Gene LmjF34.3940 (L.major)

LmjF34.3940

Species: L.major
Alias: LmajK175, LmjF34.3940
External Links:
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
LmjF34.3940.AA Protein None 2628 None Fasta, JSON
LmjF34.3940.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of LmjF34.3940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FATC LmjF34.3940.AA FATC 831-844 42 15.524274 1.51 Pfam 1-14 (33) Show / Hide 
Range on Protein: 831-844
Range on HMM: 1-14/33
Sequence Identity: 42% (6 aa)

LALDPKQQVDTLVA
. |.. |||| |..
EPLSVEQQVDRLIQ
PDZ LmjF34.3940.AA PDZ 1355-1423 14 1e-05 26.2 SMART 1-80 (80) Show / Hide 
Range on Protein: 1355-1423
Range on HMM: 1-80/80
Sequence Identity: 14% (12 aa)

QKFGINYDQDPERGVIVTKLAPNGVGARAG------VPIGAQLLAIND-IPVR--AVSDIRGLIEGL------THIELLLSYEV
. .|..       |...... |.|. ..||      . .| ..|..|. .||.     ..  .. .       ....|.. .. 
GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ LmjF34.3940.AA PDZ 1345-1420 17 0.000154 18.1 Pfam 1-86 (86) Show / Hide 
Range on Protein: 1345-1420
Range on HMM: 1-86/86
Sequence Identity: 17% (15 aa)

VVSVDRESTSQKFGINYDQDPER----GVIVTKLAPN-GVGARAG-VPIGAQLLAINDIPVR--AVSDIRGLIEGLT--HIELLLS
 |.. .. . ...|.. .  ..     |...... |. |  .|.|   .| |...||. ..|  .. ..  .| |     . |.. 
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
FAT LmjF34.3940.AA FAT 1642-1914 18 4.3e-08 27.33 Pfam 67-408 (408) Show / Hide 
Range on Protein: 1642-1914
Range on HMM: 67-408/408
Sequence Identity: 18% (65 aa)

D--ELLRYTDKVRESMLESFAD-SLNENYNRAYEGMTRLQHLRHFEELVSFTTAC-----------EERQALLKRVWHRRLVQM-SSRPDDLMTVLSINS
|  |  || ||.|. ...  .    .| |||.|  | |.| |  .||.  . . |           .|.|. ... | .||  .  .  ..    |.  .
DTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQ

LVLE--------------PEDDLHSYVYVIRCLCKSQWFSHAEHLLQRLLR---ENASLEVLCECDPELIHTYIKYVYLAKDKHGAYVELKNILS-AVEV
.|..              | .|..      .   |.  .. .|  | .|..   .. . .     .|. .. | || . ..... |. .|.  .|   . 
HVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQH

D-----------------------PEDPRAEMWG-QCWLLLGEWTMYL--------FPECGEEAIKELMCATELGPNSAA-AFHSLGILHCDLARDPSTQ
|                       .|   ... .  | ...|.|   |         .|. .|...  | ||.. |...  | |...  .  .     .|
DLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQ

GE--------VQNNHLICCINSLFKSIQLCNDVPGSLVMQDVLRILS
 .         . .|..  .   |.|| |..    | . || ||.|.
PQREEQNYTHMIIQHVVPAVKCFFHSIALSQG---SNSRQDTLRLLW
Rapamycin_bind LmjF34.3940.AA Rapamycin_bind 2023-2111 30 3.2e-38 122.45 Pfam 1-100 (100) Show / Hide 
Range on Protein: 2023-2111
Range on HMM: 1-100/100
Sequence Identity: 30% (30 aa)

EMVRIAILWTEKWHAAIQQAAY---KPNNTAAIFSMLQPLYAELDR-ASTPNELSFRCNFGQTLRRAKVALE-------EAKTDEAWGFLRQVYAQLRRG
|..|.||||.|.|| ....|..   ...|  ..|..|.||...|..  .|..| || . ||..|..|. ...       |.  ..|| .. ||. ..|. 
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase LmjF34.3940.AA PIKK 2148-2421 37 2.4e-104 352.99 In-house 1-290 (290) Show / Hide 
Range on Protein: 2148-2421
Range on HMM: 1-290/290
Sequence Identity: 37% (108 aa)

TIRKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLE
 || .  .| ||..||||..| .  .||| |..|.||||| |||.||||...|. |..| |.. .   |.|. |.|||.... |...||.|. |.   . 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

TYRQAHEVSVYEEVNL---------------IMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVG
 ..|. . .   |.                  .| ...    .|  .|  .........|.||| . .. .||    ..|.|.. |. |  ..| |.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YVLGLGDRHLNNLML-QGNGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAF
|.|||||||..|.|. . .| .||||||.|||.|| |    | ||||||| .| |.|..||.|..| .|| .|. . .| | |....|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase LmjF34.3940.AA FRAP 2177-2431 44 7.1e-99 334.78 In-house 1-251 (251) Show / Hide 
Range on Protein: 2177-2431
Range on HMM: 1-251/251
Sequence Identity: 44% (115 aa)

KYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLETYRQAHEVSVYEEVNLIMKKGGLDTIEDY
 | ||||||||.||||||||   || .. . .  .   .|||  |..|||  | | .|||..  |.  ..  ||.....    | |.. ..     ..||
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRM-----CNDY

HRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHIDFGDCFEVAMHRALYAEAV
 .||  ..  .  |.|.||  ..|. . |      | |.  |  |   || |||.||.|||||||. |.|||   | .||||||||||||| |  . | .
DHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKI

PFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAFIYDPIINWRL
||||||.|| |. ..|..| || |||| || .  | | .. .||||.|||...|||
PFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase LmjF34.3940.AA PI3Kc 2179-2492 22 1.1e-69 238.7 SMART 1-336 (336) Show / Hide 
Range on Protein: 2179-2492
Range on HMM: 1-336/336
Sequence Identity: 22% (78 aa)

RFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKML-ETYRQAH------------------EVSVYE
....|...|.|||.|.||..||...| |.| ...   | . .|..||. .. |...|| |.||. ... . . ...                  . .   
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

EVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTC-EQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHID
  ..| .. . . . .| .. . .....   |  ..... |.. ||.|. .  | | . | .. . .|...||.|.||.||||..|.||   .| ..|||
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID

FGDCFEVAMHRALYA----EAVPFRLTRLLVCALG----ITGVDGLYRMTCELAMKNLHRHSENLLSILEAFIYDPI-INWRLNTVNDVTEKSGSKSAQQ
||..|. .. . ..     |.||||||. .| . |    ..|..|..|..|. |.. . .||. .....|...|||| ..|| .          ..  ..
FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--------EKDIKYLR

ESNNGG--TAALAGETAAA-ACLGIDNAAQAEAKPVAMQLSKSVSKP
.. .    .  .| . ...  |  ....  ..  . ....   . ..
QRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase LmjF34.3940.AA PI3_PI4_kinase 2177-2431 25 2.3e-69 241.56 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2177-2431
Range on HMM: 1-300/300
Sequence Identity: 25% (80 aa)

KYRFLLKGHEDMR--QDERVMQFI-----------------------RLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLETYR-
 |.|..||..|.|  ||.|.||.|                       ||.... ..|..     ...  | .||. .. |...||.|..|. . . ||. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

--------QAHEVSVYEEVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTC-EQWLSYRQTYGQTLAAMSMVGYVLGLGDRH
        . | ...  . . ....             . |.. . .... .|||. |.. ||.|| .. | |...|...   .| |..|.|.||.||||
KCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRH

LNNLML---QGNGTVVHIDFGDCFE-VAMHRALYAEAVPFRLTR------LLVCAL------GITGVDGLYRMTCELAMKNLHRHSENLLSIL-------
..|.|.    ..| ..|||||.||. ..|..    |.||||.|.       .| |.      . .| .|..| .|. |.  | ||.. ... |       
NDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRG

EAFIYDPIINWRL
|....|....|| 
ECMVHDGLPMWRS
Kinase LmjF34.3940.AA ATR 2148-2421 30 2.4e-49 166.12 In-house 2-267 (267) Show / Hide 
Range on Protein: 2148-2421
Range on HMM: 2-267/267
Sequence Identity: 30% (84 aa)

TIRKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLE
 |  |   | .. | |||..| |  |||| |  . | ..|.|.| | |.|  ||. . . |       . .. |||||| |. ... ||.|| |.  .|.
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

T-YRQAHEVSVYEEVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLM
  ..     . . .. . | |   .  |        . |.. .. .   |    .  |       .|| | |. |  . |...||||..|||||| .|..
KLWKEKKQYMQFYQLRQCMDKKSREEWE--------KQKVFREFLLPRHP-PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNIL

LQG-NGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAF
..  || .||.|.   |          | ||||||. .| ..|  . .||.|  ||  |. .  | ....|....|
IDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase LmjF34.3940.AA ATM 2314-2432 43 2.1e-31 97.31 In-house 133-251 (304) Show / Hide 
Range on Protein: 2314-2432
Range on HMM: 133-251/304
Sequence Identity: 43% (52 aa)

WLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQGNGT-VVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSE
|   |  |    |  |.|||.|||||||  |...      .|||| |  ||         | ||||||| .|  .|||||.| .|  ||  |  .    |
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

NLLSILEAFIYDPIINWRLN
 || | |  .|||.  | .|
TLLTIVEVLLYDPLFDWTMN
Kinase LmjF34.3940.AA SMG1 2285-2363 47 2.2e-19 60.73 In-house 154-233 (242) Show / Hide 
Range on Protein: 2285-2363
Range on HMM: 154-233/242
Sequence Identity: 47% (38 aa)

KALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHIDFGDCFE
|| |   || || | |    |    | . |    | |    | ||||||..||||||| | ..    | |||||.  |||
KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase LmjF34.3940.AA DNAPK 2147-2246 35 5.4e-19 65.61 In-house 2-101 (301) Show / Hide 
Range on Protein: 2147-2246
Range on HMM: 2-101/301
Sequence Identity: 35% (35 aa)

ITIRKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKML
. |  |  || || |  .|.|| .   | .   |. || ||.||| |. |       ||  | . .   |    | .||.|   | . ||.|| .   .|
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL
Kinase LmjF34.3940.AA SMG1 2156-2237 36 1.4e-17 54.68 In-house 1-82 (242) Show / Hide 
Range on Protein: 2156-2237
Range on HMM: 1-82/242
Sequence Identity: 36% (30 aa)

VYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVE
. ..| | ||...    |||| | .| || ||.  |||.|||. ...|.|   |           |.| ||    |.. ||.
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
Kinase LmjF34.3940.AA DNAPK 2310-2431 31 1e-16 57.23 In-house 179-301 (301) Show / Hide 
Range on Protein: 2310-2431
Range on HMM: 179-301/301
Sequence Identity: 31% (39 aa)

TCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLH
||| .|  |  .  . |     ...|| ||||||| |    || .. ||||  |  |       |  ||||||  .  .   .. |...     .|. . 
TCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFR

RHSENLLSILEAFIYDPIINWRL
.    |.   . || || . |  
KDRNILTNFCDVFINDPSFDWKN
Kinase LmjF34.3940.AA ATM 2179-2235 35 1.1e-08 23.4 In-house 1-57 (304) Show / Hide 
Range on Protein: 2179-2235
Range on HMM: 1-57/304
Sequence Identity: 35% (20 aa)

RFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGW
| | || .|.|||  . |   .  |. |         | |  | |.||    ||. |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
FATC LmjF34.3940.AA FATC 2595-2628 55 3.5e-16 54.89 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2595-2628
Range on HMM: 1-33/33
Sequence Identity: 55% (19 aa)

ESLDVPHQVDRLIQEATSLDNLSDAFLTGWAPFW
|.|.|. ||||||||||. .||. ..  ||.|.|
EPLSVEQQVDRLIQEATDPENLCQMYI-GWCPWW