Gene MLK-p1_e-2 (S.moellendorffii)

MLK-p1_e-2

Species: S.moellendorffii
Alias: MLK-p1_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_e-2.AA Protein None 396 None Fasta, JSON
MLK-p1_e-2.NA RNA None 1191 None Fasta, JSON
MLK-p1_e-2.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_e-2.AA Dicty4 134-386 45 8.60000000001e-120 401.11 In-house 1-277 (277) Show / Hide 
Range on Protein: 134-386
Range on HMM: 1-277/277
Sequence Identity: 45% (125 aa)

VHIGERVGQGSFGRVYHADWQGSDVAVKVF--LDQDIRSEALEEFKREVAMIRRLRHPNIVLFMGAVT----QPPNLSLVTEFCPRGSLFRILQK-----
  |..| |.|||| || . | |..||||..  . |. ... |.||..||.    .|||||.||||| |    .|. .. |||..|.|.|...| .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

---TKLD--ERRR-LRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSR-PKNNTFLTS--KTGVGTPEWTAPEVLRNEPSDEKCDV
   .|||   ..| .|||.|. .|||.|| | | |.|||||| |||| .||..||||||||.  |  . ..   .| .||| |.||||....| .|| ||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVILWELATLQQPWA--GMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHK--LKT
|||| .|||..| | | .  .|. ||.. ||.    |.||||   | ...|.| ||. ||. |||| ||  .  | .
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-p1_e-2.AA DRK 134-386 45 1.3e-110 373.81 In-house 1-258 (258) Show / Hide 
Range on Protein: 134-386
Range on HMM: 1-258/258
Sequence Identity: 45% (118 aa)

VHIGERVGQGSFGRVYHADWQGSDVAVKVFLDQDIR-SEALEEFKREVAMIRRLRHPNIVLFMGAVTQPPNLSLVTEFCPRGSLFRIL--QKTKLDERRR
. || |.| |..| |.   | |. ||||      |   . | ||.||. .. .||||||..|||. . ||    ..|. ||||| .||  .. ..|  ..
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

LRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSR--PKNNTFLTSKTGVGTPEWTAPEVLRNEPSDEKCDVYSFGVILWELATLQQ
..|..|. |||.||| | | |.|||||| |||| |.| .|| |||||    |     . .| .||| |||||||||..  || |||||...|||..| | 
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

PWAGMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHKLKT
| .||. .||. .||    |.|.|    |  |.||. ||. ||  |||. |..  |  
PYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-p1_e-2.AA TKL 140-384 33 2.1e-110 373.11 In-house 1-364 (364) Show / Hide 
Range on Protein: 140-384
Range on HMM: 1-364/364
Sequence Identity: 33% (122 aa)

VGQGSFGRVYHADWQG----------SDVAVKVFLDQDI------------------------RSEALEEFKREVA-MIRRLRHPNIVLFMGAVTQPPN-
.|.|.|| ||.. |.|           |||||.|  ..                          .. ...|..|.. |..||||||||.|||....||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LSLVTEFCPRGSLFRILQKTKLDERRRLRMALDVSKGMNYLHRCC------PPIVHRDLKSPNLLVKENWT--------------IKV
            | .|.|.||.|||. .|.       .|.|.|||...|||||| .       |||.||||||.|.||.||||              .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

CDFGLSRPKNNTFL-------------------TSKTGVGTPEWTAPEVLRNE----------------PSDEKCDVYSFGVILWELATLQQPWAGMNSM
||||||| .....                    |. | .||| | ||||||..                . .|||||||||..|||..| ..|......|
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

QVI---------GAVGYLNQRLPIP------------DHIEPGIIALMQACWSSDPKARPSFGEIMHKL
..|           |.. ..|.|||            ... |... ||| ||..||..|||| ||...|
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-p1_e-2.AA TKL-Unique 136-384 40 8.60000000001e-107 361.09 In-house 1-290 (290) Show / Hide 
Range on Protein: 136-384
Range on HMM: 1-290/290
Sequence Identity: 40% (118 aa)

IGERVGQGSFGRVYHADWQGSDVAVKVFL-DQDIRSEALEEFKREVAMIRRLR-HPNIVLFMGAVT----QPPNLSLVTEFCPRGSLFRILQ--------
... .|.|..|.||.. | |..||.|.|    |...| ..||..||  . .|. |||||..||. .    .|||...|.|.||.|||   |.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---KTKLDERRRLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKEN-----WTIKVCDFGLSRPKNNT---FLTSK------TGVGTPEWTAPEVLRN
   ..||.  .|..||.|...||.|||.| ||| ||||||.|.|| .|     | ||.||||||. ...    ... .      | .|.. | ||||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--EPSDEKCDVYSFGVILWELATLQQ------PWAGMNSMQVIGAVGY--LNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHKL
  .  .||.||||||..|||.|| ..      |  ||.. |.. .| |   |.|.|||.|... .  |.|.|| .||  |||| || |.|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-p1_e-2.AA MLK 134-384 35 2.2e-92 313.25 In-house 1-291 (291) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-291/291
Sequence Identity: 35% (104 aa)

VHIGERVGQGSFGRVYHADWQGSD-----VAVKVFL----DQDIRSEALEEFKREVAMIRRLRHPN----IVLFMGAVTQPPN-LSLVTEFCPRGSLFRI
  . | .| |||| |. . |.. |     |||| .     |  . ..  ..|..|.   |.|.|||    |. |.|. .|||. . .|.|.|. |||...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQKTK---------------LDERRRLRMALDVSKGMNYLHRCCP-PIVHRDLKSPNLLVKE------NWTIKVCDFGLSRPKNNTFLTSKTG-VGTPEW
|   .                |    .. ||....||.|||   | ||.||||||.|.|. |      . | |.||||.|| ....  | ...  ||. |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

TAPEVL---RNEPSDEKCDVYSFGVILWELATLQQPWA-GMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHKL
 ||||.   |.|. .|||||.|.||.|||. | . | . ....|...  |.| ..|.|||  . ...  ||. ||..||. |||| .|. .|
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-p1_e-2.AA LRRK 134-386 30 8.2e-79 268.15 In-house 1-351 (351) Show / Hide 
Range on Protein: 134-386
Range on HMM: 1-351/351
Sequence Identity: 30% (108 aa)

VHIGERVGQGSFG-RVYHADWQG----------------------------SDVAVKVFLD--------------------------------QDIRSEA
. |.| .|.|.|| .|| |.|.|                            ..||.|...                                  . ...|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LEEFKREVAMIRRLRHPNIVLFMGAVTQPPNLSLVTEFCPRGSLFRILQKTKLDER-----R-----RLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLL
. || .||.....|.|||||  .|   .|  | .|.|. | |.| . |...| |..     .     .|. ||...|||.|||.. |||.|||||||| |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

V---K---------ENWTIKVCDFGLSRPKNNTFLT--SKTGVGTPEWTAPEVLR---NEPSDEKCDVYSFGVILWELATLQ-QPWAGMN----S--MQV
.   .         .. ..|..|||.||    .|..   |. ||.| | |||..|   .|  .|| |.||||.||||| |.| .|  ...    .  |  
LWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

IGAVGYLNQRLPIPDH-IEP-----GIIALMQACWSSDPKARPSFGEIMHKLKT
|       .| .|| |   |        .|.| ||. ||| ||.| .|  .|..
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-p1_e-2.AA Pkinase 134-384 27 1.4e-75 262.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

VHIGERVGQGSFGRVYHADWQGSD--VAVKVFLDQDIRSEALEEFKR--EVAMIRRLRHPNIVLFMGAVTQPPNLSLVTEFCPRG----SLFRILQ---K
 |||...|.||||.||.. ..|.   ||||..  ....|. ...  |  |... .||.||||| . .... .... .|.|.|. |    .||....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKL--DERRRLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTI----KVCDFGLSR---PKNNTFLTSKTGVGTPEWTAPEVLR-NEPSDEKCD
...  .|.   .... . .|..|.|..   |.|||||. |.|...| .|    |.|||||..     ||. .|  | .|||.. ||||.| ... . |.|
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT--TFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGVILWELATLQQPWAGM------NSMQVIGAVGYLNQRLPIPDHIE-------------------PGIIALMQACWSSDPKARPSFGEIMHK--L
..|.|.||.|... . |. |       . ||.|  ...   . ..|  ..                   .  . ..  |.  ||| ||.. .|..   .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLK-p1_e-2.AA Shk 134-384 42 5.3e-73 248.83 In-house 1-264 (269) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-264/269
Sequence Identity: 42% (113 aa)

VHIGERVGQGSFGRVYHADWQGSDVAVKVFLDQDIRSEALEEFKREVAMIRRLRHPNIVLFMGAVT-QPPNLSLVTEFCPRGSLFRIL--QKTKLD--ER
    .  |||||| || .   | .||||| . |      . .|. ||.   ...||||.||||| | ||  .. ||| .|.|.|   |  |..|..    
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

RR-LRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSR-PKNNTFLTS--KTGVGTPEWTAPEVLRNEPSDEKCDVYSFGVILWELA
.| .||..|   ||| ||   . |.|||||. |||| .||. ||||||.|   |  . |    |   ||| | ||||. | | .|| |||||| ||||..
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TLQQPWA--GMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHK--L
| | |      .  .   |.     | ||||   .    | | ||  .|. |||| ||  .  |
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRIL
Kinase MLK-p1_e-2.AA Pkinase_Tyr 134-384 33 3.2e-69 235.07 Pfam 1-270 (270) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-270/270
Sequence Identity: 33% (93 aa)

VHIGERVGQGSFGRVYHADWQ------GSDVAVKVFLDQDIRSEA--LEEFKREVAMIRRL-RHPNIVLFMGAVT--QPP-NLSLVTEFCPRGSLFRILQ
...|.  |.|.||.||.. |       . .||||.   ..  .|.  .|.| ||... . | .||||| ..|..|  . | .. .|.|..| |.|   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KT-----KLDERRRLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSRPK----NNTFLTSKTGVGTPEWTAPEVLRNEPSDEKCD
|      .|.  . | |.....|||.||..    ..||||   | ||.|| ..|.|||||.|      .  . ... |     |.|||....    .| |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSFGVILWELATL-QQP-WAGMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHKL
|.|||| .||. |. .|| ..||   .|. ...  ..|.|.|..  . |  ||. ||  ||. ||.| || ..|
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-p1_e-2.AA TyrKc 134-384 32 8.7e-68 232.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-280/280
Sequence Identity: 32% (94 aa)

VHIGERVGQGSFGRVYHADWQGSDVAVKVFLDQDIRSEALEEFKREVAMIRRL--RHPNIVLFMGAVTQP-------PNLSLVTEFCPRGSLFRILQKTK
.. |.  | | ||.||.. |   .||||.  .       .|.| ||  . ..|  .||||| . |..||.       . | .|.|..| |.|   |.|..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LDERRRLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSRPKNNT--------FLTSKTGVGTPE-----WTAPEVLRNEPSDE
  |  .  | .......||.|||.   ...||||   | ||.|| |.|..||||||   .           ..|.. |.       |.|||...     .
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KCDVYSFGVILWELATL-QQPWAG-----MNSMQVIGAVGYLNQRLPIPDH--------IEPGIIALMQACWSSDPKARPSFGEIMHKL
| ||.|||| .||. |. |||. |     |.  .||  |     |.|.|..          . .  .|. ||  ||. ||.| || ...
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_e-2.AA TK 134-384 19 7.7e-67 222.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

VHIGERVGQGSFG---RVYHA------DWQGS---------------------DVAVKVFL---DQDIRSEALEEFK---------REVAMIRRLR----
...|.  |.| ||   .|| .      .|.|.                     .||||.     ... . . .||..         .|....  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVLFMGAVTQP------------PNLSLVTEFCPRGS----LFRILQKTK----------------------------------------------
 ||||| . |..||.            . . .|.|..| |.    |   |.| .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDERRRLRMALDVSKGMNYLHRC----CPPIVHRDLKSPNLLVKENWT-----------IKVCDFG---
                               |. ...| |......|| |||..     . .|||||   | || || .           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRPKNN-TFLTSKTGVGTPE-------------------------WTAPEVLR---------NEPSDEKCDVYSFGVILWELATLQ-QPWAG-M
     |.|  .. .  ..|.. ||.                          |.|||.|.         .    .| ||.|||| .||. |.  .|..| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NS------------MQVIGAVGYL----------NQRLPIPDHIEP-------------GIIAL-MQACWSSDPKARPSFGEIMHKL
..            |. . . | |            |.| |.|  .              .... || ||. ||. ||.| .. ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-p1_e-2.AA Dicty4-Unclassified 134-384 33 2.7e-66 226.03 In-house 1-263 (263) Show / Hide 
Range on Protein: 134-384
Range on HMM: 1-263/263
Sequence Identity: 33% (89 aa)

VHIGERVGQGSFGRVYHADWQGSDVAVKVFLDQ--DIRSEALEEFKREVAMIRRLRHPNIVLFMGAVTQP----PNLSLVTEFCPRGSLFRILQ------
. |   .|.| | .|.   | | ||||| | .     | | ...||.||..   . ||| |   |.   |      .  |.|| ..| || .        
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

--KTKLDERRRLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSRPKNNTFLTSKTGVG-TPEWTAPEVLRNEPSDEKCDVYSFGV
    |||.   ...|.|. .|| .||     ..|||.|| |.|.  .  ||. |||.||   ..|    | .. || |..||.|. |    | ||||...
QQPIKLDDTLIIKYAFDIAQGMQHLHTR--NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNF--NMTTIAGTPKWESPECLMHESYNQKSDVYSYAM

ILWELATLQQPWAGMN-SMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHKL
.|.||||   |. .    | .   |     |  ||| ... .  |   ||. ||. ||.. .|  .|
MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-p1_e-2.AA TKL-ciliate2 134-385 37 7e-66 218.76 In-house 1-273 (273) Show / Hide 
Range on Protein: 134-385
Range on HMM: 1-273/273
Sequence Identity: 37% (102 aa)

VHIGERVGQGSFGRVYHADWQGSDVAVKVFLDQDIRSEALEEFKREVAMIRRLRHPNIVLFMGAVTQPPNLSLVTEFCPRGSLFRILQK--TKLDERRRL
. | ...  | .| .| | |    |||| |  .    . . .|  |   .  |||||||.|.|| |. || ... |.| ||||. .||    .|    | 
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

RMALDVSKGMNYLHRCCPPIVHRDLK--------------------SPNLLVKENWTIKVCDFGLSRPK-NNTFLTSKTGVGTPEWTAPEVLRNEPSDEK
|.|||. .|. |||   |||.|||||                    | |.|| .|   |. |||  | | .  ..| |  .||  | ||||..     ||
RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNK--IGTYQWMAPEVIKAFYYTEK

CDVYSFGVILWELATLQQPWAGMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMHKLK
 ||.|...||||.|    |. ..    |   |   | |  ||    | .  ||| ||  .   |||| ||...|.
ADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase MLK-p1_e-2.AA S_TKc 134-390 27 1.3e-61 211.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 134-390
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

VHIGERVGQGSFGRVYHADWQG--SDVAVKVFLDQDIRSEALEEFKREVAMIRRLRHPNIVLFMGAVTQPPNLSLVTEFCPR--GSLFRILQKTK-----
 .|.. .|.|.||.|| . . .    ||.|.           | ..||... .. .||||| . ..     .| .|.|.|.   |.||....| .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDERRRLRMALDVSKGMNYLHRCCPPIVHRDLKSPNLLVKENWTIKVCDFGLSRPKNNTFLTSKTGVGTPEWTAPEVLRNEPSDE-KCDVYSFGVILW
  ..| .  ...  . ....|.|.    |.|||||  |.|. |  .||.|||||.|         .| .|||.. |||||   . .  |||..|.|.||.
FPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELATLQQPWAGMNSMQVIGAVGYLNQRLPIPDHIEPGIIALMQACWSSDPKARPSFGEIMH---KLKTLPRY
|... . |.   . ....  .|             |  . ... |.  ||. ||.  |...   . |  |  
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF