Gene MLK-Un_ab (S.moellendorffii)

MLK-Un_ab

Species: S.moellendorffii
Alias: MLK-Un_ab
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_ab.AA Protein None 448 None Fasta, JSON
MLK-Un_ab.NA RNA None 1347 None Fasta, JSON
MLK-Un_ab.kin_dom Protein Kinase Domain None 175 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_ab.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_ab.AA TKL 207-439 16 1.3e-17 60.05 In-house 32-364 (364) Show / Hide 
Range on Protein: 207-439
Range on HMM: 32-364/364
Sequence Identity: 16% (56 aa)

KVILVQS-----------------------------HETKKEVAILEKLSL-HECILEFLGIFPYGES------------KPYLVFERPSEEMTT-LDEL
|.. ...                              . ..|. |. ...| |. |. |.|.  ....            ....| |    .  . |. |
KKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYC--PGGSLLHYL

INKNPGSFMSDWRVKRQIALELARGMRDSHLAG--------VVHKNFRSSNIFLSGDLQH-------------AKIFGF-----YQGRIKLEPSAKKWM-
.          | .. ..||. ||||   |  .        ..| .  |.||..  ....             .||  |      ... . . .... | 
H----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME

----------NDEQV---RWAAPEQVQRHRP--------------AFDEKCDIYSLGVVIWELITGNFPFAKYTNYRKL---------TRDRDENVA-LL
          .  |.   || |||  . . .               ..||||.|| |.|.||..|.  |...| ..  .           . |..   ..
SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPI

DDFPVE-----CKAGELGKFSRISELCRDPLPDNRPSLENIINDL
.. . .     .    .  .... . | |. |..||| . |.  |
PPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_ab.AA TKL-Unique 256-439 20 2.1e-15 50.97 In-house 83-290 (290) Show / Hide 
Range on Protein: 256-439
Range on HMM: 83-290/290
Sequence Identity: 20% (43 aa)

EMTTLDELINK--------NPGSFMSDWRVKRQIALELARGMRDSHLAG--VVHKNFRSSNIFLSGDL----QHAKIFGFYQGRIKLEPSAKKWM-----
.. .|.....         |. . .. . .. ..|.  |.||   |  .  . | . .|||. .. ..      .|| .|   ...   ....       
PGGSLYDVLHQNNNNNNNNNNNCKLN-MQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGT

-NDEQV---RWAAPEQVQRHRPAFDEKCDIYSLGVVIWELITGNF------PFAKYTNY--RKLTRDRDENVALLDDFPVECKAGELGKFSRISELCRDP
 |.. .   ||.|||   .    ..||.|.|| |.| ||..|.        |. ... .  ... ... ||  .    | .|       .. . . |...
RNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRP--PIPNHC----PKEYRDLIQQCWHH

LPDNRPSLENIINDL
 |..|||...||. |
DPSQRPSFDEIIHRL
S_TKc MLK-Un_ab.AA S_TKc 191-443 15 4.3e-12 0.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-443
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)

YMISATLTDNSSSVSRKVILVQSHE----------TKKEVAILEKLSLHECILEFLGIFPYGESKPYLVFERPSEEMTTLDELINKNPGSF----MSDWR
| |  ..   . .. .|.. . ...          ...|..||.|   |. |  ....|    .. |.|.|  .    .| ..| |...      ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

VKRQIALELARGMRDSHLAGVVHKNFRSSNIFLSGDLQHAKI--FGFYQGRIKLEPSAKKWMNDEQV---RWAAPEQVQRHRPAFDE-KCDIYSLGVVIW
... .. ......   |  |..|     .||.|.    | ||  ||.                . ..    . ||| .      ..  |||..|.|....
ARF-YMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILY

ELITGNFPFAKYTNYRKLTRDRDENVALLDDFPVECKAGELGKFSRISELCR-------DPLPDNRPSLENIIN-----DLHKLL
|...|  ||    .. .. .                           |. ..       .  |..||.   . .      .|  .
EMLCGYPPFP---QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_ab.AA MLK 341-382 40 6.8e-11 34.16 In-house 197-240 (291) Show / Hide 
Range on Protein: 341-382
Range on HMM: 197-240/291
Sequence Identity: 40% (18 aa)

VRWAAPEQVQR-HRPAFDEKCDIYSLGVVIWELITGNFPFA-KY
..| |||  |.     ..||||..| |||.||..|.  |..  |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHY
Kinase MLK-Un_ab.AA LZK 341-380 50 1.2e-09 28.61 In-house 151-188 (241) Show / Hide 
Range on Protein: 341-380
Range on HMM: 151-188/241
Sequence Identity: 50% (20 aa)

VRWAAPEQVQRHRPAFDEKCDIYSLGVVIWELITGNFPFA
| | ||| | |  |   || ||.| ||| ||. |.  |..
VAWMAPE-VIRNEPC-SEKVDIWSFGVVLWEMLTCEIPYK
Kinase MLK-Un_ab.AA MSK 344-380 40 1.2e-09 28.72 In-house 172-211 (277) Show / Hide 
Range on Protein: 344-380
Range on HMM: 172-211/277
Sequence Identity: 40% (16 aa)

AAPEQVQR---HRPAFDEKCDIYSLGVVIWELITGNFPFA
.||| ..|   . . .|| ||..||||.  .. ||  ||.
MAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQ
Kinase MLK-Un_ab.AA STE 343-388 38 1.5e-09 29.98 In-house 228-277 (359) Show / Hide 
Range on Protein: 343-388
Range on HMM: 228-277/359
Sequence Identity: 38% (19 aa)

WAAPEQVQRH----RPAFDEKCDIYSLGVVIWELITGNFPFAKYTNYRKL
| ||| .|.     ..  |.||||.||| .|.|..||. |...... | .
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAM
Kinase MLK-Un_ab.AA Pkinase 342-379 28 4.5e-09 33.15 Pfam 176-212 (293) Show / Hide 
Range on Protein: 342-379
Range on HMM: 176-212/293
Sequence Identity: 28% (11 aa)

RWAAPEQVQRHRPAFDEKCDIYSLGVVIWELITGNFPF
...||| .. ...  . |.|..|.|....|...|..||
WYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase MLK-Un_ab.AA AGC 345-379 35 5.8e-09 17.78 In-house 275-305 (395) Show / Hide 
Range on Protein: 345-379
Range on HMM: 275-305/395
Sequence Identity: 35% (13 aa)

APEQVQRHRPAFDEKCDIYS--LGVVIWELITGNFPF
||| .       .  ||..|  ||... |..||  ||
APEIL------YGKACDWWSFGLGCLMYEMLTGYPPF
Kinase MLK-Un_ab.AA TAK1 342-384 29 7.5e-09 25.92 In-house 168-230 (284) Show / Hide 
Range on Protein: 342-384
Range on HMM: 168-230/284
Sequence Identity: 29% (19 aa)

RWAAPEQ---------------------VQRHRPAFDEKCDIYSLGVVIWELITGNFPFAKYTN
|| |||                      | |...  ..|||||| |.. ||.|. . |. .. |
RWMAPEVRELFDFKSNRIIINQPTGFQKVFRCEK-YNMKCDIYSWGIIMWEVISRKHPYDHIMN
Kinase MLK-Un_ab.AA Ciliate-E2 345-379 38 9.1e-09 26.2 In-house 255-296 (365) Show / Hide 
Range on Protein: 345-379
Range on HMM: 255-296/365
Sequence Identity: 38% (16 aa)

APEQVQR-------HRPAFDEKCDIYSLGVVIWELITGNFPF
||| ...        .   |.||||.||||.. |...|..||
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase MLK-Un_ab.AA Pkinase_Tyr 341-386 33 1e-06 22.99 Pfam 178-223 (270) Show / Hide 
Range on Protein: 341-386
Range on HMM: 178-223/270
Sequence Identity: 33% (16 aa)

VRWAAPEQVQRHRPAFDEKCDIYSLGVVIWELIT-GNFP-FAKYTNYR
..| |||  .  .  | .| |..| ||..||..| |  | ..  .|..
IKWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE
TyrKc MLK-Un_ab.AA TyrKc 174-439 16 5e-06 -125.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 174-439
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

LTAVQ-------GVVTVGEALAGDYMISA---TLTDNSSSVSRKVILVQSHETKKEVAILEKL-SLHECILEFLGIFPYGE------SKPYLVFERPSEE
.|  .       |.|  |..      |     .| ...             .  .|  |. ||   |..|. ..|.   ..        ...|.|    .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME--YMP

MTTLDELINKNPGSFMSDWRVKRQIALELARGMRDSHLAGVVHKNFRSSNIFLSGDLQHAKI-------FGFYQ-------GRIKL--EPSAKKWMNDEQ
   |.. . |. .     .. . ....  |.||.  |  ...|      |. .. .. ..||       ..            ..   . ..| ..    
HGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP---

VRWAAPEQVQRHRPAFDEKCDIYSLGVVIWELIT-GNFPFAK-----YTNYRKLTRDRDENVALLDDFPVE-------CKAGELGKFSRISELCRDPLPD
.|| |||  . ..  | .| |..| ||..||. | |  |         .|.. . . .. .     . | .       |   |.  .. | . | .  |.
IRWMAPECINYGK--FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY---RMPQPPNDYPMSFVCCPDEM--YQ-IMKQCWHEDPE

NRPSLENIINDL
.||. ..|. ..
DRPTFSEIHECF
Kinase MLK-Un_ab.AA Dicty4-Unclassified 341-379 33 6e-06 16.45 In-house 172-208 (263) Show / Hide 
Range on Protein: 341-379
Range on HMM: 172-208/263
Sequence Identity: 33% (13 aa)

VRWAAPEQVQRHRPAFDEKCDIYSLGVVIWELITGNFPF
..| .|| . .|  ..  | |.|| ... .||.||. |.
PKWESPE-CLMHE-SYNQKSDVYSYAMMLYELATGDEPY
Kinase MLK-Un_ab.AA Dicty4-Unclassified 426-439 42 0.003539 6.69 In-house 250-263 (263) Show / Hide 
Range on Protein: 426-439
Range on HMM: 250-263/263
Sequence Identity: 42% (6 aa)

PDNRPSLENIINDL
|  ||... ||. |
PNKRPTMNQIIQYL
Kinase MLK-Un_ab.AA Dicty4-Unclassified 281-307 37 0.030477 3.44 In-house 114-140 (263) Show / Hide 
Range on Protein: 281-307
Range on HMM: 114-140/263
Sequence Identity: 37% (10 aa)

IALELARGMRDSHLAGVVHKNFRSSNI
.|.. |.||   |   ..|   .||||
YAFDIAQGMQHLHTRNFIHRDIKSSNI
Kinase MLK-Un_ab.AA Pkinase 207-251 19 0.038798 8.64 Pfam 31-80 (293) Show / Hide 
Range on Protein: 207-251
Range on HMM: 31-80/293
Sequence Identity: 19% (10 aa)

KVILVQSHETKK-------EVAILEKLSLHECILEFLGIFPYGESKPYLVFE
.. ..  .. |.       |..|. .|. |..|......| . ....|.|.|
IIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVME
Kinase MLK-Un_ab.AA Pkinase_Tyr 426-439 35 2.596918 1.68 Pfam 257-270 (270) Show / Hide 
Range on Protein: 426-439
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PDNRPSLENIINDL
|..||. . |...|
PEDRPTFSEIHEQL