Gene 92921.m00340 (T.vaginalis)

92921.m00340

Species: T.vaginalis
Alias: 92921.m00340, TvagK0837
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8-like

Sequence

Name Sequence Type Origin Length Description Download
92921.m00340.AA Protein None 351 None Fasta, JSON
92921.m00340.kin_dom Protein Kinase Domain None 278 None Fasta, JSON

Protein domain

Protein domains of 92921.m00340.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92921.m00340.AA CMGC 45-322 21 6.5e-62 201.86 In-house 42-513 (513) Show / Hide 
Range on Protein: 45-322
Range on HMM: 42-513/513
Sequence Identity: 21% (102 aa)

AMKRMNLKQEDTT----------IPPYIIRELAITSELN-----------------SPHIVHPAVNDISYEPK---------------DRTISYVYEYGA
|.|.. ... ...          .|  ..||. |  .||                  ..||.    || | ..               .. .  | ||  
AIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVK--LYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD

ADVKRVMSTKK--------VPLKETT------------IKSIL------FQILLGLD--YMHSRG--ISHCNVTPSNLLIMPTTSQ--------------
 | ....  ..        .||.|              ||...      .||| ||.  |.||..  | |.   |.|.|| ...                
HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC

-TPGILRFIDFSLARVAEPVQKL----------------KPLNSIY-----LGYRAPEIVLGQSDYS---------YPSDIWSAGCIFAELLT-------
   |.|. .|| |||  .| ..                 ||.  ..     . |||||| || ..|.         .| |.||.||||||..|       
QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIF

--GTLFD--------VQKINPQDQIQVMLRKYFEVIGSMS---------------QDDFPRHEKYTNWMT------------FQQMLSSNQLQMRNSKGQ
   .||           | | .. |  .| | |.|.|. .               ....| . |. .. .            ..     |..|. |....
RGKPLFPGHSEYPNDD-K-NGKSHID-QLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPW

LYQKVAS----------------------------------------LNPEIQDLLFKMLTYNPDLRITAKDALRHPYF
 . |  .                                        ..|.  ||| |||.|.|| ||||..||.||||
WPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 92921.m00340.AA CDK5 45-322 33 5.4e-44 136.6 In-house 28-287 (287) Show / Hide 
Range on Protein: 45-322
Range on HMM: 28-287/287
Sequence Identity: 33% (93 aa)

AMKRMNLKQEDTTIPPYIIRELAITSELNSPHIVHPAVNDISYEPKDRTISYVYEYGAADVKRVMSTKKVPLKETTIKSILFQILLGLDYMHSRGISHCN
|.||  | .||  .|   ||| ..  ||  . ||     |.     .. .  |.|.   | |. |   .. .   .|||...| | || . |.. . |  
ALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVR--LHDVIHS--EKKLTLVFEFCDQDLKKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRD

VTPSNLLIMPTTSQTPGILRFIDFSLARVAE-PVQKLKPLNSIYLGYRAPEIVLGQSDYSYPSDIWSAGCIFAELL-TGT-LFDVQKINPQDQIQVMLRK
  | ||||      . |.|.  || |||    ||.       . | ||.| . .|   || . |.||.||||||.  .|  ||      |  . .  | .
LKPQNLLI-----NKNGELKLADFGLARAFGIPVRCYS-HEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF------PGNDVEDQLKR

YFEVIGSMSQDDFPRHEKYTNWMTFQQMLSSNQLQMRNSKGQLYQKVASLNPEIQDLLFKMLTYNPDLRITAKDALRHPYF
 |...|. . |  |   |  ..    |     |. |.. .  . | | .|. .  ||| ||| .||. ||.||.||.||||
IFKIMGTPCEDKWPSITKLPDYKPNHQ-----QYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
S_TKc 92921.m00340.AA S_TKc 16-322 19 6.4e-42 146.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-322
Range on HMM: 1-231/231
Sequence Identity: 19% (65 aa)

FTNMENISTTQTTVISKVFKTDSSDRTPLAMKRMNLKQEDTTIPPYIIRELAITSELNSPHIVHPAVNDISYEPKDRTISYVYEYGAA---DVKRVMSTK
.. .. |      .  |. ...  .    |.|...           |.||..| .. . |.||.    |. ..     .  | ||      |.....  .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVK--LYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR

KVP-----LKETTIKSILFQILLGLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARVAEPVQKLKPLNSIYLG---YRAPEIVLGQSDYSY
. .     . | ...... ||...|.|.||.|| |. . |.|.|.          .  .|| |||.           . . |   |.|||..     |..
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGK

-PSDIWSAGCIFAELLTGTL-FDVQKINPQDQIQVMLRKYFEVIGSMSQDDFPRHEKYTNWMTFQQMLSSNQLQMRNSKGQLYQKVASLNPEIQDLLFKM
 ..|.|| |||..|.|.|   |.    ..|  .....                                                     ||  |.. |.
CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------------------------------------SPEAKDFIRKC

LTYNPDLRITAKDALR-------HPYF
|...|. |.|| .||.       ||.|
LQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92921.m00340.AA nmo 115-322 35 2.9e-35 105.43 In-house 98-292 (292) Show / Hide 
Range on Protein: 115-322
Range on HMM: 98-292/292
Sequence Identity: 35% (76 aa)

PLKETTIKSILFQILLGLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARVAEPVQKLKPLNSIYLG-YRAPEIVLGQSDYSYPSDIWSAGC
.|    .|  |.||| || |.|| .| |  . | |||.         .|.  || |||| |. |...  . .    ||||||..|   |.   |||| ||
HLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNC-----VLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGC

IFAELLTGTLFDVQKINPQDQIQVMLRKYFEVIGSMSQDDFPRHEKYTNWMTFQQMLSSNQLQMRNSKGQLYQKVAS---LNPEIQDLLFKMLTYNPDLR
||||||   .   |  .| .|.|..     ...|  |..|     ||      . ||   . .   .  .|| ...|    . |  .|| .|| ..|| |
IFAELLGRRIL-FQAQSPIQQLQMIT----DLLGTPSMEDM----KYACEGAKAHMLRMPHKPPCLQ--VLY-TLSSPDHATHEAVHLLCRMLHFDPDKR

ITAKDALRHPYF
| .|||| ||| 
ISCKDALAHPYL
Kinase 92921.m00340.AA CDC2 45-220 34 6e-32 95.08 In-house 28-204 (301) Show / Hide 
Range on Protein: 45-220
Range on HMM: 28-204/301
Sequence Identity: 34% (65 aa)

AMKRMNLKQEDTT--IPPYIIRELAITSELN-SPHIVHPAVNDISYEPKDRTISYVYEYGAADVKRVMS---TKKVPLKETTIKSILFQILLGLDYMHSR
|.|.  |.|||    .|  .|||. .  ||.  | ||     |. ..   . .  | ||   | |. |     |. .. . ..||...||| |... |.|
ALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIV--KLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQR

GISHCNVTPSNLLIMPTTSQTPGILRFIDFSLAR-VAEPVQKLKPL-NSIYLGYRAPEIVLGQSDYSYPSDIWSAGCIFAEL---LT
.| | .  |.|.||  . .     ..  || ||| .  |. .. .  . . | |||||| ||...|| | |.|| ||||||.    |
RIMHRDLKPQNILIDKKGN-----IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVT
Kinase 92921.m00340.AA CDK 190-322 31 8e-32 98.97 In-house 185-284 (284) Show / Hide 
Range on Protein: 190-322
Range on HMM: 185-284/284
Sequence Identity: 31% (45 aa)

YRAPEIVLGQSDYS--YPSDIWSAGCIFAELLT---------GTLFDVQKINPQDQIQVMLRKYFEVIGSMSQDDFPRHEKYTNWMTFQQMLSSNQLQMR
|||||. ||...||   | |.||.||||||..|         |.         .||.       |...|. . |. |  .|. ..               
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE-------IDQLFKI----FRICGTPTEDNWPGVTKLPDY---------------

NSKGQLYQKVASLNPEIQDLLFKMLTYNPDLRITAKDALRHPYF
                  ||| |||.|.|. ||.|..|| ||||
------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 92921.m00340.AA Pkinase 45-241 28 4.4e-28 100.39 Pfam 28-230 (293) Show / Hide 
Range on Protein: 45-241
Range on HMM: 28-230/293
Sequence Identity: 28% (60 aa)

AMKRMNLKQEDTTIPPYIIR--ELAITSELNSPHIVHPAVNDISYEPKDRTISYVYEYGAADVKRVMSTK-------KVPL--KETTIKSILFQILLGLD
|.|..... |.   . . .|  |..|  .||.|.||     |. ..  .. |  | ||   ... ||. .       . ..   | ..|... ||| ||.
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVR--LYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

YMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARVAEPVQKLKPLNSIY--LGYRAPEIVLGQSDYSYPSDIWSAGCIFAELLTG-TLFDVQK--
|.||.|| |. . |.|.||   . ... ... .|| ||....   .   ....   ..|.|||...|...|....|.||.|||..|.|.| ..|. ..  
YCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCW

-INPQDQIQVMLRK
 .|  ||.|.. |.
HDN-HDQMQMICRI
Kinase 92921.m00340.AA JNK 120-222 30 8.1e-21 74.04 In-house 107-204 (309) Show / Hide 
Range on Protein: 120-222
Range on HMM: 107-204/309
Sequence Identity: 30% (33 aa)

TIKSILFQILLGLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARVAEPVQKLKPLNSIYLG---YRAPEIVLGQS-DYSYPSDIWSAGCIF
.......|...|  ..|| ||.|    ||| ..      . ..|   || .|| . |       .. | .   |||||...|    |.   |||| |||.
RMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVV-----NQDCTLKICDFGHARTEDPT----FMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIM

AELLTGT
||.....
AEMIRHH
Kinase 92921.m00340.AA PITSLRE 104-221 41 9.8e-19 64.97 In-house 88-203 (295) Show / Hide 
Range on Protein: 104-221
Range on HMM: 88-203/295
Sequence Identity: 41% (51 aa)

DVKRVMSTKK---VPLKETTIKSILFQILLGLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARV-AEPVQKLKPLNSIY--LGYRAPEIVL
|.| .| . |    | |.  ||. . | |.| ..||.  | |     ||||.        |||   || |||   .|   .||. ..   | |||||. |
DLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHK-----GILKICDFGLAREYGSP---IKPYTPCVVTLWYRAPELLL

GQSDYSYPSDIWSAGCIFAELLTG
|.  || | |.|| ||||||..|.
GCKKYSTPVDMWSVGCIFAEFITM
Kinase 92921.m00340.AA MAPK 292-322 61 1.4e-16 53.61 In-house 298-328 (328) Show / Hide 
Range on Protein: 292-322
Range on HMM: 298-328/328
Sequence Identity: 61% (19 aa)

NPEIQDLLFKMLTYNPDLRITAKDALRHPYF
||.  |||.|||. .|| |||...||.||||
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 92921.m00340.AA CDC2 297-322 65 4.9e-15 42.15 In-house 276-301 (301) Show / Hide 
Range on Protein: 297-322
Range on HMM: 276-301/301
Sequence Identity: 65% (17 aa)

DLLFKMLTYNPDLRITAKDALRHPYF
||| .|| |.|  ||.||.||.||||
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase 92921.m00340.AA RCK 288-322 42 7.8e-15 43.22 In-house 264-298 (298) Show / Hide 
Range on Protein: 288-322
Range on HMM: 264-298/298
Sequence Identity: 42% (15 aa)

VASLNPEIQDLLFKMLTYNPDLRITAKDALRHPYF
. .....  .|..|||...|. ||||. ||.||||
IPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 92921.m00340.AA MAPK 190-222 52 1.7e-14 46.33 In-house 197-232 (328) Show / Hide 
Range on Protein: 190-222
Range on HMM: 197-232/328
Sequence Identity: 52% (19 aa)

YRAPEIVLG--QSDYSYPSDIWSAGCIFAELLT-GT
|||||| |.    .|.   |.||.||||||.|| ..
YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRK
Kinase 92921.m00340.AA RCK 115-172 32 3.8e-14 40.99 In-house 99-162 (298) Show / Hide 
Range on Protein: 115-172
Range on HMM: 99-162/298
Sequence Identity: 32% (21 aa)

PLKETT--IKSILFQILLGLDYMHSRGISHCNVTPSNLLIMP----TTSQTPGILRFIDFSLAR
.| |..  ||.|..|||.||..||. |. |  . | |.....       | ....  .||.|.|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCR
Kinase 92921.m00340.AA MAPK-Unclassified 190-241 30 5.9e-14 46.37 In-house 414-495 (575) Show / Hide 
Range on Protein: 190-241
Range on HMM: 414-495/575
Sequence Identity: 30% (25 aa)

YRAPEIVLGQSDYSYPSDIWSAGCIFAELLT------------GTLFDVQK------------------INPQDQIQVMLRK
|||||| |  ..|.  .||||.||||||..             . ||  |                      ||||.. . .
YRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDY
Kinase 92921.m00340.AA CDK 45-172 28 3.3e-13 38.44 In-house 33-161 (284) Show / Hide 
Range on Protein: 45-172
Range on HMM: 33-161/284
Sequence Identity: 28% (41 aa)

AMKRMNLKQ-----EDTTIPPYIIRELAITSELNSPHIVHPAVNDISYEPK---------DRTISYVYEYGAADVKRVMSTKKVPLKETTIKSILFQILL
|.|.  . .     |.. .|   ||| ..  ||  |.||   . |. .  .         ..... | ||   | | .|.          ||....|.| 
ALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVK--LHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD----------IKCYMWQLLR

GLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLAR
||.|.||..| |    |.|.||. . . ..| |   || |||
GLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
Kinase 92921.m00340.AA RCK 190-220 51 5.9e-13 37.16 In-house 179-209 (298) Show / Hide 
Range on Protein: 190-220
Range on HMM: 179-209/298
Sequence Identity: 51% (16 aa)

YRAPEIVLGQSDYSYPSDIWSAGCIFAELLT
|||||. | .  |..| |||. |||..|| .
YRAPECLLRCTYYNSPMDIWAVGCIMYELYM
Kinase 92921.m00340.AA PITSLRE 297-322 73 1.7e-12 41.95 In-house 270-295 (295) Show / Hide 
Range on Protein: 297-322
Range on HMM: 270-295/295
Sequence Identity: 73% (19 aa)

DLLFKMLTYNPDLRITAKDALRHPYF
||| .||||||  |||| ||| ||.|
DLLNQMLTYNPKNRITASDALKHPWF
Kinase 92921.m00340.AA MAPK-Unclassified 292-322 58 4.9e-11 35.63 In-house 545-575 (575) Show / Hide 
Range on Protein: 292-322
Range on HMM: 545-575/575
Sequence Identity: 58% (18 aa)

NPEIQDLLFKMLTYNPDLRITAKDALRHPYF
|.| .|.. ||| .||  |||| .|| ||||
NCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 92921.m00340.AA Pkinase 291-322 34 4.1e-10 36.86 Pfam 262-293 (293) Show / Hide 
Range on Protein: 291-322
Range on HMM: 262-293/293
Sequence Identity: 34% (11 aa)

LNPEIQDLLFKMLTYNPDLRITAKDALRHPYF
...| .|.. ..|...|  |.||...| ||.|
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 92921.m00340.AA JNK 297-322 65 1.7e-09 31.52 In-house 284-309 (309) Show / Hide 
Range on Protein: 297-322
Range on HMM: 284-309/309
Sequence Identity: 65% (17 aa)

DLLFKMLTYNPDLRITAKDALRHPYF
||||.||  ||| ||   |||.||| 
DLLFRMLVINPDDRISVDDALQHPYI
Kinase 92921.m00340.AA MAPK 103-152 32 4e-09 27.47 In-house 100-150 (328) Show / Hide 
Range on Protein: 103-152
Range on HMM: 100-150/328
Sequence Identity: 32% (17 aa)

ADVKRVMSTKKVPLKETTIKSILFQILLG--LDYMHSRGISHCNVTPSNLLI
.|  ... . . || .  |.....||| |  | |.|| .. |.   |||.|.
TDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV
Kinase 92921.m00340.AA MAPK-Unclassified 115-181 35 2e-07 22.37 In-house 105-166 (575) Show / Hide 
Range on Protein: 115-181
Range on HMM: 105-166/575
Sequence Identity: 35% (24 aa)

PLKETTIKSILFQILLGLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARVAEPVQKLK
.. .  |. .. ||| || |.||..| |    ||||||        . .|  || ..|  |  |.|.
HWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLI-----NQDCSVRICDFGMSRSIEDNQNLR
TyrKc 92921.m00340.AA TyrKc 27-322 16 0.000827 -161.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-322
Range on HMM: 1-280/280
Sequence Identity: 16% (55 aa)

TTVISK--------VFKTDSSDRTPLAMKRMNLKQEDTTIPPYIIRELAITSEL--NSPHIVHPAVNDISYEP-----KDRTISYVYEYGAA-DVKRVMS
 | . |        |.|   .  .. | | ..           ..||. | ..|  . |.||  .   .  ..      .  .  | || .  | |    
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIV--RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

TKKVPLKETTIKSILFQILLGLDYMHSRGISHCNVTPSNLLIMPTTSQTPGILRFIDFSLARVAEPV------QKLKPL----NSIY-LGYR--APEIVL
 ..  |.  .  |. .||  | .| ||... |      | |.         . .  || |.|  .        .. .      .. . | .|  |||   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

GQSD-YSYPSDIWSAGCIFAELLTGTLFDVQK-----INPQDQIQVMLRKYFEVIGSM----SQDDFPRHEKYTNWMTFQQMLSSNQLQMRNSKGQLYQK
 .   ..  ||.|| |    |..|             ...|. |.   . |   .       |                                  .  
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F--

VASLNPEIQDLLFKMLTYNPDLRITAKDALRHPYF
     .|. ..  .   ..|. | | ..   | .|
-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF