Gene LmjF24.2010 (L.major)

LmjF24.2010

Species: L.major
Alias: LmjF24.2010, LmajK168
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI3K

Sequence

Name Sequence Type Origin Length Description Download
LmjF24.2010.AA Protein None 1089 None Fasta, JSON
LmjF24.2010.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of LmjF24.2010.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Ka LmjF24.2010.AA PI3Ka 336-561 22 1.2e-13 52.53 SMART 1-232 (232) Show / Hide 
Range on Protein: 336-561
Range on HMM: 1-232/232
Sequence Identity: 22% (61 aa)

DSSAPP--GPKERHQLASLLRRPPIQLDNVTGAVVTGAGAGGVGGVRLEETRLLWKYRHFICRDGKYFLP------FMRCVDWANTHSSERRAACALIHQ
|    |   ..|| ||  ....|| .                      || .|.||.||..... .  ||      |.|||.|  ....|   | .|.||
DYDLKPRWNEEERDQLEDIMKYPPTY------------------ELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNW--SWADEVKQAYQLMHQ

W--ARPAFEDVLACLSFYFDH--VAPVRQYAVRLLRREGDGRLCQLAFQLVQAVRYD---------------------------SAEAELANFLVERAVG
|  .    || |  |...| .  .  ||||||. |..  |  | .   |||||..|.                           ... .|. ||..||. 
WWWPPIDPEDALELLDPKFPDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALC

CWELCSTLHTLLSVEV----ALEKCRTSSAAGKASDDRHGGTTLFKPLLRRLSERLTQQC-PHFVKRLRQ
   . . .. .| .|.    .|. .                    .. . .| |.. ..|  | ...|..
NPRIGHFFYWYLKSEMYDHCQLHDPHY------------------CQRFGMLLEMYCRGCCGHHMRHLFK
PI3Ka LmjF24.2010.AA PI3Ka 381-494 31 1.5e-12 44.72 Pfam 28-156 (211) Show / Hide 
Range on Protein: 381-494
Range on HMM: 28-156/211
Sequence Identity: 31% (41 aa)

LEETRLLWKYRHFICRDGKYFLP-------FMR-CVDWANTHSSERRAACALIHQ--WARPAFEDVLACLSFYFDH-VAPVRQYAVRLLRR-EGDGRLCQ
.||  |.||.||..|   .  ||       |.. || |  ......  | .|     |.    .| |  |.. | .    ||||||. |..   |  | .
AEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKW--HDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLC

LAFQLVQAVRYD-----SAEAELANFLVERA
   |||||..|.     .    |. ||..||
YLLQLVQALKYENFDEPFHDSYLSRFLLWRA
Kinase LmjF24.2010.AA PI3Kc 836-1086 26 6.9e-87 295.88 SMART 1-336 (336) Show / Hide 
Range on Protein: 836-1086
Range on HMM: 1-336/336
Sequence Identity: 26% (89 aa)

AMMYKYNDDIRQDQLIVQLIRLMNDLLQQD----GMQLYLTPYRVIATGPNEGLVEIVPQVTTFFSVQR-------------------------------
|...| .|| |||... |..||||...|.|    .. |...||..|.|||. |..| || ..|. ..|.                               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

------------------------------------DVLKYLRVYNNTA-ELLRQAMDRYTRSFAGYCVITFVLGIGDRHLENILIT-QDGRLLHIDFGY
                                    . ..... .. .. |  ..|.|..||| ||||..|..|||||||..||... ..| ..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

VLGNDPKPFPP--------PMKINREMVEVLG--GPQSTGFTEFKLYCCSAYNTLRKHAPLLLHILLLGAHTEGMPQVTGEGGDPRVNLLKVQEKLRLD-
 .|..||....        |..  ..||.| |  | .|  | .|. .||.||. .|||. |..... . .... ||. ...       . ......||| 
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----EKDIKYLRQRFRLDH

LTNAQATQYLQN-----VIADSVGSIFTNLWDVLHAAAQA
|.  .|.|| ..     .| .|..| .| . ...|  ||.
LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
PI3_PI4_kinase LmjF24.2010.AA PI3_PI4_kinase 834-1032 25 7.5e-66 229.88 Pfam 1-300 (300) Show / Hide 
Range on Protein: 834-1032
Range on HMM: 1-300/300
Sequence Identity: 25% (76 aa)

PLAMMYKYNDDIR--QDQLIVQLI-----------------------RLMNDLLQQDGMQLY----LTPYRVIATGPNEGLVEIVPQVTTFFSVQRDV--
  ... |..|| |  ||....|.|                       ||||.....||. .     ..|||.|.|||. |..| ||..|||  ..|    
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

---------------------------------------------LKYLRVYNNTA-ELLRQAMDRYTRSFAGYCVITFVLGIGDRHLENILI---TQDG
                                             ..... .| .| | . .|.|...||.||.||....||.||||..||..   . .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

RLLHIDFGYVLG-----NDPKPFPPPMKINR------EMVEVLGG----PQSTGFTEFKLYCCSAYNTLRKHAPLLLHIL-------LLGAHTEGMPQVT
 | |||||. ..      ..||...|..  .      .||...||    ..|. . .|. ||..||. ||.|. |... |       .. .|. |.|  .
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHD-GLPMWR

G
 
S
Kinase LmjF24.2010.AA PIKK 922-965 48 2.9e-12 41.3 In-house 188-232 (290) Show / Hide 
Range on Protein: 922-965
Range on HMM: 188-232/290
Sequence Identity: 48% (22 aa)

RYTRSFAGYCVITFVLGIGDRHLENILITQD-GRLLHIDFGYVLG
.|||| |  |.  ..||.||||.|||.| .. | ..|||||.  .
NYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE
Kinase LmjF24.2010.AA ATR 919-1021 25 1.3e-10 31.91 In-house 163-267 (267) Show / Hide 
Range on Protein: 919-1021
Range on HMM: 163-267/267
Sequence Identity: 25% (27 aa)

AMDRYTRSFAGYCVITFVLGIGDRHLENILITQ-DGRLLHIDFGYVLGN---DPKPFPPPMKINREMVEVLGGPQSTGFTEFKLYCCSAYNTLRKHAPLL
. . | ||.| .|.. ...|.|||| .|||| .  | . |.|.  . .       |   | .. . ||  .|  .. |   |.  |      .|.|   .
SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRDDI

LHILLLG
. ..   
MSVWDCF
Kinase LmjF24.2010.AA ATM 923-961 52 2.3e-10 28.94 In-house 140-179 (304) Show / Hide 
Range on Protein: 923-961
Range on HMM: 140-179/304
Sequence Identity: 52% (21 aa)

YTRSFAGYCVITFVLGIGDRHLENILIT-QDGRLLHIDFG
|||| |   .. ..||.||||  ||||  |   | ||| |
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG
Kinase LmjF24.2010.AA FRAP 923-961 47 7.6e-10 32.5 In-house 140-179 (251) Show / Hide 
Range on Protein: 923-961
Range on HMM: 140-179/251
Sequence Identity: 47% (19 aa)

YTRSFAGYCVITFVLGIGDRHLENILIT-QDGRLLHIDFG
|||| |   .. ..||.||||. ||..  . |...|||||
YTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG
Kinase LmjF24.2010.AA DNAPK 921-965 39 1.2e-08 27.41 In-house 188-233 (301) Show / Hide 
Range on Protein: 921-965
Range on HMM: 188-233/301
Sequence Identity: 39% (18 aa)

DRYTRSFAGYCVITFVLGIGDRHLENILIT-QDGRLLHIDFGYVLG
... |..|  |.  ..||||||||.| ..    |    ||||.  |
EHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG
Kinase LmjF24.2010.AA PIKK 837-887 38 1.4e-08 27.77 In-house 33-87 (290) Show / Hide 
Range on Protein: 837-887
Range on HMM: 33-87/290
Sequence Identity: 38% (21 aa)

MMYKYNDDIRQDQLIVQLIRLMNDLLQQD----GMQLYLTPYRVIATGPNEGLVE
...|  .|.|||| . ||..||| .||.|       | .. |.||. ... ||.|
YLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIE
Kinase LmjF24.2010.AA SMG1 923-960 43 9e-06 14.9 In-house 190-228 (242) Show / Hide 
Range on Protein: 923-960
Range on HMM: 190-228/242
Sequence Identity: 43% (17 aa)

YTRSFAGYCVITFVLGIGDRHLENILI-TQDGRLLHIDF
| || |   .. ...|.|||||.|.||    |   |||.
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase LmjF24.2010.AA FRAP 835-865 38 0.007207 6.55 In-house 2-32 (251) Show / Hide 
Range on Protein: 835-865
Range on HMM: 2-32/251
Sequence Identity: 38% (12 aa)

LAMMYKYNDDIRQDQLIVQLIRLMNDLLQQD
   . |  .|||||  . ||  |.| ||. .
YHFLLKGHEDIRQDERVMQLFGLINRLLHNN
Kinase LmjF24.2010.AA ATM 837-863 40 0.050329 1.8 In-house 2-28 (304) Show / Hide 
Range on Protein: 837-863
Range on HMM: 2-28/304
Sequence Identity: 40% (11 aa)

MMYKYNDDIRQDQLIVQLIRLMNDLLQ
 . |  ||.|||  . |   . | |||
QLVKGRDDLRQDAVMQQVFQMCNTLLQ
Kinase LmjF24.2010.AA DNAPK 838-865 46 0.136331 1.34 In-house 36-63 (301) Show / Hide 
Range on Protein: 838-865
Range on HMM: 36-63/301
Sequence Identity: 46% (13 aa)

MYKYNDDIRQDQLIVQLIRLMNDLLQQD
.||   | |||| | ||   ||  . .|
CYKGIEDLRQDQRIEQLFQVMNNIFEYD