Gene LmjF11.0510 (L.major)

LmjF11.0510

Species: L.major
Alias: LmjF11.0510, LmajK222
External Links:
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF11.0510.AA Protein None 578 None Fasta, JSON
LmjF11.0510.kin_dom Protein Kinase Domain None 376 None Fasta, JSON

Protein domain

Protein domains of LmjF11.0510.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF11.0510.AA STE 302-569 19 5.5e-32 110.28 In-house 122-359 (359) Show / Hide 
Range on Protein: 302-569
Range on HMM: 122-359/359
Sequence Identity: 19% (68 aa)

GSVADVLRRS--------------GPFPEPEIKRCMAEILSA-LQCVHEDHNCVHNDVKPHNILIFDDSSAYYAEFKYQIID------LTD---------
||. |....               ..|||..|..   .|| . |.  |. |  .| |.|| |||.              ..|      |||         
GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL------------VKLCDFGVCGQLTDSMANIQSNN

----IAPATPIEDVLRDLATERKQQQNIFSERGTVMYMSPESCLG------LGTLTSNDVWSLGITAFHMATGTLPW---RPLERQYPSMIL-----NGY
    |                  .||.  .  ||  .|.||  ..       |  |. |.||||.|. .||||  ||    |..  .. ..         
IIDCI----------------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ--

RRKFTLRSLVDVHVNDAYGASGSCYPTGTDNPLHADSDGKPRARFHASSAPGSRATGGASCTSQVFRDQYKGF-------GPILDIPDEVS---------
                                                                        |       ||.  .||..|         
------------------------------------------------------------------------FEQLCIVNGPPPPLPDHLSQNEMISYGG

--------VSSEFRSFLEQCLTENPVKRPTCRQLRS--HPFV
        .|.||. |...||. .| ||||  || .  |||.
SGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
S_TKc LmjF11.0510.AA S_TKc 196-569 16 1.5e-23 85.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 196-569
Range on HMM: 1-231/231
Sequence Identity: 16% (64 aa)

DTGGLYLGRGATALVYEGWMVVTDMMDGSEVCLAKVPVAIKEVTYNAKNRRLRNLYELAVNLRLNMVHPGIVHSYYAGTYMPRLAGFRGAEKAMVYAHIV
 . .  .|.|| . || .. .             .  ||||..         . . |...  .    || ||. |..                  . ..|
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD--------------DHLYMV

LARSVT--GSVADVLRRSGP------FPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILIFDDSSAYYAEFKYQIIDL---TDIAPATPIEDVLRD
.    .  |.. |.... |.      ||| .... |..|..||.  |.  . .| |.|| |||. .            |.|    . .            
MEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---------HIKICDFGLARQL------------

LATERKQQQNIFSERGTVMYMSPESCLGLGTLT-SNDVWSLGITAFHMATGTLPWRPLERQYPSMILNGYRRKFTLRSLVDVHVNDAYGASGSCYPTGTD
            .  ||  ||.|| .   |  . . |.||.|.. . |..|  |..    |.  |. .                                
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------------------------

NPLHADSDGKPRARFHASSAPGSRATGGASCTSQVFRDQYKGFGPILDIPDEVSVSSEFRSFLEQCLTENPVKRPTCRQLRS-------HPFV
                                                       |.|...|...||. .| ||||. ..         ||..
-------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF11.0510.AA Ciliate-E2 323-569 15 3.6e-19 62.45 In-house 166-365 (365) Show / Hide 
Range on Protein: 323-569
Range on HMM: 166-365/365
Sequence Identity: 15% (47 aa)

MAEILSALQCVHEDHNCVHNDVKPHNILIFDDSSAYYAEFKYQIIDLTDIAPATPIED-----VLRDLATERK--------------QQQNIFSERGTVM
.|.|..||.  |. .|..| | || |||.              |||.     ... ..     ... . .. |              ||. ...  || .
IACIILALEYLHSKNNIIHRDIKPENILF------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPG

YMSPESCLGLGTL---------TSNDVWSLGITAFHMATGTLPWRPLERQYPSMILNGYRRKFTLRSLVDVHVNDAYGASGSCYPTGTDNPLHADSDGKP
||.||   | .           .. |.||||.. . | .| .|.                                                        
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------------------------

RARFHASSAPGSRATGGASCTSQVFRDQYKGFGPILDIP--------------DEVSVSSEFRSFLEQ----CLTENPVKRPT-CRQLRSHPFV
                          .| |     .. |              .  ..| |   .. .    .|  .| ||.|   |.  ||. 
-------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase LmjF11.0510.AA Ciliate-E2-Unclassified 308-569 17 3.7e-16 52.57 In-house 129-352 (352) Show / Hide 
Range on Protein: 308-569
Range on HMM: 129-352/352
Sequence Identity: 17% (53 aa)

LRRSGPFPEPEIK-----RCMAEILSALQCVHEDHNCVHNDVKPHNILIFDDSSAYYAEFKYQIIDLTDI-APATPIEDVLRDL--ATERKQQQNIFSER
....  |.| ..|     . .|.||..|.  |. .|..| | || |||. .. .     ..  |||.  .  . .....   .    . . .||.. .  
MKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFC

GTVMYM----SPESCLGLGTLTS----NDVWSLGITAFHMATGTLPWR-PLERQ----------------YPSMILNG--YRRKFTLRSLVDVHVNDAYG
|| .||    .||   | .  .|     |.||||. .. | .|..|   . . |                . . |...  . .||  ..           
GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-----------

ASGSCYPTGTDNPLHADSDGKPRARFHASSAPGSRATGGASCTSQVFRDQYKGFGPILDIPDEVSVSSEFRSFLE----QCLTENPVKRPTCRQLRSHPF
                                                             .   .| |   |..    ..|  || ||.|  |.  ||.
-------------------------------------------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPW

V
 
F
Kinase LmjF11.0510.AA YSK 302-351 32 2.1e-11 30.23 In-house 82-132 (257) Show / Hide 
Range on Protein: 302-351
Range on HMM: 82-132/257
Sequence Identity: 32% (17 aa)

GSVADVLRRS--GPFPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILI
||..| ....  |.|.|. |   . ||| .| . |.. . .| |.|  |.|.
GSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSE-RKIHRDIKAANVLL
Kinase LmjF11.0510.AA STE20 539-569 51 8.5e-11 35.98 In-house 258-288 (288) Show / Hide 
Range on Protein: 539-569
Range on HMM: 258-288/288
Sequence Identity: 51% (16 aa)

SSEFRSFLEQCLTENPVKRPTCRQLRSHPFV
|.||. |...||. .| ||||  || .|||.
SPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase LmjF11.0510.AA CAMK 534-569 26 8.9e-11 30.22 In-house 384-425 (425) Show / Hide 
Range on Protein: 534-569
Range on HMM: 384-425/425
Sequence Identity: 26% (11 aa)

DEVSVS------SEFRSFLEQCLTENPVKRPTCRQLRSHPFV
|..| .       | .... ..|. .| ||.|. |  .||..
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase LmjF11.0510.AA Pkinase 528-569 27 2.4e-10 37.68 Pfam 235-293 (293) Show / Hide 
Range on Protein: 528-569
Range on HMM: 235-293/293
Sequence Identity: 27% (16 aa)

PILDIPDEVSVS-----------------SEFRSFLEQCLTENPVKRPTCRQLRSHPFV
.  |.| . |.|                 .|...|.. ||. .| ||||..|.  ||..
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Pkinase LmjF11.0510.AA Pkinase 293-351 32 5.1e-10 36.52 Pfam 76-141 (293) Show / Hide 
Range on Protein: 293-351
Range on HMM: 76-141/293
Sequence Identity: 32% (22 aa)

HIVLARSVTG----SVADVLR--RSGPF--PEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILI
..|.     |    . .|...  |.|.|  .| |.|..| .||..|.  |. ....| |.|| ||||
YMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILI
Kinase LmjF11.0510.AA STE11 527-569 42 1.6e-09 30.87 In-house 257-303 (303) Show / Hide 
Range on Protein: 527-569
Range on HMM: 257-303/303
Sequence Identity: 42% (20 aa)

GPILDIPDEVS-VS---SEFRSFLEQCLTENPVKRPTCRQLRSHPFV
.|.  ||...| .|    | | || .|.. .| |||| .||  |||.
KPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase LmjF11.0510.AA STE11-Unclassified 532-569 38 1.9e-09 29.73 In-house 262-308 (308) Show / Hide 
Range on Protein: 532-569
Range on HMM: 262-308/308
Sequence Identity: 38% (18 aa)

IPDEVS---------VSSEFRSFLEQCLTENPVKRPTCRQLRSHPFV
||   |         .|.| . ||..|.. .| |||| .|| .||| 
IPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTANQLLQHPFI
Kinase LmjF11.0510.AA YSK 539-569 38 1.2e-08 21.78 In-house 227-257 (257) Show / Hide 
Range on Protein: 539-569
Range on HMM: 227-257/257
Sequence Identity: 38% (12 aa)

SSEFRSFLEQCLTENPVKRPTCRQLRSHPFV
|  |  | | || ..| .||.  .| .| |.
SKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase LmjF11.0510.AA STE11-Unclassified 399-438 39 2.7e-08 25.58 In-house 193-238 (308) Show / Hide 
Range on Protein: 399-438
Range on HMM: 193-238/308
Sequence Identity: 39% (18 aa)

RGTVM---YMSPESCLG--L-GTLTSNDVWSLGITAFHMATGTLPW
.||..   .|.|| . .    |.... |.|||| |   ||||  ||
QGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPW
Kinase LmjF11.0510.AA STE7-Unclassified 532-569 33 3.7e-08 24.93 In-house 260-301 (301) Show / Hide 
Range on Protein: 532-569
Range on HMM: 260-301/301
Sequence Identity: 33% (14 aa)

IPDEV---SVSSEFRSFLEQCLTENPVKRPTCRQLRS-HPFV
.||.    . |.||..| ..|.  .|  ||. .||   ||..
LPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase LmjF11.0510.AA STE-Unique 301-351 31 1e-07 22.87 In-house 378-438 (616) Show / Hide 
Range on Protein: 301-351
Range on HMM: 378-438/616
Sequence Identity: 31% (19 aa)

TGSVADVLRRSGP---------FPEPEIKRCMAEILSALQCVHEDH-NCVHNDVKPHNILI
.|.. . . |.|.         ||| |...   .|| .|   |  |   .| |.|||||..
HGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFC
Kinase LmjF11.0510.AA STE-Unique 399-453 32 2.1e-07 21.78 In-house 509-570 (616) Show / Hide 
Range on Protein: 399-453
Range on HMM: 509-570/616
Sequence Identity: 32% (20 aa)

RGTVMYMSPESCLGL-----GTLTSNDVWSLGITAFHMATGTLPWRPLERQ--YPSMILNGY
.||  ||.||  ..      .  |  |.||||.. |||..|. ||  . .   |..|.....
CGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIH
Kinase LmjF11.0510.AA STE11 387-438 33 2.7e-07 22.75 In-house 174-238 (303) Show / Hide 
Range on Protein: 387-438
Range on HMM: 174-238/303
Sequence Identity: 33% (22 aa)

TERKQQ-QNIF--SERGTVM--------YMSPESCLGLG---TLTSNDVWSLGITAFHMATGTLPW
|. ... || .  | .||.         .|.|| . . |     .. |.|||| | . ||||  ||
THNMNMTQN-HCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPW
Kinase LmjF11.0510.AA STE7-Unclassified 302-351 29 4.9e-07 20.94 In-house 93-153 (301) Show / Hide 
Range on Protein: 302-351
Range on HMM: 93-153/301
Sequence Identity: 29% (18 aa)

GSVA---DVLRRS--------GPFPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILI
||.    |.. ..        |..||| ...    .. .|  .||.|. .| |.|| |||.
GSLDNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILV
Kinase LmjF11.0510.AA CAMK 306-356 37 5.8e-07 17.72 In-house 169-217 (425) Show / Hide 
Range on Protein: 306-356
Range on HMM: 169-217/425
Sequence Identity: 37% (19 aa)

DVLRRSGPFPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILIFDDSS
|.. ..| |.| | .|..  |.||..  |. .  || | || |||. |...
DIV-ERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNND
Kinase LmjF11.0510.AA Pkinase 397-439 31 1e-06 24.33 Pfam 170-213 (293) Show / Hide 
Range on Protein: 397-439
Range on HMM: 170-213/293
Sequence Identity: 31% (14 aa)

SERGTVMYMSPESCL-GLGTLTSNDVWSLGITAFHMATGTLPWR
.  ||  ||.|| .. | .  .. |.||.|.. . |..| .|..
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
TyrKc LmjF11.0510.AA TyrKc 196-569 17 2e-06 -117.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 196-569
Range on HMM: 1-280/280
Sequence Identity: 17% (70 aa)

DTGGLYLGRGATALVYEGWMVVTDMMDGSEVCLAKVPVAIKEVTYNAKNRRLRNLYELAVNLRLN-MVHPGIVHSYYAGTYMPRLAGFRGAEKAMVYAHI
 | |  ||.||   ||.| .               ..||.| .  .|    .. ... |  ..     || ||  | . |   |   |  .|  |.    
ITLGKKLGEGAFGEVYKGTWK--------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEY

VLARSVTGSVADVLRRSGP-FPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILIFDDSSAYYAEFKYQIIDLTDIAPATPIEDVL--------RDL
.      |.  | ||...| .. ..    .  | .  .  |. .||.| |    |.|. ..                          .         ||.
M----PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHS-KNCIHRDLAARNCLVGENH-------------------------TVKISDFGLSRDI

ATE-----RKQQQNI-F--SER--GTVMYMSPESC-LGLGTLTSNDVWSLGITAFHMAT-GTLPWRP-----LERQY-PSMILNGYRRKFTLR----SLV
  .     .|.        ...    .  |.||.   |  |  | |||| |.. . . | |  |.       .. |     . .|||..        |  
YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--

DVHVNDAYGASGSCYPTGTDNPLHADSDGKPRARFHASSAPGSRATGGASCTSQVFRDQYKGFGPILDIPDEVSVSSEFRSFLEQCLTENPVKRPTCRQL
                                                              |         |  ..|  .  .||  |.| .||| ...
--------------------------------------------------------------F---------VCCPDEMYQIMKQCWHEDPEDRPTFSEI

RSHPFV
  | . 
--HECF
Kinase LmjF11.0510.AA STE11 302-351 39 2e-06 19.52 In-house 98-149 (303) Show / Hide 
Range on Protein: 302-351
Range on HMM: 98-149/303
Sequence Identity: 39% (21 aa)

GSVADVLR-RSGP--FPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILI
||....|| . ||  |.|..|..    ||..||  |. |. .| |.|. |||.
GSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHS-HGIIHRDIKGANILL
Kinase LmjF11.0510.AA STE7-Unclassified 400-437 43 6e-06 16.98 In-house 182-224 (301) Show / Hide 
Range on Protein: 400-437
Range on HMM: 182-224/301
Sequence Identity: 43% (19 aa)

GTVMYMSPESCLGL------GTLTSNDVWSLGITAFHMATGTLP
|..||||||   |        ...| |.||||.| . .|||. |
GCQMYMSPERIQGQMPHRPSYSVKS-DIWSLGLTIWECATGKYP
Kinase LmjF11.0510.AA YSK 420-434 73 1e-05 12.87 In-house 183-197 (257) Show / Hide 
Range on Protein: 420-434
Range on HMM: 183-197/257
Sequence Identity: 73% (11 aa)

DVWSLGITAFHMATG
|.|||||||  ||.|
DIWSLGITAYEMAKG
Kinase LmjF11.0510.AA STE-Unique 537-569 36 1.4e-05 15.19 In-house 584-616 (616) Show / Hide 
Range on Protein: 537-569
Range on HMM: 584-616/616
Sequence Identity: 36% (12 aa)

SVSSEFRSFLEQCLTENPVKRPTCRQLRSHPFV
. . |.. |.| ||  ||..||.  ||. |.. 
KCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase LmjF11.0510.AA CAMK 400-439 25 0.000281 8.9 In-house 281-335 (425) Show / Hide 
Range on Protein: 400-439
Range on HMM: 281-335/425
Sequence Identity: 25% (14 aa)

GTVMYMS-PESCLG--------------LGTLTSNDVWSLGITAFHMATGTLPWR
||  ||. ||  .|               .   . |.||.|.  . | .|..|..
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
Kinase LmjF11.0510.AA STE20 302-351 28 0.000511 10.92 In-house 93-150 (288) Show / Hide 
Range on Protein: 302-351
Range on HMM: 93-150/288
Sequence Identity: 28% (17 aa)

GSVADVLR---RSG------PFPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILI
||. |...   . |      |. |..|   . |.| .|.  |. ....| |.|  |||.
GSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS-NHIIHRDIKADNILL
Kinase LmjF11.0510.AA STE20 420-437 66 0.006204 6.91 In-house 209-226 (288) Show / Hide 
Range on Protein: 420-437
Range on HMM: 209-226/288
Sequence Identity: 66% (12 aa)

DVWSLGITAFHMATGTLP
|.|||||||  ||.|  |
DIWSLGITAIEMAEGEPP
Kinase LmjF11.0510.AA STE11-Unclassified 302-351 40 0.032531 3.72 In-house 92-140 (308) Show / Hide 
Range on Protein: 302-351
Range on HMM: 92-140/308
Sequence Identity: 40% (20 aa)

GSVADVLRRSGPFPEPEIKRCMAEILSALQCVHEDHNCVHNDVKPHNILI
||..  |.. |.| |. ||    .||. |.  |. |. .| |.|. ||||
GSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHS-HGIIHRDIKGANILI