Gene MLK-Un_x (S.moellendorffii)
MLK-Un_x
Species: S.moellendorffii
Alias: MLK-Un_x
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MLK-Un_x.AA | Protein | None | 731 | None | Fasta, JSON |
| MLK-Un_x.NA | RNA | None | 2196 | None | Fasta, JSON |
| MLK-Un_x.kin_dom | Protein Kinase Domain | None | 107 | None | Fasta, JSON |
Protein domains of MLK-Un_x.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MLK-Un_x.AA | Pectinesterase | 385-434 | 62 | 8.7e-27 | 93.96 | Pfam | 1-50 (301) | Show / Hide |
Range on Protein: 385-434 Range on HMM: 1-50/301 Sequence Identity: 62% (31 aa) NVVVAQDGSGRYTTISAAIAAAPSRSASTYVIYIKAGTYKEKVSVPKSKT |||||.|||| |.||..|.|||| |. .|||.|||.|||.| ||| .. NVVVAKDGSGQYKTINEAVAAAPKHSEKRFVIYVKAGVYKENVEVPKKMW |
|||||||||
| Kinase | MLK-Un_x.AA | TKL | 140-245 | 22 | 1.3e-19 | 67.3 | In-house | 117-283 (364) | Show / Hide |
Range on Protein: 140-245
Range on HMM: 117-283/364
Sequence Identity: 22% (40 aa)
TEYLSGGSLYDYLHKHRSALKLPLVLRLGIDVSKGMDYRHQNN--------ILRRDFKAANLRMR------------------TRLLDFVVVRIMTAETE
.|| .||||..||| ... .|. .|...||.| |..| |. || | .|. . || | |. ...
MEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN
--------------------------TYRWMTPEVIEHK----------------LYDQKADIFSPGIVLCCLM
|.||| |||.. . |..|.|..| ||||. ..
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL
|
|||||||||
| Kinase | MLK-Un_x.AA | TKL-Unique | 140-241 | 27 | 2.5e-17 | 57.83 | In-house | 79-218 (290) | Show / Hide |
Range on Protein: 140-241
Range on HMM: 79-218/290
Sequence Identity: 27% (38 aa)
TEYLSGGSLYDYLH---------KHRSALKLPLVLRLGIDVSKGMDYRHQNN--ILRRDFKAANL----R-----MRTRLLDFVVVRIMTAE-TETYR--
.||..||||||.|| . . | . ..... ||...||.| | .. |. || | |. . .. .. || ... . . ..|..
MEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEH
-------------WMTPEVIEH--KLYDQKADIFSPGIVL
|| |||.. ..|..|.|..| ||||
KGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL
|
|||||||||
| Kinase | MLK-Un_x.AA | Dicty5 | 139-241 | 32 | 1.3e-14 | 46.66 | In-house | 77-193 (260) | Show / Hide |
Range on Protein: 139-241 Range on HMM: 77-193/260 Sequence Identity: 32% (38 aa) LTEYLSGGSLYDYLHKHRS----ALKLPLVLRLGIDVSKGMDYRHQNNILRRDFKAANL----RMRTRLLDFVVVR------IMTAETETYRWMTPEVIE .||| . ||| .|| | . .. | . ||. ..| . | || || | | . . || . | || . | || .|. VTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFN HKLYDQKADIFSPGIVL . |.||.|..| |||| GQPYHQKCDVYSFGIVL |
|||||||||
| Kinase | MLK-Un_x.AA | DRK | 140-193 | 41 | 1.9e-11 | 35.08 | In-house | 76-131 (258) | Show / Hide |
Range on Protein: 140-193 Range on HMM: 76-131/258 Sequence Identity: 41% (23 aa) TEYLSGGSLYDYLHKHRSALKLPLVLRLGIDVSKGMDYRHQNN--ILRRDFKAANL .||.. |||| || . ||......|. ||| | | | |. || | || MEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNL |
|||||||||
| Kinase | MLK-Un_x.AA | Dicty4 | 140-193 | 35 | 5.8e-11 | 32.97 | In-house | 81-145 (277) | Show / Hide |
Range on Protein: 140-193 Range on HMM: 81-145/277 Sequence Identity: 35% (23 aa) TEYLSGGSLYDYLHK----HRSALKLP--LVLR---LGIDVSKGMDYRHQ-N-NILRRDFKAANL |||.. |.|| ||. . ||. |..| ...|. .|| . | | .|. || |..|| TEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNL |
|||||||||
| Kinase | MLK-Un_x.AA | MLK | 139-193 | 28 | 7.1e-11 | 34.08 | In-house | 88-158 (291) | Show / Hide |
Range on Protein: 139-193 Range on HMM: 88-158/291 Sequence Identity: 28% (20 aa) LTEYLSGGSLYDYLHKHRS-------------ALKLPLVLRLGIDVSKGMDYRHQNN---ILRRDFKAANL ..||..|||||..|| || .. .... ....||.| |.. | .|| | |. VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNI |
|||||||||
| Kinase | MLK-Un_x.AA | LRRK | 140-192 | 31 | 1.7e-10 | 33.37 | In-house | 134-196 (351) | Show / Hide |
Range on Protein: 140-192 Range on HMM: 134-196/351 Sequence Identity: 31% (20 aa) TEYLSGGSLYDYLHKHR-SA-------LKLPLVLRLGIDVSKGMDYRHQNN--ILRRDFKAAN .||.. |.||..||... .. .. |.|.. ....|||.| | .| |. || | | MEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN |
|||||||||
| Kinase | MLK-Un_x.AA | TESK | 139-198 | 33 | 2.3e-10 | 28.5 | In-house | 71-130 (292) | Show / Hide |
Range on Protein: 139-198 Range on HMM: 71-130/292 Sequence Identity: 33% (20 aa) LTEYLSGGSLYDYLHKHRSALKLPLVLRLGIDVSKGMDYRHQNNILRRDFKAANLRMRTR ||||..||.| . | .| . ..| .|. .|| | |. .. || .| | | LTEYINGGCLEQLLADSELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQR |
|||||||||
| Kinase | MLK-Un_x.AA | TESK | 217-242 | 65 | 3.3e-10 | 27.98 | In-house | 202-227 (292) | Show / Hide |
Range on Protein: 217-242 Range on HMM: 202-227/292 Sequence Identity: 65% (17 aa) WMTPEVIEHKLYDQKADIFSPGIVLC || ||| .||.|||.|| ||||| WMAPEVLRGEWYDEKADVFSFGIVLC |
|||||||||
| Kinase | MLK-Un_x.AA | LISK | 217-242 | 53 | 2.2e-09 | 26.44 | In-house | 205-230 (296) | Show / Hide |
Range on Protein: 217-242 Range on HMM: 205-230/296 Sequence Identity: 53% (14 aa) WMTPEVIEHKLYDQKADIFSPGIVLC || ||.. . ||...|.|| ||||| WMAPEMLLGQSYDESCDVFSFGIVLC |
|||||||||
| Kinase | MLK-Un_x.AA | LISK | 139-193 | 37 | 2.5e-09 | 26.28 | In-house | 75-132 (296) | Show / Hide |
Range on Protein: 139-193 Range on HMM: 75-132/296 Sequence Identity: 37% (22 aa) LTEYLSGGSLYDYLHK---HRSALKLPLVLRLGIDVSKGMDYRHQNNILRRDFKAANL .||| .|| | .||.. | . |. |. ... |...|| | | .||. || |. |. VTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNC |
|||||||||
| Kinase | MLK-Un_x.AA | Pkinase_Tyr | 140-177 | 36 | 8.5e-09 | 30.42 | Pfam | 86-126 (270) | Show / Hide |
Range on Protein: 140-177 Range on HMM: 86-126/270 Sequence Identity: 36% (15 aa) TEYLSGGSLYDYLHKH---RSALKLPLVLRLGIDVSKGMDY .|| .|.|.|||.|| . .|... | ....|||.| MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEY |
|||||||||
| Kinase | MLK-Un_x.AA | MLK | 214-241 | 48 | 1.1e-08 | 26.41 | In-house | 196-226 (291) | Show / Hide |
Range on Protein: 214-241 Range on HMM: 196-226/291 Sequence Identity: 48% (15 aa) TYRWMTPEVI---EHKLYDQKADIFSPGIVL ||.|| |||| .. |. |.|..| |.|| TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL |
|||||||||
| S_TKc | MLK-Un_x.AA | S_TKc | 104-351 | 15 | 4.5e-08 | -58.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 104-351 Range on HMM: 1-231/231 Sequence Identity: 15% (47 aa) RSLLDHLYRGTYCGKFSAYGII--------------------------------YCFNATRFVHSYSLTEYLSG--GSLYDYLHKHRSA-----LKLPLV .|... .|.. . .. . ..| | | .||..| |.|.||..|... . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA LRLGIDVSKGMDYRHQNNILRRDFKAANL---RMRTRLLDFVVVRIMTAETETYRWMTPEVIEHKLYDQ-KADIFSPGIVLCCLMIILRPAVAVVQKYWK .. . ....| |...|. || | .|. . . . || . |..| | .| |||. |. |.|. | |..| .. | .|. .| RFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQLTTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFK DAGKQILMSDQNFVTANDRLQGKDVARGGPGRFELVSSAVKAALDGVNEELQMSEMLGGAIPDASELIRDCLSGSLSNATSSRIT-----DI-----HTW | |. .| ... | . |.| | | | KIG-------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPW M . F |
|||||||||
| Kinase | MLK-Un_x.AA | PMEI | 330-403 | 18 | 2.1e-07 | 27.79 | Pfam | 85-156 (156) | Show / Hide |
Range on Protein: 330-403 Range on HMM: 85-156/156 Sequence Identity: 18% (15 aa) DCLSGSLSNA-------TSSRITDIHTWMSSALTYHTTCFDGLSQRYQLSKFLTKPPEKAVTNVV-VAQDGSGRYTTISAAI | |. ... ... |..||.|.|.|.. || ||.. . . ... .. . | . .... || DDLQDAMQALDSSKNKWKMGDYDDVQTWLSAAMTNQDTCEDGFE----------NKEGGHMSPMTKKRNDNVTKMCSNALAI |
|||||||||
| Kinase | MLK-Un_x.AA | HH498 | 140-187 | 25 | 3e-07 | 18.61 | In-house | 82-149 (284) | Show / Hide |
Range on Protein: 140-187 Range on HMM: 82-149/284 Sequence Identity: 25% (17 aa) TEYLSGGSLYDYL--------------HKHR---SALKLPLVLRLGIDVSKGMDYRHQ---NNILRRD |.| ..|||. | | . . |. ... .|| .||.| | | || TQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRD |
|||||||||
| Kinase | MLK-Un_x.AA | Dicty4 | 217-241 | 60 | 4.5e-07 | 19.83 | In-house | 183-207 (277) | Show / Hide |
Range on Protein: 217-241 Range on HMM: 183-207/277 Sequence Identity: 60% (15 aa) WMTPEVIEHKLYDQKADIFSPGIVL || ||| |. |..||| .| |||| WMAPEVMMHQPYNEKADVYSFGIVL |
|||||||||
| Kinase | MLK-Un_x.AA | HH498 | 216-241 | 40 | 1e-06 | 16.6 | In-house | 190-216 (284) | Show / Hide |
Range on Protein: 216-241 Range on HMM: 190-216/284 Sequence Identity: 40% (11 aa) RWMTPEVIE-HKLYDQKADIFSPGIVL ||| ||| |. |.|.|| .... RWMAPEVFSQCQKYSIKVDVFSYAMCI |
|||||||||
| Kinase | MLK-Un_x.AA | LRRK | 212-241 | 30 | 2.8e-05 | 14.59 | In-house | 240-272 (351) | Show / Hide |
Range on Protein: 212-241 Range on HMM: 240-272/351 Sequence Identity: 30% (10 aa) TETYRWMTPEVIE---HKLYDQKADIFSPGIVL ... .|| ||.. . |..|.|..| |..| VGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL |
|||||||||
| TyrKc | MLK-Un_x.AA | TyrKc | 101-280 | 15 | 4.7e-05 | -140.9 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 101-280 Range on HMM: 1-280/280 Sequence Identity: 15% (43 aa) YRTRSLLDH-----LYRGTYC-----------------------GKF--SAYGIIYCFNATRFV--------HSYSLTEYLSGGSLYDYLHKHRSALKLP . | . |.||. |. . |. .. . . . ..|| ..|.| |||.||| |... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK LVLRLGIDVSKGMDYRHQNNILRRDFKA------ANLRMR------TRLLDFV--------VVRIMT--AET--ETYRWMTPEVIEHKLYDQKADIFSPG | .....||.| |..|. || | .|.... .| .. . | .. . .||| ||.| .. . | |..| | DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG IVL-----CCLMIILR-----PAVAVVQKYWKDAGKQILMSD----------------------------QNFVTANDRL ... . . . | .| |. . . . .| . ... VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | MLK-Un_x.AA | PMEI | 269-403 | 11 | 0.000252 | 5.11 | SMART | 1-162 (162) | Show / Hide |
Range on Protein: 269-403
Range on HMM: 1-162/162
Sequence Identity: 11% (21 aa)
SDQNFVTA---------------NDRLQGKDVARGGPGRFELVSSAVKAALDGVNEELQMSEMLGGAIP---------------DASELIRDCLSGSLSN
. ...... . .| .. . . .|. |.|.... .. . . .. .... . ... | |. ...
PTSKYIQSICKHTPYPDFCVSSLSSYPQ-TIPSTPSTDPKDLARIAIKVTMSQAT---KTKKFISKLLKKTKDPREKAALKDCVELYDDAVDRLNKAMEE
A--------------TSSRITDIHTWMSSALTYHTTCFDGLSQRYQLSKFLTKPPEKAVTNVVVAQDGSGRYTTISAAI
.|. . |..||.|.|.|...|| ||.. |. . |. . | . . .... |.
MKENSKKGWDWDDHDFSWDYDDVQTWLSAAMTNQDTCLDGFEE-------------KVKSPVKKRMDNMKKMCSNCLAM
|
|||||||||
| Kinase | MLK-Un_x.AA | Pkinase | 214-245 | 36 | 0.000434 | 15.54 | Pfam | 174-206 (293) | Show / Hide |
Range on Protein: 214-245 Range on HMM: 174-206/293 Sequence Identity: 36% (12 aa) TYRWMTPEVIE-HKLYDQKADIFSPGIVLCCLM |...| |||| .. |..|.|..| |..| ... TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML |
|||||||||
| Kinase | MLK-Un_x.AA | DRK | 217-241 | 48 | 0.000634 | 9.22 | In-house | 168-192 (258) | Show / Hide |
Range on Protein: 217-241 Range on HMM: 168-192/258 Sequence Identity: 48% (12 aa) WMTPEVIEHKLYDQKADIFSPGIVL | ||| | |||..| .||| WTAPEVLRNQRYTEKADVYSFAIVL |
|||||||||
| Kinase | MLK-Un_x.AA | Pkinase_Tyr | 216-241 | 34 | 0.081582 | 6.77 | Pfam | 179-204 (270) | Show / Hide |
Range on Protein: 216-241 Range on HMM: 179-204/270 Sequence Identity: 34% (9 aa) RWMTPEVIEHKLYDQKADIFSPGIVL .|| ||.| .. . | |. | |... KWMAPECINYGKFTTKSDVWSFGVLM |
|||||||||
| Kinase | MLK-Un_x.AA | Pkinase | 140-193 | 24 | 0.138136 | 6.69 | Pfam | 79-139 (293) | Show / Hide |
Range on Protein: 140-193 Range on HMM: 79-139/293 Sequence Identity: 24% (15 aa) TEYLSGG----SLYDYLH-KHRSAL--KLPLVLRLGIDVSKGMDYRHQNNILRRDFKAANL .||. || .|.||.. . . .. . . . .|..| |...|. || | .|. MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI |
|||||||||
| Pectinesterase | MLK-Un_x.AA | Pectinesterase | 444-647 | 55 | 1.3e-122 | 418.45 | Pfam | 86-293 (301) | Show / Hide |
Range on Protein: 444-647 Range on HMM: 86-293/301 Sequence Identity: 55% (116 aa) INGRGFLCRDLTIQNTAGAAKQQAVALRVSEVKVAFYKCTFEGYQDTLYTHVMRQFYRECTVYGTVDFIFGDAAAVFQSCTILARVPMDKQKNTLTAQGR ..|.||..|| |.|||||..| |||||||. . .||.| ..|||||||.| .|||||.|..|||||||||.||||||.|.|.|| ||. |.|. ||||| VVGDGFMARDMTFQNTAGPEKHQAVALRVGADRSVFYRCRMDGYQDTLYVHSHRQFYRDCDIYGTVDFIFGNAAAVFQNCNIVARKPMPNQQNMITAQGR TDPNQNTGLAFQDCTLDGTDDLK--KSGTQTYLGRPWKQYSRTVFLRCYEISVIDPAGWLAWSGNFALKTLFYAEYQCKGPGSGTGSTVSWSR-Q-LNSY .|||||||. .. |. .. ||. |. ..||||||||.|||||.. .| ..||||||. |.|.|||.||.|.||. .|||..|. |.|. . ..| KDPNQNTGIVIHNCRITADPDLMPVKNTFKTYLGRPWKEYSRTVIMQSYIDDFIDPAGWMPWNGDFALDTLYYGEYMNSGPGADTSKRVKWPGYHVIMSD AEASKYTP .||.|.|. EEAMKFTV |
|||||||||