Gene LmjF10.0830 (L.major)

LmjF10.0830

Species: L.major
Alias: LmjF10.0830, LmajK132
External Links:
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
LmjF10.0830.AA Protein None 1538 None Fasta, JSON
LmjF10.0830.kin_dom Protein Kinase Domain None 328 None Fasta, JSON

Protein domain

Protein domains of LmjF10.0830.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF10.0830.AA S_TKc 1095-1524 12 7.1e-14 26.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 1095-1524
Range on HMM: 1-231/231
Sequence Identity: 12% (59 aa)

FASAEFVGEGSFGLVWRCLTVD-GDLVAVKSCPVILRTKANIEDSFSTIREIATMRFLNEMQVPYVLPLHSAFFVHAQEALPPLAQEALEWRQRLRKRAE
.   . .|.|.|| |..|  .. | .||.|  .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

EAALEVEVRLLARGGNRRASHTGAEEDVEDAPLTLEQQVAVQMERLTAAEGPEEQATRARLQSVRLPRFLSITHDDLTQSDATVFLVMELCDG---DVEG
                                        .. |.    .           .   . ... . .|        ...|||.|||   |.  
--------------------------------------EHIRREIQILKK-----------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFD

ISRSDG----------VAKGMVYCVSSALAAMHELGLLHLDLKPSNILFAYEHGPSQQRLQRFSASGPATDAVKFYLSDFGNCRLVGPDPMDEVQDSYGT
. .. |          .|. ..| . .||. .|..| .| ||||.|||.                           ..||| .|..            ||
YIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------------HIKICDFGLARQL--------TTFCGT

FEYMDLRALRDAVCGR-PTDAFSLGATLYELLYGRRLYPKCVDPRCGGEEDHSRECFVEAASQPVVLPTVGPPTTAAMVTLVTTIGLDAAAAGHARGPHA
 .||    |     |. . |  |.| .|||.|.|. ..|                  ...  . ..                                  
PWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG----------------------------------

NGGTGSTSGLICSGPALTPLQYLTLALLRKPWAERMTAEECRR---------YL
                  ..  .   .|.|  ..|.|| |. .         ..
----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF10.0830.AA CMGC 1095-1329 11 1.1e-13 40.4 In-house 1-217 (513) Show / Hide 
Range on Protein: 1095-1329
Range on HMM: 1-217/513
Sequence Identity: 11% (36 aa)

FASAEFVGEGSFGLVWRC---------------LTVDGDLVAVKSCPVILRTKANIEDSF----------STIREIATMRFLNEM--------------Q
.   . .|||..| |..|               .. .. .||.|    | . . . |.            ...|||  .. ||.               .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIK---KIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKH

VPYVLPLHSAFFVHA---------QEALPPLAQEALEWRQRLRKRAEEAALEVEVRLLARGGNRRASHTGAEEDVEDAPLTLEQQVAVQMERLTAAEGPE
 .... |.  |  .          ..                                                                          
HNNIVKLYDIFYHKNSDGNEYEDKHI--------------------------------------------------------------------------

EQATRARLQSVRLPRFLSITHDDLTQSDATVFLVMELCDGDVEGISRSDGV-------------------------AKGMV------YCVSSALA--AMH
                  |       ..  ..||.|..| |  .. ..                             | ..      | .  .|.   .|
------------------I-S---Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ELG--LLHLDLKPSNILF
  .   .| ||||.|||.
SHWGNIIHRDLKPENILI
Kinase LmjF10.0830.AA Pkinase 1272-1414 23 6.7e-13 46.7 Pfam 70-209 (293) Show / Hide 
Range on Protein: 1272-1414
Range on HMM: 70-209/293
Sequence Identity: 23% (38 aa)

QSDATVFLVMELCDG-----DVE-------GISR--SDGVAKGMVYCVSSALAAMHELGLLHLDLKPSNILFAYEHGPSQQRLQRFSASGPATDAVKFYL
...  . .|||.|.|     |         . .   |. ..| ..| . ..|. .|. | .| ||||.|||.  .  ..                 .. .
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----------------CVKI

SDFGNCRL--VGPDPMDEVQDSYGTFEYMDLRALR-DAVCGRPTDAFSLGATLYELLYGR
.||| ...    ...    ..  || .||    .| .   |.. | .|.| .|||.| ||
CDFGLAKQFDY-NNS---MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase LmjF10.0830.AA Ciliate-E2 1271-1417 17 1.8e-12 39.11 In-house 103-296 (365) Show / Hide 
Range on Protein: 1271-1417
Range on HMM: 103-296/365
Sequence Identity: 17% (38 aa)

TQSDATVFLVMELCDG----DVEGISR-------------SDGVAKGMVYCVSS---------------ALAAMHELG-LLHLDLKPSNILFAYEHGPSQ
...| ...||||.|.|    |   ...             ..  .| . . . .               ||  .|. .  .| |.||.||||        
EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------

QRLQRFSASGPATDAVKFYLSDFGNCRLVGPD--------PMDEVQDSY-----------------------GTFEYMDLRALR---------DAVCGRP
                   ..|||... . .|         . . ..                         || .||    |.             .  
-----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYK

TDAFSLGATLYELLYGRRLY
 | .||| .|||.|.|.. .
CDIWSLGVILYEMLFGKPPF
Kinase LmjF10.0830.AA CAMK 1277-1414 17 7.4e-12 33.77 In-house 132-331 (425) Show / Hide 
Range on Protein: 1277-1414
Range on HMM: 132-331/425
Sequence Identity: 17% (37 aa)

VFLVM---ELCDGD------------VEG-------------ISRSDGVAKGMVYCVSSALAAMHELGLLHLDLKPSNILFAYEHGPSQQRLQRFSASGP
...||   |.|.|              ..                .   |. ..  . ||.. .|...  |.|||| |||. . .. |.  . . .    
MYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDP-V-E-HD---

ATD------A-VKFYLSDFGNCRLVGPDP----------------------MDEVQDSYGTFEYMD----LRALR-----------DAVCGRPTDAFSLG
  .      . .|  ..|||  . . |.                        .  ... || |||     |.  .              .|...|  |.|
--EIFDWNNNNIK--IIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG

ATLYELLYGR
  || .| |.
VILYIMLCGY
Kinase LmjF10.0830.AA Ciliate-E2-Unclassified 1272-1418 17 9.1e-11 33.6 In-house 91-271 (352) Show / Hide 
Range on Protein: 1272-1418
Range on HMM: 91-271/352
Sequence Identity: 17% (36 aa)

QSDATVFLVMELCDG----DVEGIS-------------------RSDGVAK-----GMVYCVSSALAAMHELG-LLHLDLKPSNILFAYEHGPSQQRLQR
|.. ....|||.|.|    .   ..                    ..  ||      . ... ..|  .|. .  .| |.||.||||  ...        
QDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--------

FSASGPATDAVKFY--LSDFGNCRLVGPD--------------PMDEVQDSYGTFEYMDLR-----ALRDAVCGRP----TDAFSLGATLYELLYGRRLY
           ..|  ..|||...  . .              . .. ..  || .||  .      |.    . .     | .|||  |||.|.|.. .
-----------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF

P
.
Y
Kinase LmjF10.0830.AA AGC 1304-1414 21 1.2e-08 16.96 In-house 161-302 (395) Show / Hide 
Range on Protein: 1304-1414
Range on HMM: 161-302/395
Sequence Identity: 21% (35 aa)

CVSSALAAMHE-LGLLHLD-LKPSNILFAYEHGPSQQRLQRFSASGPATDAVKFYLSDFGNCRLVGPDP-------------------------------
|. .||  .|. .|  | | ||| |||.  .                        |.||| |  .  |.                               
CIVLALEYLHSHMGIIHRDYLKPENILLDED--------------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNP

------------------MDEVQDSYG--TFEYMDLRALRDAVCGRPTDAFS--LGATLYELLYGR
                  .|  .   |  | |||    |    .|.. |  |  ||. .||.|.|.
NNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGY
Kinase LmjF10.0830.AA STE 1095-1361 11 1.8e-08 26.18 In-house 1-192 (359) Show / Hide 
Range on Protein: 1095-1361
Range on HMM: 1-192/359
Sequence Identity: 11% (37 aa)

FASAEFVGEGSFGLVWRCLTVD----------------GDLVAVKSCPVILRTK------------ANIEDSFSTIREIATMRFLNEMQVPYVLPLHSAF
.   |..|.|.|| | ... ..                |...|.|  ..   ..             |.|.  . ..|| .|. .| |  |..   . ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

FVHAQEALPPLAQEALEWRQRLRKRAEEAALEVEVRLLARGGNRRASHTGAEEDVEDAPLTLEQQVAVQMERLTAAEGPEEQATRARLQSVRLPRFLSIT
|.   .                                                                                              
FKEGHN----------------------------------------------------------------------------------------------

HDDLTQSDATVFLVMELCD-GDVEGISRS-------------------DGVAKGMVYCVSSA-LAAMHELGLLHLDLKPSNILFAYEHGPSQQRLQRFSA
    ...| .....||..| | .. | ..                     . . ... .  . |.  |...  | |.||.|||.                
----HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------------

SGPATDAVKFYLSDFG
           |.|||
---------VKLCDFG
Kinase LmjF10.0830.AA MLCK 1312-1329 55 6.6e-08 16.37 In-house 113-130 (257) Show / Hide 
Range on Protein: 1312-1329
Range on HMM: 113-130/257
Sequence Identity: 55% (10 aa)

MHELGLLHLDLKPSNILF
||. . .|||||| ||..
MHWQNIVHLDLKPENIMC
Kinase LmjF10.0830.AA CLK 1307-1330 45 4.5e-07 16.49 In-house 125-148 (350) Show / Hide 
Range on Protein: 1307-1330
Range on HMM: 125-148/350
Sequence Identity: 45% (11 aa)

SALAAMHELGLLHLDLKPSNILFA
.|.  .|...| |.|||| ||.|.
EAVKFLHDMKLTHTDLKPENICFV
Kinase LmjF10.0830.AA CDK 1274-1328 27 3e-06 16.02 In-house 90-140 (284) Show / Hide 
Range on Protein: 1274-1328
Range on HMM: 90-140/284
Sequence Identity: 27% (15 aa)

DATVFLVMELCDGDVEGISRSDGVAKGMVYCVSSALAAMHELGLLHLDLKPSNIL
. ....|.| .| |  .. .     | . .   ..|. .|. . .| ||||.|||
ENKLYMVFEYMDHDLKKYMD----IKCYMWQLLRGLHYCHSNWIMHRDLKPQNIL
Kinase LmjF10.0830.AA WEE 1305-1329 34 3e-06 17.01 In-house 120-145 (297) Show / Hide 
Range on Protein: 1305-1329
Range on HMM: 120-145/297
Sequence Identity: 34% (9 aa)

VSSALAAMHEL-GLLHLDLKPSNILF
.. .|. .|.  |..|.|.||.||..
ICQGLHHIHSNCGMVHMDIKPENIFI
Kinase LmjF10.0830.AA TyrKc 1095-1524 9 0.000147 -148.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 1095-1524
Range on HMM: 1-280/280
Sequence Identity: 9% (45 aa)

FASAEFVGEGSFGLVWRCLTVDGDLVAVKSCPVILRTKANIEDSFSTIREIAT-MRFLNEM--QVPYVLPLHSAFFVHAQE----ALPPLAQEALEW---
    .  ||| || |...       ||||..                ....   .| . .   . | .. |. .   .         . .  |  ..   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

RQRLRKRAEEAALEVEVRLLARGGNRRASHTGAEEDVEDAPLTLEQQVAVQMERLTAAEGPEEQATRARLQSVRLPRFLSITHDDLTQSDATVFLVMELC
...|||. ..                                                                                          
KDYLRKHRPK------------------------------------------------------------------------------------------

DGDVEGISRSDGVAKGMVYCVSSALAAMHELGLLHLDLKPSNILFAYEHGPSQQRLQRFSASGPATDAVKFYLSDFGNCRLVGPD-------PMDEVQ--
      .. .|     . . ...  .  |. .. | ||   |.| . .|                   ||   |||| .| .. |        .  ..  
------LCMKD--LLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------TVK--ISDFGLSRDIYDDDQQGESKDYYRKKEH

-DSY--GTFEYMDLRALRDAVCGRPTDAFSLGATLYELL-YGRRLYPK-----CVDPRCGG--EEDHSRECFVE----AASQPVVLPTVGPPTTAAMVTL
 ..        | . .... ..   .| .| | ...|.. ||   ||      . . .     .. . ...  .    .                     
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------

VTTIGLDAAAAGHARGPHANGGTGSTSGLICSGPALTPLQYLTLALLRKPWAERMTAEECRRYL
                               .  . . .  . .   .   ..| | .|.....
-------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF10.0830.AA CDK 1095-1123 28 0.002539 6.3 In-house 1-35 (284) Show / Hide 
Range on Protein: 1095-1123
Range on HMM: 1-35/284
Sequence Identity: 28% (10 aa)

FASAEFVGEGSFGLVWRCLTVD-G-----DLVAVK
.   | .|||..| | ..   . |     ..|| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK
Kinase LmjF10.0830.AA CAMK 1100-1123 27 0.003369 5.36 In-house 267-303 (425) Show / Hide 
Range on Protein: 1100-1123
Range on HMM: 267-303/425
Sequence Identity: 27% (10 aa)

FVGEGSFGLVWRCLTV-DG------------DLVAVK
  |.|||| | .|    ..              ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK
Kinase LmjF10.0830.AA MLCK 1095-1112 44 0.022259 1.51 In-house 86-103 (257) Show / Hide 
Range on Protein: 1095-1112
Range on HMM: 86-103/257
Sequence Identity: 44% (8 aa)

FASAEFVGEGSFGLVWRC
.   | .| | || | ||
YQIHEELGRGKFGIVHRC
Kinase LmjF10.0830.AA Pkinase 1095-1123 36 0.040873 8.56 Pfam 1-30 (293) Show / Hide 
Range on Protein: 1095-1123
Range on HMM: 1-30/293
Sequence Identity: 36% (11 aa)

FASAEFVGEGSFGLVWRCLTVDG-DLVAVK
.   . .|.|||| |..|  ..  ..||||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK
Kinase LmjF10.0830.AA WEE 1399-1410 75 0.184313 0.75 In-house 218-229 (297) Show / Hide 
Range on Protein: 1399-1410
Range on HMM: 218-229/297
Sequence Identity: 75% (9 aa)

DAFSLGATLYEL
| ||||.|.|||
DIFSLGITIYEL
Kinase LmjF10.0830.AA WEE 1095-1112 50 0.216804 0.51 In-house 150-167 (297) Show / Hide 
Range on Protein: 1095-1112
Range on HMM: 150-167/297
Sequence Identity: 50% (9 aa)

FASAEFVGEGSFGLVWRC
|   . .|||||| |  |
FQEVQKIGEGSFGEVYKC
Kinase LmjF10.0830.AA Ciliate-E2-Unclassified 1095-1112 33 0.228419 0.53 In-house 1-18 (352) Show / Hide 
Range on Protein: 1095-1112
Range on HMM: 1-18/352
Sequence Identity: 33% (6 aa)

FASAEFVGEGSFGLVWRC
.   .  |.|.|| |..|
YKIIKQIGQGGFGKVYKC