Gene MLK-Un_p-1 (S.moellendorffii)

MLK-Un_p-1

Species: S.moellendorffii
Alias: MLK-Un_p-1
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_p-1.AA Protein None 351 None Fasta, JSON
MLK-Un_p-1.NA RNA None 1056 None Fasta, JSON
MLK-Un_p-1.kin_dom Protein Kinase Domain None 171 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_p-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_p-1.AA TKL 108-338 20 3.2e-24 84.12 In-house 70-364 (364) Show / Hide 
Range on Protein: 108-338
Range on HMM: 70-364/364
Sequence Identity: 20% (63 aa)

ETELAILKRLSES-HVNILQFFGTYVDGKT-------------KYAVMERPGKEISTLDEFIHNKPELKDGHWSLKKNFALEIAMGLQYAHA--------
..|   .. .|   | ||.|| |   ...               . |||    .  .| ...|         |... ..||.|| |..| |.        
FFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYC--PGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTK

VGVVHKNLRSPNIFIDDS------------QDLRPKIFGF----------NQGRI--------EALKSDKRPQSKEQV---RWKAPEMLPQA--------
 ...| .| |.||..|.              | ..||  |          |. ..        | .. . | ..  |.   || |||.| ..        
PPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE-HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVG

--NRAIRRPEYSYACDIFSLGVVMWEIVTWSFPFEQIKGVRGVLE---ARARRGMTLDFSALPPGDR----------SPALQAFVQISMDCMEQDSGTRP
     ..  ||| .||..| |.|.|||.|   |.....    ..         .  ...  .|. ..          ..... . .. .||...|   ||
IDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP

NVDEVVERL
. .|...||
SFQEILKRL
Kinase MLK-Un_p-1.AA TKL-Unique 108-279 22 1.3e-16 55.23 In-house 43-237 (290) Show / Hide 
Range on Protein: 108-279
Range on HMM: 43-237/290
Sequence Identity: 22% (46 aa)

ETELAILKRLSESHVNILQFFGTYV----DGKTKYAVMERPGKEISTLDEFIH-------NKPELKDGHWSLKKNFALEIAMGLQYAHAVG--VVHKNLR
| |. ..|.| . | ||....|. .    . .  . |||   .. ..|.. .|       | .. ..  .... ..|. || |. | |  .  . | .|.
ENEVNWMKKL-HYHPNIVHYMGYCMDHQVYPPNMCIVMEY--CPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLK

SPNIFIDDS---QDLRPKIFGFNQGRIEA--LKSDKR-------PQSKEQVRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTWSF------PF
|.|. .|       .. || .|.  .. .  .|. ..       .  .   || |||.| . .       ||  .|..| |.|.|||.|.        |.
SSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-----CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY

EQI
. .
QGM
Kinase MLK-Un_p-1.AA TK-Unique 171-271 29 1.4e-15 50.26 In-house 135-234 (294) Show / Hide 
Range on Protein: 171-271
Range on HMM: 135-234/294
Sequence Identity: 29% (31 aa)

NFALEIAMGLQYAHA--VGVVHKNLRSPNIFIDDSQDLRPKIFGF---NQGRIEALKSDKRPQSKEQVRWKAPEMLPQANRAIRRPEYSYACDIFSLGVV
.|| .||.|..| .    ..||..| . |... .  |.. || .|     .. .   | .. |.. ..|| ||| |  .    ... ...  |. |.||.
HFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWSFGVL

MWEIVT
||||.|
MWEIFT
Kinase MLK-Un_p-1.AA TK 151-338 12 1.5e-13 41.03 In-house 146-486 (486) Show / Hide 
Range on Protein: 151-338
Range on HMM: 146-486/486
Sequence Identity: 12% (44 aa)

LDEFIHNKPELKDGHWSLKKN------------------------------------------------------------------------FALEIAM
|... ..... .  . . . |                                                                        ... || 
LRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIAC

GLQYAHAV------GVVHKNLRSPNIFIDDSQD---------LRPKIFGFN--------QGRIEALKSDKRPQS--------------------------
|..| |.       ..|| .|   |. ....           .  ||  |           |    ..| . .|                          
GMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGG

KEQVRWKAPEMLPQANRAIR--RPEYSYACDIFSLGVVMWEIVTWS-FPFEQIKGV--------RGVLEARARRGMTLDFS--------ALPPGDRSPAL
|  .|| ||| |             .. . |..|.||.||||.|    |.                 .  . ||| .| .          ...     . 
KLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCP

--------------QAFVQISMDCMEQDSGTRPNVDEVVERL
              ... .. ..| . |   ||. ....|.|
DWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_p-1.AA RAF 173-340 23 3.3e-13 38.86 In-house 109-282 (282) Show / Hide 
Range on Protein: 173-340
Range on HMM: 109-282/282
Sequence Identity: 23% (43 aa)

ALEIAMGLQYAHAVGVVHKNLRSPNIFIDDSQDLRPKIFGFNQGRIEALKSDKRPQSKEQ----VRWKAPEMLP------QANRAIRRPE-YSYACDIFS
.. .. |. | ||  ..|  |.| ||| ..  |.. ||  |   ... . | .. |  ||    . | |||         . .  ..    ||   |..|
SRQVCQGMDYLHAKNIIHRDLKSNNIFLHE--DMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYS

LGVVMWEIVTWSFPF-EQIKGVRGVLEARARRGMTLDFSALPPGDRSPALQAFVQISMDCMEQDSGTRPNVDEVVERLSQ
 |.||.|..| . |.  .|.    ..    |  .  | |..    |. . .|  .   ||.. .   ||   ....|.  
FGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKV----RQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
S_TKc MLK-Un_p-1.AA S_TKc 78-342 17 3.6e-12 1.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 78-342
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

YDEHTL----------CATLEQPGSSSATRVLLLYSEDLGETELAILKRLSESHVNILQFFGTYVDGKTKYAVMERPGKEISTLDEFIHNKPE------L
|. . .          ...    |   |  ..     .  . |..|||.    | || .......| .  | |||  .    .| ..|....       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KDGHWSLKKNFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDSQDLRPKIFGFNQGRIEALKSDKRPQSKEQV---RWKAPEMLPQANRAIRRPEYSY-AC
   |    . .. .|. .|.| |  |..|  |   ||..|.    . ||  |   |.           . ..    . |||.|           |.. .|
PE-H---ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----------TTFCGTPWYMAPEVL----------GYGKCKC

DIFSLGVVMWEIVTWSFPFEQIKGVRGVLEARARRGMTLDFSALPPGDRSPALQAFVQISMDCMEQDSGTRPNVDEVVE-----RLSQLV
|. |.|....| ..   ||.        ...  .. .            || .  |.   . |.. |   || . |. .     .. . .
DWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG------------SPEAKDFI---RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc MLK-Un_p-1.AA TyrKc 100-338 18 6.8e-10 -62.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 100-338
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

LLYSEDLGE-----------------------------TELAILKRLSESHVNILQFFGTYVDG-------KTKYAVMERPGKEISTLDEFIHNKPELKD
.   . |||                              |. |...|  .| ||....|  ...       .  . |||   .  . |....... .   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GD-LKDYLRKHRPK--

GHWSLKKNFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDSQDLRPKI-------FGFNQ---GRIEALKSDKRP----QSK--EQVRWKAPEMLPQANRA
  .. . .|.. || | .| |  ...|  |   |. ... .  . ||       .. .    |   . |. .|.    ..|    .|| ||| .      
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI------

IRRPEYSYACDIFSLGVVMWEIVTWSFPFEQI-----KGVRGVLEARARRGMTLDFSALPPGDRSP-----ALQAFVQISMDCMEQDSGTRPNVDEVVER
 .  ... . |..| ||.|||| |   .         .  . |.| . ..|. ..  . .     |     . ..  ||  .| . |   ||.  |..|.
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE-YVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase MLK-Un_p-1.AA Ciliate-E2 170-276 21 1.3e-09 29.18 In-house 163-296 (365) Show / Hide 
Range on Protein: 170-276
Range on HMM: 163-296/365
Sequence Identity: 21% (31 aa)

KNFALEIAMGLQYAHAVG-VVHKNLRSPNIFIDDSQDLRPKIFGFNQGRIEALKSDKR---PQSKEQVRWK-----------------------------
.... .|  .|.| |  . ..| ..   ||..       .||  |   ..   ....|   .|.|.    |                             
EFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM

APEMLP------QANRAIRRPEYSYACDIFSLGVVMWEIVTWSFPF
|||.|       |    . . .|.|.|||.||||.. | ..  .||
APEILNGKKYDNQ----QKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase MLK-Un_p-1.AA MLK 233-281 36 2.7e-09 28.54 In-house 197-242 (291) Show / Hide 
Range on Protein: 233-281
Range on HMM: 197-242/291
Sequence Identity: 36% (18 aa)

VRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTWSFPFE-QIKG
..| |||.. |    .|   || .||..| |||.||..|   |..  ...
YAWMAPEVIQQ----FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDP
Kinase MLK-Un_p-1.AA LRRK 151-200 36 2.8e-07 21.78 In-house 142-199 (351) Show / Hide 
Range on Protein: 151-200
Range on HMM: 142-199/351
Sequence Identity: 36% (21 aa)

LDEFIHNKPELK------DGHWSLKKNFALEIAMGLQYAHAVG--VVHKNLRSPNIFI
|..|.||| . .      .  |.||   ||.|| |..| |     ..| .|.||||..
LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL
Kinase MLK-Un_p-1.AA UTK 233-272 40 3.2e-07 20.76 In-house 203-236 (296) Show / Hide 
Range on Protein: 233-272
Range on HMM: 203-236/296
Sequence Identity: 40% (16 aa)

VRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTW
.|| ||| | ..        .. . |..|.|||.|||.||
IRWMAPEALTHHT------RFTTKSDVWSFGVVCWEIWTW
Kinase MLK-Un_p-1.AA LISK 108-207 24 3e-06 16.31 In-house 44-141 (296) Show / Hide 
Range on Protein: 108-207
Range on HMM: 44-141/296
Sequence Identity: 24% (25 aa)

ETELAILKRLSESHVNILQFFGTYVD-GKTKYAVMERPGKEIS--TLDEFIHNKPE-LKDGHWSLKKNFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDS
. |....|.|  .| ||.||.| ..   .  ..| |     |.  .| ........  ..  |... ..|| || |. | |. ...|  | | |. ....
LREVQMMKNL--RHPNIVQFMGVCYHNDGQLHIVTEY----INGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVREN

QDLR
 . .
DNNQ
Kinase MLK-Un_p-1.AA Pkinase 109-190 26 3e-06 23.35 Pfam 49-131 (293) Show / Hide 
Range on Protein: 109-190
Range on HMM: 49-131/293
Sequence Identity: 26% (23 aa)

TELAILKRLSESHVNILQFFGTYVDGKTKYAVMERPGKE--ISTLDEFIH--NKPELKDGHWSLKKNFALEIAMGLQYAHAVGVVH
.|..|.|||.  | ||....... |..  | |||  ..      | ..|.  ..  .  . .   |.....|. ||.| |. |..|
SEIQIMKRLN--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIH
Kinase MLK-Un_p-1.AA Pkinase 234-338 16 4e-06 22.93 Pfam 176-293 (293) Show / Hide 
Range on Protein: 234-338
Range on HMM: 176-293/293
Sequence Identity: 16% (21 aa)

RWKAPEMLPQANRAIR-RPEYSYACDIFSLGVVMWEIVTWSFPFEQI----KGVRGVLEARARRGMTLDFSALPPGDRS-----------------PALQ
.. |||        || ...|....|..|.|....| ..  .|| .     . ..     . ..|  |.|.   . ..|                 ....
WYMAPEV-------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

AFVQISMDCMEQDSGTRPNVDEVVER--L
 |.    .| ..|   ||. .....   .
DFIK---WCLCKDPKKRPTAEQILQHPWF
Kinase MLK-Un_p-1.AA LISK 252-271 50 3.4e-05 12.61 In-house 215-234 (296) Show / Hide 
Range on Protein: 252-271
Range on HMM: 215-234/296
Sequence Identity: 50% (10 aa)

EYSYACDIFSLGVVMWEIVT
.|...||.|| |.|. ||.|
SYDESCDVFSFGIVLCEIIT
Kinase MLK-Un_p-1.AA TKL-Unique 319-338 40 0.000375 10.75 In-house 271-290 (290) Show / Hide 
Range on Protein: 319-338
Range on HMM: 271-290/290
Sequence Identity: 40% (8 aa)

DCMEQDSGTRPNVDEVVERL
.|  .|.  ||..||...||
QCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_p-1.AA LRRK 258-282 30 0.000498 10.13 In-house 264-289 (351) Show / Hide 
Range on Protein: 258-282
Range on HMM: 264-289/351
Sequence Identity: 30% (8 aa)

DIFSLGVVMWEIVTWS-FPFEQIKGV
|..| |...||..| . .||......
DCYSFGMILWELLTRQHHPFDEHDFF
Kinase MLK-Un_p-1.AA MLK 318-338 33 0.000953 9.03 In-house 271-291 (291) Show / Hide 
Range on Protein: 318-338
Range on HMM: 271-291/291
Sequence Identity: 33% (7 aa)

MDCMEQDSGTRPNVDEVVERL
..|..||.. ||. ...|. |
KQCWNQDPHKRPSFRQIVQHL
Kinase MLK-Un_p-1.AA Pkinase_Tyr 247-271 40 0.001498 12.65 Pfam 185-209 (270) Show / Hide 
Range on Protein: 247-271
Range on HMM: 185-209/270
Sequence Identity: 40% (10 aa)

AIRRPEYSYACDIFSLGVVMWEIVT
.|.  ... . |. | ||.||||.|
CINYGKFTTKSDVWSFGVLMWEIFT
Kinase MLK-Un_p-1.AA LISK 312-338 33 0.001937 6.81 In-house 270-296 (296) Show / Hide 
Range on Protein: 312-338
Range on HMM: 270-296/296
Sequence Identity: 33% (9 aa)

AFVQISMDCMEQDSGTRPNVDEVVERL
.|... .|| . |  .||. .|.|..|
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase MLK-Un_p-1.AA LRRK 318-340 39 0.00276 7.46 In-house 329-351 (351) Show / Hide 
Range on Protein: 318-340
Range on HMM: 329-351/351
Sequence Identity: 39% (9 aa)

MDCMEQDSGTRPNVDEVVERLSQ
..| ..|   ||   ..|.||||
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-Un_p-1.AA UTK 108-207 23 0.004274 6.44 In-house 56-165 (296) Show / Hide 
Range on Protein: 108-207
Range on HMM: 56-165/296
Sequence Identity: 23% (27 aa)

ET-ELAILKRLSESHVNILQFFGTYVDGKTKYAVMERPGKEISTLDEFIH-NKPELK-DGHWSLKKN---FALEIAMGLQYAHAVGVVHKNLRSPNIFID
|. ||...|...  |.|.|.. |. ....  . |.|    | . |. .   ..|..  ..||  .     .|. || |.|| |  |.|| .|   |....
EARELQMMKQFH-WHPNVLRLVGVCTQEEPWMIVTEY--MENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVH

DS-------QDLR
..       .. .
MHRMMWHCMMVCK
Kinase MLK-Un_p-1.AA MLK 171-210 34 0.029672 3.78 In-house 128-174 (291) Show / Hide 
Range on Protein: 171-210
Range on HMM: 128-174/291
Sequence Identity: 34% (16 aa)

NFALEIAMGLQYAHAVG---VVHKNLRSPNIFIDD----SQDLRPKI
|.|| .| |..| |.     ..|  | |.|| ||.     ...  ||
NWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKI
Kinase MLK-Un_p-1.AA UTK 315-338 20 0.052813 2.65 In-house 273-296 (296) Show / Hide 
Range on Protein: 315-338
Range on HMM: 273-296/296
Sequence Identity: 20% (5 aa)

QISMDCMEQDSGTRPNVDEVVERL
.. ..|...|   ||. ...|...
RLMHRCWHYDPQERPDFEDLVQQM
Kinase MLK-Un_p-1.AA Pkinase_Tyr 171-203 21 0.881078 3.27 Pfam 115-147 (270) Show / Hide 
Range on Protein: 171-203
Range on HMM: 115-147/270
Sequence Identity: 21% (7 aa)

NFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDS
.....||.|..| .. . .|  |.  |. ....
QMCWQIAKGMEYLESKNCIHRDLAARNCLVTEN