Gene MLKx_g (S.moellendorffii)

MLKx_g

Species: S.moellendorffii
Alias: MLKx_g
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_g.AA Protein None 1173 None Fasta, JSON
MLKx_g.NA RNA None 3522 None Fasta, JSON
MLKx_g.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of MLKx_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_g.AA TKL 234-486 24 1.6e-74 253.85 In-house 1-364 (364) Show / Hide 
Range on Protein: 234-486
Range on HMM: 1-364/364
Sequence Identity: 24% (91 aa)

IGSGAFGSVYKAEWLG----------APVAVKEFRSGDASF----------------------------DKEVNILKELILEPHPSVLQMIGYYQKDEK-
||||.|| |||..| |           .|||| |.| . ..                            ..|.. .. ..   || ..|..|| .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYLVMELM-ERD-LTSVIRKAEGSLQLLTSVDIMLQIASGMSYLHQRN--------VVHRDLKPSNVLVKT-LK-------NHACTTC
             ..|||..   . |  ..        .   ....|.||.||.|||..|        ..|||||..|.||.  ..       |.. . |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

FDARLTDFGVSKSNFISFAPD------------------LSYQRGTIQYMAPEMLRGQ----------------KYSREVDVYSFGITCFQILTGTLPFQ
  . ..||| |.... |.                     .. |.||...||||.||||                .||  .|||||||  . |||. .|..
--CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DDGKQLVA------DKLVEAIEDGNRPDLP------------TGCPLELVVLLNRCWNRNPKDRPTFEQISRML
|..   .       . .. ....|.|| .|            . || ..  |. .||. .|..||.|..|   |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKx_g.AA S_TKc 228-488 24 1.4e-69 238.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 228-488
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LELKTLIGSGAFGSVYKAEWLG--APVAVKEFRSGDASFDKEVNILKELILEPHPSVLQMIGYYQKDEKAYLVMELMER---DLTSVIRKAEGS-----L
 |.  .||.||||.|||. . .    ||.|. .    .. .|..|||.     || . ......|  .. |.|||...    || ..|.|  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACTTCFDARLTDFGVSKSNFISFAPDLSYQRGTIQYMAPEMLRGQKYSR-EVDVYSFG
   .   .| ||.... |.|.....||||||.|.|. .             ..|||...          . . ||  |||||.|   .|.. ..|..|.|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

ITCFQILTGTLPFQDDGKQLVADKLVEAIEDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISR-------MLWS
.. .  |.|  ||.    |.. .|..               . |.  ....|....|..|||  .. .       . | 
CILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_g.AA Pkinase 228-486 26 8.9e-67 232.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 228-486
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

LELKTLIGSGAFGSVYKAEWLGAP--VAVKEFRSGDASFDK--------EVNILKELILEPHPSVLQMIGYYQKDEKAYLVMELMER-----DLTSVIR-
....  ||||.||.|||. . | .  ||||...  ... .|        |. |.|.|    || ......... . . |.|||..|      || ..|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KAEGSL--QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACTTCFDARLTDFGVSK--SNFISFAPDLSYQRGTIQYMAPEMLR-GQKY
...|..  .  .  ..|.||..|. |.|.....||||||.|.|..  ..| ..   . ...|||..|  .  .   . ..   ||. ||||| .| ||.|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA---CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

SREVDVYSFGITCFQILTGTLPFQDD----GKQLVADKLVEAIEDGNRPDLPTGCP-------------------LELVVLLNRCWNRNPKDRPTFEQIS
...||..|.|..... |.| .||...    .      ....  .  .. | |. |.                    |.  ....|....||.|||.||| 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

RM--L
    .
QHPWF
Kinase MLKx_g.AA MLK 228-486 27 3.8e-61 209.46 In-house 1-291 (291) Show / Hide 
Range on Protein: 228-486
Range on HMM: 1-291/291
Sequence Identity: 27% (82 aa)

LELKTLIGSGAFGSVYKAEWLGAP-----VAVKEFR--------SG--DASFDKEVNILKELILEP-HPSVLQMIGYYQKDEK-AYLVMELMER-DLTSV
..... ||||.||.|.|..| .       ||||..|        ..  .  |..|...|. |  .  ||.. |  |  .....  ..||| .|   | .|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRKAEG---------------SLQLLTSVDIMLQIASGMSYLHQRN---VVHRDLKPSNVLVKT----LKNHACTTCFDARLTDFGVSKSNFISFAPD-L
.. |..               .....  ....||.|.||.|||.     ..|||||..|.|.      ...       ... .|||.|.. . .   .  
LHGARSKWMDANHNQKNDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG------TLKICDFGTSRD-WHQMC-TNM

SYQRGTIQYMAPEML---RGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVEAIEDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQIS
  ..||  .||||..   |..|||. .||.|.|.   ..||. .|.... ... .  . .... |.|| .| .||  .  |...||| .|..||.| || 
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAI--AWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIV

RML
  |
QHL
Kinase MLKx_g.AA TK 228-486 19 9.2e-59 195.28 In-house 1-486 (486) Show / Hide 
Range on Protein: 228-486
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LELKTLIGSGAFG---SVYKAEWLGA---------------------------PVAVKEFRSGDASFDK------------------EVNILKELI--LE
..|   .|.|.||    |||.|| |                            |||||  ..|||. ..                  |....| .   | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPSVLQMIGYYQKD------------EKAYLVMELME-RD----LTSVIRKAEG---------------------------------------------
 || .....|.  ..            |  ..|||.|.  |    | .  ||  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLQLLTSVD-------------------IMLQIASGMSYLHQR------NVVHRDLKPSNVLVKTLKNHA---CTTCFDARLTDFGVSKS
          .|..   ..                   ...|||.||.|||..      |.|||||   |.||   .. .     ... ....||| |. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

NF----ISFAPDLSYQRGT-----------------------------IQYMAPEMLRGQK---------YSREVDVYSFGITCFQILT-G-TLPFQDDG
.         .|  | | .                             | .|||| |....         .. . ||.|||.... |.| | . .  .  
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KQLVAD-----KLVEAIEDG--------------NRPDLPTGCP--------------LELVVLLNRCWNRNPKDRPTFEQISRML
 | |.       ..| ...|              .|.  | .||               |.  |. .||...|.|||||.|. ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_g.AA TKL-Unique 230-486 30 1.1e-54 188.04 In-house 1-290 (290) Show / Hide 
Range on Protein: 230-486
Range on HMM: 1-290/290
Sequence Identity: 30% (91 aa)

LKTLIGSGAFGSVYKAEWLGAPVAVKEFRS---GDAS----FDKEVNILKELILEPHPSVLQMIGYYQ----KDEKAYLVMELMERD-LTSVIR------
   .||.|..|.|||..| | |||.| |        .    | .|||..|   |..|| ... .||      .  . ..||| ...  | .|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMK--KLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KAEGSLQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNHACTTCFDARLTDFGVSKSNFISFAPDLS--------YQRGTIQYMAP
   . .  | ..  |.. ..||.|| ||| ..  . |||||.||.||    | |    . ... ||| ||.|  . .  ..           |....|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIA---EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EMLRG--QKYSREVDVYSFGITCFQILTGTL------PFQDDGKQLVADKLVEAIEDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRML
|.||.   .||. .|||||||    |.|...      |.|.   . .. .. .  |.. || .|. || |.  |...||...| .||.|..|   |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_g.AA STE 228-488 20 5.8e-53 182.28 In-house 1-359 (359) Show / Hide 
Range on Protein: 228-488
Range on HMM: 1-359/359
Sequence Identity: 20% (78 aa)

LELKTLIGSGAFGSVYKAEWL-----------------GAPVAVKEFRSGDASF---------------DKEVNILKEL----ILEP-HPSVLQMIGYYQ
.|.   ||.||||.||||                    |  .|.|. .  . .                ... .||||.     . . || . . .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------EKAYLVMELME-RDLTSVIR---KAEGSLQ----------LLTSVDIMLQIASG-MSYLHQRNVVHRDLKPSNVLVKTLKNHACTTCFDAR
|.       .. ...||.|.   |...|.   .  ..|.                |  ||  | ..|||. ...|||.||.|.|.             . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------VK

LTDFGVSKSNFISFA---------------PDLSYQRGTIQYMAPEMLRG------QKYSREVDVYSFGITCFQILTGTLPFQD-DGK---QLVADK---
|.||||...   | |                      ||  .||||....      ..|.. .|..|.|.|.   .||  |. |        . ...   
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----LVEAIEDGNRPDLPT-------------------GCPLELVVLLNRCWNRNPKDRPTFEQISR--MLWS
     .. .| .|. | ||.                    .  |.   .|.| ...|..||| .|  .    . 
QQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MLKx_g.AA TyrKc 228-486 28 8.8e-53 182.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 228-486
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

LELKTLIGSGAFGSVYKAEWLGAPVAVKEFR--SGDASFDKEVNILKEL-ILEPHPSVLQMIGYYQKD-------EKAYLVMELMER-DLTSVIRKAEGS
..|.  .|.|||| |||..|   .||||  .  .  . | .| .|...|     || .....|.  ..       |  ..|||.|.  || . .|| .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LQLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACTTCFDARLTDFGVSKSNFIS----FAPDLSY------QR--GTIQYMAPEMLRGQ
|.. . .....|||.||.|||..|..||||   |.||.  .         .. .||| |.          . |          .    |  |||| ..  
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYSREVDVYSFGITCFQILTGTLPFQDDGKQ--LVADKLVEAIEDGNRPDLPTG--------CPLELVVLLNRCWNRNPKDRPTFEQISRML
|.. . ||.|||.... |.|   .   .  |  . .. ..| ...|.|.. |          || |.  .  .||...|.|||||..| . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_g.AA Ciliate-E2 228-488 19 3.8e-52 177.31 In-house 1-365 (365) Show / Hide 
Range on Protein: 228-488
Range on HMM: 1-365/365
Sequence Identity: 19% (77 aa)

LELKTLIGSGAFGSVYKAEWLGAP-------------------------VAVKEFR-SGDASFDKEVNILKELILEP--------------HPSVLQMIG
 ..  .||.|.||||||..    .                         .|.| .. ..  .. .| .|..|.                  || ...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

YYQ--KDEKAYLVMELMER-DLTSVIR-----------KAEGSLQLLTSVDIMLQIAS---------------GMSYLHQRN-VVHRDLKPSNVLVKTLK
..|  .|.. |||||. .  || . |.           |. ... .    .|| ||..               .. |||..| ..|||.||.|.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NHACTTCFDARLTDFGVSKSNFIS-----------FAPDLSY--------------------QRGTIQYMAPEMLRGQK---------YSREVDVYSFGI
           ..||| || . ..             .. ..                    . ||  |||||.|.|.|         |. ..|..|.|.
---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TCFQILTGTLPFQDDGKQLVADKLVEAIEDGNRPDLP------------------TGCPLELVVLLNR----CWNRNPKDRPT-FEQISRMLWS
. .. |.| .||             . .   .  |.|                    ...|   |...    . ...|. |.| .|||    | 
ILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLKx_g.AA CAMK 233-488 17 8.6e-47 148.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 233-488
Range on HMM: 1-425/425
Sequence Identity: 17% (73 aa)

LIGSGAFGSVYKAEWLGAP--------------VAVKE--------------------------------FRSGDASFDKEVNILKELILEP----HPSV
 .|.|.|| |....    .              ||.|                                   .  ... .|..|.| |        || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQMIGYYQK-------------------DEKAYLVM---ELMER-----DLTSVIRKA--------------EGSLQLLTSVDIMLQIASGMSYLHQRNV
.... .|.                    |.. |.||   |...      || . |..               .| ..      .. ||.|.. |.|..|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNVLVKTLKNHACTTC----------FDARLTDFGVSKSNFISF----------------------APDLSYQRGTIQYMA-PEMLRG-----
||||||| |.|. . ... .             ..  ..||| ..  . .                        . .. . ||  ||| ||.|.|     
VHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QKYSREVDVYSFGITCFQILTGTLPFQDD-GKQLVA--------DKLVEAIEDGNRP-DLPT----------------------GCPLELV
         . |....|. | |. ..  |.|..||..| ... .          .| | |  |.   . |                        .  |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

VLLNRCWNRNPKDRPTFEQISRMLWS
 |.... ...|..|.| ||. .  | 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MLKx_g.AA UTK 228-486 27 1.2e-43 147.13 In-house 1-296 (296) Show / Hide 
Range on Protein: 228-486
Range on HMM: 1-296/296
Sequence Identity: 27% (83 aa)

LELKTLIGSGAFGSVYKAEWLG-------APVAVKEFRSGDA---------SFDKEVN---ILKELILEPHPSVLQMIGYYQKDEKAYLVMELME-RDLT
..|  ..|.|||| |.||..         . ||||. .....          | .| .   ..| .    ||.||...|.  ..|  ..|.|.||  || 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

SVIRKAEGSLQ----LLTSVD---IMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACTTCF-DARLTDFG---VSKSNFISF--------APDLSY
|. |..  ..     .||. .    ...||.||.|||....|||||   |.||        . |. .... |||    |.   ...          ....
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRM-MWH-CMMVCKIADFGRGGMSR--RVNTFHFSNRYWESYYYM

QRG----TIQYMAPEMLRGQ-KYSREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVEAIEDG--NRPDLPTGCPLELVVLLNRCWNRNPKDRPTFE
...    .|. |||| |  . ....  ||.|||..|. |.| | ||. .    . ..........|   |.  | .||...  |..|||. .| .||.||
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG----MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

QISRML
..   .
DLVQQM
Kinase MLKx_g.AA LRRK 297-488 29 1.8e-43 150.75 In-house 132-351 (351) Show / Hide 
Range on Protein: 297-488
Range on HMM: 132-351/351
Sequence Identity: 29% (66 aa)

LVMELMER-DLTSVIRKAEGS--------LQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNH----ACTTCFDARLTDFGVSKSNFIS
.|||..   || ..... . .        .   .   |.||||.|| ||| .|  ..|||||. |.|.......    .  .   | . ||| |   | .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQC

FAPD-LSYQRGTIQYMAPEMLRGQ---KYSREVDVYSFGITCFQILTGT-LPFQD-DGKQLV--ADKLVEAIEDGNRPDLPTG-CPL-----ELVVLLNR
| .  ..   |....|||| .|.     |. .||.||||.  . .||.. .||.. |..       .. ..| .| || .|   ||      ..  |.. 
FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQH

CWNRNPKDRPTFEQISRMLWS
||. .||.||.|.||   | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_g.AA Pkinase_Tyr 228-346 32 2e-29 100.27 Pfam 1-137 (270) Show / Hide 
Range on Protein: 228-346
Range on HMM: 1-137/270
Sequence Identity: 32% (45 aa)

LELKTLIGSGAFGSVYKAEWL------GAPVAVKEF--RSGDAS-----FDKEVNILKEL-ILEPHPSVLQMIGYYQ-KDEK--AYLVMELMER-DLTSV
...   .|.||||.|||..|       . |||||     . .       | .|..|.|.|     || .....|    ..|    |.|||.|.  || . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IRKA---EGSLQLLTSVDIMLQIASGMSYLHQRNVVHRDL
 ||    ...| . . ... .|||.||.||...| .||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MLKx_g.AA Dicty4 391-488 36 4.2e-29 94.33 In-house 179-277 (277) Show / Hide 
Range on Protein: 391-488
Range on HMM: 179-277/277
Sequence Identity: 36% (37 aa)

GTIQYMAPEMLRGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVEAIED-GNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRM--LW
||  .||||....| |   .|||||||  ..|||.  |.|  .. ..  ..|.|. . ..|| .|  ||  .  |...||. .|. ||.||.|.    | 
GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYM--QFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILE

S
.
H
Kinase MLKx_g.AA Dicty4 228-353 29 2.6e-27 88.28 In-house 1-147 (277) Show / Hide 
Range on Protein: 228-353
Range on HMM: 1-147/277
Sequence Identity: 29% (44 aa)

LELKTLIGSGAFGSVYKAEWLGAPVAVKEF--RSGD------ASFDKEVNILKELILEPHPSVLQMIGYYQ----KDEKAYLVMELM-ERDLTSVIRK--
.    .||.|.||.|||. | |  |||| .  .  .       .| |||.|.. .    || ...  |.      . .|   |.|.|   .| |....  
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR---HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----AEGSLQ--LLTS-VDIMLQIASGMSYLHQRN--VVHRDLKPSNVLV
     . .|.  | ..   ... .| || .|| .|  ..|||||..| ||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV
Kinase MLKx_g.AA Pkinase_Tyr 396-486 37 1.6e-23 80.27 Pfam 181-270 (270) Show / Hide 
Range on Protein: 396-486
Range on HMM: 181-270/270
Sequence Identity: 37% (35 aa)

MAPEMLRGQKYSREVDVYSFGITCFQILT-GTLP-FQDDGKQLVADKLVEAI-EDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRML
|||| ..  |.. . ||.|||.... |.| |  | ...    .    ..|.| |||.| . | .|| |.  |. .||. .|.|||||..| ..|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG----MSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_g.AA LRRK 228-257 45 2e-09 29.49 In-house 1-31 (351) Show / Hide 
Range on Protein: 228-257
Range on HMM: 1-31/351
Sequence Identity: 45% (14 aa)

LELKTLIGSGAFG-SVYKAEWLGAPVAVKEF
|.   .||.|.|| .||.|.| |.||.|...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRM
Kinase MLKx_g.AA TKL 695-799 18 1.2e-11 38.23 In-house 1-152 (364) Show / Hide 
Range on Protein: 695-799
Range on HMM: 1-152/364
Sequence Identity: 18% (28 aa)

VGMSNHGTMFRGRWLD----------VPVMVKALGTGN-------------------------EAEKLLKELDKGHAELRNRPHPNVTQVFGYTRHGKN-
.|    |. ..|.|             .| || . . |                         ||... ... .    .... |||. |  ||   ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFVVTERVSGGH-FRVTKFPLVLTIEILLQVAQGVAYLHEHN
            |. |.| ..||  . .    . ... . |..|.|..||| .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMN
Kinase MLKx_g.AA TK 689-800 11 8.6e-07 17.97 In-house 1-255 (486) Show / Hide 
Range on Protein: 689-800
Range on HMM: 1-255/486
Sequence Identity: 11% (29 aa)

IVLLDFVGMSNHG---TMFRGRWLD---------------------------VPVMVKALGTGNEAEKLLKELD--------------KGHAELRN---R
|.|..  |  . |   . ..|.| .                           .|| || |  |.....  ....                 ... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNVTQVFGYTRHGKN------------LFVVTERVSGG-----------HFRVTKFPLVLTIE-----------------------------------
 |||. . .|.  .|..            . .|.| ...|             | ....   ...                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ILLQVAQGVAYLHEHNC
                                      . .|.|.| .|||..||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC
Kinase MLKx_g.AA Pkinase 738-800 15 9.4e-07 24.96 Pfam 54-129 (293) Show / Hide 
Range on Protein: 738-800
Range on HMM: 54-129/293
Sequence Identity: 15% (12 aa)

LRNRPHPNVTQVFGYTRHGKNLFVVTERVSGG----HFR-------VTKF--PLVLTIEILLQVAQGVAYLHEHNC
...  |||. . ... . .... .|.| . ||               ..|  .    . ...|...|..|.|....
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase MLKx_g.AA CAMK 743-799 14 5e-06 14.51 In-house 97-199 (425) Show / Hide 
Range on Protein: 743-799
Range on HMM: 97-199/425
Sequence Identity: 14% (15 aa)

HPNVTQVFGYTRHGKN-------------------LFVVT---ERVSGG------HFRVTK------------------FPLVLTIEILLQVAQGVAYLH
|||. . . .   ...                   .. |.   | .|||        ....                  |.   .  .  |....|.|.|
HPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

EHN
.||
SHN
Kinase MLKx_g.AA TKL-Unique 691-812 19 1.8e-05 15.49 In-house 1-148 (290) Show / Hide 
Range on Protein: 691-812
Range on HMM: 1-148/290
Sequence Identity: 19% (29 aa)

LLDFVGMSNHGTMFRGRWLDVPVMVKALGTGNEAEKLLKELDKGHAEL----RNRPHPNVTQVFGYTR----HGKNLFVVTERVSGG------H------
 .  .| .  |. ..| |   || .| .    .... ...... . |.    . ..|||... .||.     . .|.. |.| ..||      |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---FRVTKFPLVLTIEILLQVAQGVAYLHEHN-----CELSDLNTLLVEF
    . .|... . . . ...|||  |||  .     . |  .|.|....
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN
Kinase MLKx_g.AA UTK 689-800 19 9.7e-05 12.15 In-house 1-139 (296) Show / Hide 
Range on Protein: 689-800
Range on HMM: 1-139/296
Sequence Identity: 19% (27 aa)

IVLLDFVGMSNHGTMFRGRWLD----VPVMVKALGTGNEAEKLLKELDKG-----HAE---LRNRPH--PNVTQVFGYTRHGKNLFVVTERVSGGHFRV-
. |..  |  . |. ...|. .    ...|..|. . .. ..  .| . .     .|    .. ..|  ||| .. |.   .. . .|||  ..|. |  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

------TKF--PLVLT----IEILLQVAQGVAYLHEHNC
      | .  |. ||    ..  ...| |..|||....
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF
Kinase MLKx_g.AA MLK 689-769 23 0.001051 8.88 In-house 1-95 (291) Show / Hide 
Range on Protein: 689-769
Range on HMM: 1-95/291
Sequence Identity: 23% (23 aa)

IVLLDFVGMSNHGTMFRGRWLDVP-----VMVKALG--------TGNEAEKLLKELDKGHAELRNRPHPN----VTQVFGY-TRHGKNLFVVTERVSGG
| .. ..| .  | ...|||         | ||.          |. |.... .|      .||   |||    . |. |  .........|.| ..||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMEC----RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG
Kinase MLKx_g.AA STE 742-799 19 0.001695 8.36 In-house 87-172 (359) Show / Hide 
Range on Protein: 742-799
Range on HMM: 87-172/359
Sequence Identity: 19% (17 aa)

P-HPNVTQVFGYTRHG-------KNLFVVTERVSGGHFR---V----------------TKFPLVLTIEILLQVAQG-VAYLHEHN
. |||. . .|.  ..        .|... | ..|| ..                    ..||  . . |. |. .|  .|||.|.
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH
Kinase MLKx_g.AA LRRK 770-799 43 0.002778 7.45 In-house 155-184 (351) Show / Hide 
Range on Protein: 770-799
Range on HMM: 155-184/351
Sequence Identity: 43% (13 aa)

HFRVTKFPLVLTIEILLQVAQGVAYLHEHN
||  ....  |...| ||.| |..||| ||
HFMKAHISWMLKLKIALQIAKGMEYLHSHN
Kinase MLKx_g.AA MLK 786-798 53 0.008718 5.65 In-house 131-143 (291) Show / Hide 
Range on Protein: 786-798
Range on HMM: 131-143/291
Sequence Identity: 53% (7 aa)

LQVAQGVAYLHEH
||.|.|..|||..
LQCARGMHYLHSM
Kinase MLKx_g.AA Ciliate-E2 743-800 17 0.022475 3.94 In-house 91-182 (365) Show / Hide 
Range on Protein: 743-800
Range on HMM: 91-182/365
Sequence Identity: 17% (16 aa)

HPNVTQVFGYTR--HGKNLFVVTERVSGG----------HFRVTKFP------LVLTIEILLQVAQ---------------GVAYLHEHN-C
|||. . . .      .|.. |.| ..||          ..|  ...      .   ..|  |..|               .. |||. | .
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI
Kinase MLKx_g.AA Pkinase_Tyr 775-800 26 0.029224 8.28 Pfam 107-132 (270) Show / Hide 
Range on Protein: 775-800
Range on HMM: 107-132/270
Sequence Identity: 26% (7 aa)

KFPLVLTIEILLQVAQGVAYLHEHNC
....   ... .|.|.| .||...||
PLTMKDLLQMCWQIAKGMEYLESKNC
Kinase MLKx_g.AA Dicty4 776-800 26 0.09366 1.83 In-house 108-133 (277) Show / Hide 
Range on Protein: 776-800
Range on HMM: 108-133/277
Sequence Identity: 26% (7 aa)

FPLVLT-IEILLQVAQGVAYLHEHNC
.||..  . . . .|.|...||. |.
WPLIKRAMRMAFDAARGMNWLHCCNP
Kinase MLKx_g.AA LRRK 887-929 24 0.00027 11.08 In-house 299-351 (351) Show / Hide 
Range on Protein: 887-929
Range on HMM: 299-351/351
Sequence Identity: 24% (13 aa)

EEILLSGKLPQLSHD-CTG------IKAVIEKCLSSQP---PDFHQIVELLQS
|.. ..|  | .. . |..       .. |..| . .|   | | |||. | .
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_g.AA TKL 895-927 21 0.170714 1.16 In-house 319-364 (364) Show / Hide 
Range on Protein: 895-927
Range on HMM: 319-364/364
Sequence Identity: 21% (10 aa)

LP---------QLSHDC-TGIKAVIEKCLSSQP---PDFHQIVELL
.|         .  .|| ...|  ...| .. |   | | .|.. |
IPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_g.AA MLK 918-927 60 0.287934 0.31 In-house 282-291 (291) Show / Hide 
Range on Protein: 918-927
Range on HMM: 282-291/291
Sequence Identity: 60% (6 aa)

PDFHQIVELL
|.| |||. |
PSFRQIVQHL