MLKx_e-2

Species: S.moellendorffii
Alias: MLKx_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_e-2.AA Protein None 1142 None Fasta, JSON
MLKx_e-2.NA RNA None 3429 None Fasta, JSON
MLKx_e-2.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of MLKx_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_e-2.AA TKL 204-456 23 2.6e-72 246.55 In-house 1-364 (364) Show / Hide
Range on Protein: 204-456
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGAGAFGSVYKAEWVG----------APVAVKEFRSGDASV----------------------------DKEVNILKELILEPHPSVLQMIGSYQKDEK-
|| |.|| |||..| |           .|||| |.| . .                             ..|.. .. ..   || ..|..|. .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYLVMELM-ERD-LTSVIRKAEGSLQLLTSVDIMLQIASGMSYLHQRN--------VVHRDLKPSNVLVKT-LK-------NHACITC
             ..|||..   . |  ..        .   ....|.||.||.|||..|        ..|||||..|.||.  ..       |.. . |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

FDVRLTDFGVSKSNFISFAPD------------------LSYQRGTIQYMAPEMLKGQ----------------KYSREVDVYSFGITCFQILTGTLPFQ
  . ..||| |.... |.                     .. |.||...||||.|.||                .||  .|||||||  . |||. .|..
--CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DDGKQLVA------DKLVETIEDGNRPDLP------------TGCPLELVALLNRCWNRNPKDRPTFEHISRML
|..   .       . ..  ...|.|| .|            . || ..  |. .||. .|..||.|. |   |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

S_TKc MLKx_e-2.AA S_TKc 198-458 24 2.5e-70 240.89 SMART 1-231 (231) Show / Hide
Range on Protein: 198-458
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LELKTLIGAGAFGSVYKAEWVG--APVAVKEFRSGDASVDKEVNILKELILEPHPSVLQMIGSYQKDEKAYLVMELMER---DLTSVIRKAEGS-----L
 |.  .|| ||||.|||. ...    ||.|. .    .. .|..|||.     || . ......|  .. |.|||...    || ..|.|  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFISFAPDLSYQRGTIQYMAPEMLKGQKYSR-EVDVYSFG
   .   .| ||.... |.|.....||||||.|.|. .           . ..|||...          . . ||  |||||.|   .|.. ..|..|.|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

ITCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISR-------MLWS
.. .  |.|  ||.    |.. .|..               . |.  ....|....|..|||   . .       . | 
CILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Pkinase MLKx_e-2.AA Pkinase 198-456 25 8.6e-69 239.65 Pfam 1-293 (293) Show / Hide
Range on Protein: 198-456
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

LELKTLIGAGAFGSVYKAEWVGAP--VAVKEFRSGDASVDK--------EVNILKELILEPHPSVLQMIGSYQKDEKAYLVMELMER-----DLTSVIR-
....  ||.|.||.|||. ..| .  ||||...  ... .|        |. |.|.|    || ......... . . |.|||..|      || ..|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KAEGSL--QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVK-TLKNHACITCFDVRLTDFGVSK--SNFISFAPDLSYQRGTIQYMAPEMLK-GQK
...|..  .  .  ..|.||..|. |.|.....||||||.|.|.. .  . |     .|...|||..|  .  .   . ..   ||. ||||| .. ||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YSREVDVYSFGITCFQILTGTLPFQDD----GKQLVADKLVETIEDGNRPDLPTGCP-------------------LELVALLNRCWNRNPKDRPTFEHI
|...||..|.|..... |.| .||...    .      ..... .  .. | |. |.                    |.  ....|....||.|||.|.|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

SRM--L
     .
LQHPWF

Kinase MLKx_e-2.AA MLK 198-456 26 2.7e-60 206.62 In-house 1-291 (291) Show / Hide
Range on Protein: 198-456
Range on HMM: 1-291/291
Sequence Identity: 26% (79 aa)

LELKTLIGAGAFGSVYKAEWVGAP-----VAVKEFR--------SG--DASVDKEVNILKELILEP-HPSVLQMIGSYQKDEK-AYLVMELMER-DLTSV
..... ||.|.||.|.|..| .       ||||..|        ..  .  ...|...|. |  .  ||.. |  |  .....  ..||| .|   | .|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRKAEG---------------SLQLLTSVDIMLQIASGMSYLHQRN---VVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFISFAPD-LSYQR
.. |..               .....  ....||.|.||.|||.     ..|||||..|.|.     |  .   ... .|||.|.. . .   .    ..
LHGARSKWMDANHNQKNDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRD-WHQMC-TNMMSNA

GTIQYMAPEML---KGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
||  .||||..   ...|||. .||.|.|.   ..||. .|.... ... .  . . .. |.|| .| .||  .  |...||| .|..||.| .|   |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAI--AWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase MLKx_e-2.AA TK 198-456 18 1.7e-58 194.34 In-house 1-486 (486) Show / Hide
Range on Protein: 198-456
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

LELKTLIGAGAFG---SVYKAEWVGA---------------------------PVAVKEFRSG-DASVDK-----------------EVNILKELI--LE
..|   .|.|.||    |||.|| |                            |||||  ..| ..| .                  |....| .   | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPSVLQMIG-SYQKDEK-----------AYLVMELME-RD----LTSVIRKAEG---------------------------------------------
 || .....| . |...|            ..|||.|.  |    | .  ||  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLQLLTSVD-------------------IMLQIASGMSYLHQR------NVVHRDLKPSNVLVKTLKNHACI---TCFDVRLTDFGVSKS
          .|..   ..                   ...|||.||.|||..      |.|||||   |.||   .. . .   ... ....||| |. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

NF----ISFAPDLSYQRGT-----------------------------IQYMAPEMLKGQK---------YSREVDVYSFGITCFQILT-G-TLPFQDDG
.         .|  | | .                             | .|||| |....         .. . ||.|||.... |.| | . .  .  
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KQLVAD-----KLVETIEDG--------------NRPDLPTGCP--------------LELVALLNRCWNRNPKDRPTFEHISRML
 | |.       ..| ...|              .|.  | .||               |.  |. .||...|.|||||. . ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase MLKx_e-2.AA STE 198-458 20 4.3e-53 182.71 In-house 1-359 (359) Show / Hide
Range on Protein: 198-458
Range on HMM: 1-359/359
Sequence Identity: 20% (78 aa)

LELKTLIGAGAFGSVYKAEWV-----------------GAPVAVKEFRSGDASV---------------DKEVNILKEL----ILEP-HPSVLQMIGSYQ
.|.   || ||||.||||  .                 |  .|.|. .  . .                ... .||||.     . . || . . .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------EKAYLVMELME-RDLTSVIR---KAEGSLQ----------LLTSVDIMLQIASG-MSYLHQRNVVHRDLKPSNVLVKTLKNHACITCFDVR
|.       .. ...||.|.   |...|.   .  ..|.                |  ||  | ..|||. ...|||.||.|.|.             | 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------VK

LTDFGVSKSNFISFA---------------PDLSYQRGTIQYMAPEMLKG------QKYSREVDVYSFGITCFQILTGTLPFQD-DGK---QLVADK---
|.||||...   | |                      ||  .||||....      ..|.. .|..|.|.|.   .||  |. |        . ...   
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----LVETIEDGNRPDLPT-------------------GCPLELVALLNRCWNRNPKDRPTFEHISR--MLWS
     ..  | .|. | ||.                    .  |.   .|.| ...|..||| .   .    . 
QQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase MLKx_e-2.AA TKL-Unique 200-456 30 1.3e-52 181.16 In-house 1-290 (290) Show / Hide
Range on Protein: 200-456
Range on HMM: 1-290/290
Sequence Identity: 30% (89 aa)

LKTLIGAGAFGSVYKAEWVGAPVAVKEFR----SGDASVD---KEVNILKELILEPHPSVLQMIGSYQ----KDEKAYLVMELMERD-LTSVIR------
   .||.|..|.|||..| | |||.| |     |   ...   .|||..|   |..|| ... .|       .  . ..||| ...  | .|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMK--KLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KAEGSLQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFISFAPDLS--------YQRGTIQYMAP
   . .  | ..  |.. ..||.|| ||| ..  . |||||.||.||    | |    . ... ||| ||.|  . .  ..           |....|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIA---EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EMLKG--QKYSREVDVYSFGITCFQILTGTL------PFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
|.|..   .||. .|||||||    |.|...      |.|.   . .. .. .. |.. || .|. || |.  |...||...| .||.|. |   |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase MLKx_e-2.AA Ciliate-E2 198-458 19 1.1e-50 172.14 In-house 1-365 (365) Show / Hide
Range on Protein: 198-458
Range on HMM: 1-365/365
Sequence Identity: 19% (76 aa)

LELKTLIGAGAFGSVYKAEWVGAP-------------------------VAVKEFR-SGDASVDKEVNILKELILEP--------------HPSVLQMIG
 ..  .|| |.||||||..    .                         .|.| .. ..  .. .| .|..|.                  || ...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

SYQ--KDEKAYLVMELMER-DLTSVIR-----------KAEGSLQLLTSVDIMLQIAS---------------GMSYLHQRN-VVHRDLKPSNVLVKTLK
..|  .|.. |||||. .  || . |.           |. ... .    .|| ||..               .. |||..| ..|||.||.|.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NHACITCFDVRLTDFGVSKSNFIS-----------FAPDLSY--------------------QRGTIQYMAPEMLKGQK---------YSREVDVYSFGI
         . ..||| || . ..             .. ..                    . ||  |||||.|.|.|         |. ..|..|.|.
---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLP------------------TGCPLELVALLNR----CWNRNPKDRPT-FEHISRMLWS
. .. |.| .||             . .   .  |.|                    ...|   |...    . ...|. |.| .| |    | 
ILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase MLKx_e-2.AA TyrKc 198-456 27 4.5e-50 173.59 SMART 1-280 (280) Show / Hide
Range on Protein: 198-456
Range on HMM: 1-280/280
Sequence Identity: 27% (80 aa)

LELKTLIGAGAFGSVYKAEWVGAPVAVKEFRSGDASVDKEVNILKELIL---E--PHPSVLQMIGSYQKD-------EKAYLVMELMER-DLTSVIRKAE
..|.  .| |||| |||..|   .||||  ...      .  ...|. .       || .....|   ..       |  ..|||.|.  || . .|| .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GSLQLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFIS----FAPDLSY------QR--GTIQYMAPEMLK
. |.. . .....|||.||.|||..|..||||   |.||.  .         |. .||| |.          . |          .    |  |||| ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GQKYSREVDVYSFGITCFQILTGTLPFQDDGKQ--LVADKLVETIEDGNRPDLPTG--------CPLELVALLNRCWNRNPKDRPTFEHISRML
  |.. . ||.|||.... |.|   .   .  |  . .. ..| ...|.|.. |          || |.  .  .||...|.|||||. | . .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase MLKx_e-2.AA UTK 198-456 26 8.3e-43 144.28 In-house 1-296 (296) Show / Hide
Range on Protein: 198-456
Range on HMM: 1-296/296
Sequence Identity: 26% (81 aa)

LELKTLIGAGAFGSVYKAEWVG-------APVAVKEFRSGDASVDKEV---------N---ILKELILEPHPSVLQMIGSYQKDEKAYLVMELME-RDLT
..|  ..|.|||| |.||...        . ||||. ...... ...          .   ..| .    ||.||...|   ..|  ..|.|.||  || 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

SVIRKAEGSLQ----LLTSVD---IMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACITCF-DVRLTDFG---VSKSNFISF--------APDLSY
|. |..  ..     .||. .    ...||.||.|||....|||||   |.||          |. .... |||    |.   ...          ....
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRM-MWH-CMMVCKIADFGRGGMSR--RVNTFHFSNRYWESYYYM

QRG----TIQYMAPEMLKGQ-KYSREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVETIEDG--NRPDLPTGCPLELVALLNRCWNRNPKDRPTFE
...    .|. |||| |  . ....  ||.|||..|. |.| | ||. .    . ...... ...|   |.  | .||...  |..|||. .| .||.||
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG----MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

HISRML
 .   .
DLVQQM

Kinase MLKx_e-2.AA TK-Unique 198-456 27 3.8e-42 143.15 In-house 1-294 (294) Show / Hide
Range on Protein: 198-456
Range on HMM: 1-294/294
Sequence Identity: 27% (85 aa)

LELKTLIGAGAFGSVYKAEWVG--------APVAVKEFRSGDASVD-----KEVNILKELILEPHPSVLQMIGSYQKD-EKAYLVMELMERD-LTSVIRK
||.. .|| |||| |...| .|          ||||  . .   .|     || ...||  | .|| ..|..|  .|. |  ...|| ...  | . .|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKE--LGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

AEGS-------------------------LQLLTSVDIMLQIASGMSYLHQ--RNVVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSK--SNFISFA
  .                          ... . . .. |||.||.||..  ...|||||  .|||.           . . ..||| ..  ..    .
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYS

PDLSYQRGTIQYMAPEMLK--GQKY-SREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVETIEDGNRPDLPTGC-PLELVALLNRCWNRNPKDRPT
   |..|  | .|||| ||  .. | . . ||.|||.. . |.| |  |.     .. .....| |.|| |...| .| . |.  |. .||...|..||.
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYP----GMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPS

FEHISRML
|. |  .|
FRQIKHRL

Kinase MLKx_e-2.AA LRRK 267-458 28 6.1e-41 142.34 In-house 132-351 (351) Show / Hide
Range on Protein: 267-458
Range on HMM: 132-351/351
Sequence Identity: 28% (63 aa)

LVMELMER-DLTSVIRKAEGS--------LQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNH----ACITCFDVRLTDFGVSKSNFIS
.|||..   || ..... . .        .   .   |.||||.|| ||| .|  ..|||||. |.|.......    .  .   . . ||| |   | .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQC

FAPD-LSYQRGTIQYMAPEMLKGQ---KYSREVDVYSFGITCFQILTGT-LPFQD-DGKQLV--ADKLVETIEDGNRPDLPTG-CPL-----ELVALLNR
| .  ..   |....|||| ...     |. .||.||||.  . .||.. .||.. |..       .. . | .| || .|   ||      .. .|.. 
FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQH

CWNRNPKDRPTFEHISRMLWS
||. .||.||.|. |   | .
CWQHDPKKRPHFSQIVKRLSQ

Kinase MLKx_e-2.AA Pkinase_Tyr 198-316 32 6.8e-29 98.49 Pfam 1-137 (270) Show / Hide
Range on Protein: 198-316
Range on HMM: 1-137/270
Sequence Identity: 32% (45 aa)

LELKTLIGAGAFGSVYKAEWV------GAPVAVKEFRSGDASVD-------KEVNILKEL-ILEPHPSVLQMIGSYQ-KDEK--AYLVMELMER-DLTSV
...   .|.||||.|||..|       . |||||  . |  . .       .|..|.|.|     || .....|    ..|    |.|||.|.  || . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IRKA---EGSLQLLTSVDIMLQIASGMSYLHQRNVVHRDL
 ||    ...| . . ... .|||.||.||...| .||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase MLKx_e-2.AA Dicty4 361-458 35 3.7e-26 84.39 In-house 179-277 (277) Show / Hide
Range on Protein: 361-458
Range on HMM: 179-277/277
Sequence Identity: 35% (36 aa)

GTIQYMAPEMLKGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVETIED-GNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRM--LW
||  .||||.. .| |   .|||||||  ..|||.  |.|  .. ..  ..|. . . ..|| .|  ||  . .|...||. .|. ||.|| |.    | 
GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYM--QFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILE

S
.
H

Kinase MLKx_e-2.AA Dicty4 198-323 28 1.6e-24 78.8 In-house 1-147 (277) Show / Hide
Range on Protein: 198-323
Range on HMM: 1-147/277
Sequence Identity: 28% (43 aa)

LELKTLIGAGAFGSVYKAEWVGAPVAVKEF--RSGD------ASVDKEVNILKELILEPHPSVLQMIGSYQ----KDEKAYLVMELM-ERDLTSVIRK--
.    .|| |.||.|||. | |  |||| .  .  .       .  |||.|.. .    || ...  |.      . .|   |.|.|   .| |....  
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR---HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----AEGSLQ--LLTS-VDIMLQIASGMSYLHQRN--VVHRDLKPSNVLV
     . .|.  | ..   ... .| || .|| .|  ..|||||..| ||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV

Kinase MLKx_e-2.AA Pkinase_Tyr 366-456 37 5.9e-23 78.37 Pfam 181-270 (270) Show / Hide
Range on Protein: 366-456
Range on HMM: 181-270/270
Sequence Identity: 37% (35 aa)

MAPEMLKGQKYSREVDVYSFGITCFQILT-GTLP-FQDDGKQLVADKLVETI-EDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
|||| ..  |.. . ||.|||.... |.| |  | ...    .    ..| | |||.| . | .|| |.  |. .||. .|.|||||. | ..|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG----MSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase MLKx_e-2.AA LRRK 198-227 45 2.1e-09 29.41 In-house 1-31 (351) Show / Hide
Range on Protein: 198-227
Range on HMM: 1-31/351
Sequence Identity: 45% (14 aa)

LELKTLIGAGAFG-SVYKAEWVGAPVAVKEF
|.   .|| |.|| .||.|.| |.||.|...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRM

Kinase MLKx_e-2.AA TKL 665-769 18 4.4e-12 39.82 In-house 1-152 (364) Show / Hide
Range on Protein: 665-769
Range on HMM: 1-152/364
Sequence Identity: 18% (28 aa)

VGMSNHGTMFRGRWLD----------VPVMVKALGTGN-------------------------EAEKLLKELDKGHAELRNRPHPNVTQVIGYTRHGED-
.|    |. ..|.|             .| || . . |                         ||... ... .    .... |||. | .||   ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFVVTEQVSGGH-FRVTKFPLVLTIEILLQVAQGVAYLHQHN
            |. |.| ..||  . .    . ... . |..|.|..|||..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMN

Kinase MLKx_e-2.AA TK 659-770 11 3.9e-08 22.58 In-house 1-255 (486) Show / Hide
Range on Protein: 659-770
Range on HMM: 1-255/486
Sequence Identity: 11% (30 aa)

IVLLDLVGMSNHG---TMFRGRWLD---------------------------VPVMVKALGTGNEAEKLLKELD--------------KGHAELRN---R
|.|..  |  . |   . ..|.| .                           .|| || |  |.....  ....                 ... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNVTQVIGYTRHGED------------LFVVTEQVSGG-----------HFRVTKFPLVLTIE-----------------------------------
 |||. . .|.  .||             . .|.| ...|             | ....   ...                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ILLQVAQGVAYLHQHNC
                                      . .|.|.| .|||..||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC

Kinase MLKx_e-2.AA UTK 659-770 20 2.7e-07 21.03 In-house 1-139 (296) Show / Hide
Range on Protein: 659-770
Range on HMM: 1-139/296
Sequence Identity: 20% (28 aa)

IVLLDLVGMSNHGTMFRGRWLD----VPVMVKALGTGNEAEKLLKELDKG-----HAE---LRNRPH--PNVTQVIGYTRHGEDLFVVTEQVSGGHFRV-
. |... |  . |. ...|. .    ...|..|. . .. ..  .| . .     .|    .. ..|  ||| ...|.   .| . .|||  ..|. |  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

------TKF--PLVLT----IEILLQVAQGVAYLHQHNC
      | .  |. ||    ..  ...| |..|||....
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF

Kinase MLKx_e-2.AA TK-Unique 659-770 18 6.2e-07 20.08 In-house 1-154 (294) Show / Hide
Range on Protein: 659-770
Range on HMM: 1-154/294
Sequence Identity: 18% (29 aa)

IVLLDLVGMSNHGTMFRGRWL--------DVPVMVKALG---TGNEAEKLLKELDKGHAELRNRPHPNVTQVIGYTRHG-EDLFVVTEQVSGG-------
....|..|. . |. .||           .. | ||.|    |. .  ..|||. . . ||   .|||. | .|..    |. . . |....|       
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEI-QMMKELG--DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

-----HFRV-------------TKFPL--VLT----IEILLQVAQGVAYLHQ--HNC
     ....             ...|.   ..    . .. |.|.| .||..  ...
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI

Kinase MLKx_e-2.AA TKL-Unique 661-782 18 1.2e-05 16.08 In-house 1-148 (290) Show / Hide
Range on Protein: 661-782
Range on HMM: 1-148/290
Sequence Identity: 18% (28 aa)

LLDLVGMSNHGTMFRGRWLDVPVMVKALGTGNEAEKLLKELDKGHAEL----RNRPHPNVTQVIGYTR----HGEDLFVVTEQVSGG------H------
 . ..| .  |. ..| |   || .| .    .... ...... . |.    . ..|||... .||.     .  ... |.| ..||      |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---FRVTKFPLVLTIEILLQVAQGVAYLHQHN-----CELSDLNTLLVEF
    . .|... . . . ...|||  |||  .     . |  .|.|....
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

Kinase MLKx_e-2.AA Pkinase 708-770 15 2.1e-05 20.22 Pfam 54-129 (293) Show / Hide
Range on Protein: 708-770
Range on HMM: 54-129/293
Sequence Identity: 15% (12 aa)

LRNRPHPNVTQVIGYTRHGEDLFVVTEQVSGG----HFR-------VTKF--PLVLTIEILLQVAQGVAYLHQHNC
...  |||. . ... . . .. .|.| . ||               ..|  .    . ...|...|..|.|....
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI

Kinase MLKx_e-2.AA STE 712-769 19 6e-05 13.56 In-house 87-172 (359) Show / Hide
Range on Protein: 712-769
Range on HMM: 87-172/359
Sequence Identity: 19% (17 aa)

P-HPNVTQVIGYTRHG-------EDLFVVTEQVSGGHFR---V----------------TKFPLVLTIEILLQVAQG-VAYLHQHN
. |||. . .|.  ..       ..|... | ..|| ..                    ..||  . . |. |. .|  .|||.|.
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH

Kinase MLKx_e-2.AA Pkinase_Tyr 659-770 22 0.00103 13.2 Pfam 1-132 (270) Show / Hide
Range on Protein: 659-770
Range on HMM: 1-132/270
Sequence Identity: 22% (30 aa)

IVLLDLVGMSNHGTMFRGRWL------DVPVMVKAL--GTGNEA---EKLLKELDKGHAELRNR-PHPNVTQVIGYTR-HGED--LFVVTEQVSGG----
|...   |  . |. ..|.|       ..|| || |  |.  |.   |....|.      ...   |||. . .|    .||   ...|.| . .|    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI----MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

--HFR---VTKFPLVLTIEILLQVAQGVAYLHQHNC
  . .     ....   ... .|.|.| .||...||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC

Kinase MLKx_e-2.AA LRRK 740-769 43 0.002814 7.43 In-house 155-184 (351) Show / Hide
Range on Protein: 740-769
Range on HMM: 155-184/351
Sequence Identity: 43% (13 aa)

HFRVTKFPLVLTIEILLQVAQGVAYLHQHN
||  ....  |...| ||.| |..||| ||
HFMKAHISWMLKLKIALQIAKGMEYLHSHN

Kinase MLKx_e-2.AA MLK 659-739 23 0.004241 6.75 In-house 1-95 (291) Show / Hide
Range on Protein: 659-739
Range on HMM: 1-95/291
Sequence Identity: 23% (23 aa)

IVLLDLVGMSNHGTMFRGRWLDVP-----VMVKALG--------TGNEAEKLLKELDKGHAELRNRPHPN----VTQVIGY-TRHGEDLFVVTEQVSGG
| ..  .| .  | ...|||         | ||.          |. |.... .|      .||   |||    . |. |  .... ....|.| ..||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMEC----RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG

Kinase MLKx_e-2.AA MLK 756-768 53 0.013345 5.0 In-house 131-143 (291) Show / Hide
Range on Protein: 756-768
Range on HMM: 131-143/291
Sequence Identity: 53% (7 aa)

LQVAQGVAYLHQH
||.|.|..|||..
LQCARGMHYLHSM

Kinase MLKx_e-2.AA Dicty4 746-770 26 0.228432 0.52 In-house 108-133 (277) Show / Hide
Range on Protein: 746-770
Range on HMM: 108-133/277
Sequence Identity: 26% (7 aa)

FPLVLT-IEILLQVAQGVAYLHQHNC
.||..  . . . .|.|...||  |.
WPLIKRAMRMAFDAARGMNWLHCCNP

Kinase MLKx_e-2.AA LRRK 857-899 24 0.000736 9.52 In-house 299-351 (351) Show / Hide
Range on Protein: 857-899
Range on HMM: 299-351/351
Sequence Identity: 24% (13 aa)

EEILLSGNLPQVSHD-CTG------IKAVIEKCLSSQP---PDFHQIVELLQS
|.. ..|  | .. . |..       .. |..| . .|   | | |||. | .
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase MLKx_e-2.AA TKL 842-897 17 0.19489 0.95 In-house 275-364 (364) Show / Hide
Range on Protein: 842-897
Range on HMM: 275-364/364
Sequence Identity: 17% (16 aa)

FGIACAEMITGQTIGEEILLS------------------GNLPQVS------------HDC-TGIKAVIEKCLSSQP---PDFHQIVELL
|||   |..|...  ...  .                  |. | .             .|| ...|  ...| .. |   | | .|.. |
FGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase MLKx_e-2.AA MLK 888-897 60 0.287934 0.31 In-house 282-291 (291) Show / Hide
Range on Protein: 888-897
Range on HMM: 282-291/291
Sequence Identity: 60% (6 aa)

PDFHQIVELL
|.| |||. |
PSFRQIVQHL