Gene LmjF29.2720 (L.major)

LmjF29.2720

Species: L.major
Alias: LmjF29.2720, LmajK154
External Links:
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF29.2720.AA Protein None 323 None Fasta, JSON
LmjF29.2720.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of LmjF29.2720.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc LmjF29.2720.AA S_TKc 36-288 22 2e-25 91.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-288
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

MSEVCDMSEGSFGVVKCYRHDSDKLEYAVKQTKRPICGESNLQQQLQEIYALSSFPHRHIVRYFDGWVEDRAVFVRLEKLDD---CVASLPPP-------
   .    .|.||.|.. || ... ..|.|. |         .. ..||  |..  | .||...| ...   ... .| .|     . ..          
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VSESVLTAMLHQTSTALYELHSHGVLHMDVKPENILTRQLDADTFIFKLCDFGLARPLNGRDSVTGEHFLGLNDDDGDRRYMSPELLKNLQDVVGP-P
   .| .   ...|.  ||  .||||..| |.||||||  .        |.||||||| |              .   | . ||.||.|       |. .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-----GYGKCK

ADMYALGKTCEAMMT-----ATEDPSNTSARHLESYSPAFTALIESMLREDPARRPSAFQVVQATLP---ERLL
.|....| .   |..           ..  ...   || .  .|. .|. ||..||.| .. |. .       .
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF29.2720.AA Pkinase 44-229 27 4.1e-25 89.89 Pfam 9-199 (293) Show / Hide 
Range on Protein: 44-229
Range on HMM: 9-199/293
Sequence Identity: 27% (55 aa)

EGSFGVVKCYRHDSDKLEYAVKQTKRPICGESNLQQQLQ--EIYALSSFPHRHIVRYFDGWVEDRAVFVRLEKLDDC--VASLP--------PPV--SES
.||||.|.  .| ..  ..|||. |..   .. .|. .   ||. . .. | .|||..| . ... . . .| ..    |..|          ..  || 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

VLTAMLHQTSTALYELHSHGVLHMDVKPENILTRQLDADTFI---FKLCDFGLARPLNGRDSVTGEHFLGLNDDDGDRRYMSPELLKNLQDVVGPPADMY
..  .. |.  .|. .||.|..| |.||||||   .| .  |   .|.||||||. ..        .   ...  | ..||.||...  .   ||..||.
ECKFYMYQILRGLEYCHSMGIIHRDLKPENIL---IDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMW

ALG
..|
SCG
Kinase LmjF29.2720.AA CAMK 41-229 15 3.2e-20 61.21 In-house 1-321 (425) Show / Hide 
Range on Protein: 41-229
Range on HMM: 1-321/425
Sequence Identity: 15% (49 aa)

DMSEGSFGVVKCYRHDSDK------------LEYAVKQ-------------------TKRPICG-------ESNLQQQLQEIYALSS-------FPHRHI
   .||||.||  .| ...             ..|.|                     .   |.       ...... ..||  ...         |..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYFD-------------------GWVE-DRAVFVRL---EKLDDC------------------------VASLPPPVSESVLTAMLHQTSTALYELHSH
.. ..                    . . |. ..  .   |  .                          ..     ..|.    . .|   |.  .|||
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GVLHMDVKPENILTRQLDADT-------------FIFKLCDFGLARPLNGRDSVT-------GEHFLG-----------LNDDDGDRRYMS-PELLKNL-
.. | | ||||||  . . |.             .  |..|||.|. ... .. .       || .             ...  |   ||. ||.|.   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

-----------QDVVGPPADMYALG
           .. .||..|| ..|
HCNMQNATDEEKPYYGPKCDMWSCG
Kinase LmjF29.2720.AA WEE 37-109 39 3.2e-18 57.78 In-house 2-81 (297) Show / Hide 
Range on Protein: 37-109
Range on HMM: 2-81/297
Sequence Identity: 39% (32 aa)

SEVCDMSEGSFG-VVKCYRHDSDKLEYAVKQTKRPICGESNLQQQLQEIYALSSFP-------HRHIVRYFDGWVEDRAVF
 ||.   ||||| |.|| |. .|.  ||.|..|.|. |.|. ...|.|.||.....       | |||||.  | ||.  .
QEVQKIGEGSFGEVYKC-RCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMY
Kinase LmjF29.2720.AA STE 125-277 21 7.2e-17 56.2 In-house 147-350 (359) Show / Hide 
Range on Protein: 125-277
Range on HMM: 147-350/359
Sequence Identity: 21% (48 aa)

PVSESVLTAMLHQTSTA-LYELHSHGVLHMDVKPENILTRQLDADTFIFKLCDFGLARPLNG--------------------RDSVTGEHFLGLNDDDGD
...||.. ....|.  . || ||||.. | |.|| |||           ||||||..  |.                     |....|            
RFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----------

RRYMSPELLKNLQ----DVVGPPADMYALGKTC-------------EAM----MTATE--------------DPSNTSARHLE----------------S
  .|.|| ... .    .  .  .|.. || |.               |    |....              .|. .   ||.                .
--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHK

YSPAFTALIESMLREDPARRPSAFQ
.|| |   |.  |. ||  ||.| |
WSPEFKDFINKCLQKDPNKRPTASQ
Kinase LmjF29.2720.AA WEE 145-244 26 3.3e-14 44.14 In-house 127-238 (297) Show / Hide 
Range on Protein: 145-244
Range on HMM: 127-238/297
Sequence Identity: 26% (31 aa)

LHSH-GVLHMDVKPENILTRQLD-ADTF---------------IFKLCDFGLARPLNGRDSVTGEHFLGLNDDDGDRRYMSPELLK-NLQDVVGPPADMY
.||. | .|||.|||||.    . ..                 ..|. |||..  .|       .     ..  ||.|||.||.|  . ...  . || .
IHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNS------NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIF

ALGKTCEAMMTATEDPSN
.|| |   .... . |.|
SLGITIYELACNMDLPKN
Kinase LmjF29.2720.AA CMGC 123-184 24 8.6e-14 40.79 In-house 157-255 (513) Show / Hide 
Range on Protein: 123-184
Range on HMM: 157-255/513
Sequence Identity: 24% (25 aa)

PPPVSESV------------LTAML------HQTSTALY--ELHSHG--VLHMDVKPENILTRQ-----------------LDADTFIFKLCDFGLARPL
| | || .               ..      .|  ..|    .|||.  ..| | ||||||  .                 . .. .. |.||||||| .
PMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-QKNGRLKICDFGLARWY

N
.
H
Kinase LmjF29.2720.AA Trio 145-185 41 2.2e-13 30.01 In-house 111-151 (258) Show / Hide 
Range on Protein: 145-185
Range on HMM: 111-151/258
Sequence Identity: 41% (17 aa)

LHSHGVLHMDVKPENILTRQLDADTFIFKLCDFGLARPLNG
||....|| |.||||..  .  |     |.|||| | .|..
LHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWP
Kinase LmjF29.2720.AA DCAMKL 133-180 41 2.4e-13 37.34 In-house 119-166 (279) Show / Hide 
Range on Protein: 133-180
Range on HMM: 119-166/279
Sequence Identity: 41% (20 aa)

AMLHQTSTALYELHSHGVLHMDVKPENILTRQLDADTFIFKLCDFGLA
.|...   ||. ||. .. | |.|||| |  . .  ..  ||||||||
IMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLA
Kinase LmjF29.2720.AA MLCK 145-190 34 4.8e-13 30.19 In-house 113-157 (257) Show / Hide 
Range on Protein: 145-190
Range on HMM: 113-157/257
Sequence Identity: 34% (16 aa)

LHSHGVLHMDVKPENILTRQLDADTFIFKLCDFGLARPLNGRDS-VT
.|.....|.|.|||||.      .    |. |||||| ...... |.
MHWQNIVHLDLKPENIMCQTRTSH--QIKIIDFGLARKYDPDEKKVK
Kinase LmjF29.2720.AA GSK 145-178 58 1.9e-12 33.71 In-house 132-162 (328) Show / Hide 
Range on Protein: 145-178
Range on HMM: 132-162/328
Sequence Identity: 58% (20 aa)

LHSHGVLHMDVKPENILTRQLDADTFIFKLCDFG
|||||. |.|.||.|||   .|.|| . |.||||
LHSHGICHRDIKPQNIL---VDPDTGVLKICDFG
Kinase LmjF29.2720.AA ULK 141-184 32 2.1e-10 32.61 In-house 142-193 (329) Show / Hide 
Range on Protein: 141-184
Range on HMM: 142-193/329
Sequence Identity: 32% (17 aa)

ALYELHSHGVLHMDVKPENILTRQLDADT--------FIFKLCDFGLARPLN
.. |||.|.. | | ||.|||    .. |         ..|..|||.|. ..
GFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD
Kinase LmjF29.2720.AA ULK 144-184 34 6.7e-09 27.79 In-house 141-189 (324) Show / Hide 
Range on Protein: 144-184
Range on HMM: 141-189/324
Sequence Identity: 34% (17 aa)

ELHSHGVLHMDVKPENILTRQLDADT--------FIFKLCDFGLARPLN
|||.|.. | | ||.|||    .. |         ..|..|||.|. ..
ELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD
Kinase LmjF29.2720.AA TyrKc 36-282 16 1.5e-08 -84.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-282
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

MSEVCDMSEGSFGVVKCYRHDSDKLEYAVKQTKRPICGESNLQQQLQEIYALSSF--PHRHIVRYFDGWVED--------RAVFVRLE-----KLDDCVA
 .      || ||.|   . .   .. |||  |        ..  ..|.  ....   | .||| . | . .          ... .|      |.|   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SLPPPVSESVLTAMLHQTSTALYELHSHGVLHMDVKPENILTRQLDADTFIFKLCDFGLARPLNGR-------DSVT-----GEHF-LGLNDDDGDRRYM
.  | .. . |  . .| .     |||... | |    |.|   ....  . | .||||.| .          |  .     |... | .       | |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL---VGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-------RWM

SPELLKNL-----------------------QDVVG------PPADMYALGKTCEAMMTATEDPSNTSARHLESY-----SPAFTALIESMLREDPARRP
.|| ..                         |   |      ........ |. . |.   .|         .       ...   ....  .|||. ||
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--------P-MSFVCCPDEMYQIMKQCWHEDPEDRP

SAFQVVQAT
.  ....  
TFSEIHECF
Kinase LmjF29.2720.AA STE 36-100 19 2.4e-08 25.72 In-house 1-97 (359) Show / Hide 
Range on Protein: 36-100
Range on HMM: 1-97/359
Sequence Identity: 19% (19 aa)

MSEVCDMSEGSFG-VVKCYRHDSDKLE--------------YAVKQTKRPICG---------------ESNLQQQLQEIYALSSFP--HRHIVRYFD
   .    .|.|| |.|...|. . ..              .|.|| .   |                ....|| |.||  .. .   | .||.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG
Kinase LmjF29.2720.AA ULK 44-100 22 8.2e-05 13.08 In-house 9-82 (324) Show / Hide 
Range on Protein: 44-100
Range on HMM: 9-82/324
Sequence Identity: 22% (17 aa)

EGSFG-VVKCYR-HDSD--KLEYAVKQTKRP-ICGESNL-------QQQLQEIYALSSFP------HRHIVRYFD
.|||| .|   | ....  .  .|.|.  .  .   .|.       |.. .||  .  .       | |||...|
KGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYD
Kinase LmjF29.2720.AA WEE 250-284 28 0.000123 11.56 In-house 263-297 (297) Show / Hide 
Range on Protein: 250-284
Range on HMM: 263-297/297
Sequence Identity: 28% (10 aa)

LESYSPAFTALIESMLREDPARRPSAFQVVQATLP
....|  .. || .|. .|| .||.. | .|  . 
DNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase LmjF29.2720.AA ULK 44-100 22 0.001542 8.32 In-house 9-85 (329) Show / Hide 
Range on Protein: 44-100
Range on HMM: 9-85/329
Sequence Identity: 22% (17 aa)

EGSFGVVKCYR-HDSD---KLEYAVKQ-TKRPICGESNLQQ-------QLQEIYALSSFP--------HRHIVRYFD
.||||.|   | ....   .  .|.|.  |  .  ..|.|.         .||  .            | .||...|
KGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD
Kinase LmjF29.2720.AA Pkinase 254-281 35 0.00221 13.04 Pfam 263-290 (293) Show / Hide 
Range on Protein: 254-281
Range on HMM: 263-290/293
Sequence Identity: 35% (10 aa)

SPAFTALIESMLREDPARRPSAFQVVQA
|...  .|...|. ||..||.| |..| 
SEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase LmjF29.2720.AA CAMK 249-280 31 0.010576 3.73 In-house 391-421 (425) Show / Hide 
Range on Protein: 249-280
Range on HMM: 391-421/425
Sequence Identity: 31% (10 aa)

HLESYSPAFTALIESMLREDPARRPSAFQVVQ
|    |.    || .||. || .|... |. .
HH-FVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase LmjF29.2720.AA DCAMKL 260-280 47 0.014741 3.16 In-house 255-275 (279) Show / Hide 
Range on Protein: 260-280
Range on HMM: 255-275/279
Sequence Identity: 47% (10 aa)

LIESMLREDPARRPSAFQVVQ
||  ||  || .|..| |. |
LISHMLQVDPEKRYTAEQIMQ
Kinase LmjF29.2720.AA Trio 261-275 53 0.036695 0.62 In-house 235-249 (258) Show / Hide 
Range on Protein: 261-275
Range on HMM: 235-249/258
Sequence Identity: 53% (8 aa)

IESMLREDPARRPSA
| . | |||..||.|
ICKVLQEDPWKRPCA