88246.m00062

Species: T.vaginalis
Alias: TvagK0959, 88246.m00062
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
88246.m00062.AA Protein None 1396 None Fasta, JSON
88246.m00062.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of 88246.m00062.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Ka 88246.m00062.AA PI3Ka 932-1014 25 2e-06 23.72 Pfam 83-174 (211) Show / Hide
Range on Protein: 932-1014
Range on HMM: 83-174/211
Sequence Identity: 25% (23 aa)

WSPLKPVQALSLLVPEIMN-DKRSASYVARCFEQ-FTRDESLMFIPQLVQSLRFD------THGVMQKFLMKFSESEE-VFSHYLLWNILAE
| |..|..||.|| ..  .     ..|  .| |. .. || | ...|||| |...        ..   || . . .   ...| . |.  .|
WPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSE

PI3Ka 88246.m00062.AA PI3Ka 888-1045 14 8.7e-05 -39.5 SMART 1-232 (232) Show / Hide
Range on Protein: 888-1045
Range on HMM: 1-232/232
Sequence Identity: 14% (33 aa)

QIENLM--SPILLKIIKNTM---------------------FHAATVPEMS------LFL-------AKQQAFDKSNFLFW--SPLKPVQALSLLVPEIM
  .     .... .  ...|                     ..  ..|.         ||       | . . . .    |   |..|..|| || |.  
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP

ND--KRSASYVARCFEQFTRDESLMFIPQLVQSLRFD----------------------------THGVMQKFLMKFSESEEVFSHYLLWNILAEK----
.       .|  .| ||.. || |....|||| |...                              . .  || . . .   ..|.. |.  .|     
DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFFYWYLKSEMYDHC

--NNHVTENDNLPQILTQLETKI-IDHMTPQQR
  ...    . .  .| ..  ..   || . ..
QLHDPHY-CQRFGMLLEMYCRGCCGHHMRHLFK

PI3Kc 88246.m00062.AA PI3Kc 1139-1393 25 6.7e-80 272.68 SMART 1-336 (336) Show / Hide
Range on Protein: 1139-1393
Range on HMM: 1-336/336
Sequence Identity: 25% (86 aa)

ACIFKIHDDVRQDAMMYQFIEVFKGIFRDA----GIDCFVYPYRVFATGENRGVIELIPKSKSRHDIGS-------------------------------
| ||| .|| |||..| |...... | .      . |. ..||.. .||.. |.||..| ....| | .                               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--------------------------------ATNEDLLHYFISKYGQIGTAAFNKAQENFVRSMAPNSLICYLFQVKDRHNANIMID-EDGHVIHIDFG
                                 . ..|...|...... .  ....|..||.||.|  . ..|.....|||| |||.| ..||..|||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

FIFEISPGGNMKF-----ERAPFKLSKEMIDLMGG-SKEAAPFKLFRKLLIQCMFAARARHEEIEAITNLMRSAGF-PCFRAD--SIKKLRERFCFG-MT
.||. .  ....|     ||.||.| ..|...|||  |..  |..||..  . . |.|  ...| .. ..| ...  ||.|..  .||.||.||.   ..
HIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLS

PKEVVQTVDS-----LIAGSYEAITTTGYDAFQASQNK
 .|. | ..      ||  | |. ||. |. |.  .. 
DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

PI3_PI4_kinase 88246.m00062.AA PI3_PI4_kinase 1137-1345 21 3.4e-43 154.6 Pfam 1-300 (300) Show / Hide
Range on Protein: 1137-1345
Range on HMM: 1-300/300
Sequence Identity: 21% (66 aa)

PFACIFKIHDDVR--QDAMMYQFI-----------------------EVFKGIFRDAGIDCF----VYPYRVFATGENRGVIELIPKSKSRHDIGSATN-
  . ||| .|| |  ||. | |.|                       ...... .  | |.     . |||. .||...|.||..| . . | | . .  
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

------------------------------------------EDLLHYFISKYGQIGTAAFNKAQENFVRSMAPNSLICYLFQVKDRHNANIMI---DED
                                          ..|...|......  . .. .| .|||||.|  . . |.... |||| |||.   ...
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDA-YEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT

GHVIHIDFGFIFE-ISPGGNMKFERAPFKLSK------EMIDLMGGS---KEAAPFKLFRKLLIQCMFAARARHEEIEAIT-------NLMRSAGFPCFR
||..|||||..|.     . .|.|| ||.. .      .|...|||    ..   . .||... . . | |  .. . .         ..|  .| |..|
GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR

A
 
S

Kinase 88246.m00062.AA ATR 1228-1335 30 2.4e-14 44.89 In-house 163-267 (267) Show / Hide
Range on Protein: 1228-1335
Range on HMM: 163-267/267
Sequence Identity: 30% (33 aa)

AQENFVRSMAPNSLICYLFQVKDRHNANIMIDE-DGHVIHIDFGFIFEISPGGNMKF-ERAPFKLSKEMIDLMGGSKEAAPFKLFRKLLIQCMFAARARH
..||..||.|  ... |.    |||  ||.||.  | ..|.|.  ||    |  ..  |  ||.| . |.  ||  |      |||. ..  |   | . 
SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNS--GEQFEVPEIVPFRLTHNMVFGMGPMKTYG---LFRRACEVIMMCMRDHR

EEIEAITNLM
..| .. .  
DDIMSVWDCF

Kinase 88246.m00062.AA FRAP 1231-1275 43 2.7e-08 26.7 In-house 139-184 (251) Show / Hide
Range on Protein: 1231-1275
Range on HMM: 139-184/251
Sequence Identity: 43% (20 aa)

NFVRSMAPNSLICYLFQVKDRHNANIMID-EDGHVIHIDFGFIFEI
|. ||.|  |.. |.    |||  |||..   | ..|||||  ||.
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEV

Kinase 88246.m00062.AA ATM 1232-1299 37 3.4e-07 18.61 In-house 140-207 (304) Show / Hide
Range on Protein: 1232-1299
Range on HMM: 140-207/304
Sequence Identity: 37% (27 aa)

FVRSMAPNSLICYLFQVKDRHNANIMIDEDG-HVIHIDFGFIFE---ISPGGNMKFERAPFKLSKEMIDLMG
. ||.|  |.. |.  . |||  ||.| |    ..||| |  ||   | |      |  ||.| ....| ||
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP----TPETVPFRLTRDIVDGMG

Kinase 88246.m00062.AA PIKK 1230-1299 41 4.6e-07 22.17 In-house 187-257 (290) Show / Hide
Range on Protein: 1230-1299
Range on HMM: 187-257/290
Sequence Identity: 41% (30 aa)

ENFVRSMAPNSLICYLFQVKDRHNANIMIDED-GHVIHIDFGFIFEISPGGNMKF-ERAPFKLSKEMIDLMG
||. || |  .   |     |||  |||||.. | ..|||||..|| | ..  .. |  || | . |...||
ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE-SAMQRLPVPEKVPFRLTRNMVNAMG

Kinase 88246.m00062.AA ATM 1141-1156 56 0.014778 3.53 In-house 3-18 (304) Show / Hide
Range on Protein: 1141-1156
Range on HMM: 3-18/304
Sequence Identity: 56% (9 aa)

IFKIHDDVRQDAMMYQ
. |  ||.||||.| |
LVKGRDDLRQDAVMQQ