Gene MLKx_a (S.moellendorffii)

MLKx_a

Species: S.moellendorffii
Alias: MLKx_a
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_a.AA Protein None 487 None Fasta, JSON
MLKx_a.NA RNA None 1464 None Fasta, JSON
MLKx_a.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of MLKx_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_a.AA TKL 145-384 22 5.4e-69 235.52 In-house 1-364 (364) Show / Hide 
Range on Protein: 145-384
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

LGQGGFGTVYEAIWLGHK----------FAVKVFPQGD-------------------------------KSFAKELAVLEADKHPNVLHIAGHSFDEE--
.|.||||.|| ..| |.            |||.|.. .                               . . .|. ..   .|||.... | .....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------KQRYSLVMEKM-DMDLANYVLKKNSLPLLSIVAVMLQVATGMAWLHS--------KNIIHWDLKPQNILVGEEDN----------DLVSIR
         .  . .||| .   .| .|..      .  ..  .|..| ||..|||        ..||| |||..|||| |  .          . . . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADFGVSRPNFISSQIEAVS------------------IQGTRNFMAPEA---------WS-------SERYTKKADVYSYGMLIYQLVTGNVPFEDGMD
|.||| || .. |.. .. .                  . || ..||||.         ..       .. |..|.||||.|.... ..|. .|..| . 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

MEQVLR-------------GKRPEIP------------ATCPEFLSQLMRECWSHDAKERPSFSDICERL
|.....             |.||.||             .||. ...|| .||.||...||||..| .||
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase MLKx_a.AA Pkinase 139-384 23 1.4e-56 199.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 139-384
Range on HMM: 1-293/293
Sequence Identity: 23% (69 aa)

LKLTTHLGQGGFGTVYEAIWLGHK--FAVKVFPQGDKSFAK--------ELAVLEADKHPNVLHIAGHSFDEEKQRYSLVMEKMDM-----DLANYVL--
...   .|.|.||.||.... |    .|||...  ...  |        |....   .|||.  .  . . |.|... .||| ...     ||. |.   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNI--VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KKNSL--PLLSIVAVMLQVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSRPNF-ISSQIEAVSIQGTRNFMAPEAWS-SERYTKKADV
.....  .   .  .|.|.. |.. .||..||| ||||.|||. ....   ...|.|||...  | . ..  . .. ||...||||    .. |..|.|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK-QFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSYGMLIYQLVTGNVPFEDG-----MDMEQVLRGKRP-----EIPATCP-------------------EFLSQLMRECWSHDAKERPSFSDICER--L
.|.| ..|....|. || .      .|. |... ...     ..| .|.                   | . .... |.  | |.||.. .|..   .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLKx_a.AA TK 139-384 18 1.4e-56 187.81 In-house 1-486 (486) Show / Hide 
Range on Protein: 139-384
Range on HMM: 1-486/486
Sequence Identity: 18% (91 aa)

LKLTTHLGQGGFG---TVYEAIWLGH---------------------------KFAVKVFP----QGDKS-----------------FAKELAVLE--AD
..|   ||.| ||   .||...| |.                           . |||.      . ..                  .| |....   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNVLHIAGHSFDEEK----------QRYSLVMEKMD-MD----LANYVLKKNS---------------------------------------------
.|||.... |.....|           . . .||| |.  |    | .|  |.                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPLLSIVAVMLQVATGMAWLHSK------NIIHWDLKPQNILVGEEDN-------DLVSIRIADFG---
                               |..   .  ..|.| ||..||||      |..| ||   |.||||...       .   ..|||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VSRPNFISSQIEAVSIQGTRN-------------------------FMAPEAWSSE---------RYTKKADVYSYGMLIYQLVT-GNVPFEDGM
      .|    ..   ..| .||.                           ||||.. .          ..| | ||.|.| |.. ..| | .|.  ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

D-------------MEQVLRG--------------KRPEIPATCP--------------EFLSQLMRECWSHDAKERPSFSDICERL
.             ||.. ||               |.. |. ||              |.. .||..||..|...||.||.. |.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc MLKx_a.AA S_TKc 139-388 25 6.1e-56 193.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 139-388
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

LKLTTHLGQGGFGTVYEAIWLG--HKFAVKVFPQGDKSFAKELAVLEADKHPNVLHIAGHSFDEEKQRYSLVMEKMDM---DLANYVLKKNS------LP
 ..  ..|.|.||.|| ... .  ...|.|. .   ... .|...|.  .|||. .. ..  |   ... .||| .|    ||  |  |...      .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LLSIVAVMLQVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSRPNFISSQIEAVSIQGTRNFMAPEAWSSERYTK-KADVYSYGMLIYQ
   .  .| |.. ... .||..||| ||||.|||. |       | |.|||..|           .. ||...||||      |.| |.|..| | ..| 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LVTGNVPFEDGMDMEQVLRGKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICE-----RLKQLK
...|  ||.   .|.....  .       ||... ..| |.  | ..||.  .. .     .. .  
MLCGYPPFP---QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKx_a.AA TKL-Unique 141-384 29 2.1e-55 190.39 In-house 1-290 (290) Show / Hide 
Range on Protein: 141-384
Range on HMM: 1-290/290
Sequence Identity: 29% (86 aa)

LTTHLGQGGFGTVYEAIWLGHKFAVKVFP-QGDKS------FAKELAVLEADK-HPNVLHIAGHSFDEEKQRY--SLVMEKMDMD-LANYVL--------
    .|.||.|.|| ..| | . |.|.|  . |.|      | .|. ...  . |||..|. | ..|.  .    ..||| ...  | ..          
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--KKNSLPLLSIVAVMLQVATGMAWLHSKN--IIHWDLKPQNILVGEE-DNDLVSIRIADFGVSRPNFISSQIEAVSI----------QGTRNFMAPEAW
  ... |... .|   ...| ||  ||...  ||| |||..|.|| ..     ..|.|.||| |.  | |. ..  ..          .|. . ||||  
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK--FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

SS--ERYTKKADVYSYGMLIYQLVTGNV------PFEDGMDMEQVL-------RGKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICERL
..  . |..|.||||.|.  . ..|. .      |.. ||| ||..       ...||.||  ||. .. |...|| ||  .||||..| .||
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQ-GMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_a.AA MLK 139-384 28 1.1e-54 188.05 In-house 1-291 (291) Show / Hide 
Range on Protein: 139-384
Range on HMM: 1-291/291
Sequence Identity: 28% (85 aa)

LKLTTHLGQGGFGTVYEAIWLGHK-----FAVKVFP--------QG--DKSFAKELAVLEADKHPN----VLHIAGHSFDEEKQRYSLVMEKMDM-DLAN
... ...| |.|| |. . | .        ||| .          .  .. | .|   |   .|||    .  . | . ... . . .||| ..   |.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYN

YVLKKNS--------------LPLLSIVAVMLQVATGMAWLHSKN---IIHWDLKPQNILVGE-----EDNDLVSIRIADFGVSRPNFISSQIE-AVSIQ
.   ..|               .. ...  .||.| ||. |||.    ||| |||..|||. |     .. .|   .|.|||.||  ....  .   | .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL---KICDFGTSR--DWHQMCTNMMSNA

GTRNFMAPEAW---SSERYTKKADVYSYGMLIYQLVTGNVPFEDGMD-----MEQVLRGKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICERL
||  .||||.     .|.|..|.||.|.|.......|. ||.....|     .. .. |.|| || |||| ...|| .||. |...||||. | . |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_a.AA Dicty4 139-386 29 8.1e-53 174.56 In-house 1-277 (277) Show / Hide 
Range on Protein: 139-386
Range on HMM: 1-277/277
Sequence Identity: 29% (82 aa)

LKLTTHLGQGGFGTVYEAIWLGHKFAVKVF--PQGD------KSFAKELAVLEADKHPNVLHIAGHSF--DEEKQRYSLVMEKM-DMDLANYVLK-----
.. .  .|.|.||.|| ..| | . |||..   . .      ..|.|| . .    |||..   | .     .. . . |.| |   .|..  ..     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--KNSLPLLSIVA---VMLQVATGMAWLHSKN--IIHWDLKPQNILVGEEDNDLVSIRIADFGVSR-PNFISSQIE-AVSIQGTRNFMAPEAWSSERYTK
  . .|..  | .    .. .| ||.|||. |  ||| |||. |.||   | ... . ..||| |.    ....   . .  ||   ||||   ...|. 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV---DKNWR-VKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KADVYSYGMLIYQLVTGNVPFE-DGMDMEQVLR-----GKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICER--LKQ
||||||.|.. ....|.  |.   .|. .|. |     . ||.||. || ....|. .||.|| . ||||. | .|  |  
KADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKx_a.AA Dicty4-Unclassified 139-384 30 4.7e-52 176.56 In-house 1-263 (263) Show / Hide 
Range on Protein: 139-384
Range on HMM: 1-263/263
Sequence Identity: 30% (83 aa)

LKLTTHLGQGGFGTVYEAIWLGHKFAVKVFPQGDKSFA--------KELAVLEADKHPNVLHIAGHSFDE--EKQRYSLVMEKMDM-DLANYVL-----K
..    .|.| |  |.  .| |   ||| |  .  .|         || ..|    ||| . . | .      |  .  ||| |    |   .      .
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

KNSLPLLS--IVAVMLQVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSRPNFISSQIEAVSIQGTRNFMAPEAWSSERYTKKADVYSY
. .. | .  |... . .| ||..||..|.|| |.|  |||.    |    |.|||||.||   |.       | ||    .||    | |. |.|||||
QQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFN----IKIADFGISR--VIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GMLIYQLVTGNVPFEDGM-DMEQVL----RGKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICERL
.|. | |.||. |. .    |.       .. ||.||  |. |...|   ||. | . ||.. .| ..|
AMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKx_a.AA LRRK 234-386 36 3.6e-48 166.34 In-house 169-351 (351) Show / Hide 
Range on Protein: 234-386
Range on HMM: 169-351/351
Sequence Identity: 36% (67 aa)

VMLQVATGMAWLHSKN--IIHWDLKPQNILVGEEDND--------LVSIRIADFGVSRPNFISSQIE-AVSIQGTRNFMAPEAWS---SERYTKKADVYS
..||.| ||. |||.|  ||| |||. |||. . ...         | . ||||| ||  | . . . |    |.  .||||       | || |.|.||
IALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYS

YGMLIYQLVTGN-VPFED-G---------MDMEQVLRGKRPEIPAT-CPE-----FLSQLMRECWSHDAKERPSFSDICERLKQ
.||... |.|.   ||..           .. . ...| || || . ||.      ...|. .||.|| |.||.||.| .||.|
FGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_a.AA RIPK 145-384 27 3.3e-43 145.08 In-house 1-290 (290) Show / Hide 
Range on Protein: 145-384
Range on HMM: 1-290/290
Sequence Identity: 27% (81 aa)

LGQGGFGTVYEAIWLGHKF--AVKVFP----------QGDKSFAKELAVLEADKHPNVLHIAGHSFDEEK---QR-YSLVMEKMDMDLANYVLKKNS---
.| ||||.|. |    ...  |.|. |          |  .    | . ..  .. ... | |   .||.      |..||| |     . .|.  .   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LPLLSIVAVMLQVATGMAWLHSKN--IIHWDLKPQNILVGEEDNDLVSIRIADFGVSRPNFISSQIE------AVSI------QGTRNFMAPEAWS-
   .|.        ... ||  |||.|  ||| ||||.||||   ||..  . |||||..  .  |..         |..       ||  .|.||.   
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILV---DNNF-HVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

--SER---YTKKADVYSYGMLIYQLVTGNVPFED----GMDMEQVLRGKRP---EIPATCPEF-----LSQLMRECWSHDAKERPSFSDICERL
  . .    |.| ||||........ |.  |.||     | |  . .|.||   ..|  .||      . .||..||. |...||.| .. |. 
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase MLKx_a.AA Dicty5 231-388 34 5.9e-38 128.23 In-house 106-260 (260) Show / Hide 
Range on Protein: 231-388
Range on HMM: 106-260/260
Sequence Identity: 34% (55 aa)

IVAVMLQVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSRPNFISSQIEAVSIQGTRNFMAPEAWSSERYTKKADVYSYGMLIYQLVTG
..   . .| .| .|||.|||| |||  |.|. |.      | | |||.||  |.  . .     || ..||.|   .  |. |.||||.|   . . | 
QLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITEN----WKIKIIDFGTSR--FVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTR

NVPFEDGMDMEQ---VLRGKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICERLKQLK
  |...    ..   |  | ||.||..||   | |   ||    . ||||  ||. .... 
KEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLKx_a.AA TyrKc 139-384 28 9.3e-36 126.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 139-384
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

LKLTTHLGQGGFGTVYEAIWLGHKFAVKVFPQGD-KSFAKELAVLEAD--KHPNVLHIAGHSFDEEK-----QRYSLVMEKMDM-DLANYVLKKNS-LPL
..|   || | ||.||...|   . |||.   .  . | .|. ..     .|||.. . |   ...      . . .||| |.  || .|  |.   |..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

LSIVAVMLQVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSRPNFIS-------SQIEAVSIQGTR-----NFMAPEAWSSERYTKKAD
   .  ..|.| ||. |||||.|| ||   |.||||.      ..|.||| ||            . . . . .|..       ||||..   ..| | |
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VYSYGMLIYQLVTGNVPFEDG-----MDMEQVLR----GKRPEIPAT--------CPEFLSQLMRECWSHDAKERPSFSDICERL
|.|.| ... . |   .   |     |. ..|..    |.|...|.         ||. . |.|..|| .|...||.||.|.|..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_a.AA Pkinase_Tyr 301-384 35 1.2e-24 84.16 Pfam 181-270 (270) Show / Hide 
Range on Protein: 301-384
Range on HMM: 181-270/270
Sequence Identity: 35% (32 aa)

MAPEAWSSERYTKKADVYSYGMLIYQLVT-GNVP-FEDGMDME---QV-LRGKRPEIPATCPEFLSQLMRECWSHDAKERPSFSDICERL
||||...  ..| | ||.|.| |.. ..| |  | ...  . |   ..  .| | ..|  ||. . .||..|| .|...||.||.| |.|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_a.AA Src 301-384 40 5.9e-21 67.89 In-house 167-255 (255) Show / Hide 
Range on Protein: 301-384
Range on HMM: 167-255/255
Sequence Identity: 40% (36 aa)

MAPEAWSSERYTKKADVYSYGMLIYQLVT-GNVPFEDGMD----MEQVLRGKRPEIPATCPEFLSQ-LMRECWSHDAKERPSFSDICERL
.|||| .  |.| |.|| |.| |.. .|| | || . ||.    ..|| || |   |..||. | . .|..||  |...|| |  ... |
TAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYP-GMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MLKx_a.AA Pkinase_Tyr 139-281 30 5.3e-20 68.38 Pfam 1-159 (270) Show / Hide 
Range on Protein: 139-281
Range on HMM: 1-159/270
Sequence Identity: 30% (50 aa)

LKLTTHLGQGGFGTVYEAIWL------GHKFAVKVFPQGDKS-------FAKELAVLEAD-KHPNVLHIAGHSFDEEKQ-RYSLVMEKMDM-DLANYVLK
...   ||.| ||.||...|       . . |||. ..|  .       | .|....    .|||..   |   |.... .. .||| |   || .|  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----KNSLPLLSIVAVMLQVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSR
    |..|..  ..   .|.| ||..|.|||.|| ||   |.||.|   ..  ..|.||| .|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NN-VVKICDFGLAR
Kinase MLKx_a.AA Src 237-281 51 1.3e-12 39.07 In-house 105-145 (255) Show / Hide 
Range on Protein: 237-281
Range on HMM: 105-145/255
Sequence Identity: 51% (23 aa)

QVATGMAWLHSKNIIHWDLKPQNILVGEEDNDLVSIRIADFGVSR
||| ||| | |.|.|| ||   |.||||.        .||||  |
QVAEGMAYLESMNYIHRDLAARNVLVGENN----VCKVADFGLAR
Kinase MLKx_a.AA Src 139-193 32 7.5e-08 22.71 In-house 1-59 (255) Show / Hide 
Range on Protein: 139-193
Range on HMM: 1-59/255
Sequence Identity: 32% (19 aa)

LKLTTHLGQGGFGTVYEAIWLG-HKFAVKVFPQGD---KSFAKELAVLEADKHPNVLHI
.||   |||| || |....| |  | |||.  .|.   . | .|  ..   .|......
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQL
Kinase MLKx_a.AA LRRK 139-168 23 1.3e-05 15.81 In-house 1-59 (351) Show / Hide 
Range on Protein: 139-168
Range on HMM: 1-59/351
Sequence Identity: 23% (14 aa)

LKLTTHLGQGGFG-TVYEAIWLG----------------------------HKFAVKVF
||    .|.|||| .|| |.| |                             . |.|..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase MLKx_a.AA Dicty5 139-190 25 0.007411 5.66 In-house 1-60 (260) Show / Hide 
Range on Protein: 139-190
Range on HMM: 1-60/260
Sequence Identity: 25% (15 aa)

LKLTTHLGQGGFGTVYEAIWLGHKFAVKVFPQGD------KSFAKELAVLEADK--HPNV
  .      |  |.||  |  |   |.||. |         .| .| ... . .  |||.
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNF