Gene LmjF16.0870 (L.major)

LmjF16.0870

Species: L.major
Alias: LmjF16.0870, LmajK111
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF16.0870.AA Protein None 684 None Fasta, JSON
LmjF16.0870.kin_dom Protein Kinase Domain None 305 None Fasta, JSON

Protein domain

Protein domains of LmjF16.0870.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc LmjF16.0870.AA S_TKc 345-677 17 1.5e-24 88.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 345-677
Range on HMM: 1-231/231
Sequence Identity: 17% (59 aa)

LASPRRLGEGAQGVVDLMEVVQPTTEEVAQAGPSSAAYRFVSEHLSHESRLQKVVLKSMHFSSEAKALVEYQKSVRFMTVMQHPHLVEYLAVQLKPDRRT
    | .|.|| |.| .   .                              ..| .| ..           .. .. .   .||..| .. |        
YEILRKIGKGAFGKVYKCRHKK---------------------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DH

VGICMPYYQE--GDVGAVIRSFRGDR----FDESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQQIVLTDLDASREVLGGYQEAVQSSLG
. ..| |     ||.  .|.. .. .    |.|  ..... |. .||...|...  |.| ||| || .. .   .| ..|   .|..         .  |
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCG

TTAYMAPETLKVERLMP-SSDMWSLGVFLYVLTV-LPDFPMLLNPNTQNLDLLNADCWATEEDLRAMESYSSALNDGRSNAPSVNAGSGNCGITLGECVR
|  ||||| |      . ..|.||.|. || . .  | ||       |   ...  .                                           
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------------------------------------------

ANITRKGYSRDLAQLVVDLLSYNPLKRPTAEAVGC-----RLTEIM
        |... ...  .| ..| |||||  .       .. . .
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF16.0870.AA CAMK 425-569 19 1.1e-21 66.01 In-house 95-327 (425) Show / Hide 
Range on Protein: 425-569
Range on HMM: 95-327/425
Sequence Identity: 19% (45 aa)

MQHPHLVEYLAVQLKPD-----------------RRTVGICM---PYYQEG----DVGAVIRSFRG-------------DRFDESFVCSIALQLSLALAF
..||...  . |   |.                 .. . . |    | . |    |.   |.. ..              ||.|. .. .  |.  |...
LDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY

LHERNPPIVHGDLKVENAMFYNNK----------------QQIVLTDLDASREVLGG----------------------YQEAVQSSLGTTAYMA-PETL
.|..|  ||| ||| || .. .|.                 .| ..|   .... .|                      . .  . . || .||| || |
CHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

K--------------VERLMPSSDMWSLGVFLYVL
.               .   |..||||.|| ||..
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM
Kinase LmjF16.0870.AA CAMK-Unique 427-569 22 1.8e-21 67.48 In-house 75-286 (363) Show / Hide 
Range on Protein: 427-569
Range on HMM: 75-286/363
Sequence Identity: 22% (49 aa)

HPHLVEYLAV--QLKPDRR---------------TVGICMPYYQEGDVGAVIRS---FR---------------GDRFDE--SFVCSIALQLSLALAFLH
||.... . .   .. ||.                  | | | |.||. ..| .   |.                 .| |  . .|.| ..|  |.|..|
HPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMH

ERNPPIVHGDLKVENAMFYNN---------------KQQIVLTDLDASREVLGGYQEA-VQSSLGTTAYMAP--------------ETLK----VERLMP
. .  |||.||| || |....                  |.|.| . .... .   ..  |.  ||  ||||              |...    .. . |
SQD--IVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSP

SSDMWSLGVFLYVL
 || ||||| .| .
ASDIWSLGVIMYYM
Kinase LmjF16.0870.AA MSK 468-569 32 2.3e-20 65.57 In-house 97-203 (277) Show / Hide 
Range on Protein: 468-569
Range on HMM: 97-203/277
Sequence Identity: 32% (35 aa)

RFDESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYNN--KQQIVLTDLDASREVLGGYQEAVQSSLGTTAYMAPETLKV--ERLM---PSSDMW
.|||| .  | ..| .|. ..|..   |.|.||| || .| ..    ...|.|   .|. . . ..  .|  .|  ||||| |..  .      .. |.|
HFDESECRMIMRELVMAVDHMHQKG--IIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWW

SLGVFLYVL
|||| || .
SLGVILYTM
Kinase LmjF16.0870.AA Ciliate-E2 425-569 21 1.3e-19 63.93 In-house 89-289 (365) Show / Hide 
Range on Protein: 425-569
Range on HMM: 89-289/365
Sequence Identity: 21% (45 aa)

MQHPHLVEYLAVQLKPDRRTVGICMPYYQEGDVGAVIRSF----------RGDRFDESFVCSIALQLSL---------------ALAFLHERNPPIVHGD
..||.....  .    |. .. . | |.| ||    |...             .|.|  .. |  |.                 || .||..|. |.| |
LNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRD

LKVENAMFYNNKQQIVLTDLDASREVLGGYQ------------------------------EAVQSSLGTTAYMAPETLKVERLM---------PSSDMW
.| || .|      | ..|.  |...   .|                              . ... .||  ||||| |. .             ..|.|
IKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW

SLGVFLYVL
|||| || .
SLGVILYEM
Pkinase LmjF16.0870.AA Pkinase 419-569 25 2.5e-19 69.44 Pfam 51-205 (293) Show / Hide 
Range on Protein: 419-569
Range on HMM: 51-205/293
Sequence Identity: 25% (41 aa)

VRFMTVMQHPHLVEYLAVQLKPDRRTVGICMPYYQEG----DVGAVIRSFRGDRF--DESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQ
.. |  ..||. |... .   .|.    ..|.| . |    |  ..|.  |. .|  .|  ......|.  .|...|..   |.| ||| || ..  |. 
IQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNG

QI----VLTDLDASREV-LGGYQEAVQSSLGTTAYMAPETLK-VERLMPSSDMWSLGVFLYVL
.|     ..|   .. . .  ..   ..  ||  ||||| ..  .   |..||||.|. || .
HIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase LmjF16.0870.AA TKL 426-567 17 2.6e-19 66.2 In-house 83-280 (364) Show / Hide 
Range on Protein: 426-567
Range on HMM: 83-280/364
Sequence Identity: 17% (37 aa)

QHPHLVEYLAVQLKPDRRT-----------VGICMPYYQEGD-VGAVIRSFRGDRFDESFVCSIALQLSLALAFLHERN------PPIVHGDLKVENAMF
.||..| .... . |. ..            .| | |.. |.    ..          .  |..||. ......|| .|      |||.| ||| .| . 
RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV

YNNKQ-------------QIVLTDLDASREVLGGYQ------------------EAVQSSLGTTAYMAPETLK----------------VERLMPSSDMW
 .| .              . ..|.  ||.. .  .                  ..  .  ||...|||| |.                 .   ...|..
DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY

SLGVFLY
| |. |.
SFGIVLW
Kinase LmjF16.0870.AA Ciliate-E2-Unclassified 468-569 28 7.6e-19 62.01 In-house 134-263 (352) Show / Hide 
Range on Protein: 468-569
Range on HMM: 134-263/352
Sequence Identity: 28% (37 aa)

RFDESFVC-----SIALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQ--QIVLTDLDASREVL-----GGY----------QEAVQSSLGTTAYM--
.|.|  ..      .. |. ..| .||. |  |.| |.| || .| ||..  .| ..|.  |..         .          |.  ..  ||  ||  
IFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQ

--APETLKVERLMPS----SDMWSLGVFLYVL
  ||| |. .    |    .|.||||| || .
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase LmjF16.0870.AA RSK 469-567 32 1e-18 65.32 In-house 101-203 (278) Show / Hide 
Range on Protein: 469-567
Range on HMM: 101-203/278
Sequence Identity: 32% (34 aa)

FDESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYN--NKQQIVLTDLDASREVLGGYQEAVQSSLGTTAYMAPETLK---VER-LMPSSDMWSL
|.|. .| .. ...||. .||..   |.| ||| || .. .  |   |.||| . ...    . .  ..  .| .||||| ||    ..    . | |||
FSEDEACFYMAEIVLAVEHLHQQG--IIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVFLY
|| .|
GVLMY
Kinase LmjF16.0870.AA CAMKL 449-571 26 5.5e-15 44.13 In-house 100-231 (297) Show / Hide 
Range on Protein: 449-571
Range on HMM: 100-231/297
Sequence Identity: 26% (35 aa)

MPYYQEGD--VGAVIRSFRGDR--FDESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQ-QIVLTDLDASREVL---GGYQEAVQSSLGTT
| | . |.      |.. .. |  ..|.  . .  |.  |....|...  ||| |.| || .. .|.  .| ..|   | .      |. .    . |. 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

AYMAPETLKV--E-RLMPSSDMWSLGVFLYVLTV
.||||| ..   .    |  |.||.|| ||.. .
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVC
Kinase LmjF16.0870.AA STE 425-563 23 9.8e-15 48.57 In-house 88-255 (359) Show / Hide 
Range on Protein: 425-563
Range on HMM: 88-255/359
Sequence Identity: 23% (41 aa)

MQHPHLVEYLAVQLKPD-----RRTVGICMPYYQEGDVGAVIR---SFRG---------DRFDESFVCSIALQLSLA-LAFLHERNPPIVHGDLKVENAM
| ||. |.|.   .| .     . .. ||| |   | .  .|.   .  .         .||.|| .. |. |.  . |..||. .  |.| |.|  | .
M-HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANIL

FYNNKQQIVLTDLDASREVLGGYQ-----------EAVQ----SSLGTTAYMAPETLKVERLM------PSSDMWSLG
.      . |.|   .  .   .            |  |    .  ||  .|||| .. ..         ..|.||||
L------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLG
TyrKc LmjF16.0870.AA TyrKc 345-673 14 2.7e-09 -72.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 345-673
Range on HMM: 1-280/280
Sequence Identity: 14% (54 aa)

LASPRRLGEGAQGVVDLMEVVQPTTEEVAQAGPSSAAYRFVSEHLSHESRLQKVVLKSMHFSSEAKALVEYQKSVRFMTVM--QHPHLVEYLAVQLKPDR
.   . ||||| |.| . .                                ..|  |... ..    . .  .  | |.    .||..|  ..| ... |
ITLGKKLGEGAFGEVYKGTWK------------------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGR

-----RTVGICMPYYQEGDVGAVIRSFRGDRFDESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQQIVLTDLDASREVLGG--------Y
       . | | |   ||    .|. |.. .  .  .|...| .   ..||..  ...| ||   | . .......  .|   ||..  .        |
NFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCL-VGENHTVKISDFGLSRDIYDDDQQGESKDY

QEA----VQSSLGTTAYMAPETLKVERLM---PSSDMWSLGVFLY-VLTVLPDFPMLLNPN-----TQNLDLLNADCWATEEDLRAMESY----SSALND
  .       ..     ||||..   .     . || || || .. ..|    . .   |.       | ....   .  . . .    .    |     
YRKKEHKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFT----YGQQPYPGMIQQMMSNQEVIE---YVKQGYRMPQPPNDYPMS-----

GRSNAPSVNAGSGNCGITLGECVRANITRKGYSRDLAQLVVDLLSYNPLKRPTAEAVGCRL
                              . . .. |.  .   ..| .||| ...  ..
--------------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF16.0870.AA Dicty3 468-512 33 1.2e-08 24.43 In-house 107-150 (351) Show / Hide 
Range on Protein: 468-512
Range on HMM: 107-150/351
Sequence Identity: 33% (15 aa)

RFDESFVCSIALQLSLALAFLHERNPPIVHGDLKVENAMFYNNKQ
|| |..  .|. .| ..|...|. .  |.|.|.| .| |. |..|
RFNEHEISKIICDLVKTLNYIHKNC-HIIHRDIKCDNIMLDNDEQ
Kinase LmjF16.0870.AA Dicty3 535-563 45 8e-06 14.97 In-house 254-284 (351) Show / Hide 
Range on Protein: 535-563
Range on HMM: 254-284/351
Sequence Identity: 45% (14 aa)

SSLGTTAYMAPETLKVER--LMPSSDMWSLG
|. ||. ||||| ..  .  .  .||.||||
SICGTIHYMAPEIKLNNQCCACRKSDIWSLG
Kinase LmjF16.0870.AA Pkinase 645-673 29 0.010617 10.63 Pfam 263-293 (293) Show / Hide 
Range on Protein: 645-673
Range on HMM: 263-293/293
Sequence Identity: 29% (9 aa)

SRDLAQLVVDLLSYNPLKRPTAEAVGCR--L
|... ... ..| ..| |||||| . .   .
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF16.0870.AA CAMKL 645-669 40 0.110094 0.98 In-house 268-291 (297) Show / Hide 
Range on Protein: 645-669
Range on HMM: 268-291/297
Sequence Identity: 40% (10 aa)

SRDLAQLVVDLLSYNPLKRPTAEAV
| |. .|   .|  || ||||.. .
S-DCRDLIRKMLQVNPEKRPTIHQI