRFTCRSFTYNYKTKQCHLHDE
PAN_AP WAKc-23_c.AA PAN_AP 369-450 19 3.1e-05 24.65 SMART 1-85 (85) Show / Hide 
Range on Protein: 369-450
Range on HMM: 1-85/85
Sequence Identity: 19% (18 aa)

SSEDDFLMIQGVDYFAIRFVVAAF-----GVSTVTLEECRALCLGNCSCKAFFFRNDSSVCFHTDSIRSMLPSS------NPHNLGFIRIAKR
...|.|. . .. .      ....      .  ..||||...|| ||||..| . | .. | . .. ...  ..      .  | |..   |.
CCDDCFVRMPNMKL------FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase WAKc-23_c.AA Pkinase_Tyr 540-628 26 3.3e-10 35.18 Pfam 48-137 (270) Show / Hide 
Range on Protein: 540-628
Range on HMM: 48-137/270
Sequence Identity: 26% (24 aa)

REFQAELAAIAGLGSHSNLVALLGYCI-HGKK--RYIIYDGSTSGSRSLDEILKNPGLERAALEWSAKKEILLGIARGLAFLHANGGVHGDL
..| .|..    ||.| |.| |.| |. .|.    ||.      |  .|.. |...  .. .|  . . .. . ||.|...|.... .| ||
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG--DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
TyrKc WAKc-23_c.AA TyrKc 517-716 15 7.7e-09 -79.73 SMART 12-280 (280) Show / Hide 
Range on Protein: 517-716
Range on HMM: 12-280/280
Sequence Identity: 15% (42 aa)

FSEIESAKNTRRISVV--QLQGCSPREFQAELAAIAGLG-SHSNLVALLGYCIHGK------KRYIIYDGSTSGSRSLDEILKNPGLERAALEWSAKKEI
| |.  .. .  | |    |. .. ..|  |.     || .| |.|.|.|.|....      . . |     ..  .|.. |.... .   | .. . ..
FGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK---LCMKDLLSF

LLGIARGLAFLHANGGVHGDLVPGNVLLDLEH------------GGSS----------SPR---LAR--------------YG-----------------
 . ||.| ..|| .. .| ||   |.|.. .|            ...           ...    ..              ||                 
CWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWE

LASLMRRPPPNP----SDDVRAFGAIVAA-LLDGGDG--------APAEDQRLREIWKCCAQQEAVLRPSMAMVAETL
. ..   |.|..     .. ...  . .   ..  .         .|.|   . .| |.| . ..  ||... . | .
IFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE---MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase WAKc-23_c.AA IRAK 555-636 32 8.6e-09 27.45 In-house 62-147 (317) Show / Hide 
Range on Protein: 555-636
Range on HMM: 62-147/317
Sequence Identity: 32% (29 aa)

HSNLVALLGYCIHGKKRYIIYDGSTSGSRSLDEILKNPGLERA--ALEWSAKKEILLGIARGLAFLHANG----GVHGDLVPGNVLLD
| |.|.|.|||. . .   .|.  . |  ||   |   .   .  .|.|   ..|..|.|.|. ||| |.      |||  . |.|||
HPNIVPLYGYCTERQCHCLVYPYMPNG--SLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLD
Kinase WAKc-23_c.AA TESK 554-662 27 1.1e-08 23.08 In-house 51-157 (292) Show / Hide 
Range on Protein: 554-662
Range on HMM: 51-157/292
Sequence Identity: 27% (31 aa)

SHSNLVALLGYCIHGKKRYIIYDGSTSGSRSLDEILKNPGLERAALEWSAKKEILLGIARGLAFLHANGGVHGDLVPGNVLLDLEHGGSSSPRLARYGLA
.| | .  .| |.|  .   .     .|  .|...| .   .  .| |  | .  ..||||. .||. |  | ||   |.|         .  .. .|||
QHPNILRFMGVCVHQGQLHALTEYINGG--CLEQLLAD---SELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLA

---SLMRRPPPN
     |  ||||
RVLGCMPDPPPN
Kinase WAKc-23_c.AA TK 538-628 12 3.8e-08 22.61 In-house 67-266 (486) Show / Hide 
Range on Protein: 538-628
Range on HMM: 67-266/486
Sequence Identity: 12% (26 aa)

SPREFQA--------------ELAAIAGLGS----HSNLVALLGYCIHGKK------------RYIIYDGSTSGS--RSLDEILKNPGLERAA-------
|..||..              |..... . .    | |.| |.|.| .|.              .|.      |.   ||.. |..   ..         
SQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDN

-----------------------------------------------------------------LEWSAKKEILLGIARGLAFLHAN------GGVHGD
                                                                 |    .  . . ||.|...||..      . ||.|
QHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRD

L
|
L
Kinase WAKc-23_c.AA TKL-Unique 540-636 25 1.4e-07 23.01 In-house 40-146 (290) Show / Hide 
Range on Protein: 540-636
Range on HMM: 40-146/290
Sequence Identity: 25% (28 aa)

REFQAELAAIAGLGSHSNLVALLGYCI----HGKKRYIIYDGSTSGSRSLDEILK------NPGLERAALEWSAKKEILLGIARGLAFLHANGG--VHGD
.||  |.  .  |  | |.| . |||.    . ....|. .    |  ||.. |       |   .   | .. .  . . ||.|. .|| ...   |.|
QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGG--SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRD

LVPGNVLLD
| . |.|.|
LKSSNFLVD
Kinase WAKc-23_c.AA TKL 554-636 24 1.6e-07 23.13 In-house 83-174 (364) Show / Hide 
Range on Protein: 554-636
Range on HMM: 83-174/364
Sequence Identity: 24% (25 aa)

SHSNLVALLGYCIHGKK-------------RYIIYDGSTSGSRSLDEILKNPGLERAALEWSAKKEILLGIARGLAFLHANG--------GVHGDLVPGN
.| |.| ..|||. ...              .|...    ||  | ..|           |. .  . |.||||...||...         .| || . |
RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGS--LLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLD
.|.|
ILVD
Kinase WAKc-23_c.AA Gdt 607-635 51 2.2e-07 21.35 In-house 135-163 (289) Show / Hide 
Range on Protein: 607-635
Range on HMM: 135-163/289
Sequence Identity: 51% (15 aa)

ILLGIARGLAFLHANGGVHGDLVPGNVLL
|.. ||.| .|||.|| .|.|| | |.|.
IMIDIAKGCQFLHQNGIIHRDLKPDNILI
Kinase WAKc-23_c.AA RSK 605-653 36 2e-06 19.51 In-house 104-152 (271) Show / Hide 
Range on Protein: 605-653
Range on HMM: 104-152/271
Sequence Identity: 36% (18 aa)

KEILLGIARGLAFLHANGGVHGDLVPGNVLLDLEHGGSSSPRLARYGLA
|.... ||. ...||  | || || | |.|.| | |  .. ... .|.|
KFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA
Kinase WAKc-23_c.AA IRE 605-636 34 4e-06 16.91 In-house 119-150 (292) Show / Hide 
Range on Protein: 605-636
Range on HMM: 119-150/292
Sequence Identity: 34% (11 aa)

KEILLGIARGLAFLHANGGVHGDLVPGNVLLD
....  .. ||..||. . || || | |.| .
WQLIKQCMNGLQHLHSQNIVHRDLKPHNILIH
S_TKc WAKc-23_c.AA S_TKc 517-720 14 6e-06 -89.28 SMART 12-231 (231) Show / Hide 
Range on Protein: 517-720
Range on HMM: 12-231/231
Sequence Identity: 14% (35 aa)

FSEIESAKNTR--------RISVVQLQGCSPREFQAELAAIAGLGSHSNLVALLGYCIHGKKRYIIYDGSTSGSRSLDEILKNPGLERAA--LEWSAKKE
|..   .....        .|.         . .. |..       | |.| |.... . .. |.. .    .  .| ...|. | ..    .     . 
FGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

ILLGIARGLAFLHANGGVHGDLVPGNVLLDLEHGGSSSPRLARYGLASLMRRP-------------PPNP-SDDVRAFGAIVAALLD-------------
..  |...|...| .| .| || | |.|||          ..  ||| .. .              . .. . |. ..| |.. .|              
YMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFK

-GGDGAPAEDQRLREIWKCCAQQEAVLRPSMAMVAE-----TLSSIL
  |      .. .... . | | .   ||.   . .      .   .
KIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase WAKc-23_c.AA Jak 610-639 33 1.5e-05 15.68 In-house 126-155 (299) Show / Hide 
Range on Protein: 610-639
Range on HMM: 126-155/299
Sequence Identity: 33% (10 aa)

GIARGLAFLHANGGVHGDLVPGNVLLDLEH
.|..|. .|.... .|||. . |.|.| |.
QICWGMHYLEDKRYIHGDVCARNILVDREG
Kinase WAKc-23_c.AA LRRK 584-635 32 0.000233 11.31 In-house 141-199 (351) Show / Hide 
Range on Protein: 584-635
Range on HMM: 141-199/351
Sequence Identity: 32% (19 aa)

SLDEILKNPGLER-----AALEWSAKKEILLGIARGLAFLHANG--GVHGDLVPGNVLL
.|.. |.|.   .     | . |. | .| | ||.|...|| .    .| || . |.||
DLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL
Kinase WAKc-23_c.AA LRRK 540-567 46 0.01097 5.31 In-house 102-128 (351) Show / Hide 
Range on Protein: 540-567
Range on HMM: 102-128/351
Sequence Identity: 46% (13 aa)

REFQAELAAIAGLGSHSNLVALLGYCIH
|||. |.. . .|  |.|.| |.|.|||
REFRHEVWIMSHL-NHPNIVSLKGFCIH
Kinase WAKc-23_c.AA TKL 685-716 18 0.027931 4.03 In-house 333-364 (364) Show / Hide 
Range on Protein: 685-716
Range on HMM: 333-364/364
Sequence Identity: 18% (6 aa)

PAEDQRLREIWKCCAQQEAVLRPSMAMVAETL
|  ....... ..| ....  |||.  . ..|
PDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase WAKc-23_c.AA IRAK 697-716 40 0.044514 3.36 In-house 298-317 (317) Show / Hide 
Range on Protein: 697-716
Range on HMM: 298-317/317
Sequence Identity: 40% (8 aa)

CCAQQEAVLRPSMAMVAETL
||. . | .|..|| | ..|
CCGHHRANRRCDMAWVMQQL