Gene MLKy_b-1 (S.moellendorffii)

MLKy_b-1

Species: S.moellendorffii
Alias: MLKy_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKy

Sequence

Name Sequence Type Origin Length Description Download
MLKy_b-1.AA Protein None 688 None Fasta, JSON
MLKy_b-1.NA RNA None 2067 None Fasta, JSON
MLKy_b-1.kin_dom Protein Kinase Domain None 166 None Fasta, JSON

Protein domain

Protein domains of MLKy_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKy_b-1.AA TKL 164-313 20 3.2e-16 54.91 In-house 142-364 (364) Show / Hide 
Range on Protein: 164-313
Range on HMM: 142-364/364
Sequence Identity: 20% (45 aa)

AQGVLDLHS--------RGITALNLKPFNFLLDEHDQ--------------AVLGEFGIPFLL-----MDAISSDGP------------LVWLGTPNYMA
|.|.  |||        ..|   .||. | |.||. .              . .. ||.   .     | .......                |||..||
ARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMA

PEQWEPKLR-------------GPVSYETDSWGFACSFIEMLTGVKPWNTMSPS---------EIFHAVVEKGDKPVVP------------SGLPIALTR
||  . ..              .. |  .| . |.  . |.||. .|.  . ..         |.|  |..|| .| .|            .  |  . .
PEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKK

MLTSCLASDRRDRPTFTEIMSVL
 .. | ..| ..||.|.||.. |
LMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKy_b-1.AA S_TKc 50-318 19 3.7e-14 30.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-318
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLPAISEDHIRAFTSKLEKIFSISQGASSVTWPRGLTMKNGKACVITKFFEL---SIGDKMARL
 ..   ||.| || |.... ..        ..||.|...          . . |     . .   .    .     .. .... . .    .  | . . 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

PGNC----IPLADALRYGVNLAQGVLDLHSRGITALNLKPFNFLLDEHDQAVLGEFGIPFLLMDAISSDGPLVWLGTPNYMAPEQWEPKLRGPVSY-ETD
...     .|  .| .|   .....  .||.||    ||| | ||||  .  .. ||.  .|             |||.|||||        . .. . |
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCD

SWGFACSFIEMLTGVKPWNTMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMS----VLRSPNV
 | . | ..|||.|  |.    . ..|. ..            .  .  ..  ||  | ..|||  |..     .   | .
WWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKy_b-1.AA MLK 218-313 29 6.8e-12 37.66 In-house 195-291 (291) Show / Hide 
Range on Protein: 218-313
Range on HMM: 195-291/291
Sequence Identity: 29% (29 aa)

GTPNYMAPEQWEPKLRGPVSYETDSWGFACSFIEMLTGVKPWN-TMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
||. .||||  . .  ...|   | | ..  . ||||.  |    ..|..|.  |...|  | .||. |  . .... |  .| ..||.| .|.. |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKy_b-1.AA STE 218-308 23 1.2e-10 33.88 In-house 225-350 (359) Show / Hide 
Range on Protein: 218-308
Range on HMM: 225-350/359
Sequence Identity: 23% (30 aa)

GTPNYMAPEQWEP--KL-RGPVSYETDSWGFACSFIEMLTGVKPWNTMSPS-EIFHAVVEK-------------GDKPVVPSGLP---------------
||| .||||  ..  .  ... ..  | | . |  |||.||  || .|.|   .|..  ..             |. |  |. |                
GTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYP

----IALTRMLTSCLASDRRDRPTFTE
      .   .  ||  | ..||| ..
HKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase MLKy_b-1.AA Pkinase 218-313 20 3.2e-10 37.22 Pfam 173-293 (293) Show / Hide 
Range on Protein: 218-313
Range on HMM: 173-293/293
Sequence Identity: 20% (25 aa)

GTPNYMAPEQWEPKLR--GPVSYETDSWGFACSFIEMLTGVKPWNTM------SPSEIFHAVVEKGDKPVVPSGLP-------------------IALTR
|||.|||||     .|   . ... | |.. | ..|||.|  |.         .. ...  . ..  .   |   .                    ..  
GTPWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

MLTSCLASDRRDRPTFTEIMSV--L
 ...||. |  .|||...|.    .
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLKy_b-1.AA TyrKc 50-313 21 1.2e-09 -66.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-313
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLPAISEDHIRAFTSKLEKIFSI---------SQGASSVTWPRGLTMKNGKACVITKFFELSIG
.||.. .|.| || |...|            .|||||| . .   ...| . ..   ..           |. .    .   |  .  .... . ..  |
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPH--G

DKMARLPGNC--IPLADALRYGVNLAQGVLDLHSRGITALNLKPFNFLLDEHDQAVLGEFGIPFLLMDAISSD------GPLVWL----GTP-----NYM
|   .|  .   ....| | . .  |.|   |||...    |   | |..|  ..  . ||    |. .| .|      .         |.        |
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEQWEPKLRGPVSYETDSWGFACSFIEMLT-GVKPWNT-----MSPSEIFHAVVEKGDKPVVPSG-------LPIALTRMLTSCLASDRRDRPTFTEIM
||| .     |  . ..| | |     |..| | .|.       ||..|... | . .  |  |..        | .. .. ..| . |  |||||.|| 
APECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SVL
. .
ECF
Kinase MLKy_b-1.AA Pkinase_Tyr 251-313 32 1.5e-09 32.96 Pfam 206-270 (270) Show / Hide 
Range on Protein: 251-313
Range on HMM: 206-270/270
Sequence Identity: 32% (21 aa)

EMLT-GVKP-WNTMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
|..| | .| .  ||..|..... |.|     | . |  . .....| . |  |||||.|| . |
EIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKy_b-1.AA Dicty4 251-315 27 2.3e-09 27.58 In-house 209-277 (277) Show / Hide 
Range on Protein: 251-315
Range on HMM: 209-277/277
Sequence Identity: 27% (19 aa)

EMLTGVKPWN--TMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSV--LRS
|.||.  | .   |.. ... ||..|. .| .|.  |  ... .. |.  |   ||.| || .   | .
EILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKy_b-1.AA RIPK 218-313 25 3.1e-09 27.6 In-house 184-290 (290) Show / Hide 
Range on Protein: 218-313
Range on HMM: 184-290/290
Sequence Identity: 25% (27 aa)

GTPNYMAPEQWEPKLRGP---VSYETDSWGFACSFIEMLTGVKPWNTMSPSEIFHAVVEKGDKPV---VPSGLPIA-----LTRMLTSCLASDRRDRPTF
||  ||.||  .. .. |   |. . |   ||    | ||. .|     ..... .....|  |    ||   |..     . . ...| ..| .|||.|
GTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCF

TEIMSVL
 |. .  
QECEEWT
Kinase MLKy_b-1.AA TK 50-98 19 1.2e-08 24.25 In-house 1-71 (486) Show / Hide 
Range on Protein: 50-98
Range on HMM: 1-71/486
Sequence Identity: 19% (14 aa)

LTLKHRIGRGPFG---DVWLATIHSHRE-------------------EFDEFHEVAVKMLPAISEDHIRAF
.|| . .|.| ||   .|.... ....                    . .. ..|||||| . .... ..|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEF
Pkinase_Tyr MLKy_b-1.AA Pkinase_Tyr 50-98 26 4.8e-08 27.86 Pfam 1-50 (270) Show / Hide 
Range on Protein: 50-98
Range on HMM: 1-50/270
Sequence Identity: 26% (14 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLPAISEDH---IRAF
.|. . .|.| ||.|...| .   .. ..  .||||||.  . ..   ...|
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDF
Kinase MLKy_b-1.AA TKL-Unique 250-313 22 5.8e-08 24.37 In-house 219-290 (290) Show / Hide 
Range on Protein: 250-313
Range on HMM: 219-290/290
Sequence Identity: 22% (16 aa)

IEMLTGVK------PWNTMSPSEIFHAVVE--KGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
.|..|.        |   |.. ... .| .  ..  | .|. .|  ..  .. | ..|  .||.|.|| . |
WEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKy_b-1.AA TK 222-313 18 2.3e-07 19.91 In-house 351-486 (486) Show / Hide 
Range on Protein: 222-313
Range on HMM: 351-486/486
Sequence Identity: 18% (25 aa)

YMAPEQWEPKL------RGPVSYETDSWGFACSFIEMLT-G-VKPWNTMSP---------SEIFHAVVEK-----------GDKPVVP--SGLP------
.|||| .. .        |  . ..| | | .   |..| | . .   ||           |..  ...            |..   |   . |      
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------IALTRMLTSCLASDRRDRPTFTEIMSVL
         .. .....| . | .|||||... . |
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKy_b-1.AA Dicty4-Unclassified 251-313 23 5.2e-07 20.02 In-house 200-263 (263) Show / Hide 
Range on Protein: 251-313
Range on HMM: 200-263/263
Sequence Identity: 23% (15 aa)

EMLTGVKPWNTMS-PSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
|..||  |.     . ..   | .|. .| .|.  .  . ..   |.  | . |||. .|   |
ELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKy_b-1.AA TK-Unique 272-313 20 5.5e-07 20.26 In-house 252-294 (294) Show / Hide 
Range on Protein: 272-313
Range on HMM: 252-294/294
Sequence Identity: 20% (9 aa)

VEKGDKPVVPSGL-PIALTRMLTSCLASDRRDRPTFTEIMSVL
...|. . .|..  . ...  . ||. ... .||.|..| ..|
IRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLKy_b-1.AA TK-Unique 50-87 39 8.7e-07 19.56 In-house 1-38 (294) Show / Hide 
Range on Protein: 50-87
Range on HMM: 1-38/294
Sequence Identity: 39% (15 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKML
|... .||.| || || ... .  ...|... ||||||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKML
Kinase MLKy_b-1.AA SrcA 50-68 47 3e-06 15.13 In-house 1-19 (250) Show / Hide 
Range on Protein: 50-68
Range on HMM: 1-19/250
Sequence Identity: 47% (9 aa)

LTLKHRIGRGPFGDVWLAT
..|..|.|.| ||.||. |
IRLERRLGQGCFGEVWMGT
Kinase MLKy_b-1.AA SrcA 241-313 31 1.2e-05 13.36 In-house 178-250 (250) Show / Hide 
Range on Protein: 241-313
Range on HMM: 178-250/250
Sequence Identity: 31% (23 aa)

DSWGFACSFIEMLT-GVKPWNTMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
| | |     |..| |  |.  |   |.    ||.| .   | . |..|  ..  |   |  .||||  . | |
DVWSFGILLTELVTKGRVPYPGMNNREVLEQ-VERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase MLKy_b-1.AA MLK 50-68 36 0.000225 11.23 In-house 1-19 (291) Show / Hide 
Range on Protein: 50-68
Range on HMM: 1-19/291
Sequence Identity: 36% (7 aa)

LTLKHRIGRGPFGDVWLAT
..... || |.||.||...
IQFHEWIGSGSFGKVWKGR
Kinase MLKy_b-1.AA TKL 56-88 27 0.000542 10.28 In-house 1-35 (364) Show / Hide 
Range on Protein: 56-88
Range on HMM: 1-35/364
Sequence Identity: 27% (10 aa)

IGRGPFGDVWLATIHSHREEFD---EFHEVAVKMLP
||.| || |. .. . ...         .||||...
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFK
Kinase MLKy_b-1.AA Dicty4-Unclassified 151-200 34 0.001046 8.53 In-house 104-155 (263) Show / Hide 
Range on Protein: 151-200
Range on HMM: 104-155/263
Sequence Identity: 34% (18 aa)

IPLAD--ALRYGVNLAQGVLDLHSRGITALNLKPFNFLLDEHDQAVLGEFGI
| | |   ..|    |||   ||.| .    .|  | |.| |  .  . |||
IKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGI
Kinase MLKy_b-1.AA TKL-Unique 164-226 24 0.001167 8.99 In-house 120-196 (290) Show / Hide 
Range on Protein: 164-226
Range on HMM: 120-196/290
Sequence Identity: 24% (19 aa)

AQGVLDLHSRG--ITALNLKPFNFLLDEH-----DQAVLGEFGIPFLLM--DAISSDGP-----LVWLGTPNYMAPE
|||   ||...  |. ..||. |||.|..      .. .  ||.. ..   .. .. ..      . .|....||||
AQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase MLKy_b-1.AA Pkinase 50-88 25 0.023346 9.42 Pfam 1-33 (293) Show / Hide 
Range on Protein: 50-88
Range on HMM: 1-33/293
Sequence Identity: 25% (10 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLP
.... .||.| || |.... .. ..      .|||| ..
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIK
Kinase MLKy_b-1.AA Dicty4 50-68 42 0.128093 1.37 In-house 1-19 (277) Show / Hide 
Range on Protein: 50-68
Range on HMM: 1-19/277
Sequence Identity: 42% (8 aa)

LTLKHRIGRGPFGDVWLAT
..   |||.| || | ..|
INIEQRIGKGSFGEVYKGT
Kinase MLKy_b-1.AA Dicty4 218-226 77 0.308171 0.08 In-house 179-187 (277) Show / Hide 
Range on Protein: 218-226
Range on HMM: 179-187/277
Sequence Identity: 77% (7 aa)

GTPNYMAPE
||| .||||
GTPCWMAPE