Gene 82578.m00641 (T.vaginalis)

82578.m00641

Species: T.vaginalis
Alias: 82578.m00641, TvagK0275
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
82578.m00641.AA Protein None 802 None Fasta, JSON
82578.m00641.kin_dom Protein Kinase Domain None 182 None Fasta, JSON

Protein domain

Protein domains of 82578.m00641.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82578.m00641.AA TKL 97-276 18 3.3e-30 105.98 In-house 102-364 (364) Show / Hide 
Range on Protein: 97-276
Range on HMM: 102-364/364
Sequence Identity: 18% (51 aa)

FYVQP-----KPALITDHYPYGDLRNILFNYQDVEISPTHKVIIALCISYGMMKFHEKR--------FIHGNLNLSNIYLNNQKL--------------P
. ..|     ....... .| |.|...|         . ... .|| |. ||   | ..         || .|. .|| ...                 .
VCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VIC--GFERVN------------------------TYPDLISDPRYVAPELLNHK----------------EVDNKVDVYAFGFLLYELIEQKVAFEQYN
 ||  |. |..                        |    .  ||. |||.|. .                | . |.|||.|| .|.|..  .. ...|.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NNQII---------ALVQADK-RPQFT------------DKTPRSVATLIEQCWQQSPVNRPTFKFIYEEF
....|         ..|  .. ||               . .|.|.. |...||.. | .||.|. | ...
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 82578.m00641.AA TKL-Unique 181-276 27 1.2e-23 80.36 In-house 184-290 (290) Show / Hide 
Range on Protein: 181-276
Range on HMM: 184-290/290
Sequence Identity: 27% (29 aa)

PDLISDPRYVAPELLNH--KEVDNKVDVYAFGFLLYELIEQKV------AFEQYNNNQIIALVQA---DKRPQFTDKTPRSVATLIEQCWQQSPVNRPTF
.. .. .|..|||.|.   .  ..|.|||.||. |.|... |.       .. .. .|....|      .||   .  | .   ||.||| . |..||.|
QTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSF

KFIYEEF
  |... 
DEIIHRL
Kinase 82578.m00641.AA Dicty5 189-280 36 5.2e-23 76.03 In-house 169-260 (260) Show / Hide 
Range on Protein: 189-280
Range on HMM: 169-260/260
Sequence Identity: 36% (34 aa)

YVAPELLNHKEVDNKVDVYAFGFLLYELIEQKVAFEQYNNNQIIALVQADKRPQFTDKTPRSVATLIEQCWQQSPVNRPTFKFIYEEFAEGR
. |.|| | .  ..|.|||.||  |.|.. .| ...  ||  |  .|.   ||      | . . ||. |||| | |||.|| | . |    
WMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 82578.m00641.AA LRRK 187-278 27 3.1e-22 75.45 In-house 243-351 (351) Show / Hide 
Range on Protein: 187-278
Range on HMM: 243-351/351
Sequence Identity: 27% (30 aa)

PRYVAPELLN---HKEVDNKVDVYAFGFLLYELIEQK-VAFEQYN-------NNQIIALVQADKRPQFTDK-TPR-----SVATLIEQCWQQSPVNRPTF
|...||| ..    .| . |||.|.|| .|.||.  .  .|....       ..||  ...   || .     |.     .. .||..|||. | .||.|
PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHF

KFIYEEFAE
  | .   .
SQIVKRLSQ
Kinase 82578.m00641.AA RIPK 189-276 27 4.5e-19 61.62 In-house 188-290 (290) Show / Hide 
Range on Protein: 189-276
Range on HMM: 188-290/290
Sequence Identity: 27% (28 aa)

YVAPELLN---HKE---VDNKVDVYAFGFLLYELIEQKVAFEQ-YNNNQIIALVQADKRPQFTD---KTPRS-----VATLIEQCWQQSPVNRPTFKFIY
| .||...    |    |. | ||| |.....|.  || ..|   .  .|.. .....||. ..   ..|.         |...|||| | .||.|  . 
YMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECE

EEF
|..
EWT
Kinase 82578.m00641.AA TKL-ciliate1 187-276 24 9.1e-16 50.45 In-house 178-279 (279) Show / Hide 
Range on Protein: 187-276
Range on HMM: 178-279/279
Sequence Identity: 24% (25 aa)

PRYVAPELLN-----HKEVDNKVDVYAFGFLLYELIEQKVAF-EQYNNNQIIALVQADK-RPQF-----TDKTPRSVATLIEQCWQQSPVNRPTFKFIYE
. . ||| .       . .  |.|.||.| ..|.|.  |  | .. .   |. ..   . ||         ..| .. .|.  || | |  || |  | .
FHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQ

EF
  
IL
Kinase 82578.m00641.AA Pkinase_Tyr 188-276 27 1.9e-14 49.58 Pfam 179-270 (270) Show / Hide 
Range on Protein: 188-276
Range on HMM: 179-270/270
Sequence Identity: 27% (25 aa)

RYVAPELLNHKEVDNKVDVYAFGFLLYELIE-QKVA-FEQYNNNQIIALV-QADKRPQFTDKTPRSVATLIEQCWQQSPVNRPTFKFIYEEF
.  ||| .|...   | ||..|| |..|..   .   ..   |....... .   |    ...|  . .|. |||.. | .||||. |.|..
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 82578.m00641.AA RAF 205-276 29 2e-14 45.82 In-house 199-275 (275) Show / Hide 
Range on Protein: 205-276
Range on HMM: 199-275/275
Sequence Identity: 29% (23 aa)

DVYAFGFLLYELIEQKVAFE-QYNNNQIIALVQAD----KRPQFTDKTPRSVATLIEQCWQQSPVNRPTFKFIYEEF
||||||  .|||. .   .    .  |||. |.      .|..   ..|...  |.. || ..|  ||.|  | .. 
DVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase 82578.m00641.AA MLK 187-276 27 2.1e-14 46.46 In-house 197-291 (291) Show / Hide 
Range on Protein: 187-276
Range on HMM: 197-291/291
Sequence Identity: 27% (26 aa)

PRYVAPELL---NHKEVDNKVDVYAFGFLLYELIEQKVAFE-QYNNNQIIALVQADK-RPQFTDKTPRSVATLIEQCWQQSPVNRPTFKFIYEEF
... ||| .    .  .. |.||. .| .|.|..  .| ..  |.. .|.. | . . ||      |.. . |..|||.| | .||.|. | ...
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 82578.m00641.AA TK 99-276 12 7e-14 42.17 In-house 126-486 (486) Show / Hide 
Range on Protein: 99-276
Range on HMM: 126-486/486
Sequence Identity: 12% (46 aa)

VQPKPALITDHYPYGD----LRNILFNY------------------------------------------------------------------------
.|. . ... . |.||    ||. | .                                                                         
HQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWC

--QDVEISPTHKVIIALCISYGMMKFHEK------RFIHGNLNLSNIYLNNQKL-----------PVICGFE----------RVNTY------------P
  ..  ... ... ... |. ||   |.|      .|.|..|   |. .....              |. |           |   .            .
LTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTG

DLISD--------------------PRYVAPELLNHKE---------VDNKVDVYAFGFLLYELIE--QKVAFEQYNN---------NQIIALVQAD---
... .                     |. ||| ||...            | ||..|| |..|.    |.   .. .|          ... ....    
RPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL

-----------KRPQFTDKTP--------------RSVATLIEQCWQQSPVNRPTFKFIYEEF
            |.   .  |                .. |. |||.  |  ||||. ..|..
CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 82578.m00641.AA Fer 188-277 23 1.3e-13 42.79 In-house 183-283 (283) Show / Hide 
Range on Protein: 188-277
Range on HMM: 183-283/283
Sequence Identity: 23% (24 aa)

RYVAPELLNHKEVDNKVDVYAFGFLLYELIEQKVAFEQYNN--------NQ----IIALVQADKRPQFTDKTPRSVATLIE-QCWQQSPVNRPTFKFIYE
|. ||| .. ..   | ||..|| ...|  .   . | | .        |.    . . ........... .|  .. ... ||||. | .|||.| |..
RWLAPETWQTGIYSPKTDVWSFGVMCWEIFT--NGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQ

EFA
.. 
KLK
Kinase 82578.m00641.AA Pkinase 187-276 20 8.4e-13 46.34 Pfam 175-293 (293) Show / Hide 
Range on Protein: 187-276
Range on HMM: 175-293/293
Sequence Identity: 20% (24 aa)

PRYVAPELLN-HKEVDNKVDVYAFGFLLYELIEQKVAFEQY----NNNQIIALVQADKRPQFTDKTP-----------------------RSVATLIEQC
|.|.|||... ... . |||....| .|||..  .  | .     | .  ..... ...|..    |                       ..   .|. |
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WQQSPVNRPTFKFIYEE--F
... |  |||.. | .   |
LCKDPKKRPTAEQILQHPWF
S_TKc 82578.m00641.AA S_TKc 35-277 15 3.5e-11 -12.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-277
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)

FQKLSLINKNEFSTSFCVSDITNDENFLL--IEYNDSASELNEFLNTCYAAAQCNSSFLMPLRAFYVQPKPALITDHYPY--GDLRNILFNYQDVE----
...| .| |  |.. ... ..  .. . .  |      . ..|           .  ..  |  ...  .  ..... .   |||. .. ...       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-----HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ISPTHKVIIALCISYGMMKFHEKRFIHGNLNLSNIYLNNQKLPVICGF---ERVNTYPDLISDPRYVAPELLNHKEVDN-KVDVYAFGFLLYELIEQKVA
... |   ..  |  ..   |....||  |  .|| |..     || |    ..     ..  | |.|||.|     .  |.|....| .|||..  .  
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP

FEQYNNNQIIALVQADKRPQFTDKTPRSVATLIEQCWQQSPVNRPTFKFIYE--------EFA
|.  . .... ..            ....  .|..|.|  | .|||   . .        .. 
FP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc 82578.m00641.AA TyrKc 55-276 17 1.4e-10 -51.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-276
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

ITNDE-----NFLLIEY------------NDSASELNEFLNTCYAAAQC--NSSFLMPLRAFYVQ--------PKPALITDHYPYGDLRNILFNYQDVEI
|| ..     .|  .              ...|  . .|..      .   .   .  | .  .|        . . ... . |.|||.. | ....  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L

SPTHKVIIALCISYGMMKFHEKRFIHGNLNLSNIYLNNQKLPVICGF---ERVNTY------PDLIS-----DPR------YVAPELLNHKEVDNKVDVY
.. ... ... |. ||   |.|..||  |   |. .....   |. |     .  .       | ..     . .        ||| .|...   | ||.
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

AFGFLLYELIEQKVAFEQY------NNNQIIALVQADKRPQFTDK--------TPRSVATLIEQCWQQSPVNRPTFKFIYEEF
.|| ...|.                .| ..|..|.. .|.   .          |  . ....|||.  | .||||. |.|.|
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 82578.m00641.AA LRRK 103-156 30 0.004642 6.65 In-house 130-192 (351) Show / Hide 
Range on Protein: 103-156
Range on HMM: 130-192/351
Sequence Identity: 30% (19 aa)

PALITDHYPYGDLRNILFNYQDVE-------ISPTHKVIIALCISYGMMKFHEKR--FIHGNL
......  |.|||   |.|..  .       ||.. |  ||| |. || . | ..  .|| .|
LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDL
Kinase 82578.m00641.AA TKL-Unique 100-165 24 0.027306 4.1 In-house 69-147 (290) Show / Hide 
Range on Protein: 100-165
Range on HMM: 69-147/290
Sequence Identity: 24% (19 aa)

QPKPA---LITDHYPYGDLRNILF--------NYQDVEISPTHKVIIALCISYGMMKFHEKR--FIHGNLNLSNIYLNN
|..|.   .... .| | |.. |         | .  ....  .| .|..|. ||   | .    ||..|  ||....|
QVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDN
Kinase 82578.m00641.AA Pkinase_Tyr 105-156 22 6.911374 0.24 Pfam 84-137 (270) Show / Hide 
Range on Protein: 105-156
Range on HMM: 84-137/270
Sequence Identity: 22% (12 aa)

LITDHYPYGDLRNILFNY--QDVEISPTHKVIIALCISYGMMKFHEKRFIHGNL
... . |.|||.. | .   ..  ... ... ... |. ||   ..|..||  |
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL