Gene MLKx_c (S.moellendorffii)

MLKx_c

Species: S.moellendorffii
Alias: MLKx_c
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_c.AA Protein None 807 None Fasta, JSON
MLKx_c.NA RNA None 2424 None Fasta, JSON
MLKx_c.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of MLKx_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_c.AA TKL 260-514 23 4.5e-78 265.7 In-house 1-364 (364) Show / Hide 
Range on Protein: 260-514
Range on HMM: 1-364/364
Sequence Identity: 23% (89 aa)

IGSGTFGLVYEAGWLD----------QIVAVKIFRPGD-----------------------------YSFEKEFTALVTLQQ-HPNVVSIIGFTRDVEG-
||||.|| || . |            . ||||.|.  .                             . |..|. ... ..  |||.|...|.  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

----------KQYSIVMERM-SMD-LEKFIGEHKGAAGVPLVTAVSIMLQIAEGMAFLHS--------KNVIHRDLKPRNILVKY-LE----------VG
          .|. |||| .   . |. ..          .   ....|.|| ||..|||        ...||||||..||||.  ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

ILTKISDFGTAKTNFST-----------------SQAASATVGVGTKIYRAPEVFRSENTDEKA----------KYSKKADVYSFAIICCYLVTGRLPFE
.  ||.|||...... .                 ...      .||. . ||||.| .. ....          .||.|.|||||.|. . ..|...|..
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DIIER--I------DFAILVCAENKRPQLP------------VDCPEELTTLIRRCWNRNAEERPTFGEICDRL
|. ..  |      .....|| ...|| .|             |||...  |. .||. ..|.||.| || .||
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKx_c.AA S_TKc 254-521 26 1.6e-60 208.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 254-521
Range on HMM: 1-231/231
Sequence Identity: 26% (75 aa)

LVLGKLIGSGTFGLVYEAGWLD--QIVAVKIFRPGDYSFEKEFTALVTLQQHPNVVSIIGFTRDVEGKQYSIVMERMSM---DLEKFIGEHKGAAG---V
  ....||.|.|| || . . .  .|||.|| .    ....|   |    .|||.| .... .|   . . .||| ..    || ..| ....  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEVFRSENTDEKAKYSK-KADVYS
|  .| ..| ||.......||...||||||| |||.         ||.||| |.           |  .||  |.||||.         .|.| |.|..|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---------GYGKCKCDWWS

FAIICCYLVTGRLPFEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRRCWNRNAEERPTFGEICD--RLKRLRSLV
. .|   ...|. ||.   .   | ...             ..|.  .||.|.... |.|||  |.    .. ..   .
CGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_c.AA Pkinase 254-514 27 1.1e-57 202.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 254-514
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

LVLGKLIGSGTFGLVYEAGWLDQ--IVAVKIFRPGDYSFEK--------EFTALVTLQQHPNVVSIIGFTRDVEGKQYSIVMERMSM-----DLEKFIG-
...|. ||||.|| ||.. . .   ||||||..  . . .|        |   .  | .|||.| .... .|  .. . .||| . .     ||  .|  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-EHKGAAGVPLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGIL---TKISDFGTAKT-NFSTSQAASATVGVGTKIYRAPEVFRSENTDE
 .|..    .  .. ..|.||..|....||...||||||| |||..  . | .    ||.||| ||  .  .     .|. .||  |.|||| |     .
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR-----G

KAKYSKKADVYSFAIICCYLVTGRLPFEDI----IERIDFAILVCAENKRPQLPVDCP-----------------------EELTTLIRRCWNRNAEERP
  .|..|.|..|. .|. ....||.|| .       . . ....  ....|.|. |.|                       ||.  .|..|.... ..||
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMIC--RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

TFGEICDR--L
|. .|.    .
TAEQILQHPWF
Kinase MLKx_c.AA MLK 254-514 29 2.4e-56 193.53 In-house 1-291 (291) Show / Hide 
Range on Protein: 254-514
Range on HMM: 1-291/291
Sequence Identity: 29% (89 aa)

LVLGKLIGSGTFGLVYEAGWLDQI-----VAVKIFR-----PGD-----YSFEKEFTALVTLQQHPN----VVSIIGFTRDVEGKQYSIVMERMSM-DLE
. . . ||||.|| |. . |  ..     ||||..|      .|       ||.|.  |  | .|||    .. . |   . . ... |||| ..   | 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRIL-SHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY

KFI--GEHKGA---------AGVPLVTAVSIMLQIAEGMAFLHSKN---VIHRDLKPRNILVKY----LEVGILTKISDFGTAKTNFSTSQAASATVGVG
 ..  .. |..         . ...  |....||.|.||..|||.    .||||||..|||.      .. |.| ||.||||. . ..... .  .   |
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL-KICDFGTS-RDWHQMC-TNMMSNAG

TKIYRAPEVF---RSENTDEKAKYSKKADVYSFAIICCYLVTGRLPFEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRRCWNRNAEERPTFGEICD
| ...||||.   |.|      |||.|.||.|....   ..|...|...... .  |. | ....|| .| .||| .  |. .||| ....||.| .|  
TYAWMAPEVIQQFRCE------KYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQ

RL
 |
HL
Kinase MLKx_c.AA TK 254-514 18 7.5e-54 178.53 In-house 1-486 (486) Show / Hide 
Range on Protein: 254-514
Range on HMM: 1-486/486
Sequence Identity: 18% (90 aa)

LVLGKLIGSGTFG---LVYEAGWLD---------------------------QIVAVKIFRPG-DYSFEKEFT-----------------ALVTLQQ---
..||| .|.| ||    ||.. | .                           . ||||. ..| . | | .|                  ..  ...   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVVSIIG-FTRD---------VEGKQYSIVMERMS-MD----LEKFIGEHKGAAG------------------------------------------
 |||.|...|  |..         |... . |||| |.  |    | ..  .... .                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPLVTAVSIMLQIAEGMAFLHSK------NVIHRDLKPRNILVKYLEV--------GILTKISDFG---
                               ... . . ...|||.||..||||      |..||||  ||.||    |        |   ||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKTNFSTSQAASAT-VGVGTKIYR------------------------APEVFRSENTDEK---AKYSKKADVYSFAIICCYLVT-GRLPFEDI
      |.   | .   ...  |.|. . .                        |||....    |.    |.. | ||.|| . .  ..| |. |.   
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IERID-------FAILVCAEN---------------KRPQLPVDCP--------------EELTTLIRRCWNRNAEERPTFGEICDRL
.   |         .. . ..                |.  |..||              ||.  |...||....|.|||| .. ..|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_c.AA TKL-Unique 351-514 32 4.2e-47 162.8 In-house 113-290 (290) Show / Hide 
Range on Protein: 351-514
Range on HMM: 113-290/290
Sequence Identity: 32% (60 aa)

VSIMLQIAEGMAFLHSKN--VIHRDLKPRNILVKYL--EVGILTKISDFGTAKTNFSTSQAASA-------TVGVGTKIYRAPEVFRSENTDEKAKYSKK
|.. ..|| || .||...  .||||||..|.||     .  .  ||.|||..|.| . ..  .        .. .|. ...||||.|...    ..||.|
VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF----CQYSEK

ADVYSFAIICCYLVTGRL------PFEDIIERIDFAILVCA--ENKRPQLPVDCPEELTTLIRRCWNRNAEERPTFGEICDRL
.|||||.|.   ..|. .      |... ....  . .|    ||.|| .| .||.|.. ||..||... ..||.| ||  ||
SDVYSFGIVLWEIATRKITKTYKKPYQG-MDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_c.AA LRRK 302-516 30 9.7e-45 154.95 In-house 115-351 (351) Show / Hide 
Range on Protein: 302-516
Range on HMM: 115-351/351
Sequence Identity: 30% (74 aa)

QHPNVVSIIGFTRDVEGKQYSIVMERMSM-DLEKFIGEHKGAA------GVPLVTAVSIMLQIAEGMAFLHSKN--VIHRDLKPRNILVKYLE-------
.|||.||..||. .     . .||| ..  || .|. ..|  .        .  .   |.||||.||..|||.|  .||||||. |||.. .        
NHPNIVSLKGFCIH----PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNY

--VGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEVFRSENTDE-KAKYSKKADVYSFAIICCYLVTGR-LPFEDII--ERIDFAILVCA---EN
    .  ||.|||.    |.. . . |   ||.....|||. |    .. .  |. |.|.|||..|   |.|.. .||...     . . ...     | 
PNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMR----YNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG

KRPQLPVD-CPE-----ELTTLIRRCWNRNAEERPTFGEICDRLKR
 || .| . ||.     .. .||  ||. . ..||.| .| .||. 
LRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_c.AA TyrKc 254-514 29 2.3e-43 151.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 254-514
Range on HMM: 1-280/280
Sequence Identity: 29% (86 aa)

LVLGKLIGSGTFGLVYEAGWLDQIVAVKIFRPGD-YSFEKEFTALVTL-QQHPNVVSIIGFTRDVEG-----KQYSIVMERMSM-DLEKFIGEHKGAAGV
..||| .|.| || ||.. |  . ||||  ...    | .|   .  |  .|||.| ..|  .. ..     ... |||| |.  || ... .|..   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

PLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFGTAKTNFST---SQAASATVGV----GTK---IYR--APEVFRSENTDEK
.. . .|...|||.||..|||||.|||||  ||.||.        |||||| ..   .      ... .  .    |.|    .|  |||..       .
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI------NY

AKYSKKADVYSFAIICCY--LVTGRLPFEDIIE--RIDFAILVCAENK-RPQLPVD--------CPEELTTLIRRCWNRNAEERPTFGEICDRL
 |.. | ||.|| . |..  .  |  | ...|.    .. .. . ..  |.  | .        ||.|. .....||....|.|||| ||....
GKFTTKSDVWSFGV-CMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_c.AA STE 254-506 20 5.8e-41 142.4 In-house 1-347 (359) Show / Hide 
Range on Protein: 254-506
Range on HMM: 1-347/359
Sequence Identity: 20% (74 aa)

LVLGKLIGSGTFGLVYEA-----------------GWLDQIVAVKIFRPGDY---------------------SFEKEFTALVTLQQ-HPNVVSIIGFTR
. . . ||.|.|| || |                 |   .|.|.|. .  .                      ...||   .  ... |||.|  .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DVEGKQYSIVMERMS-MDLEKFIGEHKGAAG-----------VPLVTAVSIMLQIAEG-MAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFG
     . .. .  |.|| |.   |...| . .|  .           .|      |  || .| ...|||...||||.|| |||.         |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

TAKTNFST--------------SQAASATVGVGTKIYRAPEVFRSENTDEK-AKYSKKADVYSFAIICCYLVTGRLPFED-IIERIDFAIL---VCAE--
...   ..              ...   .  |||  . |||| . .... .  .|. |.|..|. . .. ..||. |. |    |  |.|.   ....  
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------NKRPQLPV-------------------DCPEELTTLIRRCWNRNAEERPT
       .. |.||                     . .|.   |..| ... ..|||
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase MLKx_c.AA Dicty4 322-516 30 8e-37 120.46 In-house 78-277 (277) Show / Hide 
Range on Protein: 322-516
Range on HMM: 78-277/277
Sequence Identity: 30% (64 aa)

SIVMERM-SMDLEKFIGEHK------GAAGVP--LVTA-VSIMLQIAEGMAFLHSKN--VIHRDLKPRNILV-KYLEVGILTKISDFGTAK-TNFSTSQA
.||.| | . .|.. .  |.           .  |...   ... .| ||. ||. |  .||||||. |.|| | . |    |..||| ..     ... 
CIVTEYMPKGNLYSLL--HDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRV----KVCDFGLSQYMKKHEDHK

ASATVGVGTKIYRAPEVFRSENTDEKAKYSKKADVYSFAIICCYLVTGRLPFE-DIIERIDFAILVCAENKRPQLPVDCPEELTTLIRRCWNRNAEERPT
. ..  .||  . |||| ...       |  |||||||.|.   ..|.  |.   ...   |...|| .  || .| .||  ...|| .||. . . ||.
DNQMTACGTPCWMAPEVMMHQ------PYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPS

FGEICDR--LKR
| ||  |  |  
FEEIIQRRILEH
Kinase MLKx_c.AA TAK1 350-513 28 4.8e-36 119.19 In-house 104-284 (284) Show / Hide 
Range on Protein: 350-513
Range on HMM: 104-284/284
Sequence Identity: 28% (56 aa)

AVSIMLQIAEGMAFLHSKN---VIHRDLKPRNILVKYLEVGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEV----------------------
|.| |.|.|.| |.|||.    .||||.|| | |    . .   || ||||.     ..   . |   || .. ||||                      
AMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLL--CNKHRTLKICDFGTF-----CDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKV

FRSENTDEKAKYSKKADVYSFAIICCYLVTGRLPFEDIIE---RIDFAILVCAENKRPQLPV--DCPEELTTLIRRCWNRNAEERPTFGEICDR
|| |      ||. |.|.||..||   . . ..|...|        .   .   |..|.. .  |||. .  .  .||. |.|.||.  |.   
FRCE------KYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase MLKx_c.AA Dicty4-Unclassified 353-514 33 1.3e-33 112.42 In-house 114-263 (263) Show / Hide 
Range on Protein: 353-514
Range on HMM: 114-263/263
Sequence Identity: 33% (55 aa)

IMLQIAEGMAFLHSKNVIHRDLKPRNILV-KYLEVGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEVFRSENTDEKAKYSKKADVYSFAIICCY
. . || ||..||..|.||||.|  |||. |   .    || ||| .     ..     |   ||    .||. . |       |  |.||||.|..   
YAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNI----KIADFGISRV---IDFNFNMTTIAGTPKWESPECLMHES------YNQKSDVYSYAMMLYE

LVTGRLPFEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRRCWNRNAEERPTFGEICDRL
|.||  |. .|   .. |..||    ||..|  |.  .  ||  ||      |||. .| ..|
LATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKx_c.AA Pkinase_Tyr 254-396 34 2e-28 96.91 Pfam 1-156 (270) Show / Hide 
Range on Protein: 254-396
Range on HMM: 1-156/270
Sequence Identity: 34% (55 aa)

LVLGKLIGSGTFGLVYEAGWL------DQIVAVKIFRPGDYS-------FEKEFTALVTLQQHPNVVSIIGFTRDVEGK-QYSIVMERMSM-DLEKFIGE
...|| .|.| || ||.. |       .. ||||. ..|  .       | .|   . .| .|||.|. .|   | ..  |. |||| |   || ..  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H-KGAAGVPLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFG
|  .   ... . ... .|||.||..|.||| |||||  ||.||.    .   ||.|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFG
Kinase MLKx_c.AA TK-Unique 254-448 25 1.4e-22 74.78 In-house 1-228 (294) Show / Hide 
Range on Protein: 254-448
Range on HMM: 1-228/294
Sequence Identity: 25% (62 aa)

LVLGKLIGSGTFGLVYEAGWL--------DQIVAVKIFR--PGDYS---FEKEFTALVTLQQHPNVVSIIGFTRDVEGKQYSIVMERMSMD-LEKFIGEH
|..|..||.| || |. ..          ...||||  .    | .   | ||.  .  | .|||.|...| . . .  .  |.|| ...  |.... . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

KGA-----------------AGVPLVTAVS------IMLQIAEGMAFLHS--KNVIHRDLKPRNILVKYLEVGILTKISDFGTAK---TNFSTSQAASAT
..|                    |. ...|      .. ||| ||..|.|  |...||||  ||.|.     .   ||.||| |.   |     .. | .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYT----NGVYSMM

VGVGTKIYR--APEVFRSENTDEKAKYSKKADVYSFAII
 . |. ..|  |||...     ..  .. | ||.||...
CSQGRIPIRWMAPESLKCY---HGMYHTTKSDVWSFGVL
Kinase MLKx_c.AA Pkinase_Tyr 435-514 30 7.8e-14 47.47 Pfam 190-270 (270) Show / Hide 
Range on Protein: 435-514
Range on HMM: 190-270/270
Sequence Identity: 30% (25 aa)

KYSKKADVYSFAIICCYLVT-GRLP-FEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRRCWNRNAEERPTFGEICDRL
|.. | ||.|| . .  ..| |. | ....    ..  ..  .. |   | .||.|. .|...||. ..|.|||| ||  .|
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_c.AA TKL-Unique 256-326 36 1.2e-12 41.1 In-house 1-80 (290) Show / Hide 
Range on Protein: 256-326
Range on HMM: 1-80/290
Sequence Identity: 36% (29 aa)

LGKLIGSGTFGLVYEAGWLDQIVAVKIFRP-GDYS------FEKEFTALVTLQQHPNVVSIIGFTRD--VEGKQYSIVME
 ...||.|..| || . |   .||.|.| |  | |      ||.| . . .|. |||.| ..|.. |  |  ....||||
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME
Kinase MLKx_c.AA TK-Unique 477-514 38 3e-11 35.18 In-house 256-294 (294) Show / Hide 
Range on Protein: 477-514
Range on HMM: 256-294/294
Sequence Identity: 38% (15 aa)

KRPQLPVDC-PEELTTLIRRCWNRNAEERPTFGEICDRL
.|...|  | ..|.. |...||....||||.| .| .||
YRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLKx_c.AA TAK1 256-326 26 8.2e-11 32.65 In-house 3-79 (284) Show / Hide 
Range on Protein: 256-326
Range on HMM: 3-79/284
Sequence Identity: 26% (21 aa)

LGKLIGSGTFGLVYEAGWLDQIVAVKIFR--------PGDYSFEKEFTALVTLQQHPNVVSIIGFTRDVEGKQYSIVME
. ...| ||.|.|. | | .. .|||.|.          .  .|.| . . ..  |||.. ..|     ...|.  |||
NEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQW-SRVDHPNIIKLYGMYACHRQCQC-LVME
Kinase MLKx_c.AA LRRK 254-283 23 8.5e-07 20.06 In-house 1-59 (351) Show / Hide 
Range on Protein: 254-283
Range on HMM: 1-59/351
Sequence Identity: 23% (14 aa)

LVLGKLIGSGTFG-LVYEAGWLD----------------------------QIVAVKIF
|. ...||.|.|| .|| | | .                            | ||.|..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase MLKx_c.AA Dicty4 254-283 40 2e-06 17.95 In-house 1-30 (277) Show / Hide 
Range on Protein: 254-283
Range on HMM: 1-30/277
Sequence Identity: 40% (12 aa)

LVLGKLIGSGTFGLVYEAGWLDQIVAVKIF
.. ...||.| || || . |  ..||||..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKL
Kinase MLKx_c.AA Dicty4-Unclassified 254-311 30 0.000208 10.97 In-house 1-65 (263) Show / Hide 
Range on Protein: 254-311
Range on HMM: 1-65/263
Sequence Identity: 30% (20 aa)

LVLGKLIGSGTFGLVYEAGWLDQIVAVKIFRPGDYSFE----KEFTALVTL---QQHPNVVSIIG
.   . || | |  |.   |    ||||.|  . ..|     ..| . | .    |||| | . |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYG
Kinase MLKx_c.AA TKL 564-668 21 1.5e-18 63.45 In-house 7-163 (364) Show / Hide 
Range on Protein: 564-668
Range on HMM: 7-163/364
Sequence Identity: 21% (36 aa)

GSAYRGRLVT---------GEEVAVEVLPS---------------------------------GIVEAELNFFCRVNHPNILKLIGYCNEGGR-------
|  |.|..           |..||| ...|                                    | |..   | .||||....|||....        
GEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHP

------FSTVSEYITQGSLIEHLHFGHRYNSVSLDWTRRIDTAIGAARGLYHLHELE--------IVH
      .  | ||.  ||| ..||           | .|.. |...|||...||  .        |.|
VGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIH
Kinase MLKx_c.AA TKL-Unique 588-670 32 2.2e-15 50.89 In-house 43-137 (290) Show / Hide 
Range on Protein: 588-670
Range on HMM: 43-137/290
Sequence Identity: 32% (31 aa)

EAELNFFCRVN-HPNILKLIGYCN----EGGRFSTVSEYITQGSLIEHLH--FGHR---YNSVSLDWTRRIDTAIGAARGLYHLHELE--IVHGN
| |.|   . . ||||....|||       .... |.||.  ||| ..||          |.  |.. .|.. || .|.|.|.|| .|  | |..
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRD
Kinase MLKx_c.AA Dicty4 599-668 33 1.8e-14 44.87 In-house 57-137 (277) Show / Hide 
Range on Protein: 599-668
Range on HMM: 57-137/277
Sequence Identity: 33% (27 aa)

HPNILKLIGYCN----EGGRFSTVSEYITQGSLIEHLHF--GHRYNSVSLDWTRRID---TAIGAARGLYHLHE--LEIVH
||||... |.|.    . |... |.||  .|.| . ||        |..|||....     |. ||||. .||.    |.|
HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIH
Kinase MLKx_c.AA Dicty4-Unclassified 589-668 29 8e-10 29.79 In-house 47-132 (263) Show / Hide 
Range on Protein: 589-668
Range on HMM: 47-132/263
Sequence Identity: 29% (25 aa)

AELNFFCRVNHPNILKLIGYCNEG----GRFSTVSEYITQGSLIEHLH--FGHRYNSVSLDWTRRIDTAIGAARGLYHLHELEIVH
.|      . ||| .|. |||         .  | | . .| |.|  |     .  ...|| |  |  |.  |.|. |||  ...|
KEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIH
Kinase MLKx_c.AA TK-Unique 599-671 18 4.9e-09 27.44 In-house 63-159 (294) Show / Hide 
Range on Protein: 599-671
Range on HMM: 63-159/294
Sequence Identity: 18% (18 aa)

HPNILKLIGYCNEGG-RFSTVSEYITQGSLIEHLHFGHRY--------------------NSVS-LDWTRRIDTAIGAARGLYHLHE--LEIVHGNV
||||....|.| . . ..  . ||. .|.|  .|..  ..                    .. . ..  . .  |.. |.|. .|..   .|||...
HPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDL
Kinase MLKx_c.AA TK 567-671 12 5.2e-09 25.56 In-house 19-266 (486) Show / Hide 
Range on Protein: 567-671
Range on HMM: 19-266/486
Sequence Identity: 12% (30 aa)

YRGRLVTG--------------------------EEVAVEVLP---SGIVEA--------------------ELNFFC--RVNHPNILKLIGYCNEG---
|.|.. ..                          ..||| .|    .   |.                    |.  .|    .||||..|.|.| .|   
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

---------GRFSTVSEYITQGS----LIEHLHFGHRYNSVS----------------------------------------------------------
         . .  | ||   |.    | ..|.  ... . .                                                          
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LDWTRRIDTAIGAARGLYHLHEL------EIVHGNV
             |.  ...  .  .|.|. .||..       .||...
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase MLKx_c.AA MLK 564-668 23 4.1e-07 20.86 In-house 13-150 (291) Show / Hide 
Range on Protein: 564-668
Range on HMM: 13-150/291
Sequence Identity: 23% (33 aa)

GSAYRGRLVTGEE-----VAVEVLP------------SGIVEAELNFFCRVNHPN----ILKLIGYCNEGGR-FSTVSEYITQGSLIEHLHF--------
|. ..||   ...     |||                .  .| | . . ...|||    | .. | |.. .  |  |.||.  ||| . ||         
GKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDA

--GHRYNSVSLDWTRRIDTAIGAARGLYHLHELE---IVH
  . . |..  |    .. |   |||.  ||...   |.|
NHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIH
Kinase MLKx_c.AA LRRK 598-668 29 1e-06 19.6 In-house 115-189 (351) Show / Hide 
Range on Protein: 598-668
Range on HMM: 115-189/351
Sequence Identity: 29% (23 aa)

NHPNILKLIGYCNEGGRFSTVSEYITQGSLIEHLHFGHRYNS----VSLDWTRRIDTAIGAARGLYHLHELE--IVH
|||||..|.|.| .  ..  | ||...|.| ..||  ...       ...|. ..  |.  |.|. .||     |.|
NHPNIVSLKGFCIHPLCM--VMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIH
Kinase MLKx_c.AA Pkinase_Tyr 590-668 24 2.4e-05 18.75 Pfam 53-134 (270) Show / Hide 
Range on Protein: 590-668
Range on HMM: 53-134/270
Sequence Identity: 24% (20 aa)

ELNFFCRV-NHPNILKLIGYCN-EGGR--FSTVSEYITQGSLIEHLHFGHRYNSVSLDWTRRIDTAIGAARGLYHLHELEIVH
|..  .   .||||..|.| |  .|.      | ||   |.| ..|.     .  .|.  . .. ..  |.|. .|..  ..|
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase MLKx_c.AA TAK1 587-632 41 0.000249 10.42 In-house 45-91 (284) Show / Hide 
Range on Protein: 587-632
Range on HMM: 45-91/284
Sequence Identity: 41% (20 aa)

VEAELNFFCRVNHPNILKLIG--YCNEGGRFSTVSEYITQGSLIEHLH
.| |.    ||.|||| ||.|   |....    | ||.  |||   ||
IEREIMQWSRVDHPNIIKLYGMYACHRQCQC-LVMEYMDCGSLHNFLH
Kinase MLKx_c.AA STE 564-671 17 0.002559 7.72 In-house 13-178 (359) Show / Hide 
Range on Protein: 564-671
Range on HMM: 13-178/359
Sequence Identity: 17% (29 aa)

GSAYRGRLV----------------TGEEVAVEVLP-----------------------SGIVEAELNFFCRVN--HPNILKLIGYCNEGG-------RF
|. |... .                ||| .|. ...                          .. |...  . |  |||| | .|..  .|         
GTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDEL

STVSEYITQGSLIEHLH------FGHRYNS-----VSLDWTRRIDTAIGAARG-LYHLHELEIVHGNV
  . ||.  ||| . ..      ...  |.     .. .. ..|  .    .| ||.||.. |.|  .
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYI--CRQILKGLLYYLHSHHIIHRDI
Kinase MLKx_c.AA Pkinase 596-668 26 0.004379 11.99 Pfam 56-131 (293) Show / Hide 
Range on Protein: 596-668
Range on HMM: 56-131/293
Sequence Identity: 26% (21 aa)

RVNHPNILKLIGYCNEGGRFSTVSEYITQG----SLIEHLHFGHRYNSV--SLDWTRRIDTAIGAARGLYHLHELEIVH
|.|||||..|.... ....   | ||   |    .| ....  .|....  | .  ... . |  .|||...|.  |.|
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQI--LRGLEYCHSMGIIH
Kinase MLKx_c.AA TK 714-729 62 0.001114 7.36 In-house 369-384 (486) Show / Hide 
Range on Protein: 714-729
Range on HMM: 369-384/486
Sequence Identity: 62% (10 aa)

GVLSTESDVYSFGVVM
|. .|.|||.||||.|
GKFTTKSDVWSFGVLM
Kinase MLKx_c.AA TK-Unique 714-729 58 0.001317 8.45 In-house 213-229 (294) Show / Hide 
Range on Protein: 714-729
Range on HMM: 213-229/294
Sequence Identity: 58% (10 aa)

GVL-STESDVYSFGVVM
|.  .|.|||.||||.|
GMYHTTKSDVWSFGVLM
Pkinase_Tyr MLKx_c.AA Pkinase_Tyr 714-729 62 0.006593 10.47 Pfam 189-204 (270) Show / Hide 
Range on Protein: 714-729
Range on HMM: 189-204/270
Sequence Identity: 62% (10 aa)

GVLSTESDVYSFGVVM
|. .|.|||.||||.|
GKFTTKSDVWSFGVLM
Kinase MLKx_c.AA TKL 717-729 61 0.01796 4.73 In-house 267-279 (364) Show / Hide 
Range on Protein: 717-729
Range on HMM: 267-279/364
Sequence Identity: 61% (8 aa)

STESDVYSFGVVM
|. .||||||.|.
SEKCDVYSFGIVL
Kinase MLKx_c.AA TKL-Unique 717-729 69 0.021098 4.5 In-house 206-218 (290) Show / Hide 
Range on Protein: 717-729
Range on HMM: 206-218/290
Sequence Identity: 69% (9 aa)

STESDVYSFGVVM
|. |||||||.|.
SEKSDVYSFGIVL
Kinase MLKx_c.AA LRRK 717-729 38 0.08944 2.04 In-house 260-272 (351) Show / Hide 
Range on Protein: 717-729
Range on HMM: 260-272/351
Sequence Identity: 38% (5 aa)

STESDVYSFGVVM
....|.||||...
TEKVDCYSFGMIL
Kinase MLKx_c.AA MLK 717-729 53 0.130369 1.52 In-house 214-226 (291) Show / Hide 
Range on Protein: 717-729
Range on HMM: 214-226/291
Sequence Identity: 53% (7 aa)

STESDVYSFGVVM
|  .||.|.|||.
SEKCDVWSWGVVL
Kinase MLKx_c.AA Pkinase 717-734 16 9.640923 0.17 Pfam 190-207 (293) Show / Hide 
Range on Protein: 717-734
Range on HMM: 190-207/293
Sequence Identity: 16% (3 aa)

STESDVYSFGVVMLRLVT
....|..|.|...  ...
GPKVDMWSCGCILYEMLC
Kinase MLKx_c.AA TK 780-800 19 0.000448 8.71 In-house 466-486 (486) Show / Hide 
Range on Protein: 780-800
Range on HMM: 466-486/486
Sequence Identity: 19% (4 aa)

MRCLAPEVSHRPSMRDIVLLL
..| ... ..||......  |
QQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_c.AA TKL 775-800 26 0.001192 9.03 In-house 339-364 (364) Show / Hide 
Range on Protein: 775-800
Range on HMM: 339-364/364
Sequence Identity: 26% (7 aa)

YLELGMRCLAPEVSHRPSMRDIVLLL
. .| ..| ... . |||. .|.  |
MKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_c.AA MLK 780-800 38 0.017686 4.57 In-house 271-291 (291) Show / Hide 
Range on Protein: 780-800
Range on HMM: 271-291/291
Sequence Identity: 38% (8 aa)

MRCLAPEVSHRPSMRDIVLLL
..|  .. . |||.| ||  |
KQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_c.AA Pkinase_Tyr 780-800 23 0.036824 7.94 Pfam 250-270 (270) Show / Hide 
Range on Protein: 780-800
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

MRCLAPEVSHRPSMRDIVLLL
..| ... ..||....|.  |
KQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_c.AA TAK1 781-799 31 0.039092 2.89 In-house 266-284 (284) Show / Hide 
Range on Protein: 781-799
Range on HMM: 266-284/284
Sequence Identity: 31% (6 aa)

RCLAPEVSHRPSMRDIVLL
.|     . |||| ..|  
CCWDDNPEKRPSMQECVKY
Kinase MLKx_c.AA TKL-Unique 781-800 35 0.067771 2.69 In-house 271-290 (290) Show / Hide 
Range on Protein: 781-800
Range on HMM: 271-290/290
Sequence Identity: 35% (7 aa)

RCLAPEVSHRPSMRDIVLLL
.| ... | |||  .|.  |
QCWHHDPSQRPSFDEIIHRL