Gene LmjF25.1560 (L.major)

LmjF25.1560

Species: L.major
Alias: LmajK063, LmjF25.1560
External Links:
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
LmjF25.1560.AA Protein None 809 None Fasta, JSON
LmjF25.1560.kin_dom Protein Kinase Domain None 628 None Fasta, JSON

Protein domain

Protein domains of LmjF25.1560.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF25.1560.AA CMGC 409-682 12 1.8e-26 83.19 In-house 152-392 (513) Show / Hide 
Range on Protein: 409-682
Range on HMM: 152-392/513
Sequence Identity: 12% (44 aa)

YRG------------------------LPLPLLKAVLYQVLTFLQ--FIHCRG--VVHTDLKPENVLFESSKVLSVDVGIYYTHYLRRNSDTVAKRMPSA
|.|                        ... . .   ||.|. |   ..| ..  ..|.||||||.|. . . | ... . .                  
YQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-M-W-K----------------

TETKKWSNDDCKLHSSSLEQRAHRHEQMAFTLSSPPLSSNRSVTGAAAEGEGLKSSLMEAARAAGEGAASMSSTGLSTVPVDVTPSQKGDLTLAHYVRVP
                                                                                     |              
-------------------------------------------------------------------------------------S--------------

MPVMNS----------VRVVDLGAAQFLSTFRDHSLIPGYA----------HVPVSYNPIQTSHYRSPEVLLGFG----------WNTSADIFSLGCMIP
     .          ... | | | ....  ||   . .           ..   .. ..| .||.||.||| .          ..|. |. |.||.. 
-----EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA

ELLTG--------ECLFM-----------PNHTMEHLAMMQHVIGTFH---------------DKD
|..||        . ||             ... ..|...  |.||.                ...
EMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEE
Kinase LmjF25.1560.AA SRPK 620-661 61 2.2e-23 55.64 In-house 413-454 (554) Show / Hide 
Range on Protein: 620-661
Range on HMM: 413-454/554
Sequence Identity: 61% (26 aa)

IQTSHYRSPEVLLGFGWNTSADIFSLGCMIPELLTGECLFMP
|||  ||||||..| |.||.|||.|. ||. ||.||  || |
IQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEP
Kinase LmjF25.1560.AA CLK 620-678 46 6e-22 61.94 In-house 208-267 (350) Show / Hide 
Range on Protein: 620-678
Range on HMM: 208-267/350
Sequence Identity: 46% (28 aa)

IQTSHYRSPEVLLGFGWNTSADIFSLGCMIPELLTGECLFMPNHTMEHLAMMQHVIG-TF
..| ||| ||| || ||..  |. | || . || ||. ||  .   ||||||. . |  .
VSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPI
Kinase LmjF25.1560.AA Pkinase 405-677 12 4.1e-20 72.21 Pfam 93-233 (293) Show / Hide 
Range on Protein: 405-677
Range on HMM: 93-233/293
Sequence Identity: 12% (36 aa)

RHVY---YRGL--PLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVLFESSKVLSVDVGIYYTHYLRRNSDTVAKRMPSATETKKWSNDDCKLHSSSLE
...    ....  .   .| ..||.|  |...| .|..| ||||||.|. .  ...                                            
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------------------------------------

QRAHRHEQMAFTLSSPPLSSNRSVTGAAAEGEGLKSSLMEAARAAGEGAASMSSTGLSTVPVDVTPSQKGDLTLAHYVRVPMPVMNSVRVVDLGAAQFLS
                                                                                      .|.. | | | ...
--------------------------------------------------------------------------------------CVKICDFGLAKQFD

TFRDHSLIPGYAHVPVSYNPIQTSHYRSPEVLL-GFGWNTSADIFSLGCMIPELLTGECLFMPN----HTMEHLAMMQHVIGT
          | . .  . .  |..|..|||.. | .. ...|..|.||.. |.|.|. .|       . .....|.. . |.
----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGP
S_TKc LmjF25.1560.AA S_TKc 179-806 10 6.6e-16 56.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 179-806
Range on HMM: 1-231/231
Sequence Identity: 10% (68 aa)

YLYERTLGKGTFSKVVLGIAPPSSPALATQISGDVPARVALKVFRDKEEYIEACWDEFTILNSICVDPPSVAPEEVAAAAAAGHRQGTTTSSPYISVRSV
|   |..|||.|.|| ...                  .||.|. .                                                       
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK-------------------------------------------------------

VMFTASTCGIKQQYFADQGRFLVPMGYVAHPVHPAIVFPVMGPTLLNVLNTIRQKSKEVARASRHKRLRTEAQPGKNTCSDGAFSTMPRQFSAMAASVDM
                                                                 ...| | |  |.           . . ..      
-----------------------------------------------------------------EHIRREIQILKK-----HHPNIVKLYDVFQD----

GASGEAQQPLPLPPQ--EQLQQQQQQQRRHVYYRGLPLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVLFESSKVLSVDVGIYYTHYLRRNSDTVAKR
   ..    . . ..    | .  ....|| .....|    . ..||..  |...| .|..| ||||||.|. .  .   | |.                
---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------------

MPSATETKKWSNDDCKLHSSSLEQRAHRHEQMAFTLSSPPLSSNRSVTGAAAEGEGLKSSLMEAARAAGEGAASMSSTGLSTVPVDVTPSQKGDLTLAHY
                                                                                                    
----------------------------------------------------------------------------------------------------

VRVPMPVMNSVRVVDLGAAQFLSTFRDHSLIPGYAHVPVSYNPIQTSHYRSPEVLLGFGWNT-SADIFSLGCMIPELLTGECLFMPNHTMEHLAMMQHVI
                                        .  . | .|..||||   |... ..|. |.||.. |.|.|. .|       ...|| ..|
----------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKI

GTFHDKDGIRSGTATNLRSVFACDMRTFRHYFTLQPNNRDFDLKWPVSKSMVHEQEKQQRFASAESGKTEDDGLEPLEETLPGDIDYVTRMPTLDDILAP
|                                                                                                   
G---------------------------------------------------------------------------------------------------

LPDLLDLTRRMLCYHPFKRITAEEAMQ-------HPFF
 |...|. |..|.. | ||.|| ||.|       ||.|
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF25.1560.AA SRPK 405-447 45 1.8e-15 34.77 In-house 119-162 (554) Show / Hide 
Range on Protein: 405-447
Range on HMM: 119-162/554
Sequence Identity: 45% (20 aa)

RHVYYRGLPLPLLKAVLYQVLTFLQFIHCR-GVVHTDLKPENVL
.|  |.|.|... |    |||. | ..| . |. |||.||||||
KHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVL
Kinase LmjF25.1560.AA CLK 779-806 64 2.1e-14 38.9 In-house 323-350 (350) Show / Hide 
Range on Protein: 779-806
Range on HMM: 323-350/350
Sequence Identity: 64% (18 aa)

LLDLTRRMLCYHPFKRITAEEAMQHPFF
| || |.|| | |.||||. .| |||||
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase LmjF25.1560.AA DYRK2 620-676 40 6.6e-14 41.28 In-house 163-219 (318) Show / Hide 
Range on Protein: 620-676
Range on HMM: 163-219/318
Sequence Identity: 40% (23 aa)

IQTSHYRSPEVLLGFGWNTSADIFSLGCMIPELLTGECLFMPNHTMEHLAMMQHVIG
||.  ||.||| ||   ... |. |.|| . ||.||  ||      . .|.|. |.|
IQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLG
Kinase LmjF25.1560.AA CMGC 777-806 60 7.3e-14 41.02 In-house 484-513 (513) Show / Hide 
Range on Protein: 777-806
Range on HMM: 484-513/513
Sequence Identity: 60% (18 aa)

PDLLDLTRRMLCYHPFKRITAEEAMQHPFF
|...||  .||.| | ||||||.|.|||.|
PQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase LmjF25.1560.AA RCK 777-806 50 2.1e-13 38.57 In-house 269-298 (298) Show / Hide 
Range on Protein: 777-806
Range on HMM: 269-298/298
Sequence Identity: 50% (15 aa)

PDLLDLTRRMLCYHPFKRITAEEAMQHPFF
.|...| . ||.. | |||||..| |||.|
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase LmjF25.1560.AA CDC2 780-806 59 2.9e-13 36.59 In-house 275-301 (301) Show / Hide 
Range on Protein: 780-806
Range on HMM: 275-301/301
Sequence Identity: 59% (16 aa)

LDLTRRMLCYHPFKRITAEEAMQHPFF
.|| ..||.| | |||.|.||.|||.|
IDLLMQMLQYDPQKRISAKEALQHPYF
Kinase LmjF25.1560.AA CLK 409-464 33 5.6e-12 31.47 In-house 108-163 (350) Show / Hide 
Range on Protein: 409-464
Range on HMM: 108-163/350
Sequence Identity: 33% (19 aa)

YRGLPLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVLFESSKVLSVDVGIYYTH
|...|.   ..  || .. ..| |  . .|||||||| .|..|.   .|  . |.|
YIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNH
Kinase LmjF25.1560.AA MAPK 777-806 56 9.8e-11 33.12 In-house 299-328 (328) Show / Hide 
Range on Protein: 777-806
Range on HMM: 299-328/328
Sequence Identity: 56% (17 aa)

PDLLDLTRRMLCYHPFKRITAEEAMQHPFF
|. .||  .||   | ||||.|||.|||.|
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase LmjF25.1560.AA CDK4 780-806 48 5.4e-10 30.25 In-house 264-290 (290) Show / Hide 
Range on Protein: 780-806
Range on HMM: 264-290/290
Sequence Identity: 48% (13 aa)

LDLTRRMLCYHPFKRITAEEAMQHPFF
.||  .|||| . ||..|... |||.|
DDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase LmjF25.1560.AA ERK7 777-806 50 9.9e-10 29.13 In-house 263-292 (292) Show / Hide 
Range on Protein: 777-806
Range on HMM: 263-292/292
Sequence Identity: 50% (15 aa)

PDLLDLTRRMLCYHPFKRITAEEAMQHPFF
.| .|| .|.|.. | ||.|||.|.|||. 
DDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase LmjF25.1560.AA SRPK 786-806 57 1.3e-09 19.33 In-house 534-554 (554) Show / Hide 
Range on Protein: 786-806
Range on HMM: 534-554/554
Sequence Identity: 57% (12 aa)

MLCYHPFKRITAEEAMQHPFF
|| | | ||.||.|. |||. 
MLHYNPEKRATAKECLQHPWL
Kinase LmjF25.1560.AA DYRK 620-659 50 3.5e-09 30.75 In-house 165-204 (320) Show / Hide 
Range on Protein: 620-659
Range on HMM: 165-204/320
Sequence Identity: 50% (20 aa)

IQTSHYRSPEVLLGFGWNTSADIFSLGCMIPELLTGECLF
||  .||.|||.||   ... |. |||| . ||.||. ||
IQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF
Kinase LmjF25.1560.AA DYRK 778-806 41 9.7e-09 29.07 In-house 292-320 (320) Show / Hide 
Range on Protein: 778-806
Range on HMM: 292-320/320
Sequence Identity: 41% (12 aa)

DLLDLTRRMLCYHPFKRITAEEAMQHPFF
...|. ...| . | ||||...|.|||.|
QFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase LmjF25.1560.AA Pkinase 777-806 43 1.5e-08 31.34 Pfam 264-293 (293) Show / Hide 
Range on Protein: 777-806
Range on HMM: 264-293/293
Sequence Identity: 43% (13 aa)

PDLLDLTRRMLCYHPFKRITAEEAMQHPFF
....|. ...||. | ||.|||...|||.|
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF25.1560.AA CDK4 411-454 34 2.6e-08 24.39 In-house 106-149 (290) Show / Hide 
Range on Protein: 411-454
Range on HMM: 106-149/290
Sequence Identity: 34% (15 aa)

GLPLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVLFESSKVL
|.| .  | .  | |. . | |   ..| ||||.|.|  |.. .
GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHV
Kinase LmjF25.1560.AA ERK7 625-682 33 3.7e-08 23.65 In-house 172-230 (292) Show / Hide 
Range on Protein: 625-682
Range on HMM: 172-230/292
Sequence Identity: 33% (20 aa)

YRSPEVLLGFGWNTSA-DIFSLGCMIPELLTGECLFMPNHTMEHLAMMQHVIGTFHDKD
||.||.|||  . | . |  |.|| . |.|.|  .|  . ||. .    ..|.    .|
YRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQED
Kinase LmjF25.1560.AA MAPK 625-677 29 8.6e-08 22.78 In-house 197-253 (328) Show / Hide 
Range on Protein: 625-677
Range on HMM: 197-253/328
Sequence Identity: 29% (17 aa)

YRSPEVLLG---FGWNTSADIFSLGCMIPELLT-GECLFMPNHTMEHLAMMQHVIGT
||.||..|.    . ... |. |.||   |.|| .  ||  ..... . ..  |.||
YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGT
Kinase LmjF25.1560.AA CDC2 412-447 44 1.1e-07 19.1 In-house 100-135 (301) Show / Hide 
Range on Protein: 412-447
Range on HMM: 100-135/301
Sequence Identity: 44% (16 aa)

LPLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVL
.|. |.|  .|| |  . | | |...| |||| | |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNIL
Kinase LmjF25.1560.AA ERK7 418-450 39 1.8e-07 21.26 In-house 103-135 (292) Show / Hide 
Range on Protein: 418-450
Range on HMM: 103-135/292
Sequence Identity: 39% (13 aa)

KAVLYQVLTFLQFIHCRGVVHTDLKPENVLFES
. ..||.|  ....|   |.| |||| |.| .|
QYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDS
Kinase LmjF25.1560.AA MAPK 418-447 43 4.2e-07 20.36 In-house 118-149 (328) Show / Hide 
Range on Protein: 418-447
Range on HMM: 118-149/328
Sequence Identity: 43% (14 aa)

KAVLYQVLTF--LQFIHCRGVVHTDLKPENVL
.  .||.|    |..||  .|.| ||||.|.|
QYFMYQILRGLKLKYIHSANVIHRDLKPSNIL
Kinase LmjF25.1560.AA DYRK2 409-447 38 5.9e-07 18.3 In-house 96-134 (318) Show / Hide 
Range on Protein: 409-447
Range on HMM: 96-134/318
Sequence Identity: 38% (15 aa)

YRGLPLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVL
. |. | |  .  ...|. |.| | . ..| ||||||.|
FQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase LmjF25.1560.AA DYRK 410-447 40 8e-07 21.83 In-house 97-136 (320) Show / Hide 
Range on Protein: 410-447
Range on HMM: 97-136/320
Sequence Identity: 40% (16 aa)

RGL-PLPLLKAVLYQVLTFLQFIHCR-GVVHTDLKPENVL
.|. .| | . ...|.|| | |.|     .| ||||||..
QGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM
Kinase LmjF25.1560.AA CDK4 625-652 50 1e-06 18.68 In-house 175-202 (290) Show / Hide 
Range on Protein: 625-652
Range on HMM: 175-202/290
Sequence Identity: 50% (14 aa)

YRSPEVLLGFGWNTSADIFSLGCMIPEL
||.|||||    ||  |. |.|| . |.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase LmjF25.1560.AA CDC2 625-660 40 2e-06 14.94 In-house 171-210 (301) Show / Hide 
Range on Protein: 625-660
Range on HMM: 171-210/301
Sequence Identity: 40% (16 aa)

YRSPEVLLGFG-WNTSADIFSLGCMIPEL---LTGECLFM
||.||.|||    .|. |. |.|| . |.    | . ||.
YRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFH
Kinase LmjF25.1560.AA RCK 417-447 45 1.3e-05 13.49 In-house 107-137 (298) Show / Hide 
Range on Protein: 417-447
Range on HMM: 107-137/298
Sequence Identity: 45% (14 aa)

LKAVLYQVLTFLQFIHCRGVVHTDLKPENVL
.|  .||.|  | ..|  |  | |||||| .
IKNIMYQILQGLAHMHKHGFFHRDLKPENIM
Kinase LmjF25.1560.AA DYRK2 791-806 37 2.7e-05 12.81 In-house 303-318 (318) Show / Hide 
Range on Protein: 791-806
Range on HMM: 303-318/318
Sequence Identity: 37% (6 aa)

PFKRITAEEAMQHPFF
| .|.|...| .||..
PSERMTPSQALKHPWI
Kinase LmjF25.1560.AA RCK 625-654 41 0.000187 9.73 In-house 179-209 (298) Show / Hide 
Range on Protein: 625-654
Range on HMM: 179-209/298
Sequence Identity: 41% (13 aa)

YRSPEVLLGF-GWNTSADIFSLGCMIPELLT
||.||.||     |.  ||...|| . || .
YRAPECLLRCTYYNSPMDIWAVGCIMYELYM
Kinase LmjF25.1560.AA RCK 179-198 30 0.000455 8.48 In-house 1-20 (298) Show / Hide 
Range on Protein: 179-198
Range on HMM: 1-20/298
Sequence Identity: 30% (6 aa)

YLYERTLGKGTFSKVVLGIA
|   ..||.||.. |.....
YQIIKQLGDGTYGCVMKAQN
Kinase LmjF25.1560.AA SRPK 217-242 30 0.001701 3.22 In-house 27-52 (554) Show / Hide 
Range on Protein: 217-242
Range on HMM: 27-52/554
Sequence Identity: 30% (8 aa)

VALKVFRDKEEYIEACWDEFTILNSI
||.|. . .. |.|.  ||  .|...
VAMKIVKSAPHYTETAVDEIKLLQCV
Kinase LmjF25.1560.AA CMGC 179-197 26 0.002853 5.57 In-house 1-19 (513) Show / Hide 
Range on Protein: 179-197
Range on HMM: 1-19/513
Sequence Identity: 26% (5 aa)

YLYERTLGKGTFSKVVLGI
|   . .|.||...|. ..
YEIIKKIGEGTYGVVYKCR
Kinase LmjF25.1560.AA CLK 179-194 62 0.005169 4.07 In-house 1-16 (350) Show / Hide 
Range on Protein: 179-194
Range on HMM: 1-16/350
Sequence Identity: 62% (10 aa)

YLYERTLGKGTFSKVV
|    ||| |||.|||
YEIVCTLGEGTFGKVV
Kinase LmjF25.1560.AA CLK 214-242 43 0.030816 1.7 In-house 25-54 (350) Show / Hide 
Range on Protein: 214-242
Range on HMM: 25-54/350
Sequence Identity: 43% (13 aa)

PARVALKVFRDKEEYIEACWDEFT-ILNSI
...||||. |  |.| || | | . |. .|
KKYVALKIIRNVEKYREAAWVEINQIMKKI
Kinase LmjF25.1560.AA DYRK 179-194 43 0.03343 4.37 In-house 1-16 (320) Show / Hide 
Range on Protein: 179-194
Range on HMM: 1-16/320
Sequence Identity: 43% (7 aa)

YLYERTLGKGTFSKVV
|     .|||.|..||
YEILEYIGKGSFGQVV
Kinase LmjF25.1560.AA Pkinase 179-197 31 0.069266 7.75 Pfam 1-19 (293) Show / Hide 
Range on Protein: 179-197
Range on HMM: 1-19/293
Sequence Identity: 31% (6 aa)

YLYERTLGKGTFSKVVLGI
|  .|..|.|.|..| ...
YHIGRKIGSGSFGCVYKCH