Gene MLKx_q (S.moellendorffii)

MLKx_q

Species: S.moellendorffii
Alias: MLKx_q
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_q.AA Protein None 558 None Fasta, JSON
MLKx_q.NA RNA None 1677 None Fasta, JSON
MLKx_q.kin_dom Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of MLKx_q.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc MLKx_q.AA S_TKc 256-531 23 6.8e-52 179.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 256-531
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

LVMGSVLGCGSYAAVQEVQAFG--QRYALKLFKDDASFVREAALHLQLQHPHIVQVLGHVELKRDSDLKYGLLLELMEA--GNLESYINKSKQRSGFAPP
  .. ..| |... |  ..  .  ...|.|  |   .. || ... . .||.||. ... .       .. . .|...   |.| .|| | . .     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRH-----G

----FSALVCVDMMLQIARGLKYLHSLQIIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKTVECSDQAHTSKRGTGFYRAPEVMVPDRGGGDEFCAR
    |.  ..  .| ||...|.|.||..|||||.||.||||..          .|..||| |. .       |.  || .|.||||.             
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL-------TTFCGTPWYMAPEVL------------G

YTL-KADVYSFGMTCYSILTGEVPFCETRGVDIKKIKGSWMKPGVRPSLPGYVNTLLGGVVQQCWSSNPEMRQCFQEICW-E-----LECI
|.  |.|..|.| . |  |.|. ||. .  . .|||.                  ..   ...|.  .|| |    |.   |      . .
YGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKx_q.AA TKL 262-528 20 6e-46 158.98 In-house 1-364 (364) Show / Hide 
Range on Protein: 262-528
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

LGCGSYAAVQEVQAFG----------QRYALKLFKDD--------------------------------ASFVREAALHLQLQHPHIVQVLGHVELKRD-
.| |... |   .  |          .  | | || .                                  ...|. ....|.||.||| .| .   .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SDLKYGLLLELMEAGNLESYINKSKQRSGFAPPFSALVCVDMMLQIARGLKYLHSLQ--------IIHRDVKPSNILLTRAPG-------SS
        .. ....  |... |.|..|..               . ....|.||||. |||| .        ||||| |..|||. .          . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

PSGLLLKLADFGTAKTVECSDQ-------------------AHTSKRGTGFYRAPEVMVPDRGGGDEFCA-------RYTLKADVYSFGMTCYSILTGEV
..   .|..|||...... | .                   .. ...||  . ||||.  .    .   .        |. |.||||||.  . |||...
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PF--CETRGVDIK----KIKGSWMKPGVRPSLP------------GYVNTLLGGVVQQCWSSNPEMRQCFQEICWEL
|.     . ...      .     . | || .|             .. . .    |.||...|| |  ||||  .|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase MLKx_q.AA Pkinase 256-482 28 2.3e-41 147.31 Pfam 1-226 (293) Show / Hide 
Range on Protein: 256-482
Range on HMM: 1-226/293
Sequence Identity: 28% (71 aa)

LVMGSVLGCGSYAAVQEVQAFGQR--YALKLFKDDASFV---------REAALHLQLQHPHIVQVLGHVELKRDSDLKYGLLLELMEAG----NLESYIN
.. |...| ||.. | . .  | .  .|.| .| .             .|..... |.||.||. .. .|    .|  | . .|..| |     | .|| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY-MVMEYCEGGLYVMDLFDYIS

KSKQRSGFAPPF--SALVCVDMMLQIARGLKYLHSLQIIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKTV-ECSDQAHTSKRGTGFYRAPEVMVPD
          .|  |  .| ..|.||.|||.|.||  |||||.||.|||. . .  ..    .|..||| || . . ...  |.  || .|.||||    
T-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--

RGGGDEFCARYTLKADVYSFGMTCYSILTGEVPFCET----RGVDIKKI
      ..  |. |.|..|.| ..|  |.|. ||..     . .| ...
------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQM
Kinase MLKx_q.AA CAMK 261-471 19 2.6e-37 117.27 In-house 1-334 (425) Show / Hide 
Range on Protein: 261-471
Range on HMM: 1-334/425
Sequence Identity: 19% (65 aa)

VLGCGSYAAVQEVQA-FG-------------QRYALKLFK---------------------------------DDASFVREAALHLQLQ-------HPHI
.|| ||.. | ...                 |..| |  .                                 | ... || ... .||       ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQVLGHVE----------------LKRDSDLKYGLLL---ELMEAG----NLESYINKSKQRSGFA--------PPFSALVCVDMMLQIARGLKYLHSLQ
.. . . |                   ..| .. . .   |... |     | .|| . ....             |.   .  .. ||. ...|.||. 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDVKPSNILLTRAPGSSPSGL-----------LLKLADFGTAKTVECS-----------------------DQAHTSKRGTGFYRA-PEVMVP----
|.||| || ||||.   ..|.. .            .|..||| |. .. .                       .|  .   ||  | | |||       
IVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---DRGGGDEFCARYTLKADVYSFGMTCYSILTGEVPF
     .  ||    |. |.|. | |  .|  |.|. ||
NMQN-A-TDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase MLKx_q.AA Ciliate-E2 256-483 19 1.7e-35 119.32 In-house 1-301 (365) Show / Hide 
Range on Protein: 256-483
Range on HMM: 1-301/365
Sequence Identity: 19% (63 aa)

LVMGSVLGCGSYAAVQEV-------------------------QAFGQRYALKLFKDDASFVREAALHLQ------------------LQHPHIVQVLGH
     ..| |... | ..                         .. .. ||.| .| .  .  .  .|.                   |.||.|..   .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VELKRDSDLKYGLLLELMEAGNLESYINKSKQRSGFAPP----FSALVCVDMMLQIAR---------------GLKYLHSLQ-IIHRDVKPSNILLTRAP
 . |  .| .. | .|. . |.|..||...|. ... ..    |.   . ..| ||..               .|.||||   ||||| ||.|||.    
FQEK--DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

GSSPSGLLLKLADFGTAKTV-------------------------------ECSDQAHTSKRGTGFYRAPEVMV-PDRGGGDEFCARYTLKADVYSFGMT
        .|..|||..| .                                 ... . .  ||  | |||.    . ..  .   .|. |.|..|.|..
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYKCDIWSLGVI

CYSILTGEVPFCETRGVDIKKIK
 |  |.|. ||       ...||
LYEMLFGKPPF-------QQQIK
Kinase MLKx_q.AA STE 256-473 21 3.2e-33 114.71 In-house 1-270 (359) Show / Hide 
Range on Protein: 256-473
Range on HMM: 1-270/359
Sequence Identity: 21% (62 aa)

LVMGSVLGCGSYAAVQEVQAF-----------------GQRYALKLFK----------------------DDASFVREAALHLQLQ--HPHIVQVLGHVE
.   ...| |..  |                       |...| |  .                      .  .. .|  .. ...  ||.||. .|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LK---RDSDLKYGLLLELMEAGNLESYIN-KSKQRSGFA------PPFSALVCVDMMLQIARG-LKYLHSLQIIHRDVKPSNILLTRAPGSSPSGLLLKL
 .    ..| .  . .|.|..| |.. |. | .   ..        .|.  .   .  || .| |.||||..|||||.||.||||             ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------------VKL

ADFGTAKTVECS----------------DQAHTSKRGTGFYRAPEVMVPDRGGGDEFCAR--YTLKADVYSFGMTCYSILTGEVPFCE
.|||... .. |                .|  ..  ||  . ||||. ....|      .  |. |.|..|.| |.   .||..|...
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPWHD
Kinase MLKx_q.AA TKL-Unique 325-528 24 2.4e-31 107.86 In-house 77-290 (290) Show / Hide 
Range on Protein: 325-528
Range on HMM: 77-290/290
Sequence Identity: 24% (54 aa)

LLLELMEAGNLESYINKSKQRS---GFAPPFSALVCVDMMLQIARGLKYLHSLQ--IIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKTVECSDQAH
. .| .. |.| .... .   .       ... .. |.| ..||.|. |||...  ||||| |.||.|....  . .  .  |..|||..|.   ...  
IVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAE--WNIKICDFGLSKFNSKINKMT

TSKR---------GTGFYRAPEVMVPDRGGGDEFCARYTLKADVYSFGMTCYSILTGEV------PFCETRGVDIKKIKGSWMKPGVRPSLPGYVNTLLG
..           |. ...||||.           . |. |.||||||.  . |.|...      |. .     ..... .  . . || .|   .  . 
NNEHKGTRNQTRCGSFRWMAPEVLRMNF-------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYR

GVVQQCWSSNPEMRQCFQEICWEL
   |||| ..|. |  |.||  .|
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_q.AA MLK 322-471 29 7.9e-30 100.72 In-house 84-236 (291) Show / Hide 
Range on Protein: 322-471
Range on HMM: 84-236/291
Sequence Identity: 29% (47 aa)

KYGLLLELMEAGNLESYINK-SKQRSGFA------PPFSALVCVDMMLQIARGLKYLHSLQ---IIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKT
......| .| | | ....  ... .. .         .  . .. .||.|||. ||||..   ||||| |..|||...  .    .. || .||||.. 
HFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRD

VECSDQAHTSKRGTGFYRAPEVMVPDRGGGDEFCARYTLKADVYSFGMTCYSILTGEVPF
. .... ..|..||  ..||||           | .|. |.||.|.|.  . .||.|||.
WHQMCTNMMSNAGTYAWMAPEVIQQ------FRCEKYSEKCDVWSWGVVLWEMLTREVPY
Kinase MLKx_q.AA CMGC 256-435 17 7.1e-29 91.28 In-house 1-298 (513) Show / Hide 
Range on Protein: 256-435
Range on HMM: 1-298/513
Sequence Identity: 17% (55 aa)

LVMGSVLGCGSYAAVQEVQAF----------------GQRYALKLFKDDASFV-----------------REAALHLQLQ-----------------HPH
    ...|.|.|. | . .                  ....|.| .| .  .                  ||  .  .|.                 |..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQVLGHVELKRDS-------------DLKYGLLLELMEAGNLESYINKSK--QRSGFAPPFSALV------------CVDMM------LQIARGLK--Y
||. . ..  | .              . .  |  |.|.  .|  || . .  .. .   |.|  .            .  .|       || ||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSLQ--IIHRDVKPSNILLT------------------RAPGSSPSGLLLKLADFGTAKTVECS---------------------DQAHTSKRGTGFYR
.||    ||||| ||.|||..                  .      .   ||..||| |. ..                        ...|.   | .||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYR

APEVMV
|||...
APEILL
Kinase MLKx_q.AA TK 256-471 15 9e-28 89.55 In-house 1-395 (486) Show / Hide 
Range on Protein: 256-471
Range on HMM: 1-395/486
Sequence Identity: 15% (61 aa)

LVMGSVLGCGSYA---AVQEVQAFGQRY---------------------------ALKLFK----DDAS------------------FVREAALHLQ--L
...| .|| | .     | . ...|..                            | |  |    ...                   ...|... ..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPHIVQVLGHVELKRDS--------DLKYGLLLELMEAGN----LESYINKSKQRSGF-----------------------------------------
.||.||. .|..  .. .        .  . ...|.|. |.    | .|  |.. .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------APPFSALVCVD-------------------MMLQIARGLKYLHSL------QIIHRDVKPSNILLTRAPGS----SPSGLLLKLADFG----
         ||..    ..                   |..|||.|. ||||.      ...|||.   |.|...        . .|.  |.||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----TAKTVECSDQAHTSK---RGTGFYR------------------------APEVMVPDRGGGDEFCARYTLKADVYSFGMTCYSILT-GEVPF
     |. .. .|  ....   .|... .                        |||..   .    |   ..| | ||.||| ... |.| |..|.
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPY
Kinase MLKx_q.AA LRRK 327-530 30 6.8e-27 92.17 In-house 134-351 (351) Show / Hide 
Range on Protein: 327-530
Range on HMM: 134-351/351
Sequence Identity: 30% (70 aa)

LELMEAGNLESYINKSKQRS-GFAP-PFSALVCVDMMLQIARGLKYLHSLQ--IIHRDVKPSNILLTRAP-GSSPS----GLLLKLADFGTAK--TVECS
.|..  |.| ... ..|| .  | .  .|  .    .||||.|..||||    ||||| |. |||| . | ..||         |.||||.    .. . 
MEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC-FH

DQAHTSKRGTGFYRAPEVMVPDRGGGDEFCARYTLKADVYSFGMTCYSILTGE-VPFCETRGVD----IKKIKGSWMKPGVRPSLPGY-VNT-----LLG
  .   . |.  ..|||.|   |..|.|    || |.|.|||||  . .||..  || |  ..|    . .|.   .. | ||..|    .       . 
MGVAKGCVGNPGWMAPEIM---RYNGEE---EYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDK-IIEGLRPTIPQHYCPPCQPWHMYQ

GVVQQCWSSNPEMRQCFQEICWELEC
   |.||. .|. |  |..|   |. 
DLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_q.AA RIPK 360-528 27 2.6e-25 83.21 In-house 112-290 (290) Show / Hide 
Range on Protein: 360-528
Range on HMM: 112-290/290
Sequence Identity: 27% (53 aa)

MMLQIARGLKYLHSLQ--IIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKTVECSDQAH-----------TSKR--GTGFYRAPEVMVPDRGGGDEF
|  .|..|  |||| .  ||||| ||.|||. .        .  |.|||| |.  . | .             .||   ||  | .||  ..|       
MIHEISCGMCYLHSMNPPIIHRDLKPENILVDNN-------FHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDN------

CAR---YTLKADVYSFGMTCYSILTGEVPFCETRGVDIKKIKGS-WMKPGVRPSLPGYVNT----LLGGVVQQCWSSNPEMRQCFQEICWEL
 ..    | | |||||... . .||.  |. ..    .. .. .  . | . |  . .  .     .  . |.||...|. | ||||.  . 
KKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase MLKx_q.AA Pkinase_Tyr 256-473 26 1.5e-23 80.35 Pfam 1-218 (270) Show / Hide 
Range on Protein: 256-473
Range on HMM: 1-218/270
Sequence Identity: 26% (62 aa)

LVMGSVLGCGSYAAVQEVQAF------GQRYALKLFKD--------DASFVREAALHLQL-QHPHIVQVLGHVELKRDSDLKYGLLLELMEAGNLESYIN
...| .|| |..  | .  ..      ..  | |  |.         ..| |||..  || .||.||. .| .  ....  .. . .|.|. |.| .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

KSKQRSGFAPPFSALVCVDMMLQIARGLKYLHSLQIIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKTVECSD---QAHTSKRGTGFYRAPEVMVPD
| .      .|..    ..| .|||.|. ||.| ..||||.   |.|.|.       ..  | .||| |....  |   ..... .   .  |||..   
KHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

RGGGDEFCARYTLKADVYSFGMTCYSILT-GEVP-FCE
.         .| | ||.||| ... |.| || | . .
K---------FTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase MLKx_q.AA TyrKc 256-528 22 2.9e-20 74.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 256-528
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

LVMGSVLGCGSYAAVQEVQAFGQRYALKLFKDDA--SFVREAALHLQL--QHPHIVQVLGHVELKRD---SDLKYGLLLELMEAGNLESYINKSKQRSGF
...| .||.| .  | . ..  .  | |  |.||   | ||| .  .|  .||.||. .| .  .     ..  . ...|.|. |.| .|. |.. .   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---

APPFSALVCVDMMLQIARGLKYLHSLQIIHRDVKPSNILLTRAPGSSPSGLLLKLADFGTAKTVECS-------DQAHT----SKR--GTGFYRAPEVMV
   ..    .....|||.|  |||| ..||||    |.|...           | .||| .. ..         |  ..    ...        |||.. 
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

PDRGGGDEFCARYTLKADVYSFGMTCYSILT-GEVPFCE---TRGVDIKKIKGSWMKPGVRPSLPG--------YVNTLLGGVVQQCWSSNPEMRQCFQE
        .  ..| | ||.||| ... |.| |. |  .      .. . .    .. . .|  |             .   . .|||  .||.| .|.|
--------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSE

ICWEL
|. ..
IHECF
Kinase MLKx_q.AA TK 506-528 39 6.2e-05 11.63 In-house 464-486 (486) Show / Hide 
Range on Protein: 506-528
Range on HMM: 464-486/486
Sequence Identity: 39% (9 aa)

VVQQCWSSNPEMRQCFQEICWEL
. ||||. .|| |  |...  .|
LMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_q.AA RIPK 293-336 36 0.000462 9.7 In-house 45-90 (290) Show / Hide 
Range on Protein: 293-336
Range on HMM: 45-90/290
Sequence Identity: 36% (17 aa)

REAALHLQLQHPHIVQVLGHVELK-RDSDLK-YGLLLELMEAGNLE
.||.   .|.. |||...| .. .  | | | ||.  | || |.|.
EEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLW
Kinase MLKx_q.AA Pkinase_Tyr 508-528 47 0.009714 9.9 Pfam 250-270 (270) Show / Hide 
Range on Protein: 508-528
Range on HMM: 250-270/270
Sequence Identity: 47% (10 aa)

QQCWSSNPEMRQCFQEICWEL
.|||  .||.|  |.|| ..|
KQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_q.AA MLK 508-528 38 0.063847 2.61 In-house 271-291 (291) Show / Hide 
Range on Protein: 508-528
Range on HMM: 271-291/291
Sequence Identity: 38% (8 aa)

QQCWSSNPEMRQCFQEICWEL
.|||...|. |  |..|  .|
KQCWNQDPHKRPSFRQIVQHL