Gene MLK-p1_j (S.moellendorffii)

MLK-p1_j

Species: S.moellendorffii
Alias: MLK-p1_j
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_j.AA Protein None 358 None Fasta, JSON
MLK-p1_j.NA RNA None 1077 None Fasta, JSON
MLK-p1_j.kin_dom Protein Kinase Domain None 238 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_j.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_j.AA Dicty4 111-346 43 2.5e-104 348.79 In-house 1-256 (277) Show / Hide 
Range on Protein: 111-346
Range on HMM: 1-256/277
Sequence Identity: 43% (111 aa)

LSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQYN--ESGMEDFRKEVSIMKKLRHPNIVLFLGAAS----TQDRLYIVTELMPRGSLFKLLHR-----
.   . ||.||...|..||| | .||||..  .. |  |. ...|||||.||.|.|||||.||.||      .  .. ||||.||.|.|..|||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-RPTGLDWKRKLS---MALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSR--LKHSNFLT-GNARMGTSQWMPPEVLRSEASSEKSDV
   . ||| . ..   ||.|.||||..||.|.| |.|||||| |||||||..|||.|| ||.   ||... .   .  ||  || |||.....  ||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVILWELATEEVPWK--DLDPLQVIAVVGFKDKRMPLPESLDPKYAATIQDCW
|||| .|||..| . |      .. |... |. |  | |.| . .|.... ||.||
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCW
Kinase MLK-p1_j.AA DRK 111-346 42 1e-94 320.95 In-house 1-239 (258) Show / Hide 
Range on Protein: 111-346
Range on HMM: 1-239/258
Sequence Identity: 42% (102 aa)

LSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQYN-ESGMEDFRKEVSIMKKLRHPNIVLFLGAASTQDRLYIVTELMPRGSLFKLLHRRPTGLDWKRK
      || |... | |||| |  ||||    .  | |  . .|..|. .|..||||||..|.|.        |..| |||||| . ||     .|| . 
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

LSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSR--LKHSNFLTGNARMGTSQWMPPEVLRSEASSEKSDVYSFGVILWELATEEV
..|..|.|.||.|||.|.| |.|||||| ||||| . .||| || ||    ||    .     ||  |  |||||..   || |||||...|||..| . 
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

PWKDLDPLQVIAVVGFKDKRMPLPESLDPKYAATIQDCW
|     ..||.  ||    | | |.   |||.. ..|||
PYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCW
Kinase MLK-p1_j.AA TKL 117-347 28 6e-93 315.11 In-house 1-348 (364) Show / Hide 
Range on Protein: 117-347
Range on HMM: 1-348/364
Sequence Identity: 28% (102 aa)

IGQGSCATVHRGTWCG----------LDVAVKVFHELQYNESGM-------------------------EDFRKEVSIMKKLRHPNIVLFLGAASTQDR-
||.|. ..|..|.| |           |||||.|.. . .|. .                         . ...|. .|..|||||||.|.|..   .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LYIVTELMPRGSLFKLLHRRPTGLDWKRKLSMALDVARGMTYLHNCT------PPIVHRDLKSTNLLVDKNLK--------------V
            |.||.|..|.|||. .||       | .....|||.|||| |||...      |||.|||||| |.|||.|..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVGDFSLSRLKHSNFL-------------------TGNARMGTSQWMPPEVLRSE----------------ASSEKSDVYSFGVILWELATEEVPWKDLD
|..|| ||| .. ..                    | . . || .||.||||| .                  |||.||||||..|||..| ..|..|..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PLQVI---------AVVGFKDKRMPLP------------ESLDPKYAATIQDCWK
. ..|         ..|. | .| |.|            .. .| ..  .||||.
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWD
Kinase MLK-p1_j.AA TKL-Unique 113-348 37 2.3e-91 309.82 In-house 1-275 (290) Show / Hide 
Range on Protein: 113-348
Range on HMM: 1-275/290
Sequence Identity: 37% (104 aa)

LHDQIGQGSCATVHRGTWCGLDVAVKVFH--ELQYNESGMEDFRKEVSIMKKLR-HPNIVLFLGAAS----TQDRLYIVTELMPRGSLFKLLH-------
    ||.|....| .|.| | .||.|.||  |.. ||. |..|..||..||||. |||||.. |.      .. ...||.| .|.||| ..||       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEM-MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--RRPTGLDWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKN-----LKVKVGDFSLSRLKHSN---FLTGN------ARMGTSQWMPPEVLR
  .. . |.......||.|.|.|| |||.| ||| ||||||.|.||| |     ...|. ||.||... ..   .....       |.|. .||.|||||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

S--EASSEKSDVYSFGVILWELATEEV------PWKDLDPLQVIAVVGF--KDKRMPLPESLDPKYAATIQDCWKR
.  .  ||||||||||..|||.|| ..      | ...|. |....| .  . .| |.|... . |   ||.||..
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHH
Kinase MLK-p1_j.AA Shk 106-308 45 9.3e-70 238.06 In-house 1-205 (269) Show / Hide 
Range on Protein: 106-308
Range on HMM: 1-205/269
Sequence Identity: 45% (96 aa)

ITWESLSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQYNESGMEDFRKEVSIMKKLRHPNIVLFLGAAS-TQDRLYIVTELMPRGSLFKLLHRRPTGL
|. |..     .||||  .|  |.  | .||||| |     |. | .|||||.||.|..||||.||.||   .  .. |||||||.|.| ||||   . .
INREDF-----LGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKK

D---WKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSR-LKHSNFLTG--NARMGTSQWMPPEVLRSEASSEKSDVYSFGVI
.    || . |..| | ||. ||   . |.|||||. |||||.|. |||.|| .|   |    |     .  ||  || |||.      ||.|||||| |
PFILYKRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGII

LWELATEEVP
|||..| . |
LWEILTCQEP
Kinase MLK-p1_j.AA MLK 111-347 33 1.8e-69 237.1 In-house 1-275 (291) Show / Hide 
Range on Protein: 111-347
Range on HMM: 1-275/291
Sequence Identity: 33% (93 aa)

LSLHDQIGQGSCATVHRGTWCGLD-----VAVKVFH----ELQYNESGMEDFRKEVSIMKKLRHPN----IVLFLGA-ASTQDRLYIVTELMPRGSLFKL
. .|  || ||   |..|.| . |     |||| ..    . .  ..  .||..|. . ..|.|||    |. |.|. ....  ..||.| .. |||. .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHRRPT-------------GLDWKRKLSMALDVARGMTYLHNCTP-PIVHRDLKSTNLLVD------KNLKVKVGDFSLSRLKHSNFLT-GNARMGTSQW
|| ...               |   ... ||..|||| |||.  | ||.|||||| |.|.|      .....|. || .|| .|..  |    ..||  |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MPPEVL---RSEASSEKSDVYSFGVILWELATEEVPWK-DLDPLQVIAVVGFKDKRMPLPESLDPKYAATIQDCWK
| |||.   |.|  |||.||.|.||.|||. | ||| | ..||..... |. . .| |.| . ..  .  ...||.
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWN
Kinase MLK-p1_j.AA Pkinase_Tyr 111-332 33 2.8e-65 221.7 Pfam 1-239 (270) Show / Hide 
Range on Protein: 111-332
Range on HMM: 1-239/270
Sequence Identity: 33% (81 aa)

LSLHDQIGQGSCATVHRGTWC------GLDVAVKVFHELQYNESG--MEDFRKEVSIMKKL-RHPNIVLFLGAAS-TQDR--LYIVTELMPRGSLFKLLH
...  ..|.|.  .|..|||       ...||||.  | .. ..   .||| .|..|||.| .||||| ..|. .  ..   .|||.|.|| |.| . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RR---PTGLDWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSRLKHSNFLTGNA-RMGT-----SQWMPPEVLRSEASSEK
..   .  |. |..|.|....|.|| ||..    ..||||   | ||..|..||..|| |.|.    . ...  |...       ||.||...    ..|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

SDVYSFGVILWELAT-EEVP-WKDLDPLQVIAVVGFKDKRMPLPE
|||.|||| .||. |  | | ...... .|.. .. .  ||| ||
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPE
Kinase MLK-p1_j.AA Dicty4-Unclassified 111-346 35 6.8e-62 210.75 In-house 1-246 (263) Show / Hide 
Range on Protein: 111-346
Range on HMM: 1-246/263
Sequence Identity: 35% (89 aa)

LSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQYN--ESGMEDFRKEVSIMKKLRHPNIVLFLGAASTQ----DRLYIVTELMPRGSLFKLLH------
.     ||.|  . ||.| | | ||||| | | ..   |  ..||.||| |.  . ||| |   |..         . ||.|.|..| || . |      
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

RRPTGLDWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSRLKHSNFLTGNARMGTSQWMPPEVLRSEASSEKSDVYSFGVI
 .|  ||    . .|.|.|.|| .||  |  ..|||.|| |.|.||.  .|..|| .||    || .  .  ||  |  ||.|. |.   ||||||....
QQPIKLDDTLIIKYAFDIAQGMQHLH--TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNF-NMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LWELATEEVPWKDLD-PLQVIAVVGFKDKRMPLPESLDPKYAATIQDCW
|.|||| . |. .   .. .   |  |  |  .|.. |. .   | .||
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCW
Kinase MLK-p1_j.AA CZAK 111-347 37 1.6e-61 210.69 In-house 1-263 (279) Show / Hide 
Range on Protein: 111-347
Range on HMM: 1-263/279
Sequence Identity: 37% (98 aa)

LSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQY-NESG---MEDFRKEVSIMKKLRHPNIVLFLGAASTQD--RLYIVTELMPRGSLFKLLHRRPTGL
|     ||||    | .. | | |||.|  |  |. | ..    . | |||||| ||.|||.| |||| |        ||.| |  ||| .||  .   .
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

DW--KRKLSMALDVARGMTYLHN-CTP-PIVHRDLKSTNLLVDKNLK-------------VKVGDFSLSRLKHSNFLTGNARMGTSQWMPPEVLRSEASS
      ...||.|.|||| |||   .| ||.|||| | | | | ..               |. || |||..        . ||   || ||.   |  .
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYT

EKSDVYSFGVILWELATEEVPWKDLDPLQVIAVVGFKDKRMPLPESLDPKYA---ATIQDCWK
||.|||||| |||.. | . |  .. |.       . . | |.|  .||.       |  ||.
EKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWN
Kinase MLK-p1_j.AA TKL-ciliate2 111-346 36 5.8e-60 198.66 In-house 1-255 (273) Show / Hide 
Range on Protein: 111-346
Range on HMM: 1-255/273
Sequence Identity: 36% (93 aa)

LSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQYNES-GMEDFRKEVSIMKKLRHPNIVLFLGAASTQDRLYIVTELMPRGSLFKLLHRRPTGLDWKRK
| .. .|  |    . .  |  . |||| |  .....   . ||  |   |  |||||||.||||        |. |   ||||. ||  .   | |  .
LEIQNKITEGGYGIIYKAKWREIVVAVKKFK-MDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDR

LSMALDVARGMTYLHNCTPPIVHRDLK--------------------STNLLVDKNLKVKVGDFSLSRLK-HSNFLTGNARMGTSQWMPPEVLRSEASSE
  .|||.|||. |||   |||.|||||                    | |.||| |.. |. ||   | |   |..|  ...|| ||| |||...    |
RRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMT--NKIGTYQWMAPEVIKAFYYTE

KSDVYSFGVILWELATEEVPWKDLDPLQVIAVVGFKDKRMPLPESLDPKYAATIQDCW
| ||.|...||||.|  | |...     |   |  .  |  .|    |..|  .| ||
KADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCW
Kinase MLK-p1_j.AA TyrKc 111-355 30 6.4e-59 202.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 111-355
Range on HMM: 1-280/280
Sequence Identity: 30% (87 aa)

LSLHDQIGQGSCATVHRGTWCGLDVAVKVFHELQYNESGMEDFRKEVSIMKKL--RHPNIVLFLGAASTQ-------DRLYIVTELMPRGSLFKLLHRRP
..| ...| |   .|..|||  ..||||. .|       .|||..| .||.||  .||||| ..|....|       . |.||.|.|| |.| . |... 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

TGLDWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSRLKHSN--------FLTG----NARM-GTSQWMPPEVLRSEASSE
  | .| .||.....|.|| |||    ...||||   | ||..|. ||..|| |||  ..           .     ....     ||.||...    ..
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KSDVYSFGVILWELATE-EVPWKD-----LDPLQVIAVVGFKDKRMPLPES--------LDPKYAATIQDCWKR--------YKVLPFF
||||.|||| .||. |  . |. .     ... .||. |  . .||| |..          ..    ...||..          .  .|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_j.AA LRRK 111-308 28 1.3e-55 191.08 In-house 1-282 (351) Show / Hide 
Range on Protein: 111-308
Range on HMM: 1-282/351
Sequence Identity: 28% (84 aa)

LSLHDQIGQGSCA-TVHRGTWCG----------------------------LDVAVKVFHEL----------------------QYNESGM---------
|    |||.|. . .|.|..| |                             .||.|...                        . .|. |         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

--EDFRKEVSIMKKLRHPNIVLFLGAASTQDRLYIVTELMPRGSLFKLLH---RRP-----TGLDWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNL
    ||.||.|| .|.|||||  .|   . . | .|.|..| |.| ..||   . .     . ..|  ||  ||..|.|| |||...|||.|||||| | 
AFREFRHEVWIMSHLNHPNIVSLKGF--CIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNI

LV---D---------KNLKVKVGDFSLSR----LKH--SNFLTGNARMGTSQWMPPEVLR---SEASSEKSDVYSFGVILWELATEE-VP
|.   .          . ..|..||..||    ...   ....||      .|| ||..|    |  .||.|.||||.||||| | .  |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNP-----GWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase MLK-p1_j.AA Pkinase 111-319 28 1.8e-51 182.11 Pfam 1-228 (293) Show / Hide 
Range on Protein: 111-319
Range on HMM: 1-228/293
Sequence Identity: 28% (66 aa)

LSLHDQIGQGSCATVHRGTWCGLD--VAVKVFHELQYNESG-MEDFR-KEVSIMKKLRHPNIVLFLGAASTQDRLYIVTELMPRG----SLFKLLH-RRP
. .. .||.|| ..| .... |    ||||..     ...  ....|  |..|||.|.||||| ....  . |..|.|.|... |    .|| ... .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TGL--DWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKV----KVGDFSLSRLK-HSNFLTGNARMGTSQWMPPEVLR-SEASSEKSDVY
...  ...   .... ..||. |.|..   |.|||||. |.|.|.|  .    |..|| |.... . |    . . ||. .|.|||.| ..  . |.|..
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVILWELATEEVPWKDL------DPLQVIA
|.|.||.|... . |...       |..|.|.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMIC
Kinase MLK-p1_j.AA S_TKc 111-355 23 4.1e-48 167.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 111-355
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

LSLHDQIGQGSCATVHRGTWCG--LDVAVKVFHELQYNESGMEDFRKEVSIMKKLRHPNIVLFLGAASTQDRLYIVTELMPR--GSLFKLLHRRPTG---
  ....||.|. ..|..... .    ||.|. .         |..|.|..|.|| .||||| ....  . |.||.|.|...   |.||.....|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDWKRKLSMALDVARGMTYLHNCTPPIVHRDLKSTNLLVDKNLKVKVGDFSLSRLKHSNFLTGNARMGTSQWMPPEVLRSEASSEKSDVYSFGVILWE
  ..  .  ...  ..... |.|.    |.|||||  |.|.|.   .|..|| |.|.        .   ||  .|.||||    . .|.|..|.|.||.|
FPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

LATEEVPWKDLDPLQVIAVVGFKDKRMPLPESLDPKYAATIQDCWKRY---------KV-------LPFF
... . |.   .. ... ..|            .|     |. |...                    |.|
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF