Gene WAKL_c (S.moellendorffii)

WAKL_c

Species: S.moellendorffii
Alias: WAKL_c
External Links:
Annotation:

Classification

Group: TKL
Family: WAKL

Sequence

Name Sequence Type Origin Length Description Download
WAKL_c.AA Protein None 339 None Fasta, JSON
WAKL_c.NA RNA None 1020 None Fasta, JSON
WAKL_c.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of WAKL_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WAKL_c.AA TKL 42-283 18 1e-21 74.94 In-house 1-282 (364) Show / Hide 
Range on Protein: 42-283
Range on HMM: 1-282/364
Sequence Identity: 18% (61 aa)

IGAGGCGSIFKGTITRSYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNETVSVAVKTIHSSDDEVIDL-------------------
|| || | ..||.     | . .                                   . .    ||||...| .|   ..                   
IGSGGFGEVYKGKWRGWGG-KCP-----------------------------------S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDP

------TREASSLRILQG--TRNVASVYG---------VTHN--REMQSVCIVMELVQGPDLNSFLRSGKPSSCSWSWWKTKLEIFMELVIGLSICHQ--
       .|   ....      |. . .|         | ..   .    |||||...| .| ..|            |  .. . ..   |..  |.  
EASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMN

------RGIYHGDLKGKNVLVDEFMV--------------PKLIDFGFSFRKKDVDY--------------------LRSLGGSPFWISPEL-------D
      ..| | ||| ||.|||| .               .|. |||.| ...                        . . .|.| | .||.       .
PKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYT

EAV--DEIPPEVLANPFPSDVYSLGMLLVEM
|.|  ||   . .     .|||| |..| |.
EKVGIDE-FCKGFEYSEKCDVYSFGIVLWEI
Kinase WAKL_c.AA CAMKL 107-253 24 4.1e-19 57.49 In-house 28-204 (297) Show / Hide 
Range on Protein: 107-253
Range on HMM: 28-204/297
Sequence Identity: 24% (45 aa)

VAVKTIH---SSDDEVID-------------LTREASSLRILQGTR---NVASVYGVTHNREM----QSVCIVMELVQGPD--LNSFLRS-GKPSSCSWS
||.| |.    ..|....             ..||.. .. |. ..   |. . | |  ..|.    . ...|||...| .  |  .... |..      
VAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRR-----

WWKTKLE------IFMELVIGLSICHQRGIYHGDLKGKNVLVDEFM--VPKLIDFGFS--FR---KKDVDYLRSLGGSPFWISPEL
    ...      .|  .| ... ||..|| | |.|  |.|.|| .  . |.||||||  .|   ... . |.   |||   .||.
---GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI
Pkinase WAKL_c.AA Pkinase 36-283 18 1.9e-17 62.76 Pfam 1-205 (293) Show / Hide 
Range on Protein: 36-283
Range on HMM: 1-205/293
Sequence Identity: 18% (50 aa)

FSKLTEIGAGGCGSIFKGTITRSYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNETVSVAVKTIHSSDDEVIDLTR-----EASSLR
. ..  ||.|. |. .|..   .                                                ||||.|  ....   . .     |.. ..
YHIGRKIGSGSFGCVYKCHHKGTGK---------------------------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMK

ILQGTRNVASVYGVTHNREMQSVCIVMELVQGP----DLNSFLR--SGKPSSCSWSWWKTKLEIFMELVIGLSICHQRGIYHGDLKGKNVLVDEFMVP--
 | .  |.   |.. ..   .....|||...|     || ....  .... .   |.|  |  .. ... ||  ||..|| | |||  |.|.|. ...  
RL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKF-YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA

--KLIDFGFSFR--KKDVDYLRSLGGSPFWISPELDEAVDEIPPEVLANPFPSDVYSLGMLLVEM
  |..|||..          . .. |.|....||.         .    . ..|..|.| .| ||
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-------GGQYYGPKVDMWSCGCILYEM
Kinase WAKL_c.AA CAMK 41-253 13 2.5e-17 51.72 In-house 1-291 (425) Show / Hide 
Range on Protein: 41-253
Range on HMM: 1-291/425
Sequence Identity: 13% (45 aa)

EIGAGGCGSIFKGTITRSYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNE-T-------------VSVAVKTIHSS-----------
..| |. |  .                                               .. .  |             . ||.| |  .           
TLGRGSFGKVK-----------------------------------------------LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYS

------------------DDEVIDLTREASSLRILQG------TRNVASVYGVTH------------NREMQ------SVCIVM---ELVQGP----DLN
                  .     . || . .. |||       .|. . | |              . ..|       ...||   |...|     || 
NCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLF

SFLRSGKPSSCSWSWWK-------TKL------EIFMELVIGLSICHQRGIYHGDLKGKNVLVDEFM-----------------VPKLIDFGFS--FRKK
..... .. ...             ..       .|  .. ..  ||...| | |||  |.|.|. .                   |.|||||.  |...
DYIVEHGCYGEEF---DQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG

DVDY----------------------LRSLGGSPFWIS-PEL
. ..                      ..   |.|  .. ||.
ENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase WAKL_c.AA GIN4 186-280 36 4.3e-14 41.0 In-house 137-225 (293) Show / Hide 
Range on Protein: 186-280
Range on HMM: 137-225/293
Sequence Identity: 36% (35 aa)

LEIFMELVIGLSICHQRGIYHGDLKGKNVLVDEFMV-PKLIDFGFSFRKKDVDYLRSLGGSPFWISPELDEAVDEIPPEVLANPFPSDVYSLGMLL
...|  ..||.| ||  .| | |||  |.|.|..    |. |||    . | . |.   ||| . .||.   |  || .     |.|||.| |..|
IHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETSCGSPHYAAPEI---VMGIPYHG----FASDVWSCGVIL
Kinase WAKL_c.AA MSN 36-283 22 7.5e-14 41.89 In-house 1-202 (265) Show / Hide 
Range on Protein: 36-283
Range on HMM: 1-202/265
Sequence Identity: 22% (57 aa)

FSKLTEIGAGGCGSIFKGTITRSYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNETVSVAVKTIHSSDDEVIDLTREASSLRILQGT
|.    .| |  | ..||  ..   .       | .                                             ||  ..  |   |.     
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE---------------------------------------------DEEEEIKQEINMLKKYSHH

RNVASVYGVTHNR----EMQSVCIVMELVQGPDLNSFLRSGKPSSCSWSWWKTKLEIFMELVIGLSICHQRGIYHGDLKGKNVLVDEFMVPKLIDFGFSF
||.|. ||    .    . . . .|||.     .   ... |  |    |      |  |.. ||.  ||. . | |.||.|||. .    ||.||| | 
RNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQSLKEDWI---AYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSA

R-KKDVDYLRSLGGSPFWISPELDEAVDEIPPEVLANPFPSDVYSLGMLLVEM
   . |    .  | |.|. ||   | || |       . ||..|.|.  .||
QLDRTVGRRNTFIGTPYWMAPEV-IACDENPDATYD--YRSDLWSVGITAIEM
Kinase WAKL_c.AA S_TKc 36-334 17 1.7e-13 20.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-334
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)

FSKLTEIGAGGCGSIFKGTITRSYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNETVSVAVKTIHSSDDEVIDLTREASSLRILQGT
. .| .|| |. |. .|.. ..                                                 ||.| |.      ... || . |.   . 
YEILRKIGKGAFGKVYKCRHKK---------------------------------------------TGRIVAIKIIK------EHIRREIQILKK--HH

RNVASVYGVTHNREMQSVCIVMELVQG--PDLNSFLRSGKP--SSCSWSWWKTKLEIFMELVIGLSICHQRGIYHGDLKGKNVLVDEFMVPKLIDFGFSF
 |.   |.| ..   .....|||.. |   || ..... ..    .  .   ..  .. ... .|  ||..|| | |||  |.|.||  . |..|||.. 
PNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF-YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLAR

RKKDVDYLRSLGGSPFWISPELDEAVDEIPPEVLANPFPSDVYSLGMLLVEMTIDGEIPEYMDSVLVMNKYMGGSPIELQVSRRHGGSKRER------FR
.       ... |.|....||.             .....|..|.| .| ||   |. | .   . .| | .|              |.  .      ..
QL------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQ

RD--------LCR-------GRWM
.|        . .         |.
KDPEKRPTAEALQDEWDIKCHPWF
Kinase WAKL_c.AA TK 97-290 15 2.3e-13 40.42 In-house 45-394 (486) Show / Hide 
Range on Protein: 97-290
Range on HMM: 45-394/486
Sequence Identity: 15% (54 aa)

PSEGDNETVSVAVKTIH--SSDDEVIDLT-------------REASSLRILQG----TRNVASVYG-VTHNREM---------QSVCIVMELVQGPD---
. ....... ||||...  .....   .              .||. . ...       |. . || .|.....         . ..||||.... |   
KNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDG

-LNSFLRSGKP-------------------------------------------------------SSCSWSWWK----------------TKLEIFMEL
 | ..||. .|                                                       . . .  .                 ..| . . .
SLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQI

VIGLSICHQR------GIYHGDLKGKNVLVDEFMV-----------PKLIDFGFS-------FRKKDV--DYLRSL----GGSPFWISPELDEAVDE---
  |..  |..      .. |.||   |.||.| .|            |. ||| |        |. .   || |.     |. . |  |       .   
ACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-W--P-FE----DDPW

----------------IPPEVLANPFP------------SDVYSLGMLLVEMTIDGEIP
                 .||.|.   .            |||.|.| |. |.   |. |
QDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase WAKL_c.AA Ciliate-E2 151-280 18 1.6e-12 39.32 In-house 107-286 (365) Show / Hide 
Range on Protein: 151-280
Range on HMM: 107-286/365
Sequence Identity: 18% (34 aa)

QSVCIVMELVQGPDLNSFLRSG-KPSSCSWS-----WWKTKLEIFMELV---------------IGLSICHQRG-IYHGDLKGKNVLVDEFMVPKLIDFG
... .|||..|| || .....  | . .  .      .|  ..|. ...                .|  .|... | | |.|  |.|.     .|.||||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG

FSFRKKDVDYLRSLGGSPFWISPELDE-----------------------AVDEIPPEVLANP------------FPSDVYSLGMLL
.| . .|  . |.  ..   . ..                             . .||.| .             . .|..|||..|
LSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase WAKL_c.AA MARK 188-253 36 2.2e-12 36.99 In-house 109-176 (262) Show / Hide 
Range on Protein: 188-253
Range on HMM: 109-176/262
Sequence Identity: 36% (25 aa)

IFMELVIGLSICHQRGIYHGDLKGKNVLVDEFM--VPKLIDFGFSFRKKDVDYLRSLGGSPFWISPEL
||  .| ... ||...| | |.|  |.|.|| .    |.|||||| . .    | .  |.|   .||.
IFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEI
Kinase WAKL_c.AA Ciliate-E2-Unclassified 153-280 20 2.7e-12 38.98 In-house 96-260 (352) Show / Hide 
Range on Protein: 153-280
Range on HMM: 96-260/352
Sequence Identity: 20% (37 aa)

VCIVMELVQGPDLNSFLRSGKP------------------------SSCSWSWWKTKLEIFMELVIGLSICHQRG-IYHGDLKGKNVLVDEFM---VPKL
..||||...| ||  .... |                         .       | .. .| ... ||. .|. . | | |.|  |.|.|. .    .|.
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY-------KKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKI

IDFGFS-FRKKD---------------VDYLRSLGGSPFWISPELDEAVDEIPPEVLANPFPS-------DVYSLGMLL
||||.| . ...                . . .  |.|  .. .        .|||| .  ..       |..|||..|
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase WAKL_c.AA TyrKc 36-328 18 8.9e-10 -64.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-328
Range on HMM: 1-280/280
Sequence Identity: 18% (64 aa)

FSKLTEIGAGGCGSIFKGTITRSYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNETVSVAVKTIHSSDDEVIDLTREASSLRIL-QG
 ... ..| |  | ..||| .                                                . ||||.....   . |. |||. .. |   
ITLGKKLGEGAFGEVYKGTWK------------------------------------------------IQVAVKMLKEDA--REDFMREARIMCKLGGH

TRNVASVYGVTHNR-----EMQSVCIVMELVQGPDLNSFLRSGKPSSCSWSWWKTKLEIFMELVIGLSIC------HQRGIYHGDLKGKNVLVDEFMVPK
  |.   |||         . . ..||||.. . ||...||. .|           |     | . . |.      |.... | ||   |.||.|  . |
HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVK

LIDFGFSFRKKDV-------DYLRSLG--GSP-----FWISPELDEAVDEIPPEVLANP---FPSDVYSLGMLLVEMTIDGEIPEY------MDSVLVMN
  ||| |   .|        || |. .  |.       |            .||..      . |||.| | .. |.  .|. | .      |.   |..
ISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW-----------MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE

KYMGG---SPIEL---------------------QVSRRHGGSKRERFRRDL
. . |    . .                      .       . .|  ....
YVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase WAKL_c.AA STE 191-252 25 1.1e-09 30.53 In-house 159-232 (359) Show / Hide 
Range on Protein: 191-252
Range on HMM: 159-232/359
Sequence Identity: 25% (20 aa)

ELVIG-LSICHQRGIYHGDLKGKNVLVDEFMVPKLIDFGFSFRKKD-----------------VDYLRSLGGSPFWISPE
... | |.  |. .| | |.|. |.|.      ||.|||.. .  |                 .    .. |.| | .||
QILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase WAKL_c.AA Pkinase_Tyr 87-171 25 2.3e-07 25.57 Pfam 19-100 (270) Show / Hide 
Range on Protein: 87-171
Range on HMM: 19-100/270
Sequence Identity: 25% (23 aa)

YYNSSSSGSNPSEGDNETVSVAVKTI--HSSDDE--VIDLTREASSLRILQGTRNVASVYGVTHNREMQ-SVCIVMELVQGPDLNSFLRS
...         ..||... ||||..  ......    |. |||. .. |    |. . |||   .. . ...||||.... || ..||.
TWKG--------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
Kinase WAKL_c.AA STE 36-162 10 0.001855 8.22 In-house 1-121 (359) Show / Hide 
Range on Protein: 36-162
Range on HMM: 1-121/359
Sequence Identity: 10% (17 aa)

FSKLTEIGAGGCGSIFKGTITR-----SYGVQHKLYRGVWDSKRIEGVFDPFDSYNYYNSSSSGSNPSEGDNETVS------VAVKTIHSSD--------
. .. .|| |..|. .|.         . | . .                                                .|.| .. ..        
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVEN-----------------------------------------NGETGEIMAIKQMNLENCNNKDENQ

----------DEVIDLTREASSLRILQG-TRNVASVYGVT-HNREM----QSVCIVMELVQG
          .|. .. .| . .. ..    |.   ||   .. .     ....|.||.. |
ENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDG
Kinase WAKL_c.AA MARK 151-171 22 0.01574 4.28 In-house 74-95 (262) Show / Hide 
Range on Protein: 151-171
Range on HMM: 74-95/262
Sequence Identity: 22% (5 aa)

QS-VCIVMELVQGPDLNSFLRS
|  ....||.. | .| .....
QHQIYLIMEYASGGELYDYIKA
Kinase WAKL_c.AA STE 262-283 29 0.035816 3.62 In-house 231-261 (359) Show / Hide 
Range on Protein: 262-283
Range on HMM: 231-261/359
Sequence Identity: 29% (9 aa)

PEVLANP---------FPSDVYSLGMLLVEM
|||. .          . .|..||| ...||
PEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase WAKL_c.AA Ciliate-E2 36-53 33 0.186367 0.74 In-house 1-18 (365) Show / Hide 
Range on Protein: 36-53
Range on HMM: 1-18/365
Sequence Identity: 33% (6 aa)

FSKLTEIGAGGCGSIFKG
. ..  || |. ||..|.
YKFIKKIGQGNFGSVYKC
Kinase WAKL_c.AA Ciliate-E2-Unclassified 36-52 35 0.245466 0.42 In-house 1-17 (352) Show / Hide 
Range on Protein: 36-52
Range on HMM: 1-17/352
Sequence Identity: 35% (6 aa)

FSKLTEIGAGGCGSIFK
. ..  || || |...|
YKIIKQIGQGGFGKVYK