Gene LmjF36.2630 (L.major)

LmjF36.2630

Species: L.major
Alias: LmjF36.2630, LmajK145
External Links:
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
LmjF36.2630.AA Protein None 3459 None Fasta, JSON
LmjF36.2630.kin_dom Protein Kinase Domain None 540 None Fasta, JSON

Protein domain

Protein domains of LmjF36.2630.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc LmjF36.2630.AA S_TKc 2909-3449 11 5.3e-13 13.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 2909-3449
Range on HMM: 1-231/231
Sequence Identity: 11% (63 aa)

QQNERRIGAGGYGTVTSGFVQKPGTGGDTRLPPGWGQRGSRWRPATTRGSTAASGSGAGGGGTTPQSFHMGRSVAPTAERIAPGVLDGLRVPWRTAVQRI
 .  | || |..|.|  .   |                                                                              
YEILRKIGKGAFGKVYKCRHKK------------------------------------------------------------------------------

AQAVCKCEVAIKHIPLNVQGSESGNLPLCHAEVLSMYRLRGHQHIIPLLSFDNTKDEYILVLPHYTQ--GSLRLWRQKHYS-LGCAVLTLPPGIRDSCKS
     . .|||| |.                |.  . .  .| .|. |. .  . |.. .|. .  .  |.|.   .|. .  .. ...           
----TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP-----------

GPMPTAAPVMTSSTPTPAAAPSTSLFATCARCLLQVLKGVAFMHDHHIRHGDIKCDNVLITATDASAERGEMDPPMLPSSVCLCDFGSCDTCDDDDIQSL
                           .... . |........|.|.| | |.| .|.|..                   . .||||..           
-------------------------E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------HIKICDFGLARQL--------

KHDIMAGEARFLAGRWGVGRGTEAIQPPELMSAKRRYALFRRIVTALAPAAAATPATSSLFTLSERAERGSRASSFAGASAEDLPLRSRGGELIESTGPQ
                    ||    .||..                                                                     
----------------TTFCGTPWYMAPEVL---------------------------------------------------------------------

IMELLRRAEL-SVDIWACGCLLYEMLTGRMLFGEARLGRLLVLAAVDDGEDQDPETAASKTSAAAGPLPGESRSLQKATVPTTPSVGADAGSIFTPSVSQ
           ..|.|.|||.|||||.|. .|    . ... .                                                         
------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------------------------------------------

KALDDRERRDLEAAVGKRVVDFMSTLLDLDPLQRPSAHEALQ--------YWK
                . . ||.. .|. || .||.| ||||         | 
---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF36.2630.AA Pkinase 3039-3194 17 7.2e-12 43.04 Pfam 49-159 (293) Show / Hide 
Range on Protein: 3039-3194
Range on HMM: 49-159/293
Sequence Identity: 17% (30 aa)

AEVLSMYRLRGHQHIIPLLSFDNTKDEYILVLPHYTQG----SLR----LWRQKHYSLGCAVLTLPPGIRDSCKSGPMPTAAPVMTSSTPTPAAAPSTSL
.|.  | || .| .|. |. .  .||.. .|...   |    .|                                                    ....
SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--------------------------------------------WRHGCF

---FATCARCLLQVLKGVAFMHDHHIRHGDIKCDNVLIT-ATDASAERGEMDPPMLPSSVCLCDFGSC
     .| ....|.|.|....|.. | | |.| .|.||    . .|            .|..||||..
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------CVKICDFGLA
Kinase LmjF36.2630.AA Pkinase 3316-3448 17 1e-11 42.5 Pfam 192-293 (293) Show / Hide 
Range on Protein: 3316-3448
Range on HMM: 192-293/293
Sequence Identity: 17% (25 aa)

SVDIWACGCLLYEMLTGRMLFGEA----RLGRLLVLAAVDDGEDQDPETAASKTSAAAGPLPGESRSLQKATVPTTPSVGADAGSIFTPSVSQKALDDRE
.||.|.|||.|||||.|| .| ..    ..  . ... . ...   ..   .  |      . . .                                . 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------------------------F-

RRDLEAAVGKRVVDFMSTLLDLDPLQRPSAHEALQY--W
.. .  .. .   ||.. .|..|| .||.|...||   .
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF36.2630.AA STE 3135-3194 36 1.5e-11 37.14 In-house 154-194 (359) Show / Hide 
Range on Protein: 3135-3194
Range on HMM: 154-194/359
Sequence Identity: 36% (22 aa)

ARCLLQVLKG-VAFMHDHHIRHGDIKCDNVLITATDASAERGEMDPPMLPSSVCLCDFGSC
|. . |.|||  .. |.||| | |||..|.|.                    | ||||| |
AYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------------VKLCDFGVC
Kinase LmjF36.2630.AA Ciliate-E2 3140-3202 20 8.9e-11 33.2 In-house 153-211 (365) Show / Hide 
Range on Protein: 3140-3202
Range on HMM: 153-211/365
Sequence Identity: 20% (16 aa)

QVLK---------------GVAFMHDHH-IRHGDIKCDNVLITATDASAERGEMDPPMLPSSVCLCDFGSCDTCDDDDI
|.|.               .. ..|  . | | ||| .|.|.                    ....||| .  .||| .
QILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------------------IKIIDFGLSKKYDDDNQ
Kinase LmjF36.2630.AA CMGC 3140-3194 25 1.7e-09 26.41 In-house 188-251 (513) Show / Hide 
Range on Protein: 3140-3194
Range on HMM: 188-251/513
Sequence Identity: 25% (18 aa)

QVLKGVA--FMHDHH--IRHGDIKCDNVLITATDASAERGEMDPPMLPSS-------------VCLCDFGSC
|.|.|..  ..| |   | | |.|  |.||. .  . .|  |       .             . .||||..
QILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-M-------WKSEDWNPCQKNGRLKICDFGLA
Kinase LmjF36.2630.AA AGC 3316-3333 55 1.3e-08 16.89 In-house 283-302 (395) Show / Hide 
Range on Protein: 3316-3333
Range on HMM: 283-302/395
Sequence Identity: 55% (11 aa)

SVDIWA--CGCLLYEMLTGR
..|.|.   |||.||||||.
ACDWWSFGLGCLMYEMLTGY
Kinase LmjF36.2630.AA CAMK 3134-3192 20 2.1e-08 22.46 In-house 181-241 (425) Show / Hide 
Range on Protein: 3134-3192
Range on HMM: 181-241/425
Sequence Identity: 20% (15 aa)

CARCLLQVLKGVAFMHDHHIRHGDIKCDNVLITAT-------------DASAERGEMDPPMLPSSVCLCDFG
..|.  |.. .|...|.|.| | |.|..|.|..               |           .    . ..|||
ARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD-----------WNNNNIKIIDFG
Kinase LmjF36.2630.AA Ciliate-E2 3316-3446 10 2.5e-08 24.69 In-house 276-361 (365) Show / Hide 
Range on Protein: 3316-3446
Range on HMM: 276-361/365
Sequence Identity: 10% (17 aa)

SVDIWACGCLLYEMLTGRMLFGEARLGRLLVLAAVDDGEDQDPETAASKTSAAAGPLPGESRSLQKATVPTTPSVGADAGSIFTPSVSQKALDDRERRDL
..|||..|..|||||.|.  |                                                                      ..  .  ..
KCDIWSLGVILYEMLFGKPPF----------------------------------------------------------------------QQQIKQCKI

EAA--------------------VGKRVVDFMST----LLDLDPLQRPS-AHEALQ
.                      . . . |...     .|. || .|.. . ..|.
DFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase LmjF36.2630.AA CMGC 3316-3336 34 1.3e-07 20.06 In-house 315-343 (513) Show / Hide 
Range on Protein: 3316-3336
Range on HMM: 315-343/513
Sequence Identity: 34% (10 aa)

SVDIWACGCLLYEMLTG--------RMLF
..|.|..|| ..||.||        . ||
PIDMWSVGCIFAEMYTGYQSLIFRGKPLF
Kinase LmjF36.2630.AA CDK 3138-3166 37 1.9e-07 19.71 In-house 114-142 (284) Show / Hide 
Range on Protein: 3138-3166
Range on HMM: 114-142/284
Sequence Identity: 37% (11 aa)

LLQVLKGVAFMHDHHIRHGDIKCDNVLIT
..| |.|....|...| | |.|. | ||.
MWQLLRGLHYCHSNWIMHRDLKPQNILIN
Kinase LmjF36.2630.AA CDK 3316-3336 37 3.7e-07 18.78 In-house 202-225 (284) Show / Hide 
Range on Protein: 3316-3336
Range on HMM: 202-225/284
Sequence Identity: 37% (9 aa)

SVDIWACGCLLYEMLT---GRMLF
..|.|..|| ..||.|   .. ||
PIDMWSVGCIFAEMFTDVTRKPLF
Kinase LmjF36.2630.AA TyrKc 2909-3448 8 1e-06 -115.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 2909-3448
Range on HMM: 1-280/280
Sequence Identity: 8% (52 aa)

QQNERRIGAGGYGTVTSGFVQKPGTGGDTRLPPGWGQRGSRWRPATTRGSTAASGSGAGGGGTTPQSFHMGRSVAPTAERIAPGVLDGLRVPWRTAVQRI
 . .. .| | .|.|  |                                                                                  
ITLGKKLGEGAFGEVYKGTWK-------------------------------------------------------------------------------

AQAVCKCEVAIKHIPLNVQGSESGNLPLCHAEVLSMYRL-RGHQHIIPLLSFDNTK-------DEYILVLPHYTQGSLRLWRQKHYSLGCAVLTLPPGIR
       .||.| .  .        .   . |   | .|   |..|. |.    ..       . . .|. .   |.|.   .||               
------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK------------

DSCKSGPMPTAAPVMTSSTPTPAAAPSTSLFATCARCLLQVLKGVAFMHDHHIRHGDIKCDNVLITATDASAERGEMDPPMLPSSVCLCDFGSCDTCDDD
                               ..     .|. .| .. |.... | |. . |.|...                  |  .||| .   .||
----------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------TVKISDFGLSRDIYDD

-------DIQSLK---HDI-------MAGEARFLAGRWGVGRG-------------------TEAIQPPEL-----MSAKRRYALFRRIVTALAPAAAAT
       |  . |   .         || |.           |                   |   ||..      ||... ... ..      |. .  
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-

PATSSLFTLSERAERGSRASSFAGASAEDLPLRSRGGELIESTGPQIMELLRRAELSVDIWACGCLLYEMLTGRMLFGEARLGRLLVLAAVDDGEDQDPE
|  |                                                                                                
P-MS------------------------------------------------------------------------------------------------

TAASKTSAAAGPLPGESRSLQKATVPTTPSVGADAGSIFTPSVSQKALDDRERRDLEAAVGKRVVDFMSTLLDLDPLQRPSAHEALQYW
                                                             . . . |..  . || .||.  |  ...
-------------------------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF36.2630.AA MARK 3140-3165 42 1e-06 17.83 In-house 112-137 (262) Show / Hide 
Range on Protein: 3140-3165
Range on HMM: 112-137/262
Sequence Identity: 42% (11 aa)

QVLKGVAFMHDHHIRHGDIKCDNVLI
|.. .| ..|...| | |||..|.||
QIVSAVNYCHSKNIVHRDIKPENILI
Kinase LmjF36.2630.AA CAMK 3308-3334 25 1e-06 16.63 In-house 290-332 (425) Show / Hide 
Range on Protein: 3308-3334
Range on HMM: 290-332/425
Sequence Identity: 25% (11 aa)

ELLRR----------------AELSVDIWACGCLLYEMLTGRM
|.|..                   ..|.|.||..|| ||.|..
EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP
Kinase LmjF36.2630.AA CDK5 3138-3165 53 2e-06 16.15 In-house 104-131 (287) Show / Hide 
Range on Protein: 3138-3165
Range on HMM: 104-131/287
Sequence Identity: 53% (15 aa)

LLQVLKGVAFMHDHHIRHGDIKCDNVLI
..| |||.|| |.||. | | |  | ||
MYQLLKGLAFCHEHHVLHRDLKPQNLLI
Kinase LmjF36.2630.AA NEK8 3427-3450 33 2e-06 14.53 In-house 255-278 (278) Show / Hide 
Range on Protein: 3427-3450
Range on HMM: 255-278/278
Sequence Identity: 33% (8 aa)

MSTLLDLDPLQRPSAHEALQYWKT
.. .|..|| ||||| ... ..  
VHNCLQQDPEQRPSASQIMAMPLC
Kinase LmjF36.2630.AA MARK 3317-3336 50 4e-06 16.25 In-house 187-206 (262) Show / Hide 
Range on Protein: 3317-3336
Range on HMM: 187-206/262
Sequence Identity: 50% (10 aa)

VDIWACGCLLYEMLTGRMLF
||||..| .|| |..|.  |
VDIWSLGVVLYFMVCGYFPF
Kinase LmjF36.2630.AA CDK5 3316-3336 54 7e-06 14.08 In-house 179-200 (287) Show / Hide 
Range on Protein: 3316-3336
Range on HMM: 179-200/287
Sequence Identity: 54% (12 aa)

SVDIWACGCLLYEML-TGRMLF
|.|.| ||| . ||  .|| ||
SIDMWSCGCIFAEMANAGRPLF
Kinase LmjF36.2630.AA CDKL 3316-3336 52 8e-06 15.94 In-house 180-200 (286) Show / Hide 
Range on Protein: 3316-3336
Range on HMM: 180-200/286
Sequence Identity: 52% (11 aa)

SVDIWACGCLLYEMLTGRMLF
.||||| ||.. ||..|  |.
PVDIWAIGCVMAEMIDGQPLW
Kinase LmjF36.2630.AA AGC 3140-3194 21 1.4e-05 8.82 In-house 161-202 (395) Show / Hide 
Range on Protein: 3140-3194
Range on HMM: 161-202/395
Sequence Identity: 21% (12 aa)

QVLKGVAFMHD-HHIRHGD-IKCDNVLITATDASAERGEMDPPMLPSSVCLCDFGSC
... .. ..|. ..| | | .| .|.|...                  ..|.|||.|
CIVLALEYLHSHMGIIHRDYLKPENILLDED---------------GHIKLTDFGLC
Kinase LmjF36.2630.AA CDKL 3140-3169 45 3.7e-05 13.59 In-house 106-136 (286) Show / Hide 
Range on Protein: 3140-3169
Range on HMM: 106-136/286
Sequence Identity: 45% (14 aa)

QVLKGVAFMHDHHIRHGDIKCDNVLIT-ATD
|.||...| | | . | |||  | ||| . .
QILKAINFCHKHNCIHRDIKPENILITPKNG
Kinase LmjF36.2630.AA NEK8 3318-3331 64 5.3e-05 10.08 In-house 204-217 (278) Show / Hide 
Range on Protein: 3318-3331
Range on HMM: 204-217/278
Sequence Identity: 64% (9 aa)

DIWACGCLLYEMLT
|.|| || ||||..
DMWALGCVLYEMCC
Kinase LmjF36.2630.AA NEK8 3138-3166 37 0.00026 8.08 In-house 125-153 (278) Show / Hide 
Range on Protein: 3138-3166
Range on HMM: 125-153/278
Sequence Identity: 37% (11 aa)

LLQVLKGVAFMHDHHIRHGDIKCDNVLIT
. |.. .|..||.| | | |.|  |.. |
FFQMCSAVHHMHQHNILHRDLKTQNIFMT
Kinase LmjF36.2630.AA CAMK 2914-3080 9 0.000446 8.24 In-house 1-151 (425) Show / Hide 
Range on Protein: 2914-3080
Range on HMM: 1-151/425
Sequence Identity: 9% (22 aa)

RIGAGGYGTVTSGFVQKPGTGGDTRLPPGWGQRGSRWRPATTRGSTAASGSGAGGGGTTPQSFHMGRSVAPTAERIAPGVLDGLRVPWRTAVQRIAQ---
 .| |..|.|                                                                                ....  .   
TLGRGSFGKVK------------------------------------------------------------------------------LCIHKNTTGKE

------AVCKCEVAIKHIPLN---------------VQGSESG---------NLPLCHAEVLSMYRLRG------HQHIIPLLS---------------F
         . .|||| |. .               .. |. .         ..     |.  | .|.|      | .|| |.                .
RVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET

DNT-----KDEYILVL---PHYTQGSL--RL
 ..     ......|.    . . | |  .|
-SKQVFTKDKHMYMVMEIMEYCSGGELFDDL
Kinase LmjF36.2630.AA STE 3316-3333 50 0.000819 9.49 In-house 248-265 (359) Show / Hide 
Range on Protein: 3316-3333
Range on HMM: 248-265/359
Sequence Identity: 50% (9 aa)

SVDIWACGCLLYEMLTGR
..|||  ||.. ||.||.
KCDIWSLGCTIIEMATGK
Kinase LmjF36.2630.AA CDKL 3421-3446 30 0.000824 8.91 In-house 257-282 (286) Show / Hide 
Range on Protein: 3421-3446
Range on HMM: 257-282/286
Sequence Identity: 30% (8 aa)

KRVVDFMSTLLDLDPLQRPSAHEALQ
| . |||  .|..|| .|... ....
KKALDFMKKCLHMDPDERMTCEQLMH
Kinase LmjF36.2630.AA CMGC 3424-3446 39 0.001024 7.06 In-house 487-509 (513) Show / Hide 
Range on Protein: 3424-3446
Range on HMM: 487-509/513
Sequence Identity: 39% (9 aa)

VDFMSTLLDLDPLQRPSAHEALQ
.|... .| .|| .|..| .|||
IDLLKKMLQYDPDKRITAEQALQ
Kinase LmjF36.2630.AA CDK 3425-3446 45 0.001165 7.4 In-house 259-280 (284) Show / Hide 
Range on Protein: 3425-3446
Range on HMM: 259-280/284
Sequence Identity: 45% (10 aa)

DFMSTLLDLDPLQRPSAHEALQ
|... .| .|| .| || .|||
DLLNKMLCYDPKKRISAEQALQ
Kinase LmjF36.2630.AA CDK5 3425-3448 38 0.004321 5.07 In-house 262-287 (287) Show / Hide 
Range on Protein: 3425-3448
Range on HMM: 262-287/287
Sequence Identity: 38% (10 aa)

DFMSTLLDLDPLQRPSAHEALQ--YW
|... .| ..| || || .||.  | 
DLLQKMLQCNPNQRISAKAALHHPYF
Kinase LmjF36.2630.AA CAMK 3419-3446 25 0.013711 3.36 In-house 394-421 (425) Show / Hide 
Range on Protein: 3419-3446
Range on HMM: 394-421/425
Sequence Identity: 25% (7 aa)

VGKRVVDFMSTLLDLDPLQRPSAHEALQ
| . . |. . .|  || .|......|.
VSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase LmjF36.2630.AA STE 3425-3446 40 0.01436 5.04 In-house 332-353 (359) Show / Hide 
Range on Protein: 3425-3446
Range on HMM: 332-353/359
Sequence Identity: 40% (9 aa)

DFMSTLLDLDPLQRPSAHEALQ
||..  |. || .||.|.. |.
DFINKCLQKDPNKRPTASQLLK
Kinase LmjF36.2630.AA STE 2909-2934 23 0.067297 2.64 In-house 1-39 (359) Show / Hide 
Range on Protein: 2909-2934
Range on HMM: 1-39/359
Sequence Identity: 23% (9 aa)

QQNERRIGAGGYGTVTSGFVQKPG-------------TG
... ..|| |..|||  .   |..             ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETG
Kinase LmjF36.2630.AA Pkinase 2909-2923 40 1.981554 2.6 Pfam 1-15 (293) Show / Hide 
Range on Protein: 2909-2923
Range on HMM: 1-15/293
Sequence Identity: 40% (6 aa)

QQNERRIGAGGYGTV
 . .|.||.|..|.|
YHIGRKIGSGSFGCV