Gene LmjF22.0490 (L.major)

LmjF22.0490

Species: L.major
Alias: LmjF22.0490, LmajK076
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
LmjF22.0490.AA Protein None 723 None Fasta, JSON
LmjF22.0490.kin_dom Protein Kinase Domain None 592 None Fasta, JSON

Protein domain

Protein domains of LmjF22.0490.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF22.0490.AA CMGC 43-451 15 2.4e-75 246.81 In-house 1-398 (513) Show / Hide 
Range on Protein: 43-451
Range on HMM: 1-398/513
Sequence Identity: 15% (90 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDR--------------VAIKRVHYDARLHN----------------REVAILNSVL-VDNPRHQQPSSTAVDSNDA
|  ....|.|..|||  .   .|. .              ||||..  .   ..                ||. ||  .   ..|               
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NW------------

SRRPGGAARASCTSFLSASSSSHTVEDVHLWPGT--------HHPNIVELLDFYVTYDTA----------SSEQALGADMVGAGGAGAGFEFLPSYHPAA
                                 .        ||.||| |.|.... ...          |                             
---------------------------------QRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIIS-----------------------------

HRYPLSGGSGAASASAPPVPAPLAAFAYLEMVMSYLPMDLCYVKRYYF------RFHDM-------PTIATSSSSSPIASPEQAPTELSSGELPEGTADR
                      .  | .| .|. |...||. . . .       | . .       |                                 
----------------------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHP---------------------------------

LPASPKHAGTGCNGNNSSRHSSTSSSGGDVCNHLPLRW----VKVVL------FQLARALA--FMHVRH--VCHRDLKPANVLVDPDT------------
                                    |     .|  .      .|. |.|.  ..| .   ..||||||.|.|.....            
-----------------------------------HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSED

-------GRVQVCDFGSAKQITRPAEE--------------------KNVSYICSRYYRAPELLFGA---------LHYGCAVDMWSFGCIAAELLR---
       ||. .||||.|...  . ..                     . .|...|.|||||.|.|.          ||....||||.||| ||...   
WNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQ

---ESGKPLFRGCTS-----------IDQMAELFKVLGAPS---------------KREMYAMNP
    .||||| | ..           |||... ||||| |.               ..|.. |..
SLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK
Kinase LmjF22.0490.AA GSK 319-453 53 5e-75 228.43 In-house 118-250 (328) Show / Hide 
Range on Protein: 319-453
Range on HMM: 118-250/328
Sequence Identity: 53% (72 aa)

VKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRPAEEKNVSYICSRYYRAPELLFGALHYGCAVDMWSFGCIAAELLRESG
.|.  .|. |.||. |   .||||.|| |.|||||||..  ||||||||. .   |.|.|||||||||||||.||. .|.|..|.||.||. ||.|   |
IKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLK--G

KPLFRGCTSIDQMAELFKVLGAPSKREMYAMNPQC
.||| | .|.||  | .|.|| |.|... .|||..
QPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSY
Kinase LmjF22.0490.AA CDK 224-442 24 2.7e-46 146.0 In-house 95-245 (284) Show / Hide 
Range on Protein: 224-442
Range on HMM: 95-245/284
Sequence Identity: 24% (56 aa)

MVMSYLPMDLCYVKRYYFRFHDMPTIATSSSSSPIASPEQAPTELSSGELPEGTADRLPASPKHAGTGCNGNNSSRHSSTSSSGGDVCNHLPLRWVKVVL
||. |...||  . .                                                                                .|  .
MVFEYMDHDLKKYMD--------------------------------------------------------------------------------IKCYM

FQLARALAFMHVRHVCHRDLKPANVLVDPDT----GRVQVCDFGSAKQITRP-----AEEKNVSYICSRYYRAPELLFGALHYG--CAVDMWSFGCIAAE
.|| |.|...| ... ||||||.| |.. .     ||. . ||| |.    |        .  . .  . |||||||.|. ||.  ...||||.||| ||
WQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAE

LLR-ESGKPLFRGCTSIDQMAELFKVLGAPS
...  ..|||| | . |||.   |...| |.
MFTDVTRKPLFPGDSEIDQLFKIFRICGTPT
Kinase LmjF22.0490.AA CDK7 330-445 45 2.8e-44 115.54 In-house 115-226 (288) Show / Hide 
Range on Protein: 330-445
Range on HMM: 115-226/288
Sequence Identity: 45% (53 aa)

LAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRPAEEKNVSYICSRYYRAPELLFGALHYGCAVDMWSFGCIAAEL-LRESGKPLFRGCTSI
| ..|.  . |||||| | |.... |.. . ||| |...  |  .   . .  |.|||||||||| ||| .||||| ||| ||| ||    | . |   |
LEYCHRNWILHRDLKPNNLLMNEN-GQLKIADFGLARFYGSP-NRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR---VPYLPGDSDI

DQMAELFKVLGAPSKRE
||.   |. || |. .|
DQLTRIFQTLGTPTEEE
Kinase LmjF22.0490.AA S_TKc 43-634 11 3.3e-43 150.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-634
Range on HMM: 1-231/231
Sequence Identity: 11% (74 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRVHYDARLHNREVAILNSVLVDNPRHQQPSSTAVDSNDASRRPGGAARASCTSFLSASSSSHTVEDVHLW
|. || .|.|.||.| .. ...|| .||||...                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

PGTHHPNIVELLDFYVTYDTASSEQALGADMVGAGGAGAGFEFLPSYHPAAHRYPLSGGSGAASASAPPVPAPLAAFAYLEMVMSYLPMDLCYVKRYYFR
                                                                                                    
----------------------------------------------------------------------------------------------------

FHDMPTIATSSSSSPIASPEQAPTELSSGELPEGTADRLPASPKHAGTGCNGNNSSRHSSTSSSGGDVCNH--------------------LPLRWVKVV
                   |..  |..  .       . |   |  ..  .        .      . |..                    .|  ... .
-------------------EHIRREIQILKK------HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

LFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRPAEEKNVSYICSRYYRAPELLFGALHYGC-AVDMWSFGCIAAELLRESGKPL
. |...||...| ....||||||.|.|.|    .. .||||.|.|.         ... ...|.|||.|    .||. ..|.||.||| .|.|   |.|.
MYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC--GYPP

FRGCTSIDQMAELFKVLGAPSKREMYAMNPQCAEALLRTRAMHRHQSLDNDPHSGSGGGVRQDRSCGLELEVDYQAEEEDDVELRGGAQQGGYDVDSHGE
|.      ||...||..|                                                                                  
FP------QMQMMFKKIG----------------------------------------------------------------------------------

FLRDALDDGISSQASASPGMATASPPSSSTKDPRDYKTTFSAPPSTAATAMLDDVAPTPFEEYYDVLKVRAIPWRRLFPVDTPTEAVALVASLLCYAPDK
                                                                                  . ||  ..  .|.. |.|
----------------------------------------------------------------------------------SPEAKDFIRKCLQKDPEK

RLTAAELVE-------HPFF
|.|| |. .       ||.|
RPTA-EALQDEWDIKCHPWF
Kinase LmjF22.0490.AA ERK7 319-471 37 1.6e-42 143.06 In-house 102-256 (292) Show / Hide 
Range on Protein: 319-471
Range on HMM: 102-256/292
Sequence Identity: 37% (59 aa)

VKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRPA--EEKNVS---YICSRYYRAPELLFGALHYGCAVDMWSFGCIAAEL
......|| ||. .||  .| ||||||.|.|.| .  .| ||||| |  |.     .|.|     |.  | ||||| | |. .|  .||||| ||| .|.
KQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSEC-MVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

LRESGKPLFRGCTSIDQMAELFKVLGAPSKREMYAMNPQCAEALLRTRAMHRHQSLDN
||  |||.| |   ..|.    .... |.. .. |.....|  .|     .....||.
LR--GKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQ
Kinase LmjF22.0490.AA CDC2 313-442 40 2.7e-40 121.2 In-house 99-229 (301) Show / Hide 
Range on Protein: 313-442
Range on HMM: 99-229/301
Sequence Identity: 40% (53 aa)

HLPLRWVKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRPAEEKNVS-YICSRYYRAPELLFGALHYGCAVDMWSFGCIAA
|.|.  ||  ..|. ....| | | . |||||| | |.| ..|.... ||| |. .. |  .      .  . |||||.|.|. .| ..|||||.||| |
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

ELLRE-SGKPLFRGCTSIDQMAELFKVLGAPS
|.  . . |||| |   |||    |..|| |.
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPN
Kinase LmjF22.0490.AA Pkinase 146-441 19 5.3e-40 142.53 Pfam 58-234 (293) Show / Hide 
Range on Protein: 146-441
Range on HMM: 58-234/293
Sequence Identity: 19% (62 aa)

HHPNIVELLDFYVTYDTASSEQALGADMVGAGGAGAGFEFLPSYHPAAHRYPLSGGSGAASASAPPVPAPLAAFAYLEMVMSYLPM-----DLC-YVKRY
.|||||.|.|.. .                                                             .. ||| |...     ||. |... 
NHPNIVRLYDWFED-----------------------------------------------------------KDHIYMVMEYCEGGLYVMDLFDYIST-

YFRFHDMPTIATSSSSSPIASPEQAPTELSSGELPEGTADRLPASPKHAGTGCNGNNSSRHSSTSSSGGDVCNHL--PLRWVKVVLFQLARALAFMHVRH
                                                                     .  . .  . . .| .. |..|.|...| . 
---------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMG

VCHRDLKPANVLVDPDTGRV----QVCDFGSAKQI-TRPAEEKNVSYICSRYYRAPELLFGALHYGCAVDMWSFGCIAAELLRESGKPLFRGC----TSI
..||||||.|.|.| ..| .     .||||.|||. . . .  . .. ....|.|||.. |. .|| .|||||.||| .|.|   |.|.|.|.    . .
IIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC--GRPPFPGHCWHDN-H

DQMAELFKVLGAP
|||. .....|.|
DQMQMICRIMGPP
Kinase LmjF22.0490.AA MAPK 319-471 31 2.9e-39 133.3 In-house 117-288 (328) Show / Hide 
Range on Protein: 319-471
Range on HMM: 117-288/328
Sequence Identity: 31% (55 aa)

VKVVLFQLARA--LAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITR-PAEEKN------------VSYICSRYYRAPELLFG--ALHYGCAV
..  ..|. |.  | ..|   | ||||||.|.||.   . . .|||| | .|     ....              |.  |.|||||....  . ||  ||
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DMWSFGCIAAELLRESGKPLFRGCTSIDQMAELFKVLGAPSKREMYAMN-PQCAEALLRTR---AMHRHQSLDN
|||| ||| ||.|.  .||||.|  .|||.   ..||| ||.  .  .  .. |  ... .    ..  .....
DMWSVGCIFAEMLT-DRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEK
Kinase LmjF22.0490.AA CDK-Unclassified 319-442 35 3.3e-36 116.51 In-house 123-259 (324) Show / Hide 
Range on Protein: 319-442
Range on HMM: 123-259/324
Sequence Identity: 35% (50 aa)

VKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTG-----RVQVCDFGSAKQITR---------PAE--EKNVSYICSRYYRAPELLFGALHYGCAVD
..  . |.   .|..|     |||.||.|.... ...      . . |||.|              ||.   . .. .  | |||||||||   |. .||
IRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMIT-NNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVSTRWYRAPELLFGSKCYDTGVD

MWSFGCIAAELLRESGKPLFRGCTSIDQMAELFKVLGAPS
.|||||| ||...  |||.| | | |.||.  ||.|| |.
IWSFGCIYAEWFQ--GKPIFQGRTEIEQMHHIFKMLGTPC
Kinase LmjF22.0490.AA p38 319-443 37 4.2e-31 103.34 In-house 108-225 (289) Show / Hide 
Range on Protein: 319-443
Range on HMM: 108-225/289
Sequence Identity: 37% (47 aa)

VKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRPAEEKNVSYICSRYYRAPELLFGALHYGCAVDMWSFGCIAAELLRESG
..  ..|. |.| . |   . |||||| |. |  |   . . |||      |.....   |.  | ||||| ..   ||  .||.|| |||.|||.  .|
IQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCE-LRILDFG----LARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI--TG

KPLFRGCTSIDQMAELFKVLGAPSK
..||.|.  |||. .. ||.| |..
RTLFPGDDHIDQLQRIMKVCGTPDE
Kinase LmjF22.0490.AA RCK 319-445 33 9.3e-31 94.6 In-house 107-237 (298) Show / Hide 
Range on Protein: 319-445
Range on HMM: 107-237/298
Sequence Identity: 33% (46 aa)

VKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPD--------TGRVQVCDFGSAKQITRPAEEKN--VSYICSRYYRAPELLFGALHYGCAVDMWSFGC
.|  ..|.. .||.||     |||||| | .. ..        .... ..|||... |    . |.    |. .|.|||||.|  . .|   .|.|..||
IKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREI----RSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGC

IAAELLRESGKPLFRGCTSIDQMAELFKVLGAPSKRE
|..||   . .||| |   |||  .. ||.| |.|..
IMYELY--MLRPLFPGSSEIDQIFKICKVMGTPNKKD
Kinase LmjF22.0490.AA GSK 43-88 38 6.4e-13 35.21 In-house 1-55 (328) Show / Hide 
Range on Protein: 43-88
Range on HMM: 1-55/328
Sequence Identity: 38% (21 aa)

YRPLRYVGRGSFGVVLLAEEV----HTGDR----VAIKRVHYDARLH-NREVAIL
|.  . .|.||||||  |       .|..     ||||.| .| |   |||. |.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIM
Kinase LmjF22.0490.AA CMGC 589-634 22 2.6e-12 35.85 In-house 434-513 (513) Show / Hide 
Range on Protein: 589-634
Range on HMM: 434-513/513
Sequence Identity: 22% (18 aa)

KVRAIPWRRLFPV----------------------------------DTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
... .||..|||                                   . . .|. |.  .|.| ||||.||..  .||.|
WWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase LmjF22.0490.AA RCK 584-634 25 1.6e-11 32.52 In-house 249-298 (298) Show / Hide 
Range on Protein: 584-634
Range on HMM: 249-298/298
Sequence Identity: 25% (13 aa)

YYDVLKVRAIPWRRLFPVDTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
...  .. ..|   |.|   . ... |.  .|.. |.|| ||... .||.|
NFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase LmjF22.0490.AA GSK 589-634 23 8.3e-11 28.63 In-house 262-328 (328) Show / Hide 
Range on Protein: 589-634
Range on HMM: 262-328/328
Sequence Identity: 23% (16 aa)

KVRAIPWRR-------------------LFPV-DTPTE-AVALVASLLCYAPDKRLTAAELVEHPFF
.. ..||..                   .| .  |. . .. |. ..| |.| |||.. |.  ||||
QIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase LmjF22.0490.AA Pkinase 43-91 26 4.2e-10 36.81 Pfam 1-57 (293) Show / Hide 
Range on Protein: 43-91
Range on HMM: 1-57/293
Sequence Identity: 26% (15 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRVHYDARLHNR--------EVAILNSV
|. .| .|.||||.| .. .. ||..||.|.. .. . ..         |..|....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL
Kinase LmjF22.0490.AA ERK7 598-634 35 4.3e-10 30.39 In-house 257-292 (292) Show / Hide 
Range on Protein: 598-634
Range on HMM: 257-292/292
Sequence Identity: 35% (13 aa)

LFPVDTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
..| .....|. |.  ||...|.||||| . ..||. 
MMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase LmjF22.0490.AA RCK 43-73 38 7.5e-10 27.14 In-house 1-31 (298) Show / Hide 
Range on Protein: 43-73
Range on HMM: 1-31/298
Sequence Identity: 38% (12 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKR
|  .. .|.|..|.|..|  . ||. ||||.
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKK
Kinase LmjF22.0490.AA MAPK 592-634 34 1.1e-09 29.41 In-house 283-328 (328) Show / Hide 
Range on Protein: 592-634
Range on HMM: 283-328/328
Sequence Identity: 34% (16 aa)

AIPWRRLFPV---DTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
..||. .||    ..  .|. |.  .|   ||||.|..|  .||.|
KKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase LmjF22.0490.AA p38 43-73 44 1.3e-09 28.71 In-house 1-34 (289) Show / Hide 
Range on Protein: 43-73
Range on HMM: 1-34/289
Sequence Identity: 44% (15 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDR---VAIKR
|. |..|| |..| |  || . ||..   ||||.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKK
Kinase LmjF22.0490.AA CDK 43-74 35 3.8e-09 25.23 In-house 1-37 (284) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-37/284
Sequence Identity: 35% (13 aa)

YRPLRYVGRGSFGVVLLAEEVHTG-----DRVAIKRV
|  |  .|.|..|||  |   .||     . ||.|..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKI
Kinase LmjF22.0490.AA CDC2 606-634 41 4.5e-09 23.48 In-house 273-301 (301) Show / Hide 
Range on Protein: 606-634
Range on HMM: 273-301/301
Sequence Identity: 41% (12 aa)

EAVALVASLLCYAPDKRLTAAELVEHPFF
|.. |  ..|.| | ||..| |  .||.|
EGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase LmjF22.0490.AA CDK 610-634 44 8.3e-09 24.13 In-house 260-284 (284) Show / Hide 
Range on Protein: 610-634
Range on HMM: 260-284/284
Sequence Identity: 44% (11 aa)

LVASLLCYAPDKRLTAAELVEHPFF
|  ..||| |.||..| .  .||.|
LLNKMLCYDPKKRISAEQALQHPYF
Kinase LmjF22.0490.AA Pkinase 596-634 30 1e-08 31.87 Pfam 256-293 (293) Show / Hide 
Range on Protein: 596-634
Range on HMM: 256-293/293
Sequence Identity: 30% (12 aa)

RRLFPVDTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
...| . .. |.  .. ..||. | ||.||.....||.|
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF22.0490.AA MAPK 43-74 34 1.8e-08 25.15 In-house 1-38 (328) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-38/328
Sequence Identity: 34% (13 aa)

YRPLRYVGRGSFGVVLLAEEVH------TGDRVAIKRV
|..|...| |..|||  |  .       .|..||||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKI
Kinase LmjF22.0490.AA CDK7 43-74 37 2.5e-08 17.81 In-house 1-32 (288) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-32/288
Sequence Identity: 37% (12 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRV
|  .. .| | |..| .| .  ||  ||||..
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase LmjF22.0490.AA GSK 146-242 17 9.3e-08 19.14 In-house 62-108 (328) Show / Hide 
Range on Protein: 146-242
Range on HMM: 62-108/328
Sequence Identity: 17% (17 aa)

HHPNIVELLDFYVTYDTASSEQALGADMVGAGGAGAGFEFLPSYHPAAHRYPLSGGSGAASASAPPVPAPLAAFAYLE-MVMSYLPMDLCYVKRYYFR
.||||| |. |. .. .  .|                                                      |..  || |.|..| .| |.|..
DHPNIVRLKYFFYMHYEKKDEN---------------------------------------------------HVYCNCLVMEYMPQTLYQVIRHYVK
Kinase LmjF22.0490.AA TyrKc 43-634 8 2.4e-07 -103.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-634
Range on HMM: 1-280/280
Sequence Identity: 8% (55 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRVHYDARLHN---REVAILNSV--------------LVD---------------------------NPRH
 . ..  |.| ||.| ...       ||.| .. ||  .    ||  |. ..              . .                           ..|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

QQPSSTAVDSNDASRRPGGAARASCTSFLSASSSSHTVEDVHLWPGTHHPNIVELLDFYVTYDTASSEQALGADMVGAGGAGAGFEFLPSYHPAAHRYPL
.                                                                                                   
K---------------------------------------------------------------------------------------------------

SGGSGAASASAPPVPAPLAAFAYLEMVMSYLPMDLCYVKRYYFRFHDMPTIATSSSSSPIASPEQAPTELSSGELPEGTADRLPASPKHAGTGCNGNNSS
                                                                                                    
----------------------------------------------------------------------------------------------------

RHSSTSSSGGDVCNHLPLRWVKVVLFQLARALAFMHVRHVCHRDLKPANVLVDPDTGRVQVCDFGSAKQITRP------AEEKNVSY-ICSR-----YYR
               |...      .| |.  .. | ... ||||   |.||. .  .| ..||| .. |.         . . ..   ...        
---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APELLFGALHYGCAVDMWSFGCIAAELLRESGKPLFRGC----TSIDQMAELFKVLGAPSKREMYAMNPQCAEALLRTRAMHRHQSLDNDPHSGSGGGVR
||| .     .  . | ||||    |..   |..   |      | ... |. |  . . . . .   |  .                            
APECI-NYGKFTTKSDVWSFGVCMWEIF-TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS----------------------------

QDRSCGLELEVDYQAEEEDDVELRGGAQQGGYDVDSHGEFLRDALDDGISSQASASPGMATASPPSSSTKDPRDYKTTFSAPPSTAATAMLDDVAPTPFE
                                                                                                    
----------------------------------------------------------------------------------------------------

EYYDVLKVRAIPWRRLFPVDTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
                | |  |.|   .  .   . |..| | .|.  | .|
----------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase LmjF22.0490.AA CDC2 43-74 31 3.2e-07 17.68 In-house 1-32 (301) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-32/301
Sequence Identity: 31% (10 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRV
|  .. .| |..|||  .... |.. ||.|..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKI
Kinase LmjF22.0490.AA CDK-Unclassified 43-74 40 9.6e-07 18.06 In-house 1-32 (324) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-32/324
Sequence Identity: 40% (13 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRV
|| .. .|.| || | .|    |  .||||..
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKI
Kinase LmjF22.0490.AA p38 596-634 35 2e-06 17.59 In-house 252-289 (289) Show / Hide 
Range on Protein: 596-634
Range on HMM: 252-289/289
Sequence Identity: 35% (14 aa)

RRLFPVDTPTEAVALVASLLCYAPDKRLTAAELVEHPFF
...|.  .| . . |   .|   ||||.||.|  .||.|
HHVFMGANPQA-IDLLEKMLELDPDKRITAEEAMQHPYF
Kinase LmjF22.0490.AA CDK7 606-634 24 1.6e-05 10.21 In-house 260-288 (288) Show / Hide 
Range on Protein: 606-634
Range on HMM: 260-288/288
Sequence Identity: 24% (7 aa)

EAVALVASLLCYAPDKRLTAAELVEHPFF
... |.. ..   | ||.|...  ..|.|
DLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase LmjF22.0490.AA CDK-Unclassified 610-634 28 0.000114 11.13 In-house 300-324 (324) Show / Hide 
Range on Protein: 610-634
Range on HMM: 300-324/324
Sequence Identity: 28% (7 aa)

LVASLLCYAPDKRLTAAELVEHPFF
..  .. | |..|... |.  || |
CEFQMVMYQPYNRWKCMEILQHPWF
Kinase LmjF22.0490.AA APH 338-357 54 0.000903 13.74 Pfam 172-193 (248) Show / Hide 
Range on Protein: 338-357
Range on HMM: 172-193/248
Sequence Identity: 54% (12 aa)

VCHRDLKPANVLVD--PDTGRV
.||.|..| ||..|  || |||
WCHGDFHPGNVMWDPRPDGGRV
Kinase LmjF22.0490.AA ERK7 43-78 33 0.00187 7.32 In-house 1-35 (292) Show / Hide 
Range on Protein: 43-78
Range on HMM: 1-35/292
Sequence Identity: 33% (12 aa)

YRPLRYVGRGSFGVVLLAEEVHTGDRVAIKRVHYDA
|  .. .|.| .|.|  |    |.. ||.|.. .||
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKI-FDA
Kinase LmjF22.0490.AA CDK7 146-161 25 0.050155 0.7 In-house 60-75 (288) Show / Hide 
Range on Protein: 146-161
Range on HMM: 60-75/288
Sequence Identity: 25% (4 aa)

HHPNIVELLDFYVTYD
.|.|...|.| .  ..
QHDNVIGLIDIFMHKS