Gene LmjF35.1860 (L.major)

LmjF35.1860

Species: L.major
Alias: LmajK071, LmjF35.1860
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
LmjF35.1860.AA Protein None 575 None Fasta, JSON
LmjF35.1860.kin_dom Protein Kinase Domain None 310 None Fasta, JSON

Protein domain

Protein domains of LmjF35.1860.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF35.1860.AA DYRK 243-552 37 1.1e-127 430.49 In-house 1-320 (320) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-320/320
Sequence Identity: 37% (126 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPSDLYAIIQANKFRPM-
||.....|.|.|| ||.. ||| . .||.|.|.|.. . .|| .||| ||.||. ||| ....|... . ..|.|  .|||||  .||  .  |.|..  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SHDFIYELSEQLLTALVHVRDH-KIVHCDLKPENIMISRRGGNSNSLSEL-SDFSLKLIDFGSACEESRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWSF
|   .     |.||.|..   . .|.||||||||||          | .  .   .|.|||||.|.|.. ..||||||.|||||. ||.|| .||||||.
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM----------LKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSL

GCVLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQS--RRADRFFED----------GQMK----------HNLSKKRVPHVPHSRTLRNFLKIG
||.| ||  |.|.|| ..| ..| .|.|..| .|. .....  ||...||..          .| |          |. ..  .  .| .| . ....  
GCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-C

RSHEDQLFEDFVSKCLHLDARQRLTPEAALEHPWM
   .|..| ||. ||| .| ..|.||. ||.||| 
---DDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase LmjF35.1860.AA DYRK2 243-552 36 7.50000000001e-115 375.01 In-house 1-318 (318) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-318/318
Sequence Identity: 36% (121 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPSDLYAIIQANKFRPMS
||...|.|.| || ||...|||.. .||.|.| ||  . .|| |||. |. . | |.|. .|.|..| . .||.| ...||||  .||  |  |.|   |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

HDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESR-PLFTYIQSRYYRAPEIVLGIPYTTAIDMWSFGC
   .     ..|..|.  . ..|.|||||||||.   .. .          ..|.||||| | | . ...||||||.|||||. ||..| .|||||||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRS----------GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGC

VLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQS-----RRADRFFE---------------DGQMKHNLSKKRVPHVPHSRTLRNFLKIGRSHE
.. ||  |||.|| . |.. .  . | .|  |. .. ..     .|.. ||.               . . ||  . .    .| |. . ..|| .   |
IMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGC---E

DQLFEDFVSKCLHLDARQRLTPEAALEHPWM
|..| ||...|.. |. .|.||. ||.|||.
DENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase LmjF35.1860.AA CMGC 243-552 21 5.6e-101 332.62 In-house 1-513 (513) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YEVVKVLGQGTFGIVVRALD--------------HKYHRLVAVKVIKNKPNYTKQAR-------------EEIKTLELLN-RDDPDG-----------ET
||..|..|.||.|.|... |              |.. ..||.| |||.. |. ||.              ||| |. || ..|| .           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NIVRLLGSHIFRK-----------------HYILVFELLPSDLYAIIQANKF-------RPMSHDF------------IYELS------EQLLTALV--H
|||.|. .  ...                 |  ||||... ||| .|. |.|       .|.|.              |  ..       |.|..|   .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

VRDHK--IVHCDLKPENIMISRR------------GGNSNSLSELSDFSLKLIDFGSACEESRP------------------------LFTYIQSRYYRA
   |.  |.|.|||||||.|. .              . |..  .... ||..|||.|. .. .                        . .|...|.|||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRA

PEIVLGIP----------YTTAIDMWSFGCVLCELANG--------YPIFPASSE-----------GELLERIVEYFGTIPSYLVRQSR-------RADR
||| || .          |||.|||||.||.. |. .|        .|.|| .||            . |..|.. .||.. .. ....       . . 
PEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEE

FFEDGQMKHN---------------LSK-----------KRVPHVPHSRTLRNF-------------------LKIG---------RSHEDQLFEDFVSK
...  .. ..               .|.           .  .. .. . |  .                    |..         |...|... |...|
WPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKK

CLHLDARQRLTPEAALEHPWM
.|..|  .|.|.| ||.||. 
MLQYDPDKRITAEQALQHPYF
Kinase LmjF35.1860.AA YAK 243-487 40 1.9e-90 306.77 In-house 1-239 (347) Show / Hide 
Range on Protein: 243-487
Range on HMM: 1-239/347
Sequence Identity: 40% (102 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLN-RDDPDGET---NIVRLLGSHIFRKHYILVFELLPSDLYAIIQANKF
| |  .||||||| ||         |.|||||||.. |  ||. ||..|..|| . ||...     |.|.. . ... |  ||||.|   ||  .  |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RPMSHDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWS
. .|   |     | | ...   . .|.||||||||||          |       .|.|||||.|.| . . ||||.|.||.|||.....|.|.|||||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIM----------LCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWS

FGCVLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQSRRADRFF
 ||.. ||  | ||||  || . . ||..  |  || .. | |   ..|
LGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase LmjF35.1860.AA S_TKc 243-552 24 1.3e-82 281.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-231/231
Sequence Identity: 24% (78 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPS---DLYAIIQANKFR
||.....|.|.|| | .. ..| .|.||.|.||      ...| ||. |.        .  |||.|...    .|. .|.|...    ||. .|. .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----MSHDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESRPLFTYIQSRYYRAPEIVLGIPYTT-AI
.    ..   .  .  |.. || .  .|.|.|.|||||||....               .|..|||.|..      |.. ...|.|||..   .|.. ..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKC

DMWSFGCVLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQSRRADRFFEDGQMKHNLSKKRVPHVPHSRTLRNFLKIGRSHEDQLFEDFVSKCLH
|.||.||.| |.. ||| ||   . .....|.                                                       .. . ||..|||.
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------------------------------------------SPEAKDFIRKCLQ

LDARQRLTPEAALE-------HPWM
 | ..|.|   ||.       |||.
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF35.1860.AA DYRK1 243-552 38 7.2e-79 268.32 In-house 1-321 (321) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-321/321
Sequence Identity: 38% (126 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPSDLYAIIQANKFRPMS
||.   .|.| || ||.| ||. . .||.|.||||  .  ||. ||. |||.|. |.. . .||.| .  .|| |  ||||||   || ...  .|| .|
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

HDFIYELSEQLLTALVHVR--DHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWSFG
   .  . .|..|||. .   . .|.|||||||||.          |       .|.|||||.|.  . .. |||||.||.||..|||.| .|||||| |
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENIL----------LCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLG

CVLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQSRRADRFFED-----GQMKHNLSKKRVPHVPHSRTLRNFLKI-------------GRSHED
|.| |.  | |.|  |.| . ...|||  |  |.... |. .| ..||       ..|..  ||.  . |  | |.. | .             | | ||
CILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVED

QL-FEDFVSKCLHLDARQRLTPEAALEHPWM
 | |.| . . |. | .||.||  ||.|...
YLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase LmjF35.1860.AA HIPK 243-496 37 1.4e-70 221.39 In-house 1-247 (329) Show / Hide 
Range on Protein: 243-496
Range on HMM: 1-247/329
Sequence Identity: 37% (97 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPSDLYAIIQANKFRPMS
|||. .||.|||| ||..  .  . .||.|..|| | | .| . |.. |. |   ..| | ..|| .     ..|  ||||.|   ||     ||| |. 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

HDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESRPLF-TYIQSRYYRAPEIVLGIPYTTAIDMWSFGC
   |  . .| ||||.. ..  ..| ||||||||.               .  | ||||||   |.    ||.||||||||||.||.|.  ..|||| ||
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDP--------TRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGC

VLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQSRRADRFF-EDGQMKHNL
|. ||  | | .| ..| ..   | .  .    .|. . ... ||| .| |.|. .
VIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRP
Kinase LmjF35.1860.AA CLK 243-552 27 9.3e-66 195.86 In-house 1-350 (350) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-350/350
Sequence Identity: 27% (99 aa)

YEVVKVLGQGTFGIVVRALDHKY-HRLVAVKVIKNKPNYTKQAREEIK-TLELLNRD-DPDGETN--IVRLLGSHIF-RKHYILVFELLPSDLYAIIQAN
||.|..||.|||| ||.  |||.  ..||.|.|.|   |. .|. ||.  .. .|   ||..     ..... .  .   |  .||||.   .|  . .|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FRPMSHDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRR-------------GGN--------SNSLSELSDFSLKLIDFGSAC---EE
.      ..|   | | ... ||..|.    | |..| ||||||| ..                ..        .  .. . ..  ..||||||     .
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

SRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWSFGCVLCELANGYPIFPASSEGELLERIVEYFG-TIPSYLVRQSR---RADRFF----EDGQMKHNLSK
  .  | ...| |||||..|| .. .  | ||.||.| ||  |.  |.  .. | |. . .  |  ||.   . .|     ...|    .|.   || . 
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDW-HNSDG

KRVPHVPHSRTLRNFLKIGRSHEDQLFEDFVSKCLHLDARQRLTPEAALEHPWM
. |    .   |. ....     .||| | ..|.|  |  .|.|   || ||. 
RYV--MENCKPLKQYMDCKDPEHRQLF-DLIRKMLEYDPSKRITCKDALQHPFF
Kinase LmjF35.1860.AA Pkinase 243-552 25 3e-63 221.25 Pfam 1-293 (293) Show / Hide 
Range on Protein: 243-552
Range on HMM: 1-293/293
Sequence Identity: 25% (83 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQARE-----EIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPS-----DLYAI
|......|.|.|| | .. .... ..||||.|| . .  .. ..     ||. .  ||        |||||...   ..|. .|.|...      ||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IQ---ANKFRPMSHDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSAC---EESRPLFTYIQSRYYRAPEIVL
|.    ..|  .| . .     |.| .| .  ...|.|.|||||||.|...| ..         ..|..|||.|.   . .. . |.  ...|.|||...
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--------CVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIR

-GIPYTTAIDMWSFGCVLCELANGYPIFPAS----SEGELLERIVEYFGTIPSYLVRQSRRADRFFEDGQMKHNLSKKRVPHVPHSRTLRNFLKIGRSHE
 | .|....||||.||.| |...|.|.|| .    .  . ...|..  |.....   ....  .|| . . .                    ..      
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------F-HWTF-HNW

DQLFEDFVSKCLHLDARQRLTPEAALEHPWM
.. . ||...||..|  .|.|.| .|.|||.
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF35.1860.AA DyrkP 243-487 31 1.3e-41 134.34 In-house 1-239 (323) Show / Hide 
Range on Protein: 243-487
Range on HMM: 1-239/323
Sequence Identity: 31% (79 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDGETNIVRLLGSHIFRKHYILVFELLPSDLYAIIQANKFRPMS
| ..  ||   |   .  .| .  ... .|.| |   |  |. .||| |  .|      | |..|       . |  .. |||   ||   . |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

HDF----IYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWS
  |    .  .  |.| || ..   ...|||||||||..      | .  .      |.|||||.|     |  |.||| |||||...|  |   |||||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILM-----KSYPKCQ-----VKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWS

FGCVLCELANGYPIFPASSEGELLERIVEYFGTIPSYLVRQSRRADRFF
 ||.| ||  |  .|       || |..   | .| ....  |  . ||
LGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFF
Kinase LmjF35.1860.AA CAMK 248-443 18 2.4e-39 123.93 In-house 1-324 (425) Show / Hide 
Range on Protein: 248-443
Range on HMM: 1-324/425
Sequence Identity: 18% (62 aa)

VLGQGTFGIVVRALDHKYH------------RLVAVKVIKNK-----------------------------PNYTKQAREEIKTLELLNR-----DDPDG
.||.|.||.| .. . .              . ||.|.|. |                             |.  |. | ||. . .|.      | |  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP--

ETNIVRLLGSHI------------FRKH--------YILVF---ELLPS-----DLYAIIQANKF-------------RPMSHDFIYELSEQLLTALVHV
  ||..|.                . ..        ...|.   |. .      ||.  |....              . .. .    .  |.. |. . 
--NIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYC

RDHKIVHCDLKPENIMISRRGGNSNSLSELSD-------FSLKLIDFGSA--CEESR------------------------PLFTYIQSRYYRA-PEIVL
 .|.|||.|||||||... ....|.. .| .|       . .|.|||| |  ....                         .. |.  . .| | ||...
HSHNIVHRDLKPENILLDDNNDDSDP-VE-HDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

G--------------IPYTTAIDMWSFGCVL
|               .|. ..|||| |..|
GKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase LmjF35.1860.AA PRP4 350-488 37 7.5e-28 98.85 In-house 112-240 (320) Show / Hide 
Range on Protein: 350-488
Range on HMM: 112-240/320
Sequence Identity: 37% (52 aa)

SEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACE-ESRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWSFGCVLCELAN
. ||. || |    .|.| |.|| ||...            |   ||..||||| . .   .  | .||.||||||..|.||  .||||| || | ||. 
AQQLFLALKHLKKCNILHADIKPDNILVNE-----------SKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

GYPIFPASSEGELLERIVEYFGTIPSYLVRQSRRADRFFE
|  .|| ..  . |  . .| | .|  ..| .   | .|.
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase LmjF35.1860.AA PRP4 243-325 32 2.1e-11 38.06 In-house 1-86 (320) Show / Hide 
Range on Protein: 243-325
Range on HMM: 1-86/320
Sequence Identity: 32% (28 aa)

YEVVKVLGQGTFGIVVRALDHKYHR-LVAVKVIKNKPNYTKQAREEIKTLELLNRD--DPDGETNIVRLLGSHIFRKHYILVFELL
|.|.   ||| |. |.|. |    .  ||.|.| |..   |    |.  |  ||    |..    .||.  .  .|.|  |||| .
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECM
Kinase LmjF35.1860.AA CAMK 522-552 41 7.8e-10 27.12 In-house 395-425 (425) Show / Hide 
Range on Protein: 522-552
Range on HMM: 395-425/425
Sequence Identity: 41% (13 aa)

DQLFEDFVSKCLHLDARQRLTPEAALEHPWM
.|   |...|.|  |  .|.| | .|.||||
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase LmjF35.1860.AA DyrkP 488-552 35 2.3e-09 26.28 In-house 263-323 (323) Show / Hide 
Range on Protein: 488-552
Range on HMM: 263-323/323
Sequence Identity: 35% (23 aa)

EDGQMKHNLSKKRVPHVPHSRTLRNFLKIGRSHEDQLFEDFVSKCLHLDARQRLTPEAALEHPWM
.|.| ..  . |    ||    ||  |.     .| .| ||| .|| .|   | |   ||.|||.
QDMQRQRQKTGKIQILVPKHSNLRARLRT----DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase LmjF35.1860.AA TyrKc 243-555 16 3.5e-09 -74.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 243-555
Range on HMM: 1-280/280
Sequence Identity: 16% (58 aa)

YEVVKVLGQGTFGIVVRALDHKYHRLVAVKVIKNKPNYTKQAREEIKTLELL-NRDDPDGETNIVRLLGSHIFR-------KHYILVFELLPS-DLYAII
 .  |.|| | ||.|...      . ||||..|.     .  ..|.. .  |  . .     |||||.|  .         . . .|.|. |  ||   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QANKFRPMSHDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLSELSDFSLKLIDFGSACEESRP-LF-----TYI-----QSR-----
.... .  ...   . . |      .  .....| ||   |.......              |  ||| . .            .|      ...     
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

YYRAPEIVLGIPYTTAIDMWSFGCVLCELANGYPIFPASS------EGELLERIVEYFGTIPSYLV----RQSRRADRFFEDGQMKHNLSKKRVPHVPHS
   |||      .||. | |||| .. |.   |   | .       . . . . |.  .  |                                      
RWMAPECINYGKFTTKSDVWSFGVCMWEIFT-YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------

RTLRNFLKIGRSHEDQLFEDFVSKCLHLDARQRLTPEAALEHPWMEFW
     |        | ...   ..| | |. .| | ..       |..
-----F----VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-----HECF
Kinase LmjF35.1860.AA PRP4 525-552 46 4.7e-07 21.94 In-house 293-320 (320) Show / Hide 
Range on Protein: 525-552
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FEDFVSKCLHLDARQRLTPEAALEHPWM
| |.  ||| ||   | |.. ||.|| .
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase LmjF35.1860.AA Pkinase_Tyr 243-287 27 1.2e-05 19.79 Pfam 1-49 (270) Show / Hide 
Range on Protein: 243-287
Range on HMM: 1-49/270
Sequence Identity: 27% (14 aa)

YEVVKVLGQGTFGIVVRALDH----KYHRLVAVKVIKNKPNYTKQA--REE
 .  |.||.| || |...  .    . .  ||||..  |.......  ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCRED
Kinase LmjF35.1860.AA YAK 524-552 37 3.7e-05 13.06 In-house 319-347 (347) Show / Hide 
Range on Protein: 524-552
Range on HMM: 319-347/347
Sequence Identity: 37% (11 aa)

LFEDFVSKCLHLDARQRLTPEAALEHPWM
.| ||.   | |. | | .|  | .|| .
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase LmjF35.1860.AA HIPK 525-552 39 0.000758 7.45 In-house 302-329 (329) Show / Hide 
Range on Protein: 525-552
Range on HMM: 302-329/329
Sequence Identity: 39% (11 aa)

FEDFVSKCLHLDARQRLTPEAALEHPWM
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FVHVLKKMCTWDAHKRITPCEALNHPFV