Gene 89419.m00166 (T.vaginalis)

89419.m00166

Species: T.vaginalis
Alias: TvagK0943, 89419.m00166
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
89419.m00166.AA Protein None 341 None Fasta, JSON
89419.m00166.kin_dom Protein Kinase Domain None 216 None Fasta, JSON

Protein domain

Protein domains of 89419.m00166.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89419.m00166.AA Ciliate-E2 59-267 18 9.8e-29 95.76 In-house 61-365 (365) Show / Hide 
Range on Protein: 59-267
Range on HMM: 61-365/365
Sequence Identity: 18% (58 aa)

NELIQEIEIIR----------------QLSHPNIVRVIDFLN--DDIRMYLITEFFSFMSLEGFLSYN------------VPNEHQCHIIISGIIN----
... ||| |.|                ||.||||.. ...    ||  .||..|... ..|. ..  |             ..| ..  |.  |..    
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKT

-----------GLLELHSHQ-IHHGDLTPANIFLGNKMSPKICNFAF-------------------LSQYYQKPEKHFSNY--------------NINFI
           .| .|||   | | |. | ||..     .||. | .                   . .  .. .......              . .. 
KAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM

SPERIQLDLS--------HPLQGDIWSFGVIIYLLYVKDMPFTQINEIKLIASMI-SCQYNPP----------------SITNDIIKRLIGA----ILVP
.|| ..            .  . ||||.|||.| .  .  ||       ..  .   .....|                    .  | ||      .|. 
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK

IPEDRPT-IEQIKDLYFS
 || |.| .|||..  . 
DPEKRITGWEQILNHPWF
Kinase 89419.m00166.AA PLK1 54-267 30 2.6e-26 83.3 In-house 39-253 (253) Show / Hide 
Range on Protein: 54-267
Range on HMM: 39-253/253
Sequence Identity: 30% (65 aa)

KANKWNELIQEIEIIRQLSHPNIVRVIDFLNDDIRMYLITEFFSFMSL-EGFLSYNVPNEHQCHIIISGIINGLLELHSHQIHHGDLTPANIFLGNKMSP
| .. . . |||.| |||.|..||.. .|  |.  .|.. |  .  || |         |. |   .  |..| . ||  .| | ||   |.|| ...  
KQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQV

KICNFAFLSQYYQK-PEKHFSNYNINFISPERIQLDLSHPLQGDIWSFGVIIYLLYVKDMPFTQINEIKLIASMISCQYNPPSITNDIIKRLIGAILVPI
||  |    .  ..   |.      |.| || .  .  |    |||| | |.|.| .   ||           .  ..|  ||. .   ..|| ..| | 
KIGDFGLATKCEYDGERKKTLCGTPNYIAPE-VLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPD

PEDRPTIEQIKDLYFS
|. ||||||.    | 
PTRRPTIEQVLNDEFF
Kinase 89419.m00166.AA CAMK 51-263 16 1e-25 79.24 In-house 35-421 (425) Show / Hide 
Range on Protein: 51-263
Range on HMM: 35-421/425
Sequence Identity: 16% (63 aa)

AVKK---------------------------------ANKWNELIQEIEIIRQLS-------HPNIVRVIDFLND-------------------DIRMYL
|.|                                  ...  .. .|||| ..|.       ||||.. ...  |                   | .||.
AIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYM

IT-------------EFFSFMSLEGFLSYN----------VPNEHQCHIIISGIINGLLELHSHQIHHGDLTPANIFLGNKM-----------------S
..             . |..    |  . .            .|.... ..  |. ..  .||| | | || | || | ...                  
VMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNN

PKICNFAFLSQYYQKPEKHF-------------------------SNYNINFIS-PERIQL-------------DLSHPLQGDIWSFGVIIYLLYVKDMP
 ||. |  ....... |. |                         .     ... || ..                 .. . |.|| ||| | . .  .|
IKIIDFG-FANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP

FTQI-------------NEIKLIASMISCQYN-PPS----------------ITND-------IIKRLIGAILVPIPEDRPTIEQIKD
|                |. .|    ....|. ||.                |...         | ||  .|.. ||.|.||||...
FYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase 89419.m00166.AA SAK 63-267 29 3.2e-25 82.63 In-house 48-254 (254) Show / Hide 
Range on Protein: 63-267
Range on HMM: 48-254/254
Sequence Identity: 29% (62 aa)

QEIEIIRQLSHPNIVRVIDFLNDDIRMYLITEFFSFMSLEGFLSYNVP--NEHQCHIIISGIINGLLELHSHQIHHGDLTPANIFLGNKMSPKICNFAFL
.|.||  || || |. .  . .|   .||. |.     .. ..   .    |.    ..  |. |.| |||| | | ||| .|| |  .|  ||  |   
NEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLA

SQYYQKPEKHFSNYNI-NFISPERIQLDLSHPLQGDIWSFGVIIYLLYVKDMPFTQINEIKLIASMISCQYNPPSITNDIIKRLIGAILVPIPEDRPTIE
.|     |||.      |.|||| |    .| || |.|| | ..| | .   ||      . .  ..  .|  |.      . ||  .|   |..| |..
TQLKMPHEKHYTMCGTPNYISPE-IATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLS

QIKDLYFS
 . .  | 
TVLCHPFM
Kinase 89419.m00166.AA STE 29-260 18 1.4e-20 69.5 In-house 1-350 (359) Show / Hide 
Range on Protein: 29-260
Range on HMM: 1-350/359
Sequence Identity: 18% (66 aa)

YQRCIVIGM--DGASYHCYNFN------------------TAAVKKAN----------------------KWNELIQEIEIIRQLS--HPNIVRVIDFLN
...  .||    |  | ..| .                    |.|. |                      .......||.| ....  |||||. ..   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-------IRMYLITEFFSFMSLEGFLS--YNVPN-------------EHQCHIIISGIING-LLELHSHQIHHGDLTPANIFLGNKMSPKICNFAFLS
..          ... |. .  ||. ..   | ...             |.|  .|.  |. | |  ||||.| | |. ||||.|      |.|.| . .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QYYQ-------------------KPEKHFSNYNINFISPERIQLDLSHPL------QGDIWSFGVIIYLLYVKDMPF---TQINEIKLIASMISCQ----
|  .                   |           . .||.|| . ..        . ||||.|  |  .     |.   .    . .|. .. .|    
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------YNPPSITN----------------------DIIKRLIGAILVPIPEDRPTIEQ
       .||.. .                      .  |  |   |.  |..||| .|
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 89419.m00166.AA TKL 51-265 15 2.9e-20 69.66 In-house 30-364 (364) Show / Hide 
Range on Protein: 51-265
Range on HMM: 30-364/364
Sequence Identity: 15% (54 aa)

AVKKANK--------------------------------WNELIQEIEIIRQLSHPNIVRVIDFLNDDIR-------------MYLITEFFSFMSLEGFL
|||| ..                                  ....|| ....|.|||||. . . ..                .....|. .  ||. .|
AVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYL

SYNVPNEHQCHIIISGIINGLLELHSHQ--------IHHGDLTPANIFLGNKMS--------------PKICNFAFLS---------------------Q
       || . .. .|  |.  |||..        | | ||...||.. ...               .||| | .                       |
H-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ

YYQKPEKHFSNYNINFISPERIQLD---------------LSHPLQGDIWSFGVIIYLLYVKDMPFTQINEIKLIAS-------MISCQYN-PPSIT---
  ..  ..    .... .|| .. .               ..   . |..|||.... ..    |. .....  |..       |. |. . .| |    
-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIW

---------NDI---IKRLIGAILVPIPEDRPTIEQIKDLY
         .|.   .|.|.     . ||.||. ..|..  
QNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 89419.m00166.AA Ciliate-E2-Unclassified 53-267 19 2.8e-18 60.03 In-house 46-352 (352) Show / Hide 
Range on Protein: 53-267
Range on HMM: 46-352/352
Sequence Identity: 19% (59 aa)

KKANKWNELIQEIE---------------IIRQLSHPNIVRVIDFLNDDIRMYLITEFF------SFMSLEGF------------LSYNVPNEHQCH---
|. ...||.... .               | ... ||.||. ..  .|.  .|...|..       ...  ..            .. .   | |.    
KD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKK

--IIISGIINGLLELHSHQ-IHHGDLTPANIFLGNKM---SPKICNFAFLSQYYQ---------------KPEKHFSNY-NINFI----SPERIQL-DLS
   ..  |..||  ||. . | | |..| ||.. |..    .||. | . ..| |               |...  ..  ..|..    .|| .|    .
AKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYD

HP--LQGDIWSFGVIIYLLYVKDMPFTQINEIK----------------LIASMISCQYNPPSITN------------DIIKRLIGAILVPIPEDRPTIE
|.   . ||||.|||.| .     || . |...                |.   . .... |.  .            |.|..|.  .|.  |. |.|.|
HSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFE

QIKDLYFS
||.   . 
QILNHPWF
Kinase 89419.m00166.AA S_TKc 29-266 22 4.8e-16 58.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-266
Range on HMM: 1-231/231
Sequence Identity: 22% (60 aa)

YQRCIVI--GMDGASYHCYNFN---TAAVKKANKWNELIQEIEIIRQLSHPNIVRVIDFLNDDIRMYLITEFFSF--MSLEGFLSYNVP-------NEHQ
|.   .|  |  |  | |.. .     |.|. .  . ...||.| ..  |||||. .|.  |  ..|...|. .    .|  ..  . .       .| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

CHIIISGIINGLLELHSHQIHHGDLTPANIFLGNKMSPKICNFAFLSQYYQKPEKHFSNYNINFISPERIQLDLSHPL-QGDIWSFGVIIYLLYVKDMPF
.  ..  |...|  .|||.| | || |.||.| .    ||| | .  |.      .      ....|| .    ..     |.||.|.|.| ...   ||
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPF

TQINEIKLIASMISCQYNPPSITNDIIKRLIGAILVPIPEDRPTIEQIKD--------LYF
    .....  .|           .  | .|  .|.  ||.|||. ..           .|
P---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89419.m00166.AA ULK 59-157 25 8.5e-16 51.7 In-house 48-186 (329) Show / Hide 
Range on Protein: 59-157
Range on HMM: 48-186/329
Sequence Identity: 25% (36 aa)

NE-------LIQEIEIIRQLS--------HPNIVRVIDFLNDDIR--MYLITEFFSFMSLEGFLSYNVP-----------NEHQCHIIISGIINGLLELH
.|       |..||.|...|         |||||. .|.....     |.|.|.     || ... | .           .| .. ...  |.||. |||
QEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELH

SHQIHHGDLTPANIFLGNK------------MSPKICNF
.|.| | |. |.|| . |.            .  ||. |
KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF
Kinase 89419.m00166.AA Pkinase 53-155 29 2.6e-12 44.62 Pfam 34-154 (293) Show / Hide 
Range on Protein: 53-155
Range on HMM: 34-154/293
Sequence Identity: 29% (36 aa)

KKANKWNELIQ-----EIEIIRQLSHPNIVRVIDFLNDDIRMYLITEFFSFM----SLEGFLS---YNVP--NEHQCHIIISGIINGLLELHSHQIHHGD
|. .|......     ||.| . |.|||||| .|.  |. ..|...|.        .|  ..|   ...    |..|  ..  |. ||  .||. | | |
KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRD

LTPANIFLGNKMSP----KIC
| |.||.. |.. .    |||
LKPENILIDNNGHIDACVKIC
Kinase 89419.m00166.AA Pkinase 176-266 19 1.3e-11 42.15 Pfam 175-293 (293) Show / Hide 
Range on Protein: 176-266
Range on HMM: 175-293/293
Sequence Identity: 19% (23 aa)

INFISPERIQLDLSHPLQGDIWSFGVIIYLLYVKDMPFTQI------NEIKLIASMISCQYNPPSITN---------------------DIIKRLIGAIL
.....|| |. .  ..   |.||.|.|.| .. .  || .       .....|.   ....  .. .                      .  | .|  .|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

VPIPEDRPTIEQIKDL-YF
 . |..|||.|||.   .|
CKDPKKRPTAEQILQHPWF
Kinase 89419.m00166.AA CAMKL 195-262 33 5.9e-11 31.04 In-house 218-292 (297) Show / Hide 
Range on Protein: 195-262
Range on HMM: 218-292/297
Sequence Identity: 33% (26 aa)

DIWSFGVIIYLLYVKDMPFTQIN-------EIKLIASMISCQYNPPSITNDI--IKRLIGAILVPIPEDRPTIEQIK
|||| ||| | . .  .|| . .        | .   .| |.   | | ...   ..||  .|.. ||.||||.||.
DIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIM
Kinase 89419.m00166.AA CAMKL 51-155 21 1.6e-10 29.61 In-house 29-171 (297) Show / Hide 
Range on Protein: 51-155
Range on HMM: 29-171/297
Sequence Identity: 21% (31 aa)

AVKKAN--KWNE------------------LIQEIEIIRQLS---HPNIVRVIDFLNDDIR------MYLITEFFSFMS--LEGFLSYN-----VPNEHQ
|.|  .  | ..                  . .||.| ..|.   ||||..  . . ..        .||..|  |  .  |  ..  .        ||.
AIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHE

CHIIISGIINGLLELHSHQIHHGDLTPANIFLGNKMS--PKIC
.. .   |. ..  .||| | | |. | || | ....   ||.
ARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKII
TyrKc 89419.m00166.AA TyrKc 17-265 19 7.3e-10 -63.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-265
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

YTMTKILEETRFYQ--RCIVIGMDGASYHCYNFNTAAVKKANK--WNELIQEIEIIRQL--SHPNIVRVIDFLNDD-------IRMYLITEFFSFMSLEG
 |. |.| |  | .  ... .             . |||. ..    ....|..| ..|  .|||||| .    ..         .....|. .  .|  
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLSYNV--PNEHQCHIIISGIINGLLELHSHQIHHGDLTPANIFLGNKMSPKICNFAFLSQYYQKP--------EKHF-----SN--YNINFISPERIQL
.| ..    .  . . .   | .|   |||... | ||   |. .|..   ||. |  || .             ..      ..    |   .|| |  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

DLSHPLQGDIWSFGVIIYLLYVK-DMPFTQ-----INEIKLIASMISCQYNPPSIT---------NDIIKRLIGAILVPIPEDRPTIEQIKDLY
.     . |.||||| .. ..   ..|        .. . .|.   .  . |.             | . ...       |||||| ..|... 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 89419.m00166.AA PLK 122-157 47 8.9e-09 24.83 In-house 109-144 (258) Show / Hide 
Range on Protein: 122-157
Range on HMM: 109-144/258
Sequence Identity: 47% (17 aa)

IINGLLELHSHQIHHGDLTPANIFLGNKMSPKICNF
|..||. ||.|.| | ||...|.||  .|  ||. |
IVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDF
Kinase 89419.m00166.AA PLK 241-267 44 8e-06 14.98 In-house 232-258 (258) Show / Hide 
Range on Protein: 241-267
Range on HMM: 232-258/258
Sequence Identity: 44% (12 aa)

KRLIGAILVPIPEDRPTIEQIKDLYFS
|.|| ..| . |..||||.|| .  | 
KDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 89419.m00166.AA PLK 61-82 63 7e-05 11.95 In-house 46-67 (258) Show / Hide 
Range on Protein: 61-82
Range on HMM: 46-67/258
Sequence Identity: 63% (14 aa)

LIQEIEIIRQLSHPNIVRVIDF
..||||| |||.|||||. ..|
MKQEIEIHRQLHHPNIVKFHHF
Kinase 89419.m00166.AA PLK 177-206 38 9.4e-05 11.52 In-house 165-195 (258) Show / Hide 
Range on Protein: 177-206
Range on HMM: 165-195/258
Sequence Identity: 38% (12 aa)

NFISPERI-QLDLSHPLQGDIWSFGVIIYLL
|.|.||        | .. |.||.|.|.| |
NYIAPEVLDGNKQGHSYEVDCWSLGCIMYTL
Kinase 89419.m00166.AA ULK 195-213 47 0.028831 3.82 In-house 238-256 (329) Show / Hide 
Range on Protein: 195-213
Range on HMM: 238-256/329
Sequence Identity: 47% (9 aa)

DIWSFGVIIYLLYVKDMPF
||||.|.|.| . .   ||
DIWSLGCIFYEMLYGKPPF