Gene LmjF36.2940 (L.major)

LmjF36.2940

Species: L.major
Alias: LmjF36.2940, LmajK166
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: DNAPK

Sequence

Name Sequence Type Origin Length Description Download
LmjF36.2940.AA Protein None 4183 None Fasta, JSON
LmjF36.2940.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of LmjF36.2940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF36.2940.AA PIKK 3798-3897 38 6.7e-26 91.46 In-house 1-101 (290) Show / Hide 
Range on Protein: 3798-3897
Range on HMM: 1-101/290
Sequence Identity: 38% (39 aa)

TLVGVADRVLVLKSKRFAKKVDIYTSAG-ICTYIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELMK
   . ...| |...|. .||  |  . | .  | .||.||||.|||....| . | ||   |...  .|.||||.|||.|.  ||| ||. ...|.|. |
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

E
.
Q
Kinase LmjF36.2940.AA PI3_PI4_kinase 3826-4082 19 1.8e-24 92.16 Pfam 1-300 (300) Show / Hide 
Range on Protein: 3826-4082
Range on HMM: 1-300/300
Sequence Identity: 19% (60 aa)

ICTYIVKGGEDLR--LDQRIQEVF-----------------------TFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELMKEAT-
.. .|.|||.|||   |.|. . .                       .. | |.     .|   .....| .|| .|  |.| |||..|...|. ...  
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

----PPDAHDAVARFCRARGKPQEVLSLYKTAYITGIPEQEYKGLVLRLRQ-----SALVESLESIATDH-CSWFGVRDAFLDTNAAASMASFVLGVGDR
    ... ...  . ...  ... .              .. | .| ..|.      .| . . .  .|  . |. .|| |    |  ......||.|||
KCKHKHFNKEHKMWMKMWPDWWHLM--------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDR

HAGNLLV--DLLNCELVAIGFGLAFG-DATRKLPVLELMPFRHTP------QLQRVQGVL---GDSVTRCRMRRVLH-VLRAERHVVEEMVAAL------
|..|..|  |  . .|..| ||..|.  ..  ....|..||| |.      ... . | .   ..|   ...|.... ..|| |.  .  .. |      
HNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMR

--LMPDTDAIGDEA
  .| .. .. .  
GECMVHDGLPMWRS
Kinase LmjF36.2940.AA PIKK 3946-4070 27 1.4e-20 71.93 In-house 165-290 (290) Show / Hide 
Range on Protein: 3946-4070
Range on HMM: 165-290/290
Sequence Identity: 27% (35 aa)

QSALVESLESIATDHCSWFGVRDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVLELMPFRHTPQLQRVQGVLGDS-V
.. . . ... ..|  .|. .| ... . |  .|. ..|| ||||  |...| .. |.| | ||..|..|.. ||| |..||| |...    |. | . |
PDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGV

TRCRMRRVLHVLRAERHVVEEMVAAL
 |  .  |....|  |  . . . ..
FRRCCEHVMMCMRQHRETLMTVCEVF
Kinase LmjF36.2940.AA PI3Kc 3828-4129 16 3.4e-19 71.02 SMART 1-336 (336) Show / Hide 
Range on Protein: 3828-4129
Range on HMM: 1-336/336
Sequence Identity: 16% (62 aa)

TYIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELMK-------------------------------
  |.|.|.||| |.|....|   | ..     .|   |..|.|..||..|  |.| ||| ...| ...|                               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

---------------------------EATPPDAHDAVARFCRARGKPQEVLSLYKTAYITGIPEQEYKGLVLRLRQSALVESLESIATDHCSWFGVRDA
                           .|| |   .  . ... . .  .                                         ..|. .|| 
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-----------------------------------------EDWWEARDN

FLDTNAAASMASFVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVL-----ELMPFRHTPQLQRVQGV-LGDSVTRCRMR----RVLHVLRAE
|    |. .|....||.|||| .|...|  . ... | || .|| . .|.|.      |..||| |.... | |   ..|   ...|    |.. ..| .
FTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKH

RHVVEEMVAALLMPDT-DAIGDEASHIAGHQLDVVRRKLNLE-HPADIILRDVAR-----------NAYVTQDKDVWSGVKAC
....  ......     . .  .     .. ....| ...|. .  . ... ...           ..  |. ....  ..  
SNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase LmjF36.2940.AA ATR 3959-4070 23 1.8e-15 48.79 In-house 156-267 (267) Show / Hide 
Range on Protein: 3959-4070
Range on HMM: 156-267/267
Sequence Identity: 23% (27 aa)

DHCSWFGVRDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVLELMPFRHTPQLQRVQGVLG-DSVTRCRMRRVLHVLR
|  .|.  |.... . |. .|  ...| ||||. |.|.| .| |.| . . . |.   ... | |..||| |  ..   | .. . . |  .  .. ..|
DPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSG-EQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMR

AERHVVEEMVAAL
 .|  .  .. . 
DHRDDIMSVWDCF
Kinase LmjF36.2940.AA DNAPK 3982-4032 50 3e-15 51.81 In-house 202-252 (301) Show / Hide 
Range on Protein: 3982-4032
Range on HMM: 202-252/301
Sequence Identity: 50% (26 aa)

FVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVLELMPFRHTPQ
..||.||||  | .|   | . . | || .|| ||  ||| |||||| | .
WILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRC
Kinase LmjF36.2940.AA DNAPK 3797-3895 34 1.7e-13 45.33 In-house 2-101 (301) Show / Hide 
Range on Protein: 3797-3895
Range on HMM: 2-101/301
Sequence Identity: 34% (34 aa)

CTLVGVADRVLVLKSKRFAKKVDIYTSAGI-CTYIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELM
  . |  .|| |. | |  |.. |         ...||.||||.||||   |   |  .   |     .|  ||| .||     ||| || .|  | ...
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL
Kinase LmjF36.2940.AA ATR 3797-3897 29 1.4e-12 38.72 In-house 1-102 (267) Show / Hide 
Range on Protein: 3797-3897
Range on HMM: 1-102/267
Sequence Identity: 29% (30 aa)

CTLVGVADRVLVLKSKRFAKKVDIYTSAG-ICTYIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELM
  . |  | | .| | .  ||. .  | | .   . |  .||| | | ...    | |...  ..|.  . .|||||||.    ..| ||  |  |. ..
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

KE
..
DK
Kinase LmjF36.2940.AA FRAP 3828-3897 34 1.2e-11 39.19 In-house 3-72 (251) Show / Hide 
Range on Protein: 3828-3897
Range on HMM: 3-72/251
Sequence Identity: 34% (24 aa)

TYIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELMKE
 .. || ||.| | |.   |   |  |   | ..   | |. |..|| |   ||| ||.    |. |...
HFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRD
Kinase LmjF36.2940.AA ATM 3963-4030 41 2.9e-11 31.81 In-house 133-199 (304) Show / Hide 
Range on Protein: 3963-4030
Range on HMM: 133-199/304
Sequence Identity: 41% (28 aa)

WFGVRDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVLELMPFRHT
||  | |.    | .|.  ..||.||||  |.|.     ||| |  | || .  . ||  | .||| |
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLT
Kinase LmjF36.2940.AA ATM 3829-3893 38 8.6e-10 27.04 In-house 2-66 (304) Show / Hide 
Range on Protein: 3829-3893
Range on HMM: 2-66/304
Sequence Identity: 38% (25 aa)

YIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQE
 .||| .||| |  .| ||   |  |      |   ||| || |.|.|   | . |   | |  .
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDK
Kinase LmjF36.2940.AA FRAP 3963-4030 38 7.3e-08 25.11 In-house 133-200 (251) Show / Hide 
Range on Protein: 3963-4030
Range on HMM: 133-200/251
Sequence Identity: 38% (26 aa)

WFGVRDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVLELMPFRHT
||  |  .    |  ||| ..|| ||||  |.. . .   .| | ||  |  | |.    |. ||| |
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT
Kinase LmjF36.2940.AA SMG1 3806-3896 34 1.2e-07 21.24 In-house 1-92 (242) Show / Hide 
Range on Protein: 3806-3896
Range on HMM: 1-92/242
Sequence Identity: 34% (32 aa)

VLVLKSKRFAKKVDIYTSAGIC-TYIVKGGEDLRLDQRIQEVFTFANVCLLVSPRSRLSALTIRTYAVIPVSPLVGLICWVPRTTPLQELMK
. .|  |   ||.    | |    |. || ||| || ||       |       |        | |.| |.    ||| ||   |||  | |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK
Kinase LmjF36.2940.AA SMG1 3963-4023 34 9.1e-07 18.28 In-house 183-242 (242) Show / Hide 
Range on Protein: 3963-4023
Range on HMM: 183-242/242
Sequence Identity: 34% (21 aa)

WFGVRDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNCELVAIGFGLAFGDATRKLPVLE
|. |  ..    |  ||  ...|.||||  | |.|.   | | | .   | .  .|| | |
WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICF-EKGKKLNVPE
FATC LmjF36.2940.AA FATC 4159-4183 40 6.5e-07 25.17 Pfam 9-33 (33) Show / Hide 
Range on Protein: 4159-4183
Range on HMM: 9-33/33
Sequence Identity: 40% (10 aa)

VQRLLRVASDPRLLGRAYAGWQAYM
|.|| . |.||. | ..| ||....
VDRLIQEATDPENLCQMYIGWCPWW