Gene MLKz_c (S.moellendorffii)

MLKz_c

Species: S.moellendorffii
Alias: MLKz_c
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKz

Sequence

Name Sequence Type Origin Length Description Download
MLKz_c.AA Protein None 344 None Fasta, JSON
MLKz_c.NA RNA None 1035 None Fasta, JSON
MLKz_c.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of MLKz_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKz_c.AA TKL 61-323 26 3.3e-87 296.01 In-house 1-360 (364) Show / Hide 
Range on Protein: 61-323
Range on HMM: 1-360/364
Sequence Identity: 26% (99 aa)

LGGGSSGRLYRGKYRG----------QDVAIKVIMLDEADGHSD-------------SGTLRGAPAAELLQVFKQEVSIMRMVRHKNLVQFIGACA----
.| |..|  |.||.||          .|||.|..  .. | ...             .  |.   |  . . ...|. .|.. || |.|||.|.|     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDM-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

---------NWPRLCIVTELMAGGSVRDVLESREGGLEVPAALKVLRDAAKGMDFLHR--------RGIVHRDLKSANLLIDEHDV--------------
         .|. ||||.|.. ||| ...|         .  ..  .|.|.||..||         ..|.||||||.|.|.||.                
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VKVCDFGVAR-LKPSNVNRSGSGNWP---------AEMTAETGTYRWMSPEVLEHK----------------AYDHKTDVYSFGIMIWELLTGDIPYSDL
.|.|||| .| ...|. .  .. . .              . ||.|||.||||. .                 |. |.|||||||..||.||. .||.|.
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

TPLQAA---------IGVVQRKLRPSMP------------ASVPDKLVNLAERCWNQDPQLRPEFSEV
 . .           ..|....||| .|             ..|. . .|...||..||. || |.|.
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEI
Kinase MLKz_c.AA Dicty4 55-323 35 3.4e-83 277.32 In-house 1-269 (277) Show / Hide 
Range on Protein: 55-323
Range on HMM: 1-269/277
Sequence Identity: 35% (101 aa)

VRFSRLLGGGSSGRLYRGKYRGQDVAIKVIMLDEADGHSDSGTLRGAPA-AELLQVFKQEVSIMRMVRHKNLVQFIGACA----NWPRLCIVTELMAGGS
  .  ..|.|| |  |.|. ||..||.|.  ..  .            . ...|. |..||.||   || |...| |||     . ...|||||.|  |.
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQN------------FDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGN

VRDVLES------REGGLEVPAALK---VLRDAAKGMDFLHRRG--IVHRDLKSANLLIDEHDVVKVCDFGVAR-LKPSNVNRSGSGNWPAEMTAETGTY
.  .| .       .  |. |  ..     .|||.||  || .   |.||||||.|||.|.. .||||||| ..  |.   .        . ...  || 
LYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHK-------DNQMTACGTP

RWMSPEVLEHKAYDHKTDVYSFGIMIWELLTGDIPYS--DLTPLQAAIGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEFSEV
 ||.|||. |..|. | |||||||. ||.||...||.     . |....|.. ||||..|...|...  | ..||. ||| || |.|.
CWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEI
Kinase MLKz_c.AA MLK 55-327 30 4.9e-82 278.86 In-house 1-291 (291) Show / Hide 
Range on Protein: 55-327
Range on HMM: 1-291/291
Sequence Identity: 30% (96 aa)

VRFSRLLGGGSSGRLYRGKYRGQD-----VAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMVRHKN----LVQFIGACANWPR-LCIVTEL
 .|.. .| ||.|  ..|..|..|     ||.| .  .     ||..        .  . |..|. . |...|.|     .|| |.|.. |  .|||.| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTY--------CEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEY

MAGGSVRDVLESREGGLE-----------VPAALKVL--RDAAKGMDFLHRRG---IVHRDLKSANLLIDE------HDVVKVCDFGVARLKPSN-VNRS
..|||  .|| ..... .           .. ....    . |.||..||      |.|||||| |.||||      |...|.||||..| . ..  |  
CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN--

GSGNWPAEMTAETGTYRWMSPEVL---EHKAYDHKTDVYSFGIMIWELLTGDIPYS-DLTPLQAAIGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLR
        |.   |||.||.|||.   ..  |. | ||.|.|...||.||. .||. .. |...|..|.. .||| .| . |. . .| ..||||||  |
--------MMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKR

PEFSEVRCFS
| |...  . 
PSFRQIVQHL
Kinase MLKz_c.AA TKL-Unique 57-324 32 2.6e-80 273.11 In-house 1-287 (290) Show / Hide 
Range on Protein: 57-324
Range on HMM: 1-287/290
Sequence Identity: 32% (98 aa)

FSRLLGGGSSGRLYRGKYRGQDVAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMVR-HKNLVQFIGACA----NWPRLCIVTELMAGGSVR
|. ..|.|..|. |.||.|| .||||.. . ..| .            |..| |. ||..| . . |.|.|...|.|.      |..|||.| . ||| .
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSS-----------NEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLY

DVLE---------SREGGLEVPAALKVLRDAAKGMDFLHRRG--IVHRDLKSANLLIDEH-----DVVKVCDFGVARLKPSN----VNRS-GSGNWPAEM
|||          ...  |     .|  .|.|.||..||...  | |||||| |.|.|..       .|.|||| .... ..    .|.. |..      
DVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-----N

TAETGTYRWMSPEVLEH--KAYDHKTDVYSFGIMIWELLTGDI------PYSDLTPLQAA--IGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEF
. . |..|||.||||.   . |. | |||||||. ||..|..|      ||..... | .  . .. ...||  | . |  . .| ..||..||. || |
QTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSF

SEVR
.|..
DEII
Kinase MLKz_c.AA TyrKc 55-327 26 7.7e-73 249.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-327
Range on HMM: 1-280/280
Sequence Identity: 26% (83 aa)

VRFSRLLGGGSSGRLYRGKYRGQDVAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMV--RHKNLVQFIGACANW-------PRLCIVTELM
... . || |  |. |.|... ..||.|..  |                   .. | .| .||...  .|.|.|...|.|          . |.||.|.|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

AGGSVRDVLESREGGLEVPAALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEHDVVKVCDFGVARLKPSN--------VNRSG---SGN--WPAEMTA
..|. .| | .... | ..  |.   ..|.||..||.....||||   | |..|  .||..||| .|   .         . |.    .|.  .|     
PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP-----

ETGTYRWMSPEVLEHKAYDHKTDVYSFGIMIWELLT-GDIPYSDL----TPLQAAIGVVQRKLRPSMPAS--------VPDKLVNLAERCWNQDPQLRPE
    .|||.||.. .. . .|.||.|||...||..| |. ||..      . | .|  |..  |.  |..         ||.. .. ..||. ||  || 
----IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

FSEVRCFS
|||.. . 
FSEIHECF
Kinase MLKz_c.AA Pkinase_Tyr 55-326 28 1.4e-68 232.92 Pfam 1-269 (270) Show / Hide 
Range on Protein: 55-326
Range on HMM: 1-269/270
Sequence Identity: 28% (85 aa)

VRFSRLLGGGSSGRLYRGKYR------GQDVAIKVIMLDEADGHSDSGTLRGAPAAE-LLQVFKQEVSIMRMV-RHKNLVQFIGACA-----NWPRLCIV
..| . || |. |. |.|...      ...||.|..               ||   . ... | .|..||.   .|.|.|...|.|      |  ...||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-------------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIV

TELMAGGSVRDVLESR---EGGLEVPAALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEHDVVKVCDFGVARLK-PSNVN--RSGSGNWPAEMTAETG
.|.|..|. .| | ..   .. | ..  |.  .. ||||..|......||||   | |..|  |||.|||| ||.  .       .|.| .|        
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP--------

TYRWMSPEVLEHKAYDHKTDVYSFGIMIWELLT-GDIP-YSDLTPLQAAIGVV-QRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEFSEVRCF
  .||.||.. .. . .|.||.|||. .||..| |..| | .. . .  .  . ..  |  .|   ||.. .|  .||..||. || |||.. .
-IKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ
Kinase MLKz_c.AA S_TKc 55-326 22 3.4e-66 227.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-326
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

VRFSRLLGGGSSGRLYRGKYRG--QDVAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMVRHKNLVQFIGACANWPRLCIVTELMAG--GSV
 .. |..| |. |. |... ..  . ||||.|                       . ...|..|... .|.|.|...... .  .|..|.|.. |  |..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

RDVLESREGG-----LEVPAALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEHDVVKVCDFGVARLKPSNVNRSGSGNWPAEMTAETGTYRWMSPEVL
.|....| ..     .    | ....  .......|..||.||||| .|.|.||  ..|.||||.||.                 |   ||  .|.||||
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL

EHKAYDH-KTDVYSFGIMIWELLTGDIPYSDLTPLQAAIGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEFSEVRC----------F
    |.. | |..|.|....|.|.|  |..    .|. . ..            .. . .. ..|.. ||. ||   |.            |
---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKz_c.AA Pkinase 55-318 23 1.1e-64 225.99 Pfam 1-282 (293) Show / Hide 
Range on Protein: 55-318
Range on HMM: 1-282/293
Sequence Identity: 23% (70 aa)

VRFSRLLGGGSSGRLYRGKYRGQD--VAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMVRHKNLVQFIGACANWPRLCIVTELMAGG----
 .. | .| ||.|. |... .|    ||.|.| .....   |   .|            .|..||....|.| |...... . .....|.|.. ||    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM

SVRDVLE-SREGGL--EVPAALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEHDVV----KVCDFGVARLKPSNVNRSGSGNWPAEMTAETGTYRWMS
.  |... .|.|..  .   . ....  ..|....|..||.|||||..|.|||.....    |.||||.|...          . . .||  .||...|.
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------Y-NNSMTTFCGTPWYMA

PEVLE-HKAYDHKTDVYSFGIMIWELLTGDIPYSDL------TPLQAAIGVVQRKLRPSMPASVP-------------------DKLVNLAERCWNQDPQ
|||.  .. |..| |..|.|....|.|.|  |...       ...|    . ...|. . | . .                   . .  . ..|...||.
PEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

LRP
 ||
KRP
Kinase MLKz_c.AA DRK 62-323 37 1.7e-63 213.95 In-house 8-252 (258) Show / Hide 
Range on Protein: 62-323
Range on HMM: 8-252/258
Sequence Identity: 37% (99 aa)

GGGSSGRLYRGKYRGQDVAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMVRHKNLVQFIGACANWPRLCIVTELMAGGSVRDVLESREGGL
| |. |  .||  ||  ||.|   ..  .              ..|. |..|. .|   || | .||.|.| | |  ||..| |  ||   .|      .
GRGNYGEVFRGTWRGTQVAVKMLFNHNIN------------DENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEM

EVPAALKVLRDAAKGMDFLHRRG--IVHRDLKSANLLIDEHDVVKVCDFGVA-RLKPSNVNRSGSGNWPAEMTAETGTYRWMSPEVLEHKAYDHKTDVYS
. |  ..   |.|||| .|| .   |.|||||| |||.|||  ||| ||| . | |   .   .     . ||.  ||  | .||||    |  | ||||
DWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFK--KHKQHK-----FAMTM-CGTPCWTAPEVLRNQRYTEKADVYS

FGIMIWELLTGDIPYSDLTPLQAAIGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEFSEV
|.|  ||..|  .||    ..|  . | . ..|| ||. .| | . |  .||| ||| || . |.
FAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQEC
Kinase MLKz_c.AA TK 55-327 16 2.5e-63 210.87 In-house 1-486 (486) Show / Hide 
Range on Protein: 55-327
Range on HMM: 1-486/486
Sequence Identity: 16% (84 aa)

VRFSRLLGGGSSG---RLYRGKYRG---------------------------QDVAIKVIMLDEADGHSDSGTLRGAPAAELLQVFK---------QEVS
... . || |  |   . |.|..||                           ..||.|..... |.          ...........         .|..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAM----------SQEEFFDEEMHDRDGGEDFLEEAE

IMRMVR-----HKNLVQFIGACANW------------PRLCIVTELMAGGS----VRDVLESREGG----------------------------------
.| | .     |.|.|...|.|               . ..||.|.|..|.     || | .. ..                                  
EMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHES

-----------------------------------------LEVPAALKVLRDAAKGMDFLHRR------GIVHRDLKSANLLIDEHDV-----------
                                         | ..  |   ...|.|| .||..      ..|||||   | |..|..|           
NSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPV

VKVCDFG--------VARLKPSNVNRSGSGN--------------WPAEMTAETGT---YRWMSPEVLE---------HKAYDHKTDVYSFGIMIWELLT
.|..|||         ||  .|. .   ...              | ..  ...|.    |||.||.|.         .. . .|.||.|||...||..|
CKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

-G-DIPYSDLTP--------LQAAIGVVQR--------------KLRPSMPASVPD-------------KLVNL-AERCWNQDPQLRPEFSEVRCFS
 |   .| ...         .|  .  ..|              ..|.  |.  ||             ... .   .||. ||. || ||... . 
YGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKz_c.AA Dicty4-Unclassified 55-327 32 1.2e-61 209.89 In-house 1-263 (263) Show / Hide 
Range on Protein: 55-327
Range on HMM: 1-263/263
Sequence Identity: 32% (93 aa)

VRFSRLLGGGSSGRLYRGKYRGQDVAIKVIMLDEADGHSDSGTLRGAPAAELLQVFKQEVSIMRMVRHKNLVQFIGACANW----PRLCIVTELMAGGSV
..  . .| |   . ..|  .| |||.| .        . .   |     |..| || || |.  . | |||.  |.| |       .|||.|.|  |  
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKF-------NENKFKFR----EEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL

RDVLE----SREGGLEVPA--ALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEHDVVKVCDFGVARLKPSNVNRSGSGNWPAEMTAETGTYRWMSPEV
  |       ..  .       .|.  | |.|| .|| | ..|||.||.|.|.| |  .|. |||..|    | |          ||.  || .| |||.
FEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN----------MTTIAGTPKWESPEC

LEHKAYDHKTDVYSFGIMIWELLTGDIPYSDLT-PLQAAIGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEFSEVRCFS
| | .|  | ||||...| .||.||| || .   .. ||. |  .|||| .| ...  .  |   ||  ||. || . ..    
LMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKz_c.AA LRRK 55-323 24 6.1e-57 195.49 In-house 1-345 (351) Show / Hide 
Range on Protein: 55-323
Range on HMM: 1-345/351
Sequence Identity: 24% (87 aa)

VRFSRLLGGGSSG-RLYRGKYRG----------------------------QDVAIKVIMLD---------EADG-----------HSDSGTLRGAPAAE
... ...| |..| . ||.|.||                            |.||||.. .|           ..             |   .... ...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

LLQVFKQEVSIMRMVRHKNLVQFIGACANWPRLCIVTELMAGGSVRDVLESRE-GG-------LEVPAALKVLRDAAKGMDFLHRRG--IVHRDLKSANL
 .. | .||.||.  .| |.|. .| | . | ||.|.|..  |.  ..|....  |       .     ||.  . ||||..||..   |.|||||| | 
AFREFRHEVWIMSHLNHPNIVSLKGFCIH-P-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNI

LIDEHD------------VVKVCDFGVAR----LKPSNVNRSGSGNWPAEMTAETGTYRWMSPEVLE---HKAYDHKTDVYSFGIMIWELLTGD-IPYSD
|. ...            ..|..|||  |    .... .....            |. .||.||..     . |. |.|.||||. .|||||.. .|. .
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV------------GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE

LT-P-----LQAAIGVVQRKLRPSMPAS-VPD-----KLVNLAERCWNQDPQLRPEFSEV
.. .            ....|||. | .  |       . .| . ||..||. || ||..
HDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQI
Kinase MLKz_c.AA Dicty5 110-330 33 9.4e-51 172.91 In-house 43-260 (260) Show / Hide 
Range on Protein: 110-330
Range on HMM: 43-260/260
Sequence Identity: 33% (77 aa)

FKQEVSIMRMVR--HKNLVQFIGACA-NWPRLCIVTELMAGGSVRDVLESREG----GLEVPAALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEHDV
|. || || ..   | |.. . ||   |   . .|||.   ||... |  ..      .  .  |    |.|..| .||  .|.|||||| | || |   
FYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK

VKVCDFGVARLKPSNVNRSGSGNWPAEMTAETGTYRWMSPEVLEHKAYDHKTDVYSFGIMIWELLTGDIPYSDLTPLQAAIGVVQRKLRPSMPASVPDKL
.|. |||. |    .|          .|| . ||  ||..|.   . |. | |||||||  ||..| . || ...    ..  |.   || .|. .|   
IKIIDFGTSR----FVDNR------YHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPV-MVMKGERPTIPKDCPTEI

VNLAERCWNQDPQLRPEFSE-VRCFSSRC
 || . || | |..|| | | .  | |  
SNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLKz_c.AA Shk 107-209 42 4.2e-26 90.54 In-house 40-148 (269) Show / Hide 
Range on Protein: 107-209
Range on HMM: 40-148/269
Sequence Identity: 42% (46 aa)

LQVFKQEVSIMRMVRHKNLVQFIGACA-NWPRLCIVTELMAGGSVRDVLESREGGLE---VPAALKVLRDAAKGMDFLHR--RGIVHRDLKSANLLIDEH
.  |. ||.||  ..| |.. | |||     .. ||||||  |..   | . .  ..      |..  |||| ||  ||     |.|||||.||||.|. 
MTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILYKRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQN

DVVKVCDFG
 .|||||||
WRVKVCDFG
Kinase MLKz_c.AA Shk 239-323 41 1.2e-25 88.94 In-house 172-258 (269) Show / Hide 
Range on Protein: 239-323
Range on HMM: 172-258/269
Sequence Identity: 41% (37 aa)

WMSPEVLEHKAYDHKTDVYSFGIMIWELLTGDIPYS----DLTPLQAAIGVVQRKLRPSMPASVPDKLVNLAERCWNQDPQLRPEFSEV
|| |||.  . |. | |||||||  ||.||   ||.    .. .. .||  .  |.||. |.. |. |  | ..||  .|| || |.|.
WMAPEVMMNHPYNEKADVYSFGIILWEILTCQEPYPKHHSEYDKFYEAI--CNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEI
Kinase MLKz_c.AA Dicty5 55-83 55 5.8e-10 30.48 In-house 1-29 (260) Show / Hide 
Range on Protein: 55-83
Range on HMM: 1-29/260
Sequence Identity: 55% (16 aa)

VRFSRLLGGGSSGRLYRGKYRGQDVAIKV
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VSFHDWIASGASGRVYNGIYKGMDVAIKV
Kinase MLKz_c.AA Shk 55-83 44 2e-06 19.69 In-house 1-29 (269) Show / Hide 
Range on Protein: 55-83
Range on HMM: 1-29/269
Sequence Identity: 44% (13 aa)

VRFSRLLGGGSSGRLYRGKYRGQDVAIKV
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INREDFLGQGSFGKVYKGRCRGKEVAVKV