Gene LmjF32.1020 (L.major)

LmjF32.1020

Species: L.major
Alias: LmjF32.1020, LmajK183
External Links:
Annotation:

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
LmjF32.1020.AA Protein None 811 None Fasta, JSON
LmjF32.1020.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of LmjF32.1020.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF32.1020.AA STE 545-728 24 1.2e-27 94.79 In-house 145-359 (359) Show / Hide 
Range on Protein: 545-728
Range on HMM: 145-359/359
Sequence Identity: 24% (56 aa)

ETPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKFKLADFGCGSVMED--------------RQHVERRGIDLGTILYKAPERFAAN
....|| ...  .|..| || ... .  ||| |.||||..|       ||.|||. . ..|                 ...|  . ||  . |||.   |
QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQN

ILHRIADIDDGGTGEAVVFTAKADVWSLGIMLMELAAGIHPC-D-QFKSDFWNYG-----------------TMLKLSKMTK--------------PLNW
  .                ..|.|.||||....|.| | .|. | .  .  ..                   .  .|   ..              | .|
GQG-R----------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKW

SESFYDFILRSVCVDVSLRWSVQQLLK--HPFV
|..| ||| .    | . |....||||  |||.
SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LmjF32.1020.AA Pkinase 542-728 22 3.3e-27 97.29 Pfam 95-293 (293) Show / Hide 
Range on Protein: 542-728
Range on HMM: 95-293/293
Sequence Identity: 22% (50 aa)

VK--RETPM--PEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKF----KLADFGCGSVMEDRQHVERRGIDLGTILYKAPERFAANILH
..  |....  .|  . . .. .| ||. .|   .|||.||||.|...  ..       |..|||.  ...   . .      ||. | |||     |. 
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV----IR-

RIADIDDGGTGEAVVFTAKADVWSLGIMLMELAAGIHPCDQF-----KSDFWNYGTMLK----------LSKM-----------TKPLNWSESFYDFILR
           ..   . |.|.||.|..| |.. |  |...       .. . .   ..           |..           |.  ||||.. ||| .
-----------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKW

SVCVDVSLRWSVQQLLKHPFV
  |.| . |.. .|.|.||..
CLCKDPKKRPTAEQILQHPWF
Kinase LmjF32.1020.AA SLK 542-728 28 9.5e-20 63.19 In-house 88-259 (259) Show / Hide 
Range on Protein: 542-728
Range on HMM: 88-259/259
Sequence Identity: 28% (54 aa)

VKRETPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKFKLADFGCGSVMEDRQHVERRGIDLGTILYKAPERFAANILHRIADIDDG
|  | |. |  . .... .. .|| || .  .|| |||  |...  | .  .|||||       ......|   .||  . |||  .   ..        
VELEHPLTEDQIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGD-VRLADFGV--SAKNKHTMQKRDTFIGTPYWMAPEVVMCETFK--------

GTGEAVVFTAKADVWSLGIMLMELAAGIHPCDQFKSDFWNYGTMLKLSK-----MTKPLNWSESFYDFILRSVCVDVSLRWSVQQLLKHPFV
       .  |||.||||| |.|.| .  |    ...      .||. |     . .|  ||..| ||. ...  |.  ||. .||..|..|
----DQPYDYKADIWSLGITLIEMAQMEPP----HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
S_TKc LmjF32.1020.AA S_TKc 376-728 15 4.9e-18 67.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 376-728
Range on HMM: 1-231/231
Sequence Identity: 15% (59 aa)

VVVEVMIGKGTQGTVFRVRL--DGKLYALKCMNIDEAMNATNDVERQGYKKGLVKELTMITLQRSRPPPAYLMQMFNAVASLDAEKKQLSILMELMSFTV
  .   ||||. |.|...|   .|...|.|...                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

ENIQQMVSRIPSEELMRVTQSTFRNYMSGDPSAQQAMRECCKDQ-------LLYGSPRHALGRSTYKEPATW-----EKNVKRETP------MPEVLLSM
                                 ....||    .        ||.. ..        | .        .  |.  .      .||     
---------------------------------EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

LARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKFKLADFGCGSVMEDRQHVERRGIDLGTILYKAPERFAANILHRIADIDDGGTGEAVVFTA-KAD
... .. .|. .|    |||.||||.|..|.      |..|||   ..             ||  | ||| .                     ..  |.|
YMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------------------GYGKCKCD

VWSLGIMLMELAAGIHPCDQFKSDFWNYGTMLKLSKMTKPLNWSESFYDFILRSVCVDVSLRWSVQQLLK-------HPFV
.||.|..| |...|  | .       .. .|.|. .       |... ||| .  ..| . |... ..|.       ||..
WWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF32.1020.AA TKL 556-726 18 2e-14 48.39 In-house 137-364 (364) Show / Hide 
Range on Protein: 556-726
Range on HMM: 137-364/364
Sequence Identity: 18% (42 aa)

LARDVLMGLNELHTDY-------SIIHCDLKPANVMLC-CDQ------------QKFKLADFG---CGSVMEDRQHVE--------------RRGIDLGT
.|.|.  |.| ||..         |||.|||..|...    .             . |..|||   . | ... .. .              ...   ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

ILYKAPERFAANILHRIADIDDGGTGEAVVFTAKADVWSLGIMLMELAAGIHPCDQFKSDFWNYG-------TMLKLSKMTKPLN--------------W
. . ||| .  ..  . . . |.   .   .. |.||.| ||.| |.... .| ...... .  .        |  . ..  |.                
PRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDC

SESFYDFILRSVCVDVSLRWSVQQLLKHP
 .|. . . .    | . | | |..||. 
PPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LmjF32.1020.AA STE7-Unclassified 617-728 24 9.5e-12 37.76 In-house 182-301 (301) Show / Hide 
Range on Protein: 617-728
Range on HMM: 182-301/301
Sequence Identity: 24% (32 aa)

GTILYKAPERFAANILHRIADIDDGGTGEAVVFTAKADVWSLGIMLMELAAGIHPCD------QFKSD-------FWNYGTMLKLSK---MTK---PLNW
|.  | .|||.  .. ||             . ..| |.||||... |.| | .|..      |           ||.  ..   ..     .    ..|
GCQMYMSPERIQGQMPHR------------PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIW

SESFYDFILRSVCVDVSLRWSVQQLLK-HPFV
|..| ||| . .  .   | .. |||. ||..
SKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase LmjF32.1020.AA STE7 650-728 23 5.4e-11 36.6 In-house 191-288 (288) Show / Hide 
Range on Protein: 650-728
Range on HMM: 191-288/288
Sequence Identity: 23% (24 aa)

TAKADVWSLGIML-MELAAGIHPCDQFKS-----------------DFWNYGTMLKL-S--KMTKPLNWSESFYDFILRSVCVDVSLRWSVQQLLK-HPF
. ..|||||||.. .|.| | .|.. ...                  | .    ..  .  .     ..|..| ||. .    | . | . .||.| |||
DVRSDVWSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPF

V
.
I
Kinase LmjF32.1020.AA PAKA 696-728 51 1.4e-09 29.9 In-house 228-260 (260) Show / Hide 
Range on Protein: 696-728
Range on HMM: 228-260/260
Sequence Identity: 51% (17 aa)

NWSESFYDFILRSVCVDVSLRWSVQQLLKHPFV
.||..| ||  .  ||||  |.|.|.||.||| 
KWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase LmjF32.1020.AA Ciliate-E2 552-625 21 1.5e-09 28.93 In-house 154-257 (365) Show / Hide 
Range on Protein: 552-625
Range on HMM: 154-257/365
Sequence Identity: 21% (24 aa)

LLS-------MLARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKFKLADFG-----------------CGSVMEDRQHVERRGIDL-----------
.|.       . .. .. .|..||   .||| |.|| |...       |..|||                 |.  |. ..  .|   ..           
ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNT

--GTILYKAPE
  ||  |.|||
ICGTPGYMAPE
Kinase LmjF32.1020.AA CMGC 543-598 20 2.4e-09 25.91 In-house 155-249 (513) Show / Hide 
Range on Protein: 543-598
Range on HMM: 155-249/513
Sequence Identity: 20% (20 aa)

KRETPMPEVL------------LSMLA------RDVLMGLN--ELHTDY-SIIHCDLKPANVMLCCDQQKF-------------------KLADFG
||  |..|                 .       . .| ||.   .|    .|||.||||.|.... . . .                   |..|||
KRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase LmjF32.1020.AA STE20 696-728 42 2.4e-09 30.63 In-house 256-288 (288) Show / Hide 
Range on Protein: 696-728
Range on HMM: 256-288/288
Sequence Identity: 42% (14 aa)

NWSESFYDFILRSVCVDVSLRWSVQQLLKHPFV
.|| .| ||. .  ..|.. |....|||||||.
KWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase LmjF32.1020.AA Ciliate-E2 652-728 21 3.7e-09 27.56 In-house 276-365 (365) Show / Hide 
Range on Protein: 652-728
Range on HMM: 276-365/365
Sequence Identity: 21% (20 aa)

KADVWSLGIMLMELAAGIHPCDQFKSDFWNYGTMLKLSKMT-------------KPLNWSESFYDFILR----SVCVDVSLRWS-VQQLLKHPFV
|.|.||||..| |.  | .|         .    .....               ....||..  |.| .      ..| . | .  .|.|.||. 
KCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase LmjF32.1020.AA ULK 573-625 30 3.8e-09 28.16 In-house 151-221 (329) Show / Hide 
Range on Protein: 573-625
Range on HMM: 151-221/329
Sequence Identity: 30% (23 aa)

IIHCDLKPANVMLCCDQQK-----------FKLADFGCGSVME-D-------RQHV-ERRGIDL---GTILYKAPE
|||.|.||.|...  .|.|           .|.|||| . ... |          | |         || || ||.
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE-----KRLCGTPLYMAPQ
Kinase LmjF32.1020.AA STE7-Unclassified 542-598 38 1.1e-07 23.28 In-house 111-165 (301) Show / Hide 
Range on Protein: 542-598
Range on HMM: 111-165/301
Sequence Identity: 38% (22 aa)

VKRETPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKFKLADFG
. | ...||. |. .|  |. || .|| .. ||| |.|| |. |.  .   |..|||
I-RGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNI-LVNSKGQVKICDFG
Kinase LmjF32.1020.AA ULK 650-728 24 3e-06 17.8 In-house 234-329 (329) Show / Hide 
Range on Protein: 650-728
Range on HMM: 234-329/329
Sequence Identity: 24% (24 aa)

TAKADVWSLGIMLMELAAGIHP--CDQFKSDFWNYGTMLKLSKM---------TKPLN---------WSESFYDFILRSVCVDVSLRWSVQQLLKHPFV
..|.|.||||... |.  |  |  .  | ......  . || .          ..||.          |. . |.| |  ..| . | | ..|..||..
DYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQI--IQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase LmjF32.1020.AA STE20 650-668 52 9e-06 17.4 In-house 205-223 (288) Show / Hide 
Range on Protein: 650-668
Range on HMM: 205-223/288
Sequence Identity: 52% (10 aa)

TAKADVWSLGIMLMELAAG
. |.|.|||||...|.| |
DYKCDIWSLGITAIEMAEG
Kinase LmjF32.1020.AA TKL 382-409 23 1.1e-05 16.39 In-house 1-38 (364) Show / Hide 
Range on Protein: 382-409
Range on HMM: 1-38/364
Sequence Identity: 23% (9 aa)

IGKGTQGTVFRVRLDG----------KLYALKCMNIDE
||.|. |.|.. .. |          |  | | .....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHN
Kinase LmjF32.1020.AA CMGC 674-728 11 1.4e-05 13.29 In-house 417-513 (513) Show / Hide 
Range on Protein: 674-728
Range on HMM: 417-513/513
Sequence Identity: 11% (11 aa)

QFKSDFWNYGTMLKLSKMTKPLNWS------------------------------------------ESFYDFILRSVCVDVSLRWSVQQLLKHPFV
..... .||  . .  .. .| .|.                                          . . |.. .  . | . |....| |.||. 
HWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase LmjF32.1020.AA PAKA 652-668 58 1.6e-05 15.55 In-house 183-199 (260) Show / Hide 
Range on Protein: 652-668
Range on HMM: 183-199/260
Sequence Identity: 58% (10 aa)

KADVWSLGIMLMELAAG
| |.||||||..|.. |
KVDIWSLGIMAIEMIEG
Kinase LmjF32.1020.AA TyrKc 376-731 13 4.9e-05 -141.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 376-731
Range on HMM: 1-280/280
Sequence Identity: 13% (52 aa)

VVVEVMIGKGTQGTVFRVRLDGKLYALKCMNIDEAMNATNDVERQGYKKGLVKELTMITLQ--RSRPPPAYLMQMFNAVASLDAEK----KQLSILMELM
.. . ..| |  |.|.. ...    | |... |              .. . .|. . .    .       . ... .|.. . ..    ..| |.||.|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------------REDFMREARIMCKLGGHHP----NIVRLY-GVCTQQGRNFMYIEPLMIVMEYM

SFTVENIQQMVSRIPSEELMRVTQSTFRNYMSGDPSAQQAMRECCKDQLLYGSPRHALGRSTYKEPATWEKNVKRETPMPEVLLSMLARDVLMGLNELHT
.    . ..   .   .                                                              .   |   . ..  | . || 
PH--GDLKDYLRKHRPK-------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHS

DYSIIHCDLKPANVMLCCDQQKFKLADFGCGSVMEDR-------QHVER----RGIDLGTILYKAPERFAANILHRIADIDDGGTGEAVVFTAKADVWSL
   .|| ||   |...  ..   | .|||     .|        .         | ..  |   ||| .                    .|| | |||| 
K-NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----------------NYGKFTTKSDVWSF

GIMLMELAA-GIHPCDQ----FKSDFWNYGTMLKLSKMTKPLN--------WSESFYDFILRSVCVD-VSLRWSVQQLLKHPFVIKF
|... |.   |  |       ..|..  .    .   | .| |         ..  |. | .. .    . | . ...     . .|
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-----HECF
Kinase LmjF32.1020.AA STE7 540-583 38 0.000119 13.27 In-house 93-142 (288) Show / Hide 
Range on Protein: 540-583
Range on HMM: 93-142/288
Sequence Identity: 38% (19 aa)

KNVKRE------TPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANV
|.||.       ...||  |   |  |. ||. ||....||| | || |.
KRVKKVYRGIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNI
Kinase LmjF32.1020.AA CMGC 376-411 17 0.000868 7.3 In-house 1-51 (513) Show / Hide 
Range on Protein: 376-411
Range on HMM: 1-51/513
Sequence Identity: 17% (9 aa)

VVVEVMIGKGTQGTVFRVRL----------------DGKLYALKCMNIDEAM
  .   ||.|| |.|.. |                 .....|.| .  .. .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-Y
Kinase LmjF32.1020.AA STE20 382-412 29 0.002677 8.26 In-house 7-43 (288) Show / Hide 
Range on Protein: 382-412
Range on HMM: 7-43/288
Sequence Identity: 29% (11 aa)

IGKGTQGTVFRVRLD--GKL----YALKCMNIDEAMN
||.|. |.|....    |..    .| | ||.....|
IGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDN
Kinase LmjF32.1020.AA STE20 546-585 42 0.006014 6.96 In-house 112-150 (288) Show / Hide 
Range on Protein: 546-585
Range on HMM: 112-150/288
Sequence Identity: 42% (17 aa)

TPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVML
.|| |.  .   |.|| ||. ||    ||| |.| .|..|
HPMNEEQIAYICREVLQGLDYLH-SNHIIHRDIKADNILL
Kinase LmjF32.1020.AA Ciliate-E2 376-406 17 0.009268 5.28 In-house 1-56 (365) Show / Hide 
Range on Protein: 376-406
Range on HMM: 1-56/365
Sequence Identity: 17% (10 aa)

VVVEVMIGKGTQGTVFRVRL-------------------------DGKLYALKCMN
  .  .||.|..|.|....                          ..|.||.|.|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMK
Kinase LmjF32.1020.AA STE 376-409 23 0.027865 4.01 In-house 1-51 (359) Show / Hide 
Range on Protein: 376-409
Range on HMM: 1-51/359
Sequence Identity: 23% (12 aa)

VVVEVMIGKGTQGTVFRVRLD-----------------GKLYALKCMNIDE
     .||||. |||.. .                   |...| | ||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLEN
Kinase LmjF32.1020.AA ULK 376-392 29 0.11755 1.66 In-house 1-17 (329) Show / Hide 
Range on Protein: 376-392
Range on HMM: 1-17/329
Sequence Identity: 29% (5 aa)

VVVEVMIGKGTQGTVFR
 ..  ..|||. |.|..
YCLNHCLGKGSFGKVYK
Kinase LmjF32.1020.AA PAKA 547-598 34 0.118018 1.77 In-house 99-148 (260) Show / Hide 
Range on Protein: 547-598
Range on HMM: 99-148/260
Sequence Identity: 34% (18 aa)

PMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCCDQQKFKLADFG
.|.|   .   | .| ||. .| . ..|| |.|  |. |  | .  |..|||
YMDEGQIAYVCRECLQGLEFIH-SKHRIHRDIKSDNILLGMDGS-VKITDFG
Kinase LmjF32.1020.AA CMGC 649-668 35 0.12806 0.04 In-house 312-331 (513) Show / Hide 
Range on Protein: 649-668
Range on HMM: 312-331/513
Sequence Identity: 35% (7 aa)

FTAKADVWSLGIMLMELAAG
.| . |.||.| .. |.  |
YTTPIDMWSVGCIFAEMYTG
Kinase LmjF32.1020.AA Pkinase 376-410 21 0.256438 5.74 Pfam 1-37 (293) Show / Hide 
Range on Protein: 376-410
Range on HMM: 1-37/293
Sequence Identity: 21% (8 aa)

VVVEVMIGKGTQGTVFRVRLDGK--LYALKCMNIDEA
 ...  ||.|. |.|.. .  |   ..|.|... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHE