Gene LmjF14.1070 (L.major)

LmjF14.1070

Species: L.major
Alias: LmajK072, LmjF14.1070
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRKP

Sequence

Name Sequence Type Origin Length Description Download
LmjF14.1070.AA Protein None 908 None Fasta, JSON
LmjF14.1070.kin_dom Protein Kinase Domain None 439 None Fasta, JSON

Protein domain

Protein domains of LmjF14.1070.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF14.1070.AA DyrkP 577-784 58 1.7e-104 345.16 In-house 27-233 (323) Show / Hide 
Range on Protein: 577-784
Range on HMM: 27-233/323
Sequence Identity: 58% (122 aa)

VCLKIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAHIVRLIDAFYYKEHVMLVTELLRDTLYDYGKYNREEEKEFYFTLPRLRRLTRQIVEALTYVHSLN
.|.||| | ||.||||.|||.||  .|   | |.  ..|  | || |||. ..||||.| ||.. |.||| |.  |||. || ..| ||. || |.||| 
MCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQRYFTVGRLQKITQQILIALDYIHSLR

LIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSDHLSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTGDVLFTSDTVPEMLARIVYVCGTPFP
||| |||||||.  ||..| ||.||||||||. ||||||.||||||||||..|| || |||.|||| || |. || |||  |..  .|||.. . | |||
LIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIG-PFP

RRMLWEGR
  |. |||
EWMMQEGR
Kinase LmjF14.1070.AA DYRK 577-903 32 2.3e-95 323.14 In-house 27-320 (320) Show / Hide 
Range on Protein: 577-903
Range on HMM: 27-320/320
Sequence Identity: 32% (109 aa)

VCLKIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAHIVRLIDAFYYKEHVMLVTELLRDTLYDYGKYNREEEKEFYFTLPRLRRLTRQIVEALTYVHSL-
|..|||.| |.|..|...||..| .||.| . | .|.|.. | ||...|. .|.|||   ||.. | |.. .    |.| . |. ..||...| . |.. 
VAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF---FSLNLVRKFAQQILTCLKFLHKNE

NLIHTDLKPENIMFVSY-SRCIVKVIDFGSSCFLSDHLSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTGDVLFTSDTVPEMLARIVYVCGTP
|.|| |||||||| ..  ... .|||||||||| ......||||| |||||| ||| |.  ||.|||| ||.|..|| .||  ..  ..||.|. | | .
NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLG-M

FPRRMLWEG--RHTSDYINKFGCIYEYGGGADGQHGLHEKGDTDDGEEPYCLYTPVPTMAPHTCASS-RKSRAAAAAPPPPRTTTAPYSVLREKL---AA
.|. |. .|  |..  ....                                    ...  .. ..  .|.  .   |.. .| .  .  . ..    ..
PPKWMIDKGRCRRKHKFFDC------------------------------------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPR

AKMVDEEFIAFVEACLMLDHKKRPTSAELLEHPFI
 .  |..|. |.. ||..| .||.| .. |.||..
HQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase LmjF14.1070.AA CMGC 465-903 16 3.3e-77 253.04 In-house 1-513 (513) Show / Hide 
Range on Protein: 465-903
Range on HMM: 1-513/513
Sequence Identity: 16% (106 aa)

YEIIQMLGKATFSRAVRCYDLQ-----DPIYNEDEESDDGEYEDDDVDDDDANSAAASPADGAEDVACVGKGGVTTASCRVSDTATTASAIKQQVKPVNT
||||. .|. |..  ..|.| .     |                                                                        
YEIIKKIGEGTYGVVYKCRDKRTNQKKD------------------------------------------------------------------------

ATKSRLKPKRKILGYGQVCLKIINNTKDFFDQSL-------------DEIRLLTLLNRQRDP-----------DDAHIVRLIDAFYYKE-----------
     .. . .. .  .| .|.| | . . .| .             .||..|  ||.. ||           .. .||.|.| ||.|.           
----NGQ-AHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHI

------HVMLVTELLRDTLYDYGKYNRE--------EEKEFY---------------FTLPRLRRLTRQIVEALT--YVHSLN--LIHTDLKPENIMFVS
      |. ||.|..  .||.| | |.         . .|                 |..   |  ..|| ..|   | || .   ||.|||||||.. .
ISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINH

------------------YSRCIVKVIDFGSSCFLSDH------------------------LSSYIQSRSYRAPEVVLGCD----------YDGRIDVW
                  ... ..|..|||.......|                        ...|...| |||||. ||.           |.  ||.|
NCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMW

SLGAILVEMVTG--------DVLFTSDTV-----------PEMLARIVYVCGTPF---------------PR----------------------------
|.| |. ||.||        . ||  ..             ..|..|. |.|||                ..                            
SVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWS

------------RMLWEGRHTSDYINK-------------FGCIYEYGGGADGQHGLHEKGDTDDGEEPYCLYTPVPTMAPHTCASSRKSRAAAAAPPPP
               | ... .. . .             | .|||                                                      
EFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYE------------------------------------------------------

RTTTAPYSVLREKLAAA--------KMVDEEFIAFVEACLMLDHKKRPTSAELLEHPFI
           || .          |. |...| ... .| .|..||.| .. |.||..
-----------EKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase LmjF14.1070.AA S_TKc 465-903 16 5e-60 206.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 465-903
Range on HMM: 1-231/231
Sequence Identity: 16% (77 aa)

YEIIQMLGKATFSRAVRCYDLQ----------DPIYNEDEESDDGEYEDDDVDDDDANSAAASPADGAEDVACVGKGGVTTASCRVSDTATTASAIKQQV
|||.. .|| .|..  .|..            .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

KPVNTATKSRLKPKRKILGYGQVCLKIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAHIVRLIDAFYYKEHVMLVTELLRD---TLYDYGKYNREEEKEF
                                   .. . ||..|         .  .||.|.|.|.  .|. .|.|..     .|.|| | .. . . |
-----------------------------------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

YFTLPRLRRLTRQIVEALTYVHSLNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSDHLSSYIQSRSYRAPEVVLGCDYDG-RIDVWSLGAILVEMVT
.|.  . |....||..|| | ||.. || |||||||.. .     .|..|||....|    .... .. |.||||.    |.. ..|.||.| || ||..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GDVLFTSDTVPEMLARIVYVCGTPFPRRMLWEGRHTSDYINKFGCIYEYGGGADGQHGLHEKGDTDDGEEPYCLYTPVPTMAPHTCASSRKSRAAAAAPP
|  .|   .. .|. .|.                                                                                  
GYPPFP--QMQMMFKKIG----------------------------------------------------------------------------------

PPRTTTAPYSVLREKLAAAKMVDEEFIAFVEACLMLDHKKRPTSAELLE-------HPFI
                      ..|.. |.. ||  | .||||  |.|.       ||..
----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF14.1070.AA DYRK2 577-755 43 1.3e-57 185.82 In-house 27-202 (318) Show / Hide 
Range on Protein: 577-755
Range on HMM: 27-202/318
Sequence Identity: 43% (80 aa)

VCLKIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAH-IVRLIDAFYYKEHVMLVTELLRDTLYDYGKYNREEEKEFY--FTLPRLRRLTRQIVEALTYVH
|..|.| | | |  | . ||| |  . |. |.| .. .|.. | ||.  |. ...|||   ||.| | |       .  |.|   || ...|...|   |
VAIKMIRNKKRFHNQAYEEIRILHHI-RRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNH------FQGFSLQLVRRFAHSILQCLRFLH

SLNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSD-HLSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTGDVLF
  |.|| |||||||.  .  |  .||||||||||    ..  ||||| |||||| ||. |.. || ||.| |..|..||  ||
KNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF
Kinase LmjF14.1070.AA DYRK1 576-792 41 1e-53 184.81 In-house 26-239 (321) Show / Hide 
Range on Protein: 576-792
Range on HMM: 26-239/321
Sequence Identity: 41% (92 aa)

QVCLKIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAHIVRLIDAFYYKEHVMLVTELLRDTLYDYGKYNREEEKEFY-FTLPRLRRLTRQIVEALTYVHS
.| .||| | | |..| . ||||| |.|..   .  .||.|   | ...|. ||.|||   |||  .       .|    |   |.. .|.. || .. .
YVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLR-----NTHFRGVSLNLTRKFAQQMCTALLFMST

--LNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSDHLSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTGDVLFTSDTVPEMLARIVYVCG
  |..|| |||||||. .   |  .|.||||||| | . .  ||||| ||.|||.|| .||  ||.|||| ||||| ||. ||.     . . .|| | |
PELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLG

TPFPRRMLWEGRHTSDYINK
 | |..|. ..  .  | .|
MP-PKHMIDQAPKAHKYFEK
Kinase LmjF14.1070.AA YAK 580-747 39 1.1e-45 153.0 In-house 30-197 (347) Show / Hide 
Range on Protein: 580-747
Range on HMM: 30-197/347
Sequence Identity: 39% (69 aa)

KIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAH----IVRLIDAFYYKEHVMLVTELLRDTLYDYGKYNREEEKEFY-FTLPRLRRLTRQIVEALTYVHS
|.| |   .| |.  ||..| .|| | ||.. .    |.|..| | .| |  || |.|   ||.| | |.     |  |     |  | || ...    .
KVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNK-----FCGFSFQLIRQWTKQILDGMCVLEN

LNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSDHLSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVE
 ..|| ||||||||     .  .|.|||||||     .  |||.| ||.||....  |   || |||| |..|
KQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE
Kinase LmjF14.1070.AA HIPK 577-751 41 7.9e-42 129.19 In-house 27-199 (329) Show / Hide 
Range on Protein: 577-751
Range on HMM: 27-199/329
Sequence Identity: 41% (73 aa)

VCLKIINNTKDFFDQSLDEIRLLTLLNRQRDPDDAHIVRLIDAFYYKEHVMLVTELLRDTLYDYGKYNREEEKEFYFTLPRLRRLTRQIVEALTYVHSLN
| .||. |   .  |   |...|  | .| ..|..|.||  . |  |.|..|| |.|   |||. | |    |     |  .| .. |.. ||    .| 
VAIKILKNHPYYARQGQIEVSILHCL-SQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN----KFMPLPLKHIRPILQQVLTALMKLKELG

LIHTDLKPENIMFVSYSRC--IVKVIDFGSSCFLSDHL-SSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTG
||| |||||||| |  .||   ||||||||   .|.   . |.||| |||||..||  .   .|.|||| .. |   |
LIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG
Kinase LmjF14.1070.AA Pkinase 573-777 28 1.5e-39 140.88 Pfam 22-237 (293) Show / Hide 
Range on Protein: 573-777
Range on HMM: 22-237/293
Sequence Identity: 28% (65 aa)

GYGQ-VCLKIINNTKDFFDQ---SLD--EIRLLTLLNRQRDPDDAHIVRLIDAFYYKEHVMLVTELLRDTLYDYGKYN----REEEKEFYFTLPRLRRLT
|.|. |..|||.  ..  ..    .   ||...  ||        .||||.|.|..| |. .|.|... .||          ..... |||.   ...  
GTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYM

RQIVEALTYVHSLNLIHTDLKPENIMFVSYSRC--IVKVIDFGSSC---FLSDHLSSYIQSRSYRAPEVVL-GCDYDGRIDVWSLGAILVEMVTGDVLFT
.||...| | || . || |||||||....   .  .||..|||...     .......  .. |.||||.. | .|. ..|.||.| || ||..|  .| 
YQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP

SD----TVPEMLARIVYVCGTPFPR
..    .  .....|. . |.|...
GHCWHDN-HDQMQMICRIMGPPLHF
Kinase LmjF14.1070.AA STE 465-777 15 7e-30 102.74 In-house 1-302 (359) Show / Hide 
Range on Protein: 465-777
Range on HMM: 1-302/359
Sequence Identity: 15% (62 aa)

YEIIQMLGKATFSRAVRCYDL-QDPIY------NEDEESDDGEYEDDDVDDDDANSAAASPADGAEDVACVGKGGVTTASCRVSDTATTASAIKQQVKPV
.|.|...|| .|   .....  ...|.      |                                                                  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVEN------------------------------------------------------------------

NTATKSRLKPKRKILGYGQ------VCLKIINNTK------------------DFFDQSLDEIRLLTLLNRQRDPDDAHIVRLIDAFYYK-------EHV
                  .      .  |..|  .                  . ..| | ||...  .|        .||. .......       ...
------------------NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH---M-HPNIVKYYGCYFKEGHNHKNDDEL

MLVTELLR-DTLYDYGKYNREEEKE--------FYFTLPRLRRLTRQIVEA-LTYVHSLNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSD------
 .. |..   .| |  | . .  |.        ..|  . ... .|||... | | ||.. || |.|| ||..       || .||| .  |.|      
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDFGVCGQLTDSMANIQ

-------------HLSSYIQSRSYRAPEVVLG------CDYDGRIDVWSLGAILVEMVTGDVLFTSDTVPEMLARIV--YVCGT----------PFPR
             .  . . .  . ||||...       .|| . |.||||  ..||.|| . .   . .... .|   |...           | |.
SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPP
Kinase LmjF14.1070.AA PRP4 576-792 32 1.8e-29 104.23 In-house 27-241 (320) Show / Hide 
Range on Protein: 576-792
Range on HMM: 27-241/320
Sequence Identity: 32% (73 aa)

QVCLKIINNTKDFFDQSLDEIRLLTLLNRQ-RDPDD-AHIVRLIDAFYYKEHVMLVTEL----LRDTLYDYGKYNREEEKEFYFTLPRLRRLTRQIVEAL
.|  ||| |     .  | |.  |  || .  |..|  |.||. . |... |  || |     ||. |  ||       |.  . |   |  ..|.  ||
MVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYG-------KDVGLHLKAVRSYAQQLFLAL

TYVHSLNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSDH-LSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTGDVLFTSDTVPEMLARIV
.    .| .| |.|| ||. |. |. . | .||||    ..  .  | .|| |||||...|  ||  ||.|| |  | |. || ..|   |  .||  . 
KHLKKCNILHADIKPDNIL-VNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFM

YVCGTPFPRRMLWEGRHTSDYINK
 . |  .|..|.  |   . . ..
DYKGK-MPNKMIRKGQFKDNHFDQ
Kinase LmjF14.1070.AA CLK 575-691 32 2e-25 72.58 In-house 26-149 (350) Show / Hide 
Range on Protein: 575-691
Range on HMM: 26-149/350
Sequence Identity: 32% (40 aa)

GQVCLKIINNTKDFFDQSLDEIR-LLTLLNRQRDPDDAHI---VRLIDAFYY-KEHVMLVTELLRDTLYDYGKYNR---EEEKEFYFTLPRLRRLTRQIV
..| |||| | . . ...  ||.  .  .|   ||.  .    ....| | | . |. .|.||.   .||  | |.      |.  . .   |....|. 
KYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSNNSKMPN-KYIPYPIDHIRHMAYQLC

EALTYVHSLNLIHTDLKPENIMFVS
||.   |.. |.||||||||| ||.
EAVKFLHDMKLTHTDLKPENICFVD
Kinase LmjF14.1070.AA CLK 697-779 43 3.2e-23 65.83 In-house 186-271 (350) Show / Hide 
Range on Protein: 697-779
Range on HMM: 186-271/350
Sequence Identity: 43% (37 aa)

VKVIDFGSSC---FLSDHLSSYIQSRSYRAPEVVLGCDYDGRIDVWSLGAILVEMVTGDVLFTSDTVPEMLARIVYVCGTPFPRRM
..||||||     |   | |  ...| ||||||.||. .  . |||| | ||.| .||. ||      | || .  ..|.|.| .|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWM
Kinase LmjF14.1070.AA STE 874-903 50 7e-11 34.77 In-house 328-359 (359) Show / Hide 
Range on Protein: 874-903
Range on HMM: 328-359/359
Sequence Identity: 50% (16 aa)

EEFIAFVEACLMLDHKKRPTSAELLE--HPFI
.||. |.. ||  | .||||. .||.  ||||
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LmjF14.1070.AA Pkinase 872-903 43 7.4e-08 28.86 Pfam 262-293 (293) Show / Hide 
Range on Protein: 872-903
Range on HMM: 262-293/293
Sequence Identity: 43% (14 aa)

VDEEFIAFVEACLMLDHKKRPTSAELLEHPFI
..||.. |.. || .| ||||| ...|.||..
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF14.1070.AA DyrkP 873-903 48 1.2e-07 20.55 In-house 293-323 (323) Show / Hide 
Range on Protein: 873-903
Range on HMM: 293-323/323
Sequence Identity: 48% (15 aa)

DEEFIAFVEACLMLDHKKRPTSAELLEHPFI
|  || ||  || .|  .|||  | |.||..
DHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase LmjF14.1070.AA TyrKc 568-903 16 2.4e-07 -103.79 SMART 3-280 (280) Show / Hide 
Range on Protein: 568-903
Range on HMM: 3-280/280
Sequence Identity: 16% (64 aa)

KRKILG---YGQVCL---------KIINNTKDFFDQSLDEIRLLTLL--NRQRDPDDAHIVRLIDAFYYK-------EHVMLVTEL-----LRDTLYDYG
. |.||   .|.|..         | ... .      ..|.|... |  .        .||||. .   .       | .|.|.|.     |.| | ...
LGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGH------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KYNREEEKEFYFTLPRLRRLTRQIVEALTYVHSLNLIHTDLKPENIMFVSYSRCIVKVIDFGSSCFLSDH-----LSSYIQSR---SYR--------APE
.          .... |     || .   | || |.|| ||   |.. |.  . .||. ||| | .. |.      ..|. ..   . .        |||
PK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VVLGCDYDGRIDVWSLGAILVEMVT-GDVLFTS-----DTVPEMLARIVYVCGTPFPRR---MLWEGRHTSDYINKFGCIYEYGGGADGQHGLHEKGDTD
.   . .    |||| |  . |. | |.           .  |.....      | |     |                                     
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------

DGEEPYCLYTPVPTMAPHTCASSRKSRAAAAAPPPPRTTTAPYSVLREKLAAAKMVDEEFIAFVEACLMLDHKKRPTSAELLEHPFI
                                                         .|     . | . | ..||| .|.  | ..
---------------------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase LmjF14.1070.AA PRP4 879-903 60 3.4e-07 22.45 In-house 296-320 (320) Show / Hide 
Range on Protein: 879-903
Range on HMM: 296-320/320
Sequence Identity: 60% (15 aa)

FVEACLMLDHKKRPTSAELLEHPFI
. . ||||| ||| |  | |.||||
LLDKCLMLDPKKRITCNEALKHPFI
Kinase LmjF14.1070.AA DYRK 465-486 40 4e-07 22.95 In-house 1-22 (320) Show / Hide 
Range on Protein: 465-486
Range on HMM: 1-22/320
Sequence Identity: 40% (9 aa)

YEIIQMLGKATFSRAVRCYDLQ
|||....|| .|.  |.|.| .
YEILEYIGKGSFGQVVKCWDHK
Kinase LmjF14.1070.AA DYRK2 870-903 38 5.9e-07 18.31 In-house 285-318 (318) Show / Hide 
Range on Protein: 870-903
Range on HMM: 285-318/318
Sequence Identity: 38% (13 aa)

KMVDEEFIAFVEACLMLDHKKRPTSAELLEHPFI
.. || || |.  |.  | ..| |... |.||.|
GCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase LmjF14.1070.AA DyrkP 465-486 50 9e-06 14.18 In-house 1-22 (323) Show / Hide 
Range on Protein: 465-486
Range on HMM: 1-22/323
Sequence Identity: 50% (11 aa)

YEIIQMLGKATFSRAVRCYDLQ
| |.  || | ||.|. | |.|
YQIMEYLGSAAFSKAIQCQDKQ
Kinase LmjF14.1070.AA CLK 874-903 30 4.4e-05 10.41 In-house 321-350 (350) Show / Hide 
Range on Protein: 874-903
Range on HMM: 321-350/350
Sequence Identity: 30% (9 aa)

EEFIAFVEACLMLDHKKRPTSAELLEHPFI
....  .. .|. |  ||.| .. | ||| 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase LmjF14.1070.AA CLK 465-484 50 0.000143 8.83 In-house 1-20 (350) Show / Hide 
Range on Protein: 465-484
Range on HMM: 1-20/350
Sequence Identity: 50% (10 aa)

YEIIQMLGKATFSRAVRCYD
|||.  ||  ||.. |.| |
YEIVCTLGEGTFGKVVECWD
Kinase LmjF14.1070.AA HIPK 465-482 44 0.000163 9.59 In-house 1-18 (329) Show / Hide 
Range on Protein: 465-482
Range on HMM: 1-18/329
Sequence Identity: 44% (8 aa)

YEIIQMLGKATFSRAVRC
||.. .||. ||   |.|
YEVLEFLGRGTFGQVVKC
Kinase LmjF14.1070.AA HIPK 875-903 37 0.000452 8.17 In-house 301-329 (329) Show / Hide 
Range on Protein: 875-903
Range on HMM: 301-329/329
Sequence Identity: 37% (11 aa)

EFIAFVEACLMLDHKKRPTSAELLEHPFI
||.    . . .| .|| | .| |.|||.
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase LmjF14.1070.AA DYRK2 465-484 50 0.000948 7.7 In-house 1-20 (318) Show / Hide 
Range on Protein: 465-484
Range on HMM: 1-20/318
Sequence Identity: 50% (10 aa)

YEIIQMLGKATFSRAVRCYD
|||  ..||  |   |.|||
YEILEVIGKGSFGQVVKCYD
Kinase LmjF14.1070.AA DYRK1 465-487 43 0.007624 5.25 In-house 1-23 (321) Show / Hide 
Range on Protein: 465-487
Range on HMM: 1-23/321
Sequence Identity: 43% (10 aa)

YEIIQMLGKATFSRAVRCYDLQD
|||. ..||  |   |. || |.
YEIDSLIGKGSFGQVVKAYDHQE
Kinase LmjF14.1070.AA YAK 876-903 35 0.011856 4.39 In-house 320-347 (347) Show / Hide 
Range on Protein: 876-903
Range on HMM: 320-347/347
Sequence Identity: 35% (10 aa)

FIAFVEACLMLDHKKRPTSAELLEHPFI
|| |.   | |. ..| .     .||||
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase LmjF14.1070.AA PRP4 465-485 33 0.062037 2.97 In-house 1-21 (320) Show / Hide 
Range on Protein: 465-485
Range on HMM: 1-21/320
Sequence Identity: 33% (7 aa)

YEIIQMLGKATFSRAVRCYDL
|....  |.  ||  .|| |.
YRVYGYCGQGVFSNVCRCRDQ
Kinase LmjF14.1070.AA YAK 465-482 44 0.072246 1.68 In-house 1-18 (347) Show / Hide 
Range on Protein: 465-482
Range on HMM: 1-18/347
Sequence Identity: 44% (8 aa)

YEIIQMLGKATFSRAVRC
| .  |||. ||   | |
YIVLDMLGQGTFGQVVKC