MLK-Un_b

Species: S.moellendorffii
Alias: MLK-Un_b
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_b.AA Protein None 635 None Fasta, JSON
MLK-Un_b.NA RNA None 1908 None Fasta, JSON
MLK-Un_b.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_b.AA TKL 418-626 20 4.7e-34 119.45 In-house 84-364 (364) Show / Hide
Range on Protein: 418-626
Range on HMM: 84-364/364
Sequence Identity: 20% (59 aa)

HANVLPIRGIWIDGRN-------------LWAVSKLVSGGSLRDLVDRREKIELRSVLRMACDIAEGMQFLHECG--------IVHRQVNLKLSNILLDD
| |.... |. .....             |. |  ...||||....       .   .|.| ||| ||..|| ..        |.||  .|| .|||.|.
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHR--DLKSKNILVDE

NGC--------------AVIGGLRIARAIKSPTKDERSFKDGEEED--------KTSWPV------PPEV-----DLEK----------SAITPKADVYS
|.               . |. . ..| ..  ...... ... |          .|. ..      .|||     ....          .  ..|.||||
NWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME-SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

FGTLLCELVSCHTTAD-----------------QNIGKEKETPRRS-----RTTRSMPAPVVPLDCFPLLKYLIHQCWASNPLDRPDFCEILEMV
|| .|.|.... .  .                   ...... | .      .    . . . . || | .| |. .||...| .|| | |||.  
FGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase MLK-Un_b.AA TKL-Unique 441-626 26 9e-19 62.96 In-house 82-290 (290) Show / Hide
Range on Protein: 441-626
Range on HMM: 82-290/290
Sequence Identity: 26% (58 aa)

VSGGSLRDLVD----------RREKIELRSVLRMACDIAEGMQFLHECG--IVHRQVNLKLSNILLDDN-----GCAVIGGLRIARAIKSPTKDERSFK-
..||||.|. .          .  |. .  ...|| ||| || .|| |.  | ||  .|| ||.|.| |       . | .  ...  .. .|   . . 
CPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHR--DLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHK

---DGEEEDKTSWPVPPEVDLEK--SAITPKADVYSFGTLLCELVSCHT-----------TADQNIGKEKETPRRSRTTRSMPAPVVPLDCFPLLKYLIH
   . .... . | ..||| |.   . .. |.||||||. | |... .            . .| . ..... ...|       | .| .| . .. || 
GTRNQTRCGSFRW-MAPEV-LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYR-------PPIPNHCPKEYRDLIQ

QCWASNPLDRPDFCEILEMV
|||...| .|| | ||..  
QCWHHDPSQRPSFDEIIHRL

Kinase MLK-Un_b.AA UTK 416-563 25 5.4e-15 47.73 In-house 66-235 (296) Show / Hide
Range on Protein: 416-563
Range on HMM: 66-235/296
Sequence Identity: 25% (45 aa)

FA-HANVLPIRGIWIDGRNLWAVSKLVSGGSLRDLVD--------RREKIELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNG-------C
|. | |||   |.  ..  .. |. . ..|.||...         ...   |.. | || |||.|||.||.||.|||  .|   |.|.....        
FHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHR--DLAARNCLVHMHRMMWHCMMV

AVIGGLR---IARAIKSPTKDERSFKDGEEEDKTS---WPV---PPEVDLEKS-AITPKADVYSFGTLLCELVS
..|...     .|.... . .  . .. ... ...   ||.    ||. | .    | | ||.||| .. |...
CKIADFGRGGMSRRVNTFH-FSNRYWESYYYMAQHQDRWPIRWMAPEA-LTHHTRFTTKSDVWSFGVVCWEIWT

S_TKc MLK-Un_b.AA S_TKc 370-628 19 3.9e-14 30.44 SMART 1-231 (231) Show / Hide
Range on Protein: 370-628
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

LEKEEAI--------PTARARFGGEAVALELINPPGDGDRELQEEVLWLCTRSGFAHANVLPIRGIWIDGRNLWAVSKLVSG--GSLRDLVDRREK----
 |. . |          .| .  |. ||.  |.      . .. |.  |       | |.  . ... |  .|. |  ...|  |.|.|. ..| .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNGCAVIGGLRIARAIKSPTKDERSFKDGEEEDKTSWPVPPEVDLEKSAITP-KADVY
  .    . .... |.......|. ||.||   || .|||||.  .  |.   .|| .                  | | ..|||       .. |.|..
FPFPE-HARFYMYQICCALEYCHSHGIIHR--DLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCDWW

SFGTLLCELVSCHTTADQNIGKEKETPRRSRTTRSMPAPVVPLDCFPLLKYLIHQCWASNPLDRPDFCEILE-------MVAT
|.| .| |...  .  . .. .  .  .                  | .| .| .|.  .| .||   |.|.       .   
SCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MLK-Un_b.AA TK 418-483 12 1.4e-12 37.69 In-house 102-264 (486) Show / Hide
Range on Protein: 418-483
Range on HMM: 102-264/486
Sequence Identity: 12% (20 aa)

HANVLPIRGIWIDGRN------------LWAVSKLVSGGS----LRDLVDRREK----------------------------------------------
| |.. . |.  .|..            .. |  ....|.    |||   .. .                                              
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD

------------------------------IELRSVLRMACDIAEGMQFLHEC------GIVHR
                              . ..  | |...||.||..||..      ..|||
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR

TyrKc MLK-Un_b.AA TyrKc 370-626 20 3.1e-12 -24.76 SMART 1-280 (280) Show / Hide
Range on Protein: 370-626
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

LEKEEAIPT--------ARARFGGEAVALELINPPGDGDRELQEEVLWLCTRSGF--AHANVLPIRGIWIDG-------RNLWAVSKLVSGGSLRDLV-D
..... .          ....   . ||   ...     ... .|   .|    .   | |.. . |. ...         |. |  ....|.|.|   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCK---LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RREKIELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNGCAVIGGLRIARAIKSP----TKDERSFKDGEEEDKTSWPV---PPEVDLEKSA
.|.|. ..  | .. .||.||..||. ...||   |   |.|...|... |.    .|.|..       ..   | ...  || .|.   .||. . .. 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHR--DLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC-INYGK

ITPKADVYSFGTLLCELVSCHTTADQNIG------KEKETPRRSRTTRSMPAPVVPLD-----CFPLLKYLIHQCWASNPLDRPDFCEILEMV
 |.| ||.||| .. |. .    .    |      . .|  .. .. . || |  ..      | . .  .. |||. .| ||| | || |  
FTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase MLK-Un_b.AA MLK 414-502 23 8e-11 33.9 In-house 60-174 (291) Show / Hide
Range on Protein: 414-502
Range on HMM: 60-174/291
Sequence Identity: 23% (27 aa)

SGFAHAN----VLPIRGIWID-GRNLWAVSKLVSGGSLRDLV-DRREKIE-------------LRSVLRMACDIAEGMQFLHECG---IVHRQVNLKLSN
. . | |    . ...|. .. . ..  |.  ..|||| ..  ..| |..             . .... | ..|.||..||.     |.||   || .|
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR--DLKSHN

ILLDD------NGCAVI
||.|.      .| ..|
ILIDEICHDMHHGTLKI

Kinase MLK-Un_b.AA Pkinase 418-498 26 5.4e-10 36.41 Pfam 59-145 (293) Show / Hide
Range on Protein: 418-498
Range on HMM: 59-145/293
Sequence Identity: 26% (24 aa)

HANVLPIRGIWIDGRNLWAVSKLVSGG----SLRDLVD--RREKI--ELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNG
| |.. ..... |..... |  .. ||    .| |..   |. ..  . . . ...  |..|....|..||.||   ||..|||.|.||
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR--DLKPENILIDNNG

Kinase MLK-Un_b.AA NZAK 536-626 26 1.2e-09 28.11 In-house 241-329 (329) Show / Hide
Range on Protein: 536-626
Range on HMM: 241-329/329
Sequence Identity: 26% (24 aa)

PEVDLEKSAITPKADVYSFGTLLCELVSCHTTADQNIGKEKETPRRSRTTRSMPAPVVPLDCFPLLKYLIHQCWASNPLDR-PDFCEILEMV
||. .  . |. | ||.||| .  ....        |   ||        .    |..|      .| .| |||  .|. |  || .. |  
PEN-KNNHRINEKSDVWSFGCTVWQMFGYNPP--NTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL

Kinase MLK-Un_b.AA Dicty4 451-497 37 4.7e-09 26.52 In-house 99-150 (277) Show / Hide
Range on Protein: 451-497
Range on HMM: 99-150/277
Sequence Identity: 37% (20 aa)

DRREKIELR--SVLR---MACDIAEGMQFLHE--CGIVHRQVNLKLSNILLDDN
.  ..|.|    ..|   || |.| ||. ||.  . |.||   || .|.| |.|
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHR--DLKSHNLLVDKN

Kinase MLK-Un_b.AA Pkinase_Tyr 418-483 23 9.9e-09 30.19 Pfam 63-135 (270) Show / Hide
Range on Protein: 418-483
Range on HMM: 63-135/270
Sequence Identity: 23% (17 aa)

HANVLPIRGIWI-DGRN--LWAVSKLVSGGSLRDLVDR----REKIELRSVLRMACDIAEGMQFLHECGIVHR
| |..   |. . .|.   .. |  .. .|.|.|   .    .... .   | |. .||.||..|.. ...||
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHR

Kinase MLK-Un_b.AA TKL-ciliate1 443-495 35 2e-08 24.93 In-house 83-139 (279) Show / Hide
Range on Protein: 443-495
Range on HMM: 83-139/279
Sequence Identity: 35% (21 aa)

GGSLRDLVDRREK----IELRSVLRMACDIAEGMQFLHECG--IVHRQVNLKLSNILLD
.|.. |.  |  .    |     .|.  ||| |||.||     ..||  .||  |||.|
KGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHR--DLKMQNILYD

Kinase MLK-Un_b.AA RIPK 463-497 45 8.6e-08 22.6 In-house 111-145 (290) Show / Hide
Range on Protein: 463-497
Range on HMM: 111-145/290
Sequence Identity: 45% (17 aa)

RMACDIAEGMQFLHECG--IVHRQVNLKLSNILLDDN
||   |..||..||  .  | ||   ||..|||.| |
RMIHEISCGMCYLHSMNPPIIHR--DLKPENILVDNN

Kinase MLK-Un_b.AA RIPK 601-626 38 1.9e-07 21.43 In-house 265-290 (290) Show / Hide
Range on Protein: 601-626
Range on HMM: 265-290/290
Sequence Identity: 38% (10 aa)

LKYLIHQCWASNPLDRPDFCEILEMV
.. |. .||...| ||| | |. | .
MIELMQRCWQQDPNDRPCFQECEEWT

Kinase MLK-Un_b.AA TKL-ciliate1 593-626 35 3.5e-07 20.63 In-house 246-279 (279) Show / Hide
Range on Protein: 593-626
Range on HMM: 246-279/279
Sequence Identity: 35% (12 aa)

VPLDCFPLLKYLIHQCWASNPLDRPDFCEILEMV
.. || . .  |.  ||  || .||.| ||.. .
IHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL

Kinase MLK-Un_b.AA TK 594-626 25 4.1e-07 19.07 In-house 440-486 (486) Show / Hide
Range on Protein: 594-626
Range on HMM: 440-486/486
Sequence Identity: 25% (12 aa)

PLDCF--------------PLLKYLIHQCWASNPLDRPDFCEILEMV
| .|               ...  |. |||. .| |||.| ...|. 
PPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase MLK-Un_b.AA Pkinase 534-626 16 8.4e-07 25.14 Pfam 178-293 (293) Show / Hide
Range on Protein: 534-626
Range on HMM: 178-293/293
Sequence Identity: 16% (20 aa)

VPPEVDLEKSAITPKADVYSFGTLLCELVSCHTTADQNIGKEKETPRRSRTTRSMPAPVVPLDCF-----------------------PLLKYLIHQCWA
..||| .. . ..||.|..|.| .| |... ..  .. .  ...  .     .    | .. |..                       . .| .|  |..
MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

SNPLDRPDFCEILEM--V
 .| .|| . .||.   .
KDPKKRPTAEQILQHPWF

Kinase MLK-Un_b.AA MLK 593-626 35 9.2e-07 19.63 In-house 258-291 (291) Show / Hide
Range on Protein: 593-626
Range on HMM: 258-291/291
Sequence Identity: 35% (12 aa)

VPLDCFPLLKYLIHQCWASNPLDRPDFCEILEMV
.| .| . .| |..||| ..| .||.| .|..  
IPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase MLK-Un_b.AA NZAK 430-498 27 1e-06 17.74 In-house 73-142 (329) Show / Hide
Range on Protein: 430-498
Range on HMM: 73-142/329
Sequence Identity: 27% (20 aa)

DGRNLWAVSKLVSGGSLRDLV-DRREKIELRSVLR--MACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNG
|  .   ..  ..|| | ... . .   . .  ..  |  ||||.| .||  .|.||   .| .|..|| |.
DDNYHCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHR--DIKSNNVILDFNK

Kinase MLK-Un_b.AA CZAK 443-497 38 1e-06 20.24 In-house 86-145 (279) Show / Hide
Range on Protein: 443-497
Range on HMM: 86-145/279
Sequence Identity: 38% (24 aa)

GGSLRDLVDRREKIELR---SVLRMACDIAEGMQFLHE----CGIVHRQVNLKLSNILLDDN
||||| | . .    .      . || |||.|| .||       |.||   |  .|||||..
GGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHR--DLSSRNILLDHS

Kinase MLK-Un_b.AA CZAK 604-626 47 3e-06 18.75 In-house 257-279 (279) Show / Hide
Range on Protein: 604-626
Range on HMM: 257-279/279
Sequence Identity: 47% (11 aa)

LIHQCWASNPLDRPDFCEILEMV
|| .|| .||  || | .||.  
LIEMCWNKNPDERPSFKQILQHL

Kinase MLK-Un_b.AA Pkinase_Tyr 607-626 55 1.5e-05 19.41 Pfam 251-270 (270) Show / Hide
Range on Protein: 607-626
Range on HMM: 251-270/270
Sequence Identity: 55% (11 aa)

QCWASNPLDRPDFCEILEMV
|||. .| ||| | ||.|. 
QCWHYDPEDRPTFSEIHEQL

Kinase MLK-Un_b.AA Dicty4 591-628 37 1.6e-05 14.61 In-house 238-277 (277) Show / Hide
Range on Protein: 591-628
Range on HMM: 238-277/277
Sequence Identity: 37% (15 aa)

PVVPLDCFPLLKYLIHQCWASNPLDRPDFCEILEM--VAT
| .| .| | .| ||  ||  .|  || | ||..     .
PPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase MLK-Un_b.AA CZAK 546-564 52 6.8e-05 13.88 In-house 200-218 (279) Show / Hide
Range on Protein: 546-564
Range on HMM: 200-218/279
Sequence Identity: 52% (10 aa)

TPKADVYSFGTLLCELVSC
|.|.|||||| .| ... |
TEKVDVYSFGMILWCIITC

Kinase MLK-Un_b.AA UTK 604-626 39 0.000103 12.06 In-house 274-296 (296) Show / Hide
Range on Protein: 604-626
Range on HMM: 274-296/296
Sequence Identity: 39% (9 aa)

LIHQCWASNPLDRPDFCEILEMV
| |.||...| .|||| .... .
LMHRCWHYDPQERPDFEDLVQQM

Kinase MLK-Un_b.AA Dicty4 548-562 66 0.011354 4.93 In-house 197-211 (277) Show / Hide
Range on Protein: 548-562
Range on HMM: 197-211/277
Sequence Identity: 66% (10 aa)

KADVYSFGTLLCELV
|||||||| .| |..
KADVYSFGIVLWEIL

Kinase MLK-Un_b.AA TK 546-563 50 0.011746 3.87 In-house 372-389 (486) Show / Hide
Range on Protein: 546-563
Range on HMM: 372-389/486
Sequence Identity: 50% (9 aa)

TPKADVYSFGTLLCELVS
|.| ||.||| |. |...
TTKSDVWSFGVLMWEIFT

Kinase MLK-Un_b.AA RIPK 535-563 41 0.016701 4.31 In-house 190-223 (290) Show / Hide
Range on Protein: 535-563
Range on HMM: 190-223/290
Sequence Identity: 41% (14 aa)

PPEVDL--EKSAI---TPKADVYSFGTLLCELVS
|||  .  .|..|   ||| |||||. .. |. .
PPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLT

Kinase MLK-Un_b.AA TKL-ciliate1 545-563 31 0.02238 3.94 In-house 196-214 (279) Show / Hide
Range on Protein: 545-563
Range on HMM: 196-214/279
Sequence Identity: 31% (6 aa)

ITPKADVYSFGTLLCELVS
|. |.|.|..| .. .|..
INEKIDIYAYGIVMYILCF

Kinase MLK-Un_b.AA MLK 536-564 32 0.034047 3.57 In-house 202-232 (291) Show / Hide
Range on Protein: 536-564
Range on HMM: 202-232/291
Sequence Identity: 32% (10 aa)

PEVD--LEKSAITPKADVYSFGTLLCELVSC
|||   .. .  . |.||.|.| .| |....
PEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR

Kinase MLK-Un_b.AA Pkinase_Tyr 546-563 50 0.989027 3.1 Pfam 192-209 (270) Show / Hide
Range on Protein: 546-563
Range on HMM: 192-209/270
Sequence Identity: 50% (9 aa)

TPKADVYSFGTLLCELVS
| | ||.||| |. |...
TTKSDVWSFGVLMWEIFT