Gene MLK-p1_a-2 (S.moellendorffii)

MLK-p1_a-2

Species: S.moellendorffii
Alias: MLK-p1_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_a-2.AA Protein None 481 None Fasta, JSON
MLK-p1_a-2.NA RNA None 1446 None Fasta, JSON
MLK-p1_a-2.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_a-2.AA Dicty4 165-419 49 8.9e-138 461.94 In-house 1-277 (277) Show / Hide 
Range on Protein: 165-419
Range on HMM: 1-277/277
Sequence Identity: 49% (138 aa)

INIGERVGIGSYGEVYHGEWSGTEVAVKKF--LDQDFSGDAMMEFRSEVQIMRGLKHPNVVLFMGAVA----HPPNLAIVTEYLPRGSLFKLLHR-----
|||..| | ||.|||| | | |.||||||.  . |.|. . . ||| || ||  . |||..|||||      ||. . |||||.|.|.|..|||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-PHNQLD--RRRR-LQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSR-IKHSTFLSS--KSTAGTPEWMAPEVLRNEPSNEKSDV
 .  .||  ...| ..||.|.| |||.||.| |||.|||||| ||||| ||.|||||||||. .|  . ..   ....||| ||||||....| |||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

FSFGVILWELATSQKPWH--GMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILND--LQA
.||| .|||..| | |    .|..||.| ||.  . |.|||....||... ||.|| .||..||||| |..   | .
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-p1_a-2.AA DRK 165-419 46 4.5e-123 415.17 In-house 1-258 (258) Show / Hide 
Range on Protein: 165-419
Range on HMM: 1-258/258
Sequence Identity: 46% (120 aa)

INIGERVGIGSYGEVYHGEWSGTEVAVKKFLDQDFS-GDAMMEFRSEVQIMRGLKHPNVVLFMGAVAHPPNLAIVTEYLPRGSLFKLLHRPHNQLDRRRR
| || |.| |.||||. | | ||.||||.         . . ||. |. .|  | |||...|||.   ||   |..||.||||| . || .  ..|  ..
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

LQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSR----IKHSTFLSSKSTAGTPEWMAPEVLRNEPSNEKSDVFSFGVILWELATS
.||..|.| ||.|||.| |.|.|||||| ||||| .| ||| |||||     .|  .|   .   ||| | |||||||..  || ||.||...|||..| 
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKF--AMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR

QKPWHGMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILNDLQA
| |  ||...||| .||    |.|.|. . |  .  ...||  ||..|||.. .|  | |
QDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-p1_a-2.AA TKL-Unique 167-417 41 3.7e-110 372.28 In-house 1-290 (290) Show / Hide 
Range on Protein: 167-417
Range on HMM: 1-290/290
Sequence Identity: 41% (119 aa)

IGERVGIGSYGEVYHGEWSGTEVAVKKFL-DQDFSGDAMMEFRSEVQIMRGLK-HPNVVLFMGAVA----HPPNLAIVTEYLPRGSLFKLLH--------
... .| |.||.||.|.| |..||.|.|    |.| . | ||..|| .|  |. |||.|..||. .    .|||. ||.||.|.||| ..||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-RPHNQLDRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRN-----WVVKVCDFGLSRIKHSTFLSSKSTA---------GTPEWMAPEVLRN
 .... |.  .|..||.|.| ||.|||.|.| | ||||||.|.|||.|     | .|.||||||... .   .....          |.. ||||||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--EPSNEKSDVFSFGVILWELATSQK------PWHGMNPMQVVGAVGF--QHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILNDL
  .  .|||||.|||..|||.||..       | .||.. |.  .| .     |.|||..  ...  .||.||  ||||||||. |.. |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-p1_a-2.AA TKL 171-417 31 2.1e-106 359.78 In-house 1-364 (364) Show / Hide 
Range on Protein: 171-417
Range on HMM: 1-364/364
Sequence Identity: 31% (117 aa)

VGIGSYGEVYHGEWSG----------TEVAVKKFLDQDFSGDAM-------------------------MEFRSEVQIMRGLKHPNVVLFMGAVAHPPN-
.| |..||||.|.| |          ..||||||  .. . . .                          ... |. .|. |.|||.|.|||..  ||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LAIVTEYLPRGSLFKLLHRPHNQLDRRRRLQMALDVAEGMNYLHSCK------PVIVHRDLKSPNLLVDRNWV--------------V
            |.||.|| |.|||. .||         .|...|||.| |||||||..      | |.||||||.|.|||.||               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVCDFGLSRIKHSTFLSSKS-------------------TAGTPEWMAPEVLRNE----------------PSNEKSDVFSFGVILWELATSQKPWHGMN
|.||||||| .. .. ....                     ||| ||||||||..                . .||.||.|||..|||..| ..|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PMQVV---------GAVGFQHRRLPIP------------PDVDPSIASIIQECWQNDPSQRPSFEKILNDL
.|...           |.   .|.|||            ||..||.....|.||. ||..||||..||  |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-p1_a-2.AA MLK 165-417 36 2.5e-95 322.98 In-house 1-291 (291) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-291/291
Sequence Identity: 36% (107 aa)

INIGERVGIGSYGEVYHGEWSGTE-----VAVKKFLDQDFSGDAMME-----FRSEVQIMRGLKHPN----VVLFMGAVAHPPN-LAIVTEYLPRGSLFK
|.. | .| ||.|.|. |.| ...     ||||..    |   . ..     |. |. . | |.|||    .. |.|. . ||. ..||.||.. |||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHR-P-------HNQL-----DRRRRLQMALDVAEGMNYLHSCKPV-IVHRDLKSPNLLVDR------NWVVKVCDFGLSRIKHSTFLS-SKSTAGTPE
.||  .       |||      |    .. ||..|.||.|||| .|. |.||||||.|.|.|.      . ..|.||||.|| .|..  .   |.|||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

WMAPEVL---RNEPSNEKSDVFSFGVILWELATSQKPWH-GMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILNDL
||||||.   |.|. .||.||.|.||.|||. | . | . ...||..   |.  . |.|||.. ...... ...||. ||..||||  |.  |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-p1_a-2.AA Shk 165-417 45 2.9e-93 316.17 In-house 1-264 (269) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-264/269
Sequence Identity: 45% (121 aa)

INIGERVGIGSYGEVYHGEWSGTEVAVKKFLDQDFSGDAMMEFRSEVQIMRGLKHPNVVLFMGAVA-HPPNLAIVTEYLPRGSLFKLLHRPHNQLD--RR
||  .  | ||.| || |   | |||||. . | |.   | .|| ||.||  . |||..|||||    |  . ||||  |.|.| |||| .  ...    
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

RR-LQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSR-IKHSTFLSS--KSTAGTPEWMAPEVLRNEPSNEKSDVFSFGVILWELA
.| ..|..| | ||| ||.  ..|.|||||. ||||| ||.|||||||.|  .|  . |.   |. .||| ||||||. | | |||.||.||| ||||..
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TSQKPWH--GMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILND--L
| | |      .  . . |.   . | ||| |  .|    || ||  .|..||||. |.    |
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRIL
Kinase MLK-p1_a-2.AA Pkinase_Tyr 165-417 33 1.1e-78 267.05 Pfam 1-270 (270) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-270/270
Sequence Identity: 33% (93 aa)

INIGERVGIGSYGEVYHGEWS------GTEVAVKKFLDQDFSGDA--MMEFRSEVQIMRGL-KHPNVVLFMGAVA--HPP-NLAIVTEYLPRGSLFKLLH
| .|.  | |..||||.|.|       ...||||.   .. . ..  . .| .|..||. | .|||.| ..|..     | .. ||.|| | |.| . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RP---HNQLDRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSRIKHSTFLSSKS-TAGT-----PEWMAPEVLRNEPSNEK
..    ..|.  . |||....|.||.||.| .  ..||||   | ||..| |||.|||||.|     .  .   ....       |||||....   ..|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

SDVFSFGVILWELAT-SQKP-WHGMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILNDL
||| |||| .||. |  ..| . || . .|. ... . .|.|.|..  . | .....||. ||..||.|. |...|
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-p1_a-2.AA LRRK 165-419 30 1.5e-77 263.97 In-house 1-351 (351) Show / Hide 
Range on Protein: 165-419
Range on HMM: 1-351/351
Sequence Identity: 30% (107 aa)

INIGERVGIGSYG-EVYHGEWSG----------------------------TEVAVKKFLD--------------------------------QDFSGDA
. |.| .| |..| .|| ..| |                            ..||.||..                                  ...  |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

MMEFRSEVQIMRGLKHPNVVLFMGAVAHPPNLAIVTEYLPRGSLFKLLHRPH-NQ-------LDRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLL
  ||| || ||..|.|||.|  .|   ||  |..|.||.| |.| ..|| .. ..       ...  .|. ||..|.||.||||..| |.|||||||| |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

V---D---------RNWVVKVCDFGLSRIKHSTFLS--SKSTAGTPEWMAPEVLR---NEPSNEKSDVFSFGVILWELATSQ-KPWHGMN-P-----MQV
.   .          . ..|..|||.||.  ..|..   |   |.| |||||..|   .|  .||.|..|||.||||| | |  |  ... .     |  
LWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

VGAVGFQHRRLPIPPD-VDP-----SIASIIQECWQNDPSQRPSFEKILNDLQA
.       .| .||..   |     .  . ||.|||.|| .||.|..|.  |  
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-p1_a-2.AA Dicty4-Unclassified 165-417 35 2.6e-73 249.84 In-house 1-263 (263) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-263/263
Sequence Identity: 35% (95 aa)

INIGERVGIGSYGEVYHGEWSGTEVAVKKFLDQDFSGD--AMMEFRSEVQIMRGLKHPNVVLFMGAVAHP----PNLAIVTEYLPRGSLFKLLH-RPHNQ
| |   .| |   .|. | | | .|||||| .  |.     . .|. || |.  . ||| |   |.   |      . ||.| ...| || . | .|  |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

-----LDRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSRIKHSTFLSSKSTAGTPEWMAPEVLRNEPSNEKSDVFSFGVI
     ||    . .|.|.| || .||.    ..|||.|| |.|.|..  .|. |||.||    .|      |||| | .||.|. |  | ||||.|....
QQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMT-TIAGTPKWESPECLMHESYNQKSDVYSYAMM

LWELATSQKPWHGMN-PMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILNDL
|.||||   |. .   .| .   |     |  ||  .|. . . |  || |||  ||....| . |
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-p1_a-2.AA TyrKc 165-417 33 5.1e-72 246.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-280/280
Sequence Identity: 33% (96 aa)

INIGERVGIGSYGEVYHGEWSGTEVAVKKFLDQDFSGDAMMEFRSEVQIMRGL--KHPNVVLFMGAVAHP-------PNLAIVTEYLPRGSLFKLLHRPH
|  |.  | | .||||.|.|. ..||||.  .       ...|..| .||. |  .|||.| . |.. ..       . | ||.|| | |.| . |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

NQLDRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSRIKHST--------FLSSKSTAGTPE-----WMAPEVLRNEPSNE
..|  .  |......|.||.|||| .  ..||||   | ||..| .||..||||||  ..           ..|.. |.       |||||...    ..
PKLCMKDLLSFCWQIACGMEYLHSKN--CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KSDVFSFGVILWELATS-QKPWHG-----MNPMQVVGAVGFQHRRLPIPPD--------VDPSIASIIQECWQNDPSQRPSFEKILNDL
||||.|||| .||. |  |.|. |     |.. .|.  |  | .|.|.||.          . . .|...||. ||..||.|. |  ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_a-2.AA Pkinase 165-417 27 1.1e-70 245.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

INIGERVGIGSYGEVYHGEWSGTE--VAVKKFLDQDFSGDAMMEFRS--EVQIMRGLKHPNVVLFMGAVAHPPNLAIVTEYLPRG----SLFKLLH-RPH
. ||...| ||.|.||.. . ||.  ||||..  .. . .  .. |   |.|||. |.|||.| . ...  .... .|.||.. |    .|| ... . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NQL--DRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVV----KVCDFGLSRIK-HSTFLSSKSTAGTPEWMAPEVLR-NEPSNEKSDVF
. .  . .    ... ...|..|.||.   |.|||||. |.|.|.| ..    |.|||||.. . .      .. .|||..|||||.| ...   |.|..
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVILWELATSQKPWHGM------NPMQVVGAVGFQHRRLPIPPDVD-------------------PSIASIIQECWQNDPSQRPSFEKILND--L
|.|.||.|... . |. |       ..||..  ..    . ..| . .                   ..  ..|  |.. ||..||..| ||..  .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLK-p1_a-2.AA TK 165-417 20 9.7e-69 229.31 In-house 1-486 (486) Show / Hide 
Range on Protein: 165-417
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

INIGERVGIGSYG---EVYHGEWSG---------------------------TEVAVKKFLDQ-DFSGDAMME--------------FRSEVQIMRG--L
| .|.  | | .|   ||| ||| |                           |.||||   .  . | .....              . .| ..|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNVVLFMGAVAHP------------PNLAIVTEYLPRGS----LFKLLHRPHN---------------------------------------------
.|||.| . |.. ..            . . ||.|| | |.    | . |.. ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLDRRRRLQMALDVAEGMNYLHSCKP----VIVHRDLKSPNLLVDRNWV-----------VKVCDFG---
                              ||. ...| |....|.|| ||||..      .|||||   | ||..| |           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRIKHS-TFLSSKSTAGTPE-------------------------WMAPEVLR---------NEPSNEKSDVFSFGVILWELAT-SQKPWHG-M
     |.|  .| .   .||. ||.                          |||||.|.         .    .||||.|||| .||. |  |.|..| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NP---------MQVVGAV--GFQH-----------RRLPIPPDVD--------------PSIASIIQECWQNDPSQRPSFEKILNDL
.           .|.  .  | ..            |.| ||.                . .. ..|.||. ||..||.|. ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-p1_a-2.AA TKL-ciliate2 165-418 37 2.5e-68 227.06 In-house 1-273 (273) Show / Hide 
Range on Protein: 165-418
Range on HMM: 1-273/273
Sequence Identity: 37% (103 aa)

INIGERVGIGSYGEVYHGEWSGTEVAVKKFLDQDFSGD-AMMEFRSEVQIMRGLKHPNVVLFMGAVAHPPNLAIVTEYLPRGSLFKLLHRPHNQLDRRRR
..| ...  | || .|   |  . ||||||   |.  .  . .| .| . |  |.|||.|.|.||  . || .|. ||  ||||. ||     .|    |
LEIQNKITEGGYGIIYKAKWREIVVAVKKF-KMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDR

LQMALDVAEGMNYLHSCKPVIVHRDLK--------------------SPNLLVDRNWVVKVCDFGLSRIK-HSTFLSSKSTAGTPEWMAPEVLRNEPSNE
 ..|||.| |. |||| .| |.|||||                    | |.||| |   |. |||  |.|    ..  |   ||  ||||||..     |
RRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNK--IGTYQWMAPEVIKAFYYTE

KSDVFSFGVILWELATSQKPWHGMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILNDLQ
| ||||...||||.|    |. ..    |   |  .  |  || .. | .| ..| ||.|.   ||||..|. .|.
KADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase MLK-p1_a-2.AA S_TKc 165-425 26 1.9e-63 217.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 165-425
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

INIGERVGIGSYGEVYHGEW--SGTEVAVKKFLDQDFSGDAMMEFRSEVQIMRGLKHPNVVLFMGAVAHPPNLAIVTEYLPR--GSLFKLLHRPHNQ---
  |.. .| |..|.|| . .  .| .||.|.             .|.|.||..  .|||.| . ..  .  .| .|.||..   |.||.....   .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDRRRRLQMALDVAEGMNYLHSCKPVIVHRDLKSPNLLVDRNWVVKVCDFGLSRIKHSTFLSSKSTAGTPEWMAPEVLRNEPSNE-KSDVFSFGVILW
  ..  .   ..  ......|.|| .  |.|||||  |.|.|.  ..|.|||||.|.        ..  |||..||||||   . .  |.|. |.|.||.
FPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELATSQKPWHGMNPMQVVGAVGFQHRRLPIPPDVDPSIASIIQECWQNDPSQRPSFEKILN-DLQALQRPVL
|... . |..  .....   .|            .|.  ..|. |.| ||..||.  ..|. .. . . | .
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF